• Proceedings of the PSK Conference
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• 2002.10a
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• pp.200-200
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• 2002

Cadmium (Cd) is an environmental pollutant and categorized as a human carcinogen, which has a tendency to accumulate in the human body. The level of Cd in renal cortex and liver are good indicators as an index of Cd exposure in general population. Geometric mean concentration of Cd is 27.4 and 3.1 /g wet weight in renal cortex and liver, respectively, in Korean. Cd is toxic to a number of tissues, notably the liver, kidney, testis, lung, lymphoid tissue and lung. (omitted)

• Journal of Yeungnam Medical Science
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• v.28 no.2
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• pp.105-115
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• 2011

Mercury is a toxic, persistent pollutant that bioaccumulates and biomagnifies through food webs. People are exposed to methyhnercruy mainly through their diet, especially through the consumption of freshwater and marine fish and of other animals that consume fish (e.g., marine mammals). All humans are exposed to low levels of mercury. Dietary patterns can increase exposure to a fish-eating population where the fish and seafood are contaminated with mercury. The primary toxicity targets of mercury and mercury compounds are the nervous system, kidneys, and cardiovascular system. It is generally accepted that developing organ systems are most sensitive to the toxic effects of mercury. The fetal-brain mercury levels appear to be significantly higher than the maternal-blood mercury levels, and the developing central nervous system of the fetus is currently regarded as the main system of concern as it demonstrates the greatest sensitivity. The subpopulation that may be at greater risk for mercury toxicity are those exposed to higher levels of methylmercury due to carnivorous fish, including sharks.

• Toxicological Research
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• v.33 no.3
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• pp.233-238
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• 2017

Xylene is a cyclic hydrocarbon and an environmental pollutant. It is also used in medical technology, paints, dyes, polishes and in many industries as a solvent; therefore, an understanding of the interaction between xylene and human lymphocytes is of significant interest. Biochemical assessment was used to demonstrate that exposure of lymphocytes to xylene induces cytotoxicity (at 6 hr), generates intracellular reactive oxygen species, collapse of mitochondrial membrane potential, lysosomal injury, lipid peroxidation and depletion of glutathione (at 3 hr). The findings show that xylene triggers oxidative stress and organelle damage in lymphocytes. The results of our study suggest that the use of antioxidant, mitochondrial and lysosomal protective agents can be helpful for individuals subject to chronic exposure to xylene.

• Proceedings of the Korea Water Resources Association Conference
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• 2007.05a
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• pp.909-910
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• 2007

The volatile organic compounds exposure is governed by the source distance and dispersion of the pollutant into air and groundwater. The purpose of this study was to validate suggested models for the prediction of concentration distributions. The study design was organized into different methods to simulate industry site. The distribution models generally showed a fair agreement with measured data. For graphical representation of concentration of volatile hydrocarbon, it has to obtain a continuous representation of the contamination of the site. Therefore, the used interpolative methods examined for this project are the IDW(inverse Distance Weighting) and kriging method. In the results, in summary, all two different methods can be used to quantify exposures at a particular source area, and thus provide, a solid foundation for making risk-based decisions. All the calculations can be performed using Excel's built-in functions, and the capabilities of geospatial analysis allow the results to be displayed visually. However, anyone who uses these methods should understand all of the assumptions and limitation.

• Clinical and Experimental Pediatrics
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• v.62 no.1
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• pp.22-29
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• 2019

Particulate matter (PM) is a ubiquitous air pollutant that is a growing public health concern. Previous studies have suggested that PM is associated with asthma development and exacerbation of asthma symptoms. Although several studies have suggested increased risks of atopic dermatitis, allergic rhinitis, and allergic sensitization in relation to PM exposure, the evidence remains inconsistent. The plausible mechanisms underlying these effects are related to oxidative stress, enhancement of sensitization to allergens, inflammatory and immunological responses, and epigenetics. This review discusses the effect of PM on childhood allergic diseases, along with plausible mechanisms. Further studies are required to understand the role of PM exposure on childhood allergic diseases, to reduce these diseases in children.

• Asian Pacific Journal of Cancer Prevention
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• v.16 no.6
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• pp.2347-2350
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• 2015

Childhood acute lymphoblastic leukemia (ALL) is one of the most common hematologic malignancies, accounting for one fourth of all childhood cancer cases. Exposure to environmental factors around the time of conception or pregnancy can increase the risk of ALL in the offspring.This study aimed to evaluted the role of prenatal and postnatal exposure to high voltage power lines on the incidence of childhood ALL.This cross-sectional case control study was carried out on 22 cases and 100 controls who were born and lived in low socioeconomic families in Isfahan and hospitalized for therapeutic purposes in different hospitals from 2013-2014.With regard to the underlying risk factors, familial history and parental factors were noted but in this age, socioeonomic and zonal matched case control study, prenatal and childhood exposure to high voltage power lines was considered as the most important environmental risk factors of ALL (p=0.006, OR=3.651, CI 95%, 1.692-7.878). As the population was of low socioeconomic background, use of mobiles, computers and microwave was negligible. Moreover prenatal and postnatal exposure to indoor electrically charged objects was not determined to be a significant environmental factor. Thus, pre and post natal exposure to high voltage power lines and living in pollutant regions as well as familial influence could be described as risk factors of ALL for the first time in a low socioeconomic status Iranian population.

