• 동의생리병리학회지
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• 제19권6호
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• pp.1504-1512
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• 2005

We will develop new sasang constitution diagnosis program. Therefore we need new golden standard for sasang constitution diagnosis. First, we investigated old records and journal of sasang constitutional medicine. Next, we consulted with 10 sasang constitutional experts about new golden standard for sasang constitution diagnosis. The result as follows : Golden standard for Taeyangin : It be made up 42 items(body type 6 items, external appearance 10 items, mental characteristics 16 items, physiology&pathologic symptoms 10 items). (2) Golden standard for Soyangin. It be made up 63 items(body type 7 items, external appearance 28 items, mental characteristics 17 items, physiology&pathologic symptoms 10 items). (3) Golden standard for Taeeumin : It be made up 71 items(body type 12 items, external appearance 19 items, mental characteristics 28 items, physiology&pathologic symptoms 12 items). (4) Golden standard for Soeumin : It be made up 54 items(body type 11 items, external appearance 13items, mental characteristics 21 items, physiology&pathologic symptoms 9 items).

• 동의생리병리학회지
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• 제20권1호
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• pp.209-214
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• 2006

This study is validity study of the questionnaire for doctors for Sasang constituion diagnosis. (an objects of this study : 314 patients) We analyzed the results of questionnaires about 314 patients who were diagnosed in Department of Sasang Constitutional Medicine from June to November, 2004. The questionnaire for doctors consists of objective valuation about the patients for Sasang constituion diagnosis. In the analysis about all variables, we obtain the diagnosis accuracy of 92%. In the analysis about body type variable, we obtain the diagnosis accuracy of 44-48%. In the analysis about external appearance, mental characteristics, physiology & pathologic symptoms variables, we obtain the diagnosis accuracy of 46-72%. After all, in order to increase of the diagnosis accuracy, we have to analysis total variables(body type, external appearance, mental characteristics, physiology & pathologic symptoms) for sasang constituion diagnosis. Hereafter, We need many data and standardization for sasang constituion diagnosis.

• 동의생리병리학회지
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• 제32권4호
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• pp.211-216
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• 2018

Generally, clause 273 of Shanghan-lun was called as a principle of Taeeum-byung and was regarded that it contains essential substances of Taeeum-byung. In this study, I compared the text of diverse woodblock-printed versions, the opinions of many annotators, and other clauses of Shanghan-lun which related with clause 273 in pathologic view points. As results, "the symptoms become worsen by purgative medicine" of remained version is more reasonable rather than "diarrhea become worsen" of Song version, in the side of pathologic interpretation of Taeeum-byung and to understand the reason of mistreatment. In addition, the symptoms of "an intermittent and autonomous abdominal cramp" and "feeling hard on sub-chest region" should be recognized as transformed symptoms by mistreatment of purgative medicine. Thus, diarrhea cannot be accepted as a peculiar symptom of Taeeum-byung, but should be regarded as a possible symptom transformed from Taeeum-byung or its preceding diseases by purgative medicine.

• 동의생리병리학회지
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• 제21권4호
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• pp.835-841
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• 2007

The followings are concluded from the treatment of headache in Hyungsang medicine, focussed on 11 kinds of headaches in Donguibogam. Headache is classified into overall headache and migraine according to the affected region. The causes are divided into exogenous affection and internal injury; The former brings on headache due to Wind-Cold and headache due to Damp-Heat. The latter, reversal headache, headache due to adverse rising of phlegm, headache due to regurgitation of Gi, headache due to excessive Heat, headache due to excessive Damp, true headache, and alcoholic headache. Headache due to internal injury generally tends to show deficiency syndrome with external affection. Headache due to exogenous affections is common to those who have big head or white skin and to Bangkwang type, and woman. The primary causes are Wind-Cold and Wind-Heat. When the body is observed in the perspective of eight phases, Damp-Heat is to be produced in the front, and Dry-Damp, in the back. Headache due to Damp-Heat is susceptible to Yangmyeong meridian type whose body develops more in the front and to woman. In the perspective of the upper and the lower, Yangdu(that is, head) is related to Eumdu(that is, glans of penis). Headache is also caused by the problems of Eumdu ,such as deficiency of Essence in man, pathologic change of uterus in women, and San syndrome in lower abdomen. In the case of man, headache is frequently severe and difficult to treat because head is a root for man. Disharmony of Gi and blood between the right and the left brings out migraine and headache due to regurgitation of Gi. Migraine is usually accompanied by symptoms of exogenous affection and often afflicts Gi-type, Shin-type, Soyang meridian type, deer type, and Dam-type. Headache due to regurgitation of Gi is brought by Gi deficiency or blood deficiency so that symptoms of exogenous affection do not show. It is mainly common with old people and those who have sunken eyes induced by deficiency of stomach Gi. In the perspective of the upper, the middle, and the lower, the pathologic change of head, chest and abdomen also bring about headache. The pathologic cause of head is Wind-Heat ,which triggers overall headache, migraine, headache due to Wind-Cold, headache due to excessive Heat, The pathogen of chest is phlegm-Fire and brings out headache due to Damp-Heat and headache due to adverse rising of phlegm. The pathologic factor in abdomen is Cold-Damp and produces headache due to adverse rising of phlegm and headache due to excessive Damp. In case of women, headache is generally caused by phlegm-Fire and retention of undigested food.

