• 한국주거학회논문집
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• 제11권1호
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• pp.57-68
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• 2000

This study has been performed to review critical issues affecting continuous residence in profit(self-paid) assistant living facilities for the elderly in the United States. There are three factors influencing continuous residence of frail elderly in the facilities as long as they want without involuntary discharge : Financial ability, behavioral aspects, and facility management situation. Regarding financial ability, income, purchase of insurance policy, cashable assets, willingfulness to pay, and health status were found to be crucial determinants of continuous residence. Overall, 40-50% of those aged 65+ are financially able to stay in the assistant facilities as long as they want, without involuntary discharge. As for behavioral aspects, extroversions, congeniality, culture & life style, conscientiousness, preference for person, and physiological habits were found to be crucial determinants of continuous residence. As for the management situation, it is essential that facilities reach nature level of self-governing rights of the older residents and good local images, and conflicts among the residents and managing parties be resolved on the agreeable standards of inspectors. finally in this study, it is proposed that in Korea, national pension authority offer a liability package for assistant residence, for the case of individual bankruptcy.

• 전기학회논문지
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• 제56권11호
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• pp.2051-2057
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• 2007

In Oriental medicine, the status of a tongue is the important indicator to diagnose one's health like physiological and clinicopathological changes of inner parts of the body. The method of tongue diagnosis is not only convenient but also non-invasive and widely used in Oriental medicine. However, tongue diagnosis is affected by examination circumstances a lot like a light source, patient's posture and doctor's condition. To develop an automatic tongue diagnosis system for an objective and standardized diagnosis, segmenting a tongue is inevitable but difficult since the colors of a tongue, lips and skin in a mouth are similar. The proposed method includes preprocessing, graph-based over-segmentation, detecting positions with a local minimum over shading, detecting edge with color difference and estimating edge geometry from the probable structure of a tongue, where preprocessing performs down-sampling to reduce computation time, histogram equalization and edge enhancement. A tongue was segmented from a face image with a tongue from a digital tongue diagnosis system by the proposed method. According to three oriental medical doctors' evaluation, it produced the segmented region to include effective information and exclude a non-tongue region. It can be used to make an objective and standardized diagnosis.

• Journal of Oral Medicine and Pain
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• 제40권1호
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• pp.3-9
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• 2015

The etiopathogenesis of burning mouth syndrome (BMS) seems to be complex and many patients probably involves interactions among local, systemic, and/or psychological factors in the pathophysiologic mechanism. Although there are controversies over whether the psychological factor is a cause or a result of BMS, several studies have supported strong relationships between psychological factors and chronic pain. It has been suggested that somatic complaints from unfavorable life experiences may influence both individual personality and mood changes; however, initiation of BMS symptoms is not necessarily correlated with stressful life events despite their elevated psychological stress. If the psychological distress is not a causal factor of BMS, it seems that BMS patients may be particularly vulnerable to psychological problems, primarily depression, anxiety, and hostility due to the characteristic entities of BMS such as chronic persistent pain itself. It seems likely that both physiological and psychological factors play a role in causing, perpetuating and/or exacerbating BMS; therefore, both two components of the patient's symptoms must be addressed. The acceptance of psychological factors by the patient is often an important element of BMS, management. The evaluation of psychological and emotional status of BMS patient enables clinicians to recognize prolonged negative and subclinical factors which can complicate the management of pain or indirectly perpetuate other physical factors. This evaluation improves the doctor-patient relationships, motivation, and compliance through a correct understanding of the clinical problem. Appropriate emotional and psychological evaluation may be required prior to developing a treatment plan in order to gain the successful treatment outcome.

• 한국식생활문화학회지
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• 제8권2호
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• pp.103-116
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• 1993

The purpose of this study was to assess the nutrition education and training needs as a basis for program planning for day care children. Nutrition achievement test developed by American National Dairy Council and Iowa state University was modified and used for measuring the level of basic knowledge of food and nutrition for day care children. The results of this study can be summarized as follows 1. Over 70% of mothers indicated their children had a certain degree of food behavior and feeding problems in terms of unbalanced food habit, irregular meal period. 2. Mean score for the nutrition achievement test for day care children was 9.3. 3. The nutrition achievement test score for children with high socio-economic status was significantly higher than those of children with middle and lower group. 4. Inspection of the difficulty difference indices showed that over the 50% of the children had more items that were easier in the content of physiological facts than in the food handling and social psychological aspects of foods.

• 동의생리병리학회지
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• 제23권6호
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• pp.1503-1507
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• 2009

The objectives of this study were to examine the present state of Oriental clinical service based on Constitutional medicine and to make an accurate estimate of it's scale in 2015. The data for this study were collected from a questionnaire survey to 335 Traditional Korean Medical doctors who were selected as random samples. And this questionnaire is consist of several inquiries related with management and application of constitutional medicine. The 38.8% facilities of all Oriental medical centers and Clinics in the whole country are applying Constitutional medicine for treating patients. The 8,870 persons in all health workers are engaged in Constitutional clinical service. The proportion of sales by Constitutional clinical services to the total sales by Traditional clinical service is 26.6% in 2007. The proportion of application to medical care insurance by Constitutional clinical service is 21.6% of all amounts. After taking these results into consideration, the sales of Constitutional clinical service now are estimated to make up 26.6% percent of the total traditional medical service and the amount of it's sales in 2015 is expected to increase up to 2.8 times as much as the current quantity.

