• Bulletin of the Korean Chemical Society
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• v.24 no.11
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• pp.1609-1612
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• 2003

The electrooxidation of 8-(3-acetylimino-6-methyl 2,4-dioxopyran)-1-aminonaphthaline (AMDAN) in aqueous and non aqueous media led to the formation of polymeric films, poly (AMDAN). The monomer, undergo anodic oxidation through the formation of a monocation radical irrespective of the nature of the medium. In aqueous medium, the monocation radical undergoes, through its resonance structures, dimerisation involving tail-to-tail, head-to-tail and even head-to-head coupling. The products formed, being more easily oxidisable than the parent substance, undergo further oxidation at the same potential so that the overall oxidation involves a one-step (i.e., a single wave), two-electron process. In non-aqueous medium, the monocation radical does not undergo dimerisation through coupling reactions. Retaining its identity, monomer oxidise in two steps involving one electron in each step. The fact that the cathodic peaks corresponding to these anodic peaks are rarely observed indicates fast consumption of the electrogenerated monocation radicals and dications by follow-up chemical reactions to produce polymeric products (poly AMDAN). The electrochemical behavior of the formed polymer films was investigated in both non aqueous and aqueous media. The films prepared in non aqueous medium were found to be more electroactive than that the films prepared in aqueous medium. This is confirmed with the results in litreature which illustrate that the film prepared in aqueous solution hold water in its structure via hydrogen bonding, which causes decomposition reactions.

• Journal of Microbiology and Biotechnology
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• v.31 no.3
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• pp.349-357
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• 2021

Monoclonal antibodies are widely used as diagnostic reagents and for therapeutic purposes, and their demand is increasing extensively. To produce these proteins in sufficient quantities for commercial use, it is necessary to raise the output by scaling up the production processes. This review describes recent trends in high-density cell culture systems established for monoclonal antibody production that are excellent methods to scale up from the lab-scale cell culture. Among the reactors, hollow fiber bioreactors contribute to a major part of high-density cell culture as they can provide a tremendous amount of surface area in a small volume for cell growth. As an alternative to hollow fiber reactors, a novel disposable bioreactor has been developed, which consists of a polymer-based supermacroporous material, cryogel, as a matrix for cell growth. Packed bed systems and disposable wave bioreactors have also been introduced for high cell density culture. These developments in high-density cell culture systems have led to the monoclonal antibody production in an economically favourable manner and made monoclonal antibodies one of the dominant therapeutic and diagnostic proteins in biopharmaceutical industry.

• Elastomers and Composites
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• v.54 no.2
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• pp.142-148
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• 2019

In this study, the effects of filler particle size and shape on the physical properties of silicone rubber composites were investigated using inorganic fillers (Minusil 5, Celite 219, and Nyad 400) except silica, which was already present as a reinforcing filler of silicone rubber. Fillers with small particle sizes are known to facilitate the formation of the bound rubber by increasing the contact area with the polymer. However, in this experiment, the bound rubber content of Celite 219-added silicone composite was higher than that of Minusil 5-added silicone composite. This was attributed to the porous structure of Celite 219, which led to an increase in the internal surface area of the filler. When the inorganic fillers were added, both thermal decomposition temperature and thermal stability were improved. The bound rubber formed between the silicone rubber and inorganic filler affected the degree of crosslinking of the silicone composite. It is well-known that as the size of the reinforcing filler decreases, the reinforcing effect increases. However, in this experiment, the hardness of the composite material filled with Celite 219 was the highest compared to the other three composites. Furthermore, the highest value of 2.19 MPa was observed for 100% modulus, and the fracture elongation was the lowest at 469%. This was a result of excellent interaction between Celite 219 filler and silicone rubber.

