• Title/Summary/Keyword: phosphatidvlinositol kinase

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Effects of sodium molybdate on myo-inositol phospholipid metabolism-related enzymes in peripheral nerves of lead-intoxicated rats. (Sodium molybdate가 납중독 랫드의 말초신경내 myo-inositol 인지질 대사 관련 효소에 미치는 영향)

  • 박성환;정명규;조해용;최창하;김명녀
    • Journal of environmental and Sanitary engineering
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    • v.16 no.4
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    • pp.1-8
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    • 2001
  • We have previously demonstrated that sodium molybdate(Mo) improved lead-intoxicated status by enhancing the metabolism of mao-inositol-related phospholipids in sciatic nerves isolated from rats. In this study, in order to address the reduction mechanism of Mo for lead toxicity, effects of Mo on cystidine-diglyceride transferase, phosphatidylinositol kinase, and phosphatidyl inositol-4-phosphate kinase, involved in mao-inositol metabolism of nerve, were investigated in vivo and in vitro. Mo significantly increased the activities of cystidine- diglyceride transferase and phosphatidylinositol kinase in lead-intoxicated rat, and the pattern of increase was dose-dependent manner. However, Mo did not affect the activity of phosp- hatidylinositiol-4-phosphate kinase in normal and lead-intoxicated rats. We also found that Mo affected the activities of phopholipid metabolism-related enzymes not by the indirect manner such as activation of another metabolic pathway but by the direct manner. These results suggest that the improvement mechanism of Mo for lead-intoxicated status might be a normalization of the activities of phospholipid metabolism-related enzymes in sciatic nerve.

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