• Biomolecules & Therapeutics
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• v.14 no.4
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• pp.226-234
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• 2006

Disturbance of antioxidant system is very common in chronic alcoholics and herbal or natural products with antioxidant activity have been used for its treatment. This study was to investigate the effect of Vitis vinifera extract(V), Schisandra chinensis extract(S), Taraxacum officinale extract(T), Gardenia jasminoides extract(G), Angelica acutiloba extract(A) and Paeonia japonica extract(P), and their combinations on the antioxidant and ethanol oxidation system. Male Sprague-Dawley rats were subjected to Lieber-DeCarli ethanol liquid diet(ED) and were then given different herbal extract mixtures for 6 weeks including VST(V 100+S 150+T 150mg/kg/day), VSG(V 100+S 150+G 150mg/kg/day), VTG(V 100+T 150+G 150mg/kg/day), and VAP(V 100+A 150+P 150mg/kg/day). When the activity of alcohol dehydrogenase(ADH) and acetaldehyde dehydrogenase(ALDH) were compared between ED only group and herbal extracts treatment group, the differences were statistically significant. Phase I and II(glutathione-S-transferase, phenol sulfatransferase) enzyme activities were found to be significantly higher in the VAT treatment group compared to the ED group. Herbal extracts not only repressed the ethanol-induced elevation of malondialdehyde level, but also protected against ethanol-induced decrease in glutathione content, glutathione reductase, glutathione peroxidase, catalase and superoxide dismutase activities. The administration of the herbal extracts was found to be effective in eliminating lipid-peroxides induced by long-term consumption of alcohol by activating various enzyme systems and physiological active compound formation system. After a chronic consumption of alcohol, Angelica Radix protected the liver via activating the ethanol-metabolism enzyme system, and Paeoniae Radix via activating the ethanol-metabolism enzyme and the phase I, II-metabolism enzyme system. Taraxaci Herba was also effective in liver protection via activating the ethanol-metabolism enzyme system and the phase I, II-metabolism enzyme system, Gardeniae Fructus via activating the phase II-metabolism enzyme system and the anti-oxidation system enzyme, and Schisandra Fructus and a grapestone via activating the anti-oxidation system. Our data suggest that these herbal extracts may be useful as a health functional food or new drug candidate for fatty liver and hepatotoxicity induced by chronic alcohol consumption.

• Proceedings of the Korean Ceranic Society Conference
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• 2000.04a
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• pp.28.1-28.1
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• 2000

• Textile Coloration and Finishing
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• v.13 no.2
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• pp.128-134
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• 2001

Following the prior studs regarding that 1.0g of cotton fabric round be dyed uniformly with a reactive dye in the solvent mixture of $2m\ell$ of water and $23m\ell$ of dichloromethane, silk fabric was dyed with C. I. Reactive Blue 203 in the water/dichloromethane two-phase immiscible solvent media. In order to minimize dye loss due to its hydrolysis, the reactive dyeing was carried out in dichloromethane containing a small amount of water. With only $3m\ell$ of water in $22m\ell$ of dichloromethane, 1.0g of silk fabric could be dyed perfectly. The uptake ratio was increased greatly, compared wish that of normal reactive dyeing in a water medium. It would seem that the one of hydrophobic solvents, dichloromethane, can assist the Even dyeing as it disperses a small amount of dye-dissolved phase and conveys this water phase to the fabric entirely and uniformly.

• Journal of the Korea Safety Management & Science
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• v.12 no.2
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• pp.147-152
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• 2010

Project implementation plan is a blueprint that confirms project performance activities and specifies required man-hour, period and resource imput ratio. Various figures, the results of implementation plan, are predicted through estimation, and because of superiority of objectivity and repeatability, numerical formula-based estimation model is often used overseas. COCOMO model is the representative estimation model whose theories and formulas are publicized and it predicts the total man-hour required for software system development. This model is publicized in "Software Engineering Economics" written by Professor Barry Boehm of the U.S., and is the most widely applied numerical formula-based estimation model. This study is conducted to provide a series of methods that are optimal for KTDS environment by choosing COCOMO II model among various types of COCOMO models. In establishing implementation plan, COCOMO II model alone is not sufficient, it is necessary to link with and apply standard WBS system and standard man-hour. In establishing specific implementation plan, phased standard WBS system in order of the first phase of all the activities implemented in the project, Activity, Task, and Role, and the man-hour put into this should be distributed according to standard ratio from COCOMO II model's total man-hour. This study provides explainations by establishing standard WBS system and linking with COCOMO II model.

• Korean Membrane Journal
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• v.4 no.1
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• pp.36-40
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• 2002

The diffusion coefficients of ions in the reverse transport system using the carrier mediated membrane were estimated from the diffusional membrane permeabilities and the ion activity in membrane system. In the aqueous alkali metal ions-membrane system diffusional flux of alkali metal ions driven by coupled proton was analyzed. The aqueous phase I contained NaOH solution and the aqueous phase II also contained NaCl and HCl mixed solution. The concentration of Na ions of both phases were $10^{0},\;10^{-1},\;10^{-2},\;5{\times}10^{-1}\;and\;5{\times}10^{-2}\;mol{\cdot}dm^{-3}$ and the concentration of HCI in aqueous phase II was always kept at $1{\times}10^{-1}\;mol{\cdot}dm^{-3}$. Moreover, the carrier concentration in liquid membrane was $10^{-2}\;mol{\cdot}dm^{-3}$. The results indicated that the diffusion coefficients depend strongly on the concentration of both phases electrolyte solution equilibriated with the membrane. The points were interpreted in terms of the energy barrier theory. Furthermore, eliminating the potential terms from the membrane equation was derived.