• 대한의용생체공학회:의공학회지
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• 제18권3호
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• pp.315-323
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• 1997

Driving is a complex vigilance task that includes improper lookout, excessive speed and inattention. The primary objective of this research is to detect driver drowsiness so that the driver can be alerted to an impending traffic accident in performance. We developed the automatic detection and warning system during drowsy driving. A drowsiness detection system must be able to monitor driver status and detect the detrimental changes of a driver performance. Eyeblink has been found to be a reliable factor of drowsiness detection in earlier studies. As an additional parameter, we also considered the yawning which often occurs in a low vigilance state and predicts the drowsy state. We used a computer vision method to extract the eyeblink and yawning in the face image sequences. When the drowsy state was detected, the driver was refreshed by alarming device and menthol scent generator after deciding the warning level by fuzzy logic. For the evaluation of our system, we measured the physiological parameters such as EOG and EEG. The results indicated that it is possible to detect and alert the driver drowsiness temporarily or continuously by using our system.

• The Korean Journal of Physiology
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• 제16권1호
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• pp.63-68
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• 1982

The change of plasma renin activity is one of the most important parameters explaining the pathological physiology of the hypertension. The relation between renal renin activity and plasma renin activity has not well been documented since last decades. In an attempt to clarify the relationship a series of experiments have been done in rats. The following results were observed. 1) Renal renin activity of clamped kidney increased after silver clipping and the increments were maintained until four to five weeks of operation. 2) Renal renin activity of the untouched contralateral kidney was vulnerable to be suppressed just after clamping, and the activity disappered almost below the limitation of the radioimmunoassay sensitivity up to four weeks. 3) Plasma lenin activity was changed by the renal renin activity, but the regression coefficient from the two kidney one clip Goldblatt hypertensive rats was different from the sham-operated, or age-matched control rats. 4) Plasma renin activity of all the groups tested has the exponential curve in terms of renal renin activity. These data suggest that the renal renin activity is important to control the plasma renin activity in certain experimental condition, especially in chronic status.

• 동의생리병리학회지
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• 제31권5호
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• pp.294-303
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• 2017

The purpose of this study was to investigate self care, depression, and Yangsaeng and to confirm the factors related to Yangsaeng of diabetes mellitus patients. The survey was conducted on 116 subjects who consented to Institutional Review Board for diabetes mellitus patients in the area and data were collected by self-report questionnaire. The questionnaires consisted of self care, depression, and Yangsaeng. Date analysis was done by SPSS 22.0 with T-test, ANOVA, $Scheff{\acute{e}}$ test, Pearson correlation coefficient, and multiple regression. Yangsaeng was significantly related to the educational level, partner, income, perceived health status, depression, and admission for diabetes mellitus. Yangsaeng and self care showed positive correlation, on the other hand Yangsaeng and depression showed negative correlation. Yangsaeng was found to be related to education level, self care, and depression through the multiple regression. In conclusion, the Yangsaeng score increased with improving of blood glucose level and depression. Based on these results, we considered various characteristics such as patient's age and illness characteristics, therefore it is necessary to develop a method to measure Yangsaeng.

• 한국해양바이오학회지
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• 제5권4호
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• pp.15-25
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• 2011

Marine sponges are a rich source of highly diversified bioactive compounds. These medicinally valuable molecules represent extreme physiological and ecological functions in sponges, more presumably involving in the resistance to the feeding by other marine organisms like fish and fouling by barnacles, bacteria, fungi, etc. This feature of attaining resistance made sponges as successful poriferans that possess an impressive array of biological properties ranging from antimicrobial to anticancerous activities. The diversified bioactive principle of sponges might be due to their spacio-temporal distribution and although, the gateway for exploiting the sponges for isolating these distinct, potential molecules is open, suitable technical and methodological approaches are yet to be implemented in order to bring the sponges as successful pharmaceutical leads in the field of marine biotechnology. Despite of the identified difficulties of marine sponge research from past few decades, one should concentrate not only on the basic and applied technical/methodological considerations, but also on the novel strategies like in vitro sponge cell, fragment and whole sponge culture; sponge symbiont cell culture; in situ and ex situ sponge cultivation; and sponge bioreactors and metagenomic approaches, for the successful exploitation of marine sponges towards the novelty in sponge biotechnology. The present review narrates the pros and cons of the nowadays-marine sponge research by focusing on the suggestive ecobiotechnological approaches, based on the latest studies for feasible ecological exploitation and biotechnological application of sponges from the sea.

• BMB Reports
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• 제54권10호
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• pp.522-527
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• 2021

Lysine-specific demethylase 1 (LSD1) is an epigenetic regulator that modulates the chromatin status, contributing to gene activation or repression. The post-translational modification of LSD1 is critical for the regulation of many of its biological processes. Phosphorylation of serine 112 of LSD1 by protein kinase C alpha (PKCα) is crucial for regulating inflammation, but its physiological significance is not fully understood. This study aimed to investigate the role of Lsd1-S112A, a phosphorylation defective mutant, in the cigarette smoke extract/LPS-induced chronic obstructive pulmonary disease (COPD) model using Lsd1^SA/SA mice and to explore the potential mechanism underpinning the development of COPD. We found that Lsd1^SA/SA mice exhibited increased susceptibility to CSE/LPS-induced COPD, including high inflammatory cell influx into the bronchoalveolar lavage fluid and airspace enlargement. Additionally, the high gene expression associated with the inflammatory response and oxidative stress was observed in cells and mice containing Lsd1-S112A. Similar results were obtained from the mouse embryonic fibroblasts exposed to a PKCα inhibitor, Go6976. Thus, the lack of LSD1 phosphorylation exacerbates CSE/LPS-induced COPD by elevating inflammation and oxidative stress.