• 고려인삼학회:학술대회논문집
• /
• 고려인삼학회 1988년도 학술대회지
• /
• pp.11-18
• /
• 1988

인삼 추출물의 피부도말에 의한 미용효과는 거의 연구된 바 없다. 미용에 관한 문헌을 고찰해 보아도, 늘어지거나 주름진 피부를 활성화 시켜주고, 건성이나 유성피부에 바람직한 효과가 있다고 강조한 연구결과는 거의 없다. 인삼의 지용성추출물 제제 몇가지가 피부내성에 관하여 설명된 것이 없는 반면 노화된 피부에 관한 주제로 피부에 영향을 준다는 효과는 관찰되어 지고 있다. 본 연구는 "Phytosome" 라고 명명한 인삼 사포닌과 인지질의 물리화학적 상호작용에 의하여 얻어진 특정 추출 유도체의 제조방법에 관한 것이다. 이 복합물들은 NMR spectroscopy와 electron-microscopy로 확인되었다. 더욱이 이들은 새롭고 안정하며 수성 liposome 형태구조안에 수성미세분산형이다. 이 화합물들의 미용효과는 노화피부에 대한 영향과 피부층의 수화능력과 피부탄력성을 연구하기 위하여 corneometry elastometry를 이용하여 실험하였다.

• Asian Pacific Journal of Cancer Prevention
• /
• 제15권13호
• /
• pp.5311-5316
• /
• 2014

Nuclear factor erythroid 2-related factor 2 (Nrf2) has been recognized as a transcription factor that controls mechanisms of cellular defense response by regulation of three classes of genes, including endogenous antioxidants, phase II detoxifying enzymes and transporters. Previous studies have revealed roles of Nrf2 in resistance to chemotherapeutic agents and high level expression of Nrf2 has been found in many types of cancer. At physiological concentrations, luteolin as a flavonoid compound can inhibit Nrf2 and sensitize cancer cells to chemotherapeutic agents. We reported luteolin loaded in phytosomes as an advanced nanoparticle carrier sensitized MDA-MB 231 cells to doxorubicin. In this study, we prepared nano phytosomes of luteolin to enhance the bioavailability of luteolin and improve passive targeting in breast cancer cells. Our results showed that cotreatment of cells with nano particles containing luteolin and doxorubicin resulted in the highest percentage cell death in MDA-MB 231cells (p<0.05). Furthermore, luteolin-loaded nanoparticles reduced Nrf2 gene expression at the mRNA level in cells to a greater extent than luteolin alone (p<0.05). Similarly, expression of downstream genes for Nrf2 including Ho1 and MDR1 were reduced significantly (p<0.05). Inhibition of Nrf-2 expression caused a marked increase in cancer cell death (p<0.05). Taken together, these results suggest that phytosome technology can improve the efficacy of chemotherapy by overcoming resistance and enhancing permeability of cancer cells to chemical agents and may thus be considered as a potential delivery system to improve therapeutic protocols for cancer patients.