• 동의생리병리학회지
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• 제22권1호
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• pp.252-255
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• 2008

Phlegm-retention disease, which is called dameum(痰飮), is a kind of a pathologic secretion products, accumulated excessive water in a special part of a body. Urticaria is a common dermatopathy, coming under “eun-jin(隱疹)” in Korean herbal medicine. Headache and vertigo is a very common diseases in life. There are so many causes which induce uticaria, headache and vertigo. We experienced 31-year old woman case suffering from chronic urticaria, headache, vertigo with digestive disorder, nausea. We diagnosed those symptoms as dameum(痰飮). So we administered Jeongjeongamiyijintang-gamibang(正傳加味二陳湯加味方) to the urticaria, and Banhabaekchulcheonma-tang (半夏白朮天麻湯) to the headache, vertigo. They are both famous herbal medicines for treating dameum-related symptoms, because both of them contains Yijin-tang(二陳湯) which is the main Herbal medicine for dameum(痰飮). We suggest that dameun-related urticaria, headache, vertigo can be treated by preceding medicines.

• 동의생리병리학회지
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• 제22권4호
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• pp.914-917
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• 2008

Primary carcinoma of the fallopian tube is exceedingly rare, accounting for 0.3 percent of female genital tract cancer. It is usually unilateral, but 20 percent of cases are bilateral. It occurs most commonly in women between 40 and 60 years old. Approximately 50 percent of the patients are nulliparous. Because of variable presenting symptoms and rarely incidence, preoperative diagnosis of fallopian tube carcinoma is seldom made. Evaluation and treatment are also essentially the same at that of ovarian carcinoma. We experienced a case of bilateral primary fallopian tube carcinoma in women presented with vaginal bleeding and pelvic mass, postoperatively pathologic examination of resected specimen after laparatomy and reported with brief review of literature.

• 동의생리병리학회지
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• 제23권6호
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• pp.1267-1272
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• 2009

The purpose of this study is to survey the importance of items for the physiological and pathological symptoms for estimating a health condition according to Sasang constitution to establish the SHI(Sasangin Health Index) which will reflect the concept of inherent vitality. We surveyed expert opinion with questionnaires from 20 Sasang constitution specialists. The questionnaire was composed of 57 items on physiological and pathological symptoms and specialist opinions. Each item was marked from A to E according to importance in evaluating health state in each constitution, and if the mean score of an item was over 3.0, the item was regarded as important. Important indexes among physiological symptoms were diet, digestion condition, perspiration condition, frequency of defecation, heat and cold response, and temperature of drinking water in Soeumin, pathologic perspiration and defecation condition in Soyangin, repast, perspiration condition, and the amount of drinking water in Taeeumin, and urination frequency in Taeyangin. Important indexes among pathological symptoms were sighing, indigestion, and abdominal pain in Soeumin, oral condition, chest distress, brash, and amnesia in Soyangin, eye condition, palpitation, and edema in Taeeumin, and vomiting and incapacity of the lower limbs in Taeyangin. There are different health evaluating index and priority order in it according to Sasang constitution.

• 동의생리병리학회지
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• 제16권4호
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• pp.630-636
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• 2002

