• Proceedings of the Korean Fiber Society Conference
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• 2003.04a
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• pp.218-220
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• 2003

지방족 폴리에스터계 고분자인 폴리락타이드 (polylactide, PLA), 폴리글리콜라이드 (polyglycolide, PGA) 및 이들의 공중합체인 락타이드-글라이콜라이드 공중합체 (PLGA)는 생체 친화성이고 생분해성이며 물리적 강도가 우수하고 쉽게 성형할 수 있다. 그리고, 전기방사는 수 마이크로에서 수십 나노크기의 지름을 가지는 초극세 섬유인 나노섬유의 제조 기술로서 기존의 섬유 방사방식과는 근본적으로 다른 새로운 방사기술로 산업적인 융용 가능성이 무한한 미래지향적 기술로 최근 주목을 받고 있다. (중략)

• Biomaterials and Biomechanics in Bioengineering
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• v.2 no.2
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• pp.85-96
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• 2015

This study developed biodegradable bi-layered drug-eluting beads and investigated the in-vitro release of fluorouracil and cisplatin from the beads. To manufacture the drug-eluting beads, poly[(d,l)-lactide-co-glycolide] (PLGA) with lactide:glycolide ratios of 50:50 and 75:25 were mixed with fluorouracil or cisplatin. The mixture was compressed and sintered at $55^{\circ}C$ to form bi-layered beads. An elution method was employed to characterize the release characteristic of the pharmaceuticals over a 30-day period at $37^{\circ}C$. The influence of polymer type (i.e., 50:50 or 75:25 PLGA) and layer layout on the release characteristics was investigated. The experiment suggested that biodegradable beads released high concentrations of fluorouracil and cisplatin for more than 30 days. The 75:25 PLGA released the pharmaceuticals at a slower rate than the 50:50 PLGA. In addition, the bi-layered structure reduced the release rate of drugs from the core layer of the beads. By adopting the compression sintering technique, we will be able to manufacture biodegradable beads for long-term drug delivery of various anti-cancer pharmaceuticals.

• Polymer(Korea)
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• v.31 no.3
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• pp.201-205
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• 2007

Biodegradable polymers such as polylactide, polyglycolide and poly (lactide- co-glycolide) (PLGA) have been extensively investigated because of easily controlled drug release rate, completely degradable materials without the toxic by-product, and good biocompatibility. But, according to the bulk erosion property of PLGA in vitro test, it had the disadvantage that first-order release reduced releasing amount slowly after excessive initial burst. In this study we used PLGA powder obtained through recrystallization to revise bulk erosion property of PLGA. The PLGA used in this study was prepared by vacuum drying method and to estimate release profiles of BCNU loaded PLGA wafer. We also evaluated the release profile of drug with the water soluble additive. It was found that the drug loaded PLGA recrystallized by vacuum drying method exhibited the initial burst and the constant rate of drug release compared to that prepared by a conventional method.