• Korean Journal of Biological Psychiatry
• /
• v.19 no.4
• /
• pp.179-186
• /
• 2012

Depression and executive dysfunction are common neuropsychiatric sequelae of stroke. Patients with stroke are more predisposed to depression and executive dysfunction compared to patients with similar degree of physical disability. Both depression and executive dysfunction are also associated with poor prognosis such as high mortality and delayed recovery after stroke. Complex neurobiological and anatomical mechanisms are associated with the development of depression and executive dysfunction after stroke. Activation of pro-inflammatory cytokines is thought to be associated with onset of depression, whereas injuries in frontal-subcortical circuit are thought to be a link between depression and executive dysfunction. Early detection of depressive symptoms and both pharmacological and non-pharmacological treatment would be helpful. In this review paper, the authors investigated 1) biological and neuroanatomical substrate for poststroke depression and executive dysfunction, 2) the relationship and common etiopathology for poststroke depression and executive dysfunction, and 3) pharmacological and non-pharmacological treatment for poststroke depression. The contents of the paper are as follows : the prevalence, clinical manifestation, and biological etiology for poststroke depression, neuroanatomical abnormalities as a common etiological factor for depression and executive dysfunction, pharmacotherapy and non-pharmacological approach.

• Journal of the Korean Academy of Child and Adolescent Psychiatry
• /
• v.1 no.1
• /
• pp.77-88
• /
• 1990

Management of the child with Attention-Deficit Hyperativity Disorder(ADHD) reguires a comprehensive approach of cognitive-behavioral, educational, and pharmacological interventions. Establishing the valid diagnosis is the first step of management. After the diagnosis is made, the clinician must then interpret the diagnosis and its impliations to the child, parents, and teachers. The pharmacotherapy is most effeceive, and the CNS stimulants (methylphenidate) is drug of choice. Although generally not as effective as stimulants, triacyclic antidepressants, clonidine, antipsychotics offer the alternatives to stimulants therapy. Additional treatments, including psychotherapy, cogntive-behavioral approach, educational infervention, parental counseling are also essential in managing the child with ADHD. Finally, controversial approaches-diet therapy, mineral therapy, hypoglycemia, megavitamin therapy, refined sugars, neurophysiological retraining approaches are reviewed.

• CELLMED
• /
• v.10 no.2
• /
• pp.17.1-17.5
• /
• 2020

Background: Chronic kidney disease (CKD) is affective a large portion of the world population prompting the need for extensive healthcare resources such as lifelong dialysis or kidney transplantation. The beneficial effect of conventional therapy in controlling the CKD progression remains a challenge due to their relative efficacy, safety, and accessibility. On the other hand, Unani medicine provides a therapeutic regimen that consists of a combination of treatment from rehabilitation to herbal pharmacotherapy. Methods: Two cases of chronic kidney disease were treated with dietotherapy, regimenal therapy ('bukhoor aam') and oral herbal drugs for 2-3 weeks. Endpoints of evaluation were symptoms and signs of the CKD, kidney function test, urine albumin, urine RBC, hemoglobin and liver function test. Result: Notable improvement was observed in the endpoints. Conclusion: Unani treatment was observed preliminarily beneficial in the treatment of chronic kidney disease. Rigorous pharmacological and clinical studies should be performed to warrant their efficacy and safety in CKD individuals.

• Analytical Science and Technology
• /
• v.30 no.3
• /
• pp.122-129
• /
• 2017

Methamphetamine addiction is a critical issue due to the lack of effective pharmacotherapy and high potential for relapse. Nevertheless, there are no distinct biomarkers for diagnosis or prognosis for methamphetamine addiction. In the present study, a rat model for methamphetamine self-administration was established and alteration of urinary metabolites by methamphetamine addiction was investigated by the targeted metabolite analysis using mass spectrometry. Rat urine samples were collected at three time points (before and after addiction and after extinction) from the methamphetamine-addicted group as well as the age-matched control group. The collected samples were prepared using AbsoluteIDQ p180 kit and analyzed using flow injection analysis (FIA) - or high performance liquid chromatography (HPLC) - tandem mass spectrometry (MS/MS). The levels of lysine, acetylornithine and methioninesulfoxide were distinctively altered depending on the status of metheamphetamine addiction or extinction. In particular, the level of acetylornithine was reversely changed from addiction to extinction, for which further studies could be useful for biomarker discovery or mechanistic studies for methamphetamine addiction.

• Journal of the Korean Academy of Child and Adolescent Psychiatry
• /
• v.26 no.2
• /
• pp.75-85
• /
• 2015

Internet gaming disorder (IGD), one of the common subtypes of internet addiction, is now classified in Section 3 of DSM-5 and is increasingly regarded as a growing health concern in many parts of the world. Consequently, many psychotherapeutic and psychopharmacological approaches have been considered and some research regarding therapeutic strategies has been conducted. However, treatment of IGD is in its early stages and therefore is not yet well established. This article reviews multiple therapeutic modalities including our own treatment model for IGD according to clinical and biological effects, thus providing suggestions for standard treatment strategies. The two main streams are psychopharmacological treatment and cognitive-behavior treatment, and the cognitive-behavior approach includes cognitive reconstruction, psychoeducation, and parenting coach. Many other non-pharmacological treatments are also recommended for personalized treatment of IGD.