After The Yellow Emperor's Canon of Internal Medicine, The text researches of pathologic change to the liver disease concluded the next, 1, The category of liver-disease(肝病) include the Symptoms of abnormality due to vital energy and blood motion, emotion and intention, muscular and reproductive function, and legions around descending liver channel. 2. In the theory that Liver-Yang energy(肝陽氣) is always overproducing, Liver-Yin blood(肝陰血) is always lacking, pathologic characteristics for liver disease is functional change of malfunction of the use of body(體用失調), So nourishing the liver and kidney is used for the principal aspects of a disease. regulating and calm the liver is used for the secondary aspects of a disease as the treatment plan, 3. If malfunctioning of the functions of dispersion and discharge(疏泄), Iiver-energy(肝氣) is becoming degected, So overproduct and overflow of ascent and exhalation of liver-yang(肝陽) is becoming blood are ascending following energy. complete usage of Yin-blood(陰血) is responsible for some kinds of mass formed by blood stasis in the early stage of pathogenesis of liver disease syndrome of the energy system as the progession of disease extravasated blood is forming. the pathologic characteristics is appeared loss of control of the vital energy and blood(體用失調) at the liver disease. 4. Sthenia-syndrome of liver(肝實證) and liver-heat syndrome(肝熱證) is appered that overproducing and overflow of dispersion(疏泄太過) and discharge is responsible for overfunctioning of liver disease or some kinds of heat syndrome such as liver fire(肝火), Sthenia of liver-yang(肝陽上亢), the syndromes of sthenic liver heat(肝實熱) are appered. deficiency of the liver(肝虛證) and cold syndrome of liver(肝寒證) is classified pathologic characteristics of cold and heat, deficiency and excess that regression of sensory, motor, mental due to lack of dispersion and discharge(疏泄不及), or intruding of the cold miasma, are degected. 5. The liver is close relation of physiologic function and internal organ such as spleen, stomach, lung, heart, kidney, gall bladder by the meridian channels, because of property of wind Zang, rapid progession is classified by phthologic charateristics.

• The Korean Journal of Physiology and Pharmacology
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• 제8권3호
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• pp.117-127
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• 2004

The heterodimeric amino acid transporter family is a subfamily of SLC7 solute transporter family which includes 14-transmembrane cationic amino acid transporters and 12-transmembrane heterodimeric amino acid transporters. The members of heterodimeric amino acid transporter family are linked via a disulfide bond to single membrane spanning glycoproteins such as 4F2hc (4F2 heavy chain) and rBAT $(related\;to\;b^0,\;^+-amino\;acid\;transporter)$. Six members are associated with 4F2hc and one is linked to rBAT. Two additional members were identified as ones associated with unknown heavy chains. The members of heterodimeric amino acid transporter family exhibit diverse substrate selectivity and are expressed in variety of tissues. They play variety of physiological roles including epithelial transport of amino acids as well as the roles to provide cells in general with amino acids for cellular nutrition. The dysfunction or hyperfunction of the members of the heterodimeric amino acid transporter family are involved in some diseases and pathologic conditions. The genetic defects of the renal and intestinal transporters $b^{0,+}AT/BAT1\;(b^{0,+}-type\;amino\;acid\;transporter/b^{0,+}-type\;amino\;acid\;transporter\;1)$ and $y^+LAT1\;(y^+L-type\;amino\;acid\;transporter\;1)$ result in the amino aciduria with sever clinical symptoms such as cystinuria and lysin uric protein intolerance, respectively. LAT1 is proposed to be involved in the progression of malignant tumor. xCT (x-C-type transporter) functions to protect cells against oxidative stress, while its over-function may be damaging neurons leading to the exacerbation of brain damage after brain ischemia. Because of broad substrate selectivity, system L transporters such as LAT1 transport amino acid-related compounds including L-Dopa and function as a drug transporter. System L also interacts with some environmental toxins with amino acid-related structure such as cysteine-conjugated methylmercury. Therefore, these transporter would be candidates for drug targets based on new therapeutic strategies.

• 동의생리병리학회지
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• 제23권3호
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• pp.521-527
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• 2009

According to <> and <>, Taeum is strongly related to dampness, earth, and canter. The origin of Taeum is dampness and the presentation of it is dryness, thus spleen plays a greater role than lung in physiologic and pathologic aspect. Taeum meridian cooperates with Soeum and Guelum meridian, and spreads yin gi through spleen and lung meridian. Among six meridian types that are invented by Ji-San, Taeum type possesses lowered eyes and nose and displays characteristics of Taeum disease. Instead of five jang organs and six bu orqans, meridians are major factor of Taeum type. Thus SiDongByung (disease of gi) and SoSaengByung (disease of blood) are considered more significantly than internal and external symptoms of organs. Personality of Taeum type is realistic, pragmatic, diligent, and occasionally selfish. Medications for Taeum type are described as following. GwakHyangJungKi-San or InSamYangWi-Tang can be considered for the complication of intrinsic and extrinsic diseases, which are caused by yin symptom of SangHan. If cold stomach affected by Taeum disease causes an abdominal pain and diarrhea, YiJoong-Tang or PalMiYiJoong-Tang are suggested.