• YAKHAK HOEJI
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• v.32 no.1
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• pp.26-39
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• 1988

Eudragit $RS^{\circledR}$ polymer was used as a wall material for the microencapsulation of aspirin by a phase separation method from chloroform-cyclohexane system with 5% polyisobutylene (PIB) in cyclohexane, and microcapsules obtained were evaluated by particle size analysis, scanning electron microscopy (SEM), drug release and drug stability test. With PIB as a coacervation inducing agent, smooth and tight microcapsules with less aggregation were obtained. Below 1 : 0.3 core-wall ratio, it was possible to coat individual particle. Variation of production conditions showed that increasing the proportion of wall material, particle size and wall thickness of microcapsules and the concentration of paraffin wax in cyclohexane as a sealant sustained drug release rates effectively. SEM confirmed that larger microcapsules after drug release did not rupture into smaller particles but contained a few small pores on the surface. Aspirin release from Eudragit $RS^{\circledR}$ coated microcapsules was independent of the pH of medium, and the mechanism of drug release from non-sealed and sealed microcapsules appeared to fit Higuchi matrix model kinetics. Aspirin in the mixture of aspirin microcapsules and sodium bicarbonate was by far more stable than that in the mixture of pure aspirin and sodium bicarbonate.

• Transactions of the Korean Society of Mechanical Engineers
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• v.10 no.3
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• pp.298-304
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• 1986

The friction reduction by dilute polymer solutions was investigated experimentally in journal bearings. Flow pattern visualization and torque measurements were performed for a concentric case (.epsilon.=0). The effects of polymer concentration, bearing clearance, and polymer molecular weight on friction reduction were examined. The frictional torque and the intensity of vortices of the case of polymer solution were reduced compared with those of base oil only.

• The Korean Journal of Rheology
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• v.10 no.3
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• pp.173-183
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• 1998

본 연구에서는 Advanced Rheometric Expansion System(ARES)를 사용하여 대진폭 진동 전단 변형하에서 발생하는 폴리이소부틸렌(PIB) 농후 용액의 비선형 점탄성 거동을 저 장탄성율과 동적점도의 변형량 의존성 및 응력파형의 fast Fourier transform(FFT) 해석을 통해 고찰하였다. 스트레인 진촉을 단계적으로 증가시키면서 측정한 동적 점탄성으로 부터 저장탄성율 및 동적점도의 선형응답한계를 결정하고 이들에 미치는 각주파수의 영향을 조사 하였다. 그리고 응력파형의 Fourier 전개로부터 유도되는 비선형 점탄성함수를 사용하여 비 선형 거동을 설명하였다. 끝으로 비선형 점탄성 거동의 정도를 나타내는 비선형 거동 지수 를 정의하고 이들에 미치는 각주파수의 영향에 대해 검토하였다. 이상의 연구를 통해 얻어 진 결과를 요약하면 다음과 같다.(1) 선형 응답한계는 고분자 용액의 특성시간의 역수보다 높은 각주파수 범위에서는 일정한 값을 유지하지만 특성시간의 역수보다 낮은 각주파수 영 역에서는 각주파수가 감소할수록 증가한다. (2)선형응답한계 이상의 대변형하에서는 3차비선 형 점탄성 함수 이상의 고차항의 영향이 크게 작용하며 이로인해 비선형 거동이 발생된다. (3) 스트레인 진폭을 단계적으로 증가시키면서 측정한 저장탄성율 및 동적점도의 변형량 의 존성은 응력파형의 Fourier transform으로부터 유도된 1차 비선형 점탄성 함수의 변형량 의 존성을 나타낸다 (4) 저장탄성율 및 동적점도의 변형량 의존성으로부터 유도된 비선형 거동 지수는 탄성적 서질과 점성적 성질에 대한 비선형 특성을 평가하기 위한 유요한 방법으로 인정된다. (5) 비선형 점탄성 거동의 정도를 나탄는 비선형 거동지수는 특정한 각주파수에서 최대치를 가지며 또한 탄성적 거동이 점성적 거동에 비해 더욱 큰 각주파수 의존성을 나타낸다.

• The Korean Journal of Rheology
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• v.10 no.4
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• pp.234-246
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• 1998

The objective of this study is to investigate the correlation between steady shear flow (nonlinear behavior) and dynamic viscoelastic (linear behavior) properties for concentrated polymer solutions. Using both an Advanced Rheometic Expansion System(ARES) and a Rheometics Fluids Spectrometer (RFS II), the steady shear flow viscosity and the dynamic viscoelastic properties of concentrated poly(ethylene oxide)(PEO), polyisobutylene(PIB), and polyacrylamide(PAAm) solutions have been measured over a wide range of shear rates and angular frequencies. The validity of some previously proposed relationships was compared with experimentally measured data. In addition, the effect of solution concentration on the applicability of the Cox-Merz rule was examined by comparing the steady flow viscosity and the magnitude of the complex viscosity Finally, the applicability of the Cox-Merz rule was theoretically discussed by introducing a nonlinear strain measure. Main results obtained from this study can be summarized as follows : (1) Among the previously proposed relationships dealt with in this study, the Cox-Merz rule implying the equivalence between the steady flow viscosity and the magnitude of the complex viscosity has the best validity. (2) For polymer solutions with relatively lower concentration, the steady flow viscosity is higher than the complex viscosity. However, such a relation between the two viscosities is reversed for highly concentrated polymer solutions. (3) A nonlinear strain measure is decreased with increasing stran magnitude, after reaching the maximum value in small strain range. This behavior is different from the theoretical prediction demonstrating the shape of a damped oscillatory function. (4) The applicability of the Cox-Merz rule is influenced by the $\beta$ value, which indicates the slope of a nonlinear stain measure (namely, the degree of nonlinearity) at large shear deformations. The Cox-Merz rule shows better applicability as the $\beta$ value becomes smaller.