• The Journal of Internal Korean Medicine
• /
• v.21 no.3
• /
• pp.505-510
• /
• 2000

In the treatment of trigeminal neuralgia, it is known that the operative mothods, such as neurovascular decompression, rhizotomy etc. are the most effectious therapies on its pain control. But, due to some side effects and complication, the healing by the first intention of trigeminal neuralgia has been the pharmacotherapy. The cabamazepine is the most common agent, but it is not often effectious in some cases, and attenuated as time goes, engaged in some symptoms, such as dizziness, nausea, vomit, etc., and caused in aplastic anemia, thus it has much deficacies in being the first intention. Recently we have experienced a 77-year old woman who had suffered from the severe trigeminal neuralgia for 21 years, and her condition and pain control were improved through the Korean medical treatments, so we report it for the better treatment.

• Korean Journal of Psychosomatic Medicine
• /
• v.2 no.1
• /
• pp.34-45
• /
• 1994

The author reviewed psychosomatic aspects of bronchial asthma including psychological aspect of bronchial asthma, patients' reactions to illness, reactions of therapists and families, effect of bronchial asthma on mental function, psychotherapy and pharmacotherapy. The therapists' understanding of these aspects is likely to be helpful in their predicting and understanding the type of adaptation their asthmatic patients are making to their illness. Thus, the therapists need to recognize the asthmatics' psychological needs. They also should understand the vicious cycle of anxiety-hyperventilation-panic-fear-avoidance in patients with bronchial asthma and should try to break this cycle. To make it possible, the patients' panic-fear level should be assessed and sometimes it will require psychiatrists' advice. On the other hand, the asthmatics should be trained to be shaped to relate subjective feeling of pulmonary function with objective pulmonary measures, which will enable these patients to perceive their early symptoms and to cope with asthma attack effectively. The therapists need to pay attention to their emotion during evaluation and treatment of patients with bronchial asthma, because they are less likely to perceive stress and express their emotion.

• Journal of Korean Physical Therapy Science
• /
• v.6 no.1
• /
• pp.889-895
• /
• 1999

Pain is the most common symptom that brings a patient to the hospital. In general, two major interventions in pain control are pharmacotherapy and physical therapy. But recently introduced taping method that release pain at one time. The 7 patient with shoulder problems were applied Arikawa taping approaches. The flexor or extensor patterns were determined by Arikawa method at first, and the patients were tested and applied taping at comfortable patterns. We found that: 1)We applied taping approach to the 7 patient, and all of them improved pain and ROM; 2)If the symptoms and patterns were similar, the taping was attached same point; 3)Although several therapist participated in treatment, the effects are regular. It' s caused by ordinary character of taping approach; 4)The patient can attache easily himself; 5)The taping approach has side effects(skin problems, increasing pain, etc.). But if remove them, it's subside immediately. Thus the taping approach is not hazard.

• Journal of the Korean Association of Oral and Maxillofacial Surgeons
• /
• v.46 no.2
• /
• pp.87-98
• /
• 2020

The aim of this study was to determine the efficacy of oral splints in reducing the intensity of pain in patients with temporomandibular joint dysfunction in both short and long-term treatment durations. Electronic databases, Cochrane Library, MEDLINE via PubMed, Web of Science, Egyptian Knowledge Bank, and EMBASE were searched for randomized controlled trials comparing different types of splints to non-occluding splints, behavioral therapy, pharmacotherapy, counseling, and no treatment. The risk of bias was assessed by using Cochrane risk of bias recommendations. Fixed and random effects were used to summarize the outcomes. The effect estimates were expressed as standardized mean differences (SMD) or risk ratios with a 95% confidence interval (CI). Subgroup analyses were carried out according to the treatment duration. Twenty-two studies met the inclusion criteria. A meta-analysis of short-term studies up to three months revealed no significant difference between the study groups. However, long-term studies exhibited a significant difference in pain reduction in favor of the control group. Total analysis revealed that the control group resulted in significant pain reduction (SMD 0.14, 95% CI 0.05-0.23, P=0.002, I²=0%). Oral splints are not effective in reducing pain intensity or improving function in patients with temporomandibular joint dysfunction.

• Korean Journal of Biological Psychiatry
• /
• v.11 no.1
• /
• pp.14-25
• /
• 2004

The current understanding of the mechanisms of pharmacotherapy for depression is characterized by an emphasis on increasing synaptic availability of serotonin, noradrenaline, and possibly dopamine, while minimizing side effects. The acute effects of current available effective antidepressants include blocking selective serotonin or noradrenaline reuptake, alpha2 autoreceptors or monoamine oxidase. Although efficacious, current treatments often produce partial or limited symptomatic improvement rather than remission. While current pharmacotherapies target monoaminergic systems, distinct neurobiological underpinnings and other systems are likely involved in the pathogenesis of depression. Recently, several promising hypotheses of depression and antidepressant action have been formulated. These hypotheses are largely based on dsyregulation of neural plasticity, CREB, BDNF, corticotropin-releasing factor, glucocorticoid, hypothalamic-pituitary adrenal axis and cytokines. Based on these new theories and hypotheses of depression, a number of new and novel agents, including corticotropin-releasing factor antagonists, antiglucocorticoids, and substance P antagonists show a considerable promise for refining treatment options for depression. In this article, the current available pharmacotherapies, current understanding of neurobiology and pathogenesis of depression and new and promising directions in pharmacological research on depression will be discussed.