• Journal of the Korea Institute of Military Science and Technology
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• v.22 no.6
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• pp.824-831
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• 2019

For effective development in consideration of the maintainability of the weapon system, it is necessary to understand whether the maintainability design requirements are satisfied at the early phase of development. This requires the application of an early design phase maintainability prediction process to provide opportunities for improvement. By defining the ambiguity group definition, fault isolation level, fault isolation probability, and countermeasures for faults, it was possible to predict early phase development. The MTTR of the initial design phase applying Procedure V to the artillery system was 3.46H, which is about 16 % higher than 2.98H, the MTTR using Procedure II. This is a result of system design ambiguity that has not been specified in the early phase of development.

• Journal of Microbiology and Biotechnology
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• v.2 no.2
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• pp.135-140
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• 1992

The partitioning of recombinant human interleukin-2(rhII-2) in PEG 8000-dextran 38800 aqueous two-phase system has been investigated using three different sources of rhIL-2. In the case of pure rhIL-2, the solubility in a PEG-dextran two-phase system was low and most of rhIL-2 was partitioned into the bottom phase. For the recovery of rhIL-2 from insoluble protein aggregates, the inclusion bodies of recombinant E. coli were solubilized by the treatment with sodium dodecyl sulfate (SDS). The addition of SDS significantly enhanced not only the solubility of rhIL-2 but also the partitioning of rhIL-2 to the top phase. When the ratio of SDS to rhIL-2 was 2.0, the partition coefficient(K) and the recovery yield(Y) at the top phase were 4.5 and 88%, respectively, at pH 6.8. In order to reduce the recovery steps further, SDS was directly added to the intact recombinant E. coli cells and then partitioned into the PEG/dextran aqueous two-phase system. The observed partition coefficient ($K{\cong{3.0$) and recovery yield ($Y{\geq}80%$ )of this method were comparable to the rhIL-2 recovery from insoluble protein aggregates. The results obtained in this work indicate that PEG-dextran two-phase partitioning might provide a simple way for the recovery and partial purification of recombinant proteins which are produced as inclusion bodies.

• The Journal of Korean Academy of Prosthodontics
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• v.32 no.4
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• pp.553-564
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• 1994

Using Sirognathograph Analyzing System, the patterns of chewing movement were analyzed into opening phase and closing phase, each phase to frontal plane, horizontal plane, and sagittal plane by maruyama's classification. In opening phase, the chewing patterns of frontal plane were classifed into Chopping Opening, Grinding Opening, Concave Opening, Lateral Shift Opening, Vertical Guide Opening, Convergence Opening. Those of horizontal plane were classified into Chopping Opening, Grinding Opening, Concave Opening, Protrusive Shift Opening, Posterior Guide Opening, Convergence Opening. Those of sagittal plane were classified into Normal Opening, Protrusive Shift Opening, Vertical Guide Opening, Convergence Opening. In closing phase, the chewing patterns of frontal plane were classified into Normal Closure, Concave Closure, Lateral Shift Closure, Lateral Guide Closure, Vertical Guide Closure, Convergence Closure, Those of horzontal plane were classified into Normal Closure, Concave Closure, Lateral Shift Closure, Protrusive Shift Closure, Lateral Guide closure, Posterior Guide Closure, Convergence Closure. Those of sagittal plane were classified into Normal Closure, Protrusive Shift Closure, Vertical Guide. Closure, Convergence Closure. Results were summarized as follows : 1. Opening phase in chewing movement The Normal Openings in 3 planes(frontal, horizontal, sagittal), the Concave Openings in frontal plane and horizontal plane, the Vertical Guide Opening in frontal plane and the Posterior Guide Opening in horizontal plane were many observed. 2. Closing phase in chewing movement The Concave Closure in frontal and horizontal plane, the Normal Closure in 3 planes (frontal, horizontal, sagittal), the Concave Closure in horizontal plane were many observed.

• Proceedings of the KSR Conference
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• 2007.05a
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• pp.45-57
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• 2007

During the design phase of a system, which requires high reliability and safety such as aircraft, high speed train and nuclear power plant, reliability engineer must set up the target system reliability. To meet a reliability goal for the system, reliability allocation should be done gradually from the system to its element. For this end, first of all, we need to construct functional block diagram based on the design output and PWBS(Project Work Breakdown System). Another important input data for reliability allocation is the relationship between the cost and the reliability. In this study we investigate various reliability allocation models, which can be applicable to aircraft, vehicle, and power plant, and etc. And we suggest a proper reliability allocation model which can be effectively applicable to KTX-II high speed train to achieve the target system reliability.

• Journal of the Korean Society for Railway
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• v.10 no.3 s.40
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• pp.319-326
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• 2007

During the design phase of a system, which requires high reliability and safety such as aircraft, high speed train and nuclear power plant, reliability engineer must set up the target system reliability. To meet a reliability goal for the system, reliability allocation should be done gradually from the system to its element. For this end, first of all, we need to construct functional block diagram based on the design output and PWBS(Project Work Breakdown System). Another important input data for reliability allocation is the relationship between the cost and the reliability. In this study we investigate various reliability allocation models, which can be applicable to aircraft, vehicle, and power plant, and etc. And we suggest a proper reliability allocation model which can be effectively applicable to KTX-II high speed train to achieve the target system reliability.