• 제목/요약/키워드: polyacetylene

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Analysis of Ginsenosides and Non-Saponin Components of Red Ginseng from Landraces and New Varieties

  • Ahn, Seung Il;Kim, Sae Kyul;Yang, Byung Wook;Lee, Eun Sup;Kang, Chang Sung;Hahm, Young Tae
    • 원예과학기술지
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    • 제34권5호
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    • pp.790-798
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    • 2016
  • We quantitatively analyzed eight varieties of 6-year-old red ginseng, including four local landraces from the Inje, Geumsan, Jinan, and Punggi regions and four new varieties, Chunpoong, Yunpoong, Guempoong, and K-1, for 10 ginsenosides, acidic polysaccharide, crude polyacetylene, and total polyphenol content to find out which varieties are most suitable for producing red ginseng. Most of the new varieties contained more ginsenosides than the local landraces. While the acidic polysaccharide content of Geumsan red ginseng was lower than that of the others, its crude polyacetylene content was the highest, with a mean of 33.99%. The Inje, Geumsan, and Jinan red ginseng had a significantly higher total polyphenol content than the others.

활성화한 RAW 264.7 세 포주에서 인삼 Polyacetylene류의 Nitric Oxide 생성저해 (Inhibitors of Nitric Oxide Synthesis from Ginseng in Activated Macrophages)

  • 류재하;장세란
    • Journal of Ginseng Research
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    • 제22권3호
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    • pp.181-187
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    • 1998
  • Nitric Oxide (NO), derived from L-arginine, is produced by two types (constitutive and inducible) of nitric oxide synthase (NOS). The NO produced in large amounts by the inducible NOS is known to be responsible for the vasodilation and hypotension observed in septic shock. We have found three polyacetylene compounds which inhibited the production of NO in LPS-activated RAW 264.7 cells. Their structures were identified as panauynol, ginsenoyne A and PQ-6 by the spec- troscopic analysis (IC50 values were 32.3 $\mu$M, 2.3 $\mu$M, 1.5 $\mu$M, respectively). These polyacetylenes may be useful candidates for the development of new drug to treat endotoxemia and inflammation accompanied by the overproduction of NO.

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도라지(Platycodon grandirorum) 뿌리조직에서 고농도 함유 모상근의 유도 및 배양 (Induction and Culture of High Polyacetylene-Yielding Hairy Roots in Ballon Flower (Pathycodon grandiflorum))

  • Hwang, Baik
    • Journal of Plant Biology
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    • 제38권4호
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    • pp.337-341
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    • 1995
  • Hairy roots of Korean ballon flower (Platycodon grandiflorum A. DC) were induced from the root tissues infected with Agrobacterium rhizogenes ATCC 15834. Growth and polyacetylene [lobetyol (1), lobetyolin (2) and lobetyolinin (3)] production fo ten hairy root clones cultured in 1/4 Gamborg B5 (B5) liquid medium were determined. One selected hairy root clone (D6) grew well in hormone free-B5 liquid medium and showed maximum content of polyacetylenes at week 6 for 1 (0.375% dry wt) and at week 7 for 2 and 3 (3.030% and 0.206% dry wt, respectively) whose levels were much higher than those of the intact plant root (1:0.019%, 2:0.077% dry wt, 3 was not detected).

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Polyacetylene Compounds from Panax Ginseng C. A. Meyer

  • Shim, Sang-Chul;Koh, Hun-Yeoung;Han, Byung-Hoon
    • Bulletin of the Korean Chemical Society
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    • 제4권4호
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    • pp.183-188
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    • 1983
  • Two major and two minor polyacetylenes were isolated from fresh white Korean ginseng roots. The petroleum ether-ethyl ether fractions containing the polyacetylene compounds were collected through solvent fractionation, partition and silica gel column chromatography. Further separation of polyacetylenic fractions was proceeded by bonded normal phase HPLC utilizing a moderately nonpolar microparticulate column. The low pressure liquid chromatography was used for the semi-preparative separation. The chemical structures of the two major polyacetylenes separated were determined by UV, IR, $^1H$ NMR, $^{13}C$ NMR, mass spectra and elemental analysis. One of them is identified to be heptadeca-1-en-4, 6-diyne-3, 9, 10-triol, a new structure, and the other is heptadeca-1, 9-dien-4, 6-diyn-3-ol, known as panaxynol.

New Polyacetylene Compounds from Panax Ginseng C. A. Meyer$^\dag$

  • Shim, Sang-Chul;Chang, Suk-Ku;Hur, Chan-Woo;Kim, Chang-Kew
    • Bulletin of the Korean Chemical Society
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    • 제8권4호
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    • pp.272-275
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    • 1987
  • Two polyacetylene compounds having diyn-ene chromophore were isolated from fresh Korean ginseng roots through solvent fractionation, partition and silica gel column chromatography. The low pressure semi-preparative liquid chromatography and high performance preparative liquid chromatography were used for final separation of polyacetylenic fractions. The chemical structures of these polyacetylenes were determined to be heptadeca-1,8-dien-4,6-diyn-3,10-diol and heptadeca-1,4-dien-6,8-diyn-3,10-diol by UV, FT-IR, $^1H\;NMR,\;^{13}C\;NMR,$ mass spectra and elemental analysis.