• Earthquakes and Structures
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• v.27 no.2
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• pp.97-111
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• 2024

In this paper, buckling conditions and retrofitting of cylindrical steel water storage tanks with different roof types and wall thicknesses were investigated by using finite element method. Four roof types of cylindrical steel tanks which are open-top, flat-closed, conical-closed and torispherical-closed and three wall thicknesses of 4, 6 and 8 mm were considered in FE modeling of cylindrical steel tanks. The roof shapes significantly affect load distribution on the tank shell under the seismic action. Composite FRP materials are widely used for winding thin-walled cylindrical steel structures. The retrofitting efficiency of cylindrical steel water tank is tested under the seismic loading with the externally bonded CFRP laminates. In retrofitting of cylindrical steel tank, the CFRP composite material coating method was used to improve of seismic performance of cylindrical steel tanks. ANSYS software was used to analyze the cylindrical steel tanks and maximum equivalent (von-Mises) and directional deformation were obtained. Equivalent (von-Mises) stresses significantly decreased due to the coating of the tank shell with FRP composite material. In thin-walled steel structures, excessive stress causes buckling and deformations. Therefore, retrofitting led to decrease in stress, reductions in directional and buckling deformation of the open-top, flat-closed, conical-closed and torispherical-closed tanks.

• Structural Engineering and Mechanics
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• v.91 no.4
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• pp.335-347
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• 2024

This paper presents the behavior of geopolymer concrete beams reinforced with glass fiber reinforced polymer (GFRP) bars. In the study, ordinary Portland cement concrete and geopolymer concrete beams having GFRP bars were prepared and tested under four-point loading. The load-deflection diagrams and load capacities of the tested beams were obtained. It was observed that the tested beams exhibited good ductility and significant deflection capacity. The results showed that increasing the tension GFRP reinforcement ratio caused enhancement in the strength capacity of geopolymer concrete beams. In addition, the tested beams were analyzed to obtain the load capacity and the load-deflection responses. The theoretical load-deflection curves and load bearing capacities have been predicted well with the test results. Parametric study has been performed to determine the influences of concrete strength, shear span to depth ratio (a/d) and reinforcement ratio on the behavior of geopolymer concrete beams longitudinally reinforced with GFRP bars. It was concluded that increasing concrete strength led to an increase in load capacity. Besides, the ultimate load increased as the reinforcement ratio increased. On the other hand, increasing a/d ratio reduced the ultimate load value of GFRP reinforced geopolymer concrete beams.

• Polymer(Korea)
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• v.27 no.5
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• pp.458-463
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• 2003

The effect of ozone surface treatment of montmorillonite (MMT) was investigated in thermal stabilities of polypropylene (PP) nanocomposites. Sodium montmorillonite (Na$\^$+/-MMT) was organically modified with dodecylammonium chloride. The surface properties of MMT, including the specific surface area (S$\_$BET/), equilibrium spreading pressure ($\pi$$\_$e/), and London dispersive component (${\gamma}$s$\^$L/), were studied by the BET method with $N_2$ adsorption. Also, the thermal stabilities of the nanocomposites were investigated in DSC and TGA. As experimental results, $\pi$$\_$e/ and ${\gamma}$s$\^$L/ of the ozonized dodecylammonium chloride (DA-MK ( $O_3$)) were increased in about 1.7 and 3.5 mJ/ $m^2$, resulting from the increasing of the micropores. From the DSC results, it was found that the melting temperature and crystallization temperature of PP/DA-MK and PP/DA-MK ( $O_3$) were higher that those of pure PP. These results were explained that dodecylammonium chloride of nano-scale led to a nucleation effect for PP crystallization. Also, it was found that E$\_$t/ of the PP/DA-MK ( $O_3$) nanocomposies was increased within about 64 kJ/mol. These results were probably explained by the improvement of dispersivity of DA-MK ( $O_3$) in a PP matrix.