• Asian Pacific Journal of Cancer Prevention
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• v.16 no.17
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• pp.7613-7618
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• 2015

Childhood acute lymphoblastic leukemia (ALL) is one of the most common hematologic malignancies which accounts for one fourth of all childhood cancer cases. Exposure to environmental factors around the time of conception or pregnancy can increase the risk of ALL in the offspring. This study aimed to evaluate the influence of prenatal and postnatal exposure to high voltage power lines on the incidence of childhood ALL. It also examines the role of various factors such as environmental factors and alpha-amylase as a marker in the development of leukemia.This cross-sectional case control study was carried out on 22 cases and 100 controls who born and lived in low socioeconomic families in Tehran and were hospitalized for therapeutic purposes in different hospitals ofrom 2013-2014. With regard to the underlying risk factors; familial history and parental factors were detected as risk factors of ALL but in this age, socioeonomic and zonal matched case control study, prenatal and childhood exposure to high voltage power lines was considered as the most important environmental risk factor (p=0.006, OR=3.651, CI 95% 1.692-7.878). As the population study was from low socioeconomic state, use of mobiles, computers and microwaves was negligible. Moreover prenatal and postnatal exposure to all indoor electrically charged objects were not detected as significant environmental factors in the present study. This work defined the risk of environmental especially continuous pre and postnatal exposure to high voltage power lines and living in pollutant regions through the parents or children as well as the previously described risk factors of ALL for the first time in low socioeconomic status Iranian population.

• Korean Journal of Environmental Biology
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• v.27 no.4
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• pp.391-396
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• 2009

The biological effects of carcinogenic polycyclic aromatic hydrocarbons (cPAHs) including benzo[a]pyrene (BaP), dibenzo[a,h]anthracene (DBA), benzo[a]anthracene (BaA), benzo[b] fluoranthene (BbF), benzo[k]fluoranthene (BkF), and indeno[1,2,3-c, d]pyrene (InP) on transcriptomic changes were determined in the liver of Oryzias latipes. Differentially expressed genes (DEGs) by binary exposure to cPAHs (BaP+BaA, BaP+BbF, BaP+BkF, BaP+DbA, BaP+InP) were screened by annealing control primers-based polymerase chain reaction followed by sequence analysis and BLAST searching. The results showed that four DEGs were commonly expressed by cPAHs and they were identified as ribosomal protein S4, coagulation factor II, elongation factor 1 beta, and a predicted protein similar to human immunodeficiency virus type I enhancer binding protein 3. This finding suggests that binary exposure to cPAHs interferes protein synthesis required for fundamental liver functions in fish.

• Journal of Korean Society for Atmospheric Environment
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• v.7 no.2
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• pp.119-126
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• 1991

Air pollution is directly and indirectly associated with the toxicology through the increase of mortality, the decrease of oviposition rate, and the decline of insect population, as well as the disruption of equilibria with higher or lower trophic levels. To investigate intrinsic decrease rates, oviposition period, and emerging rates of pupae of house fly under air pollution stresses, healthy individuals of Musca domestica L. were collected in the field, cultured in the laboratory for 2 $\sim$ 3 generations, and artificially exposed to $O_3 (4 ppm) in automatically controlled air pollutant fumigation chambers. Results from this study are summarized as follows: 1. Survivorship curves of both control group and exposed groups of healthy house fly to 4 ppm $O_3$ have linearly or stair-like decreasing trends of revers S-shape. 2. For cohorts exposed to 4 ppm of $O_3$, intrinsic decrease rate of cohort exposed for 2 hours significantly increases compared to that of control group, slight increases were observed for those exposed for 4 hours and 8 hours, which shows no distinct relationships between exposure period and intrinsic decrease rate. 3. While the numbers of pupae of exposed cohorts increase with the increase of exposure period, emerging rate shows a distinct decrease. 4. The relationships between emerging rate (E) of pupae and the exposure period (T) for cohorts exposed to 4 ppm of $O_3$ are expressed with the equation, E (%)=21.027 - 7.942 ln (T).

• Journal of Preventive Medicine and Public Health
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• v.34 no.2
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• pp.119-126
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• 2001

Air pollution epidemiologic studies are intrinsically difficult because the expected effect size at general environmental levels is small, exposure and misclassification of exposure are common, and exposure is not selective to a specific pollutant. In this review paper, epidemiologic study designs and analytic methods are described, and two nationwide projects on air pollution epidemiology are introduced. This paper also demonstrates that possible confounding issues in time-series analysis can be resolved and the impact on the use of data from ambient monitoring stations may not be critical. In this paper we provide a basic understanding of the types of air pollution epidemiologic study designs that be subdivided by the mode of air pollution effects on human health (acute or chronic). With the improvements in the area of air pollution epidemiologic studies, we should emphasize that elaborate models and statistical techniques cannot compensate for inadequate study design or poor data collection.