• Composites Research
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• v.25 no.4
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• pp.98-104
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• 2012

In recent years, degenerative spinal instability has been effectively treated with a cage. However, little attention is focused on the stiffness of the cage. Recent advances in the medical implant industry have resulted in the use of medical carbon fiber reinforced polymer (CFRP) cages. The biomechanical advantages of using different cage material in terms of stability and stresses in bone graft are not fully understood. A previously validated three-dimensional, nonlinear finite element model of an intact L2-L5 segment was modified to simulate posterior interbody fusion cages made of CFRP and titanium at the L4-L5 disc with pedicle screw, to investigate the effect of cage stiffness on the biomechanics of the fused segment in the lumbar region. From the results, it could be found that the use of a CFRP cage would not only reduce stress shielding, but it might also have led to increased bony fusion.

• Polymer(Korea)
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• v.30 no.5
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• pp.385-390
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• 2006

In this work, the effect of carbon nanofiber (CNF) on thermal properties, and friction and wear behavior of CNF/PMMA composites were examined. While thermal properties of the composites were investigated with differential scanning calorimetry, thermograyimetric analyzer, and dynamic mechanical analyzer friction and wear behaviors were examined using a friction and wear tester. The glass transition temperature (Tg), integral procedural decomposition temperature (IPDT), storage modulus (E'), and tan ${\delta}$ appeared at higher temperatures with increasing CNF content, which were probably attributed to the presence of strong interactions between the carbonaceous fillers and the PMMA resins matrix. The wear loss in the composites decreased at 0.1 wt% CNF and then increased with 5-10 wt% CNF content. This was due to the existence of large aspect ratio CNF in PMMA which led to an alignment of PMMA chains and an increase of mechanical interlocking, resulting in the formation of crosslinked structures between CNF and PMMA in the composite.

• Polymer(Korea)
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• v.32 no.3
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• pp.246-250
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• 2008

Colloidal stability of the biodegradable nanoparticle was characterized by measuring the variation of particle size with time using photon correlation spectroscopy. Three kinds of polymers, namely, poly(D,L-lactide-co-glycolide)(PLGA), PLGA/poly(L-lactide) blends, and PLGA/poly(L-lactide)-g-poly(ethylene glycol) blends were used as matrix material for nanoparticle preparation. Nanoparticles were prepared with or without using poly(vinyl alcohol)(PVA) as suspension stabilizer to evaluate the condition of preparation. Nanoparticles from the blend of amphiphilic graft copolymer with short poly(ethylene glycol) chain and PLGA maintained suspension for 1 day when protein stock solution was introduced. This is somewhat improvement in colloidal stability against protein adsorption compared with that of nanoparticles without PEG moiety. Suspension stabilizer, PVA, had a significant effect on the colloidal stability against freezing and protein adsorption which led to coagulation of nanoparticles. It is important to consider effect of suspension stabilizer as well as materials used to prepare nanoparticle on the colloidal stability.

• Earthquakes and Structures
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• v.5 no.6
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• pp.703-731
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• 2013

In order to verify the applicability of buckling restrained braces (BRB's) and fiber reinforced polymer (FRP) sheets to the seismic strengthening of a low-rise RC building having the irregularities of a soft/weak story and torsion at the ground story, a series of earthquake simulation tests were conducted on a 1:5 scale RC building model before, and after, the strengthening, and these test results are compared and analyzed, to check the effectiveness of the strengthening. Based on the investigations, the following conclusions are made: (1) The BRB's revealed significant slips at the joint with the existing RC beam, up-lifts of columns from RC foundations and displacements due to the flexibility of foundations, and final failure due to the buckling and fracture of base joint angles. The lateral stiffness appeared to be, thereby, as low as one seventh of the intended value, which led to a large yield displacement and, therefore, the BRB's could not dissipate seismic input energy as desired within the range of anticipated displacements. (2) Although the strengthened model did not behave as desired, great enhancement in earthquake resistance was achieved through an approximate 50% increase in the lateral resistance of the wall, due to the axial constraint by the peripheral BRB frames. Finally, (3) whereas in the original model, base torsion was resisted by both the inner core walls and the peripheral frames, the strengthened model resisted most of the base torsion with the peripheral frames, after yielding of the inner core walls, and represented dual values of torsion stiffness, depending on the yielding of core walls.