• Title/Summary/Keyword: pharmaceutical research

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Four New Acetylated Ginsenosides from Processed Ginseng(Sun Ginseng)

  • Park, Il-Ho;Han, Sang-Beom;Kim, Jong-Moon;Piao, Longzhu;Kwon, Sung-Won;Kim, Na-Young;Kang, Tak-Lim;Park, Man-Ki;Park, Jeong-Hill
    • Archives of Pharmacal Research
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    • v.25 no.6
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    • pp.837-841
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    • 2002

  • Four new acetylated ginsenosides were isolated from the processed ginseng (SG, sun ginseng). Their structures were determined to be $3{\beta},{\;}12{\beta}-dihydroxydammar-20(22),24-diene-3-O-{\beta}-D-glucopyranosyl(1{\rightarrow}2)-{\beta}-D-6"-O-acetylglucopyranoside;{\;}3{\beta},12{\beta}-dihydroxydammar-20(21),{\;}24-diene-3-O-{\beta}-D-glucopyranosyl(1{\rightarrow}2)-{\beta}-D-6"-O-acetylglucopyranoside;{\;}3{\beta},{\;}6{\alpha},12{\beta}-trihydroxydammar-20(22),24-diene-6-O-{\beta}-D-6'-O-acetylglucopyranoside{\;}and{\;}3{\beta},6{\alpha},12{\beta}-trihydroxydammar-20(21),24-diene-6-O-{\beta}-D-6'-O-acetylglucopyranoside$ based on spectroscopic evidences. The compounds were named ginsenoside $Rs_4,{\;}Rs_5,{\;}RS_6{\;}and{\;}Rs_7$, respectively.pectively.

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Lignans of Rosa multiflora Roots

  • Yeo, Hosup;Chin, Young-Won;Park, Shin-Young;Kim, Jin-Woong
    • Archives of Pharmacal Research
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    • v.27 no.3
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    • pp.287-290
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    • 2004

  • Five known lignans, (+)-pinoresinol (1), (+)-8-hydroxypinoresinol (2), (-)- dehydrodiconiferyl alcohol (3), (+)-trans-dehydrodiconiferyl alcohol (4), and (-)-olivil (5), were isolated from the roots of Rosa multiflora for the first time. Their structures were determined using spectroscopic data.

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Comparison of CYP 3A4 metabolism between DA-8159 and Sildenafil in vitro and in vivo

  • Park, Kyung-Jin;Youn, Hae-Sun;Shim, Hyun-Joo;Kim, Soon-Hoe;Yoo, Moo-Hi;Kim, Won-Bae
    • Proceedings of the PSK Conference
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    • 2002.10a
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    • pp.253.1-253.1
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    • 2002

  • DA-8159 is a new PDEV inhibitor, synthesized by Dong-A Pharm, as an oral agent to treat male erectile dysfunction. DA-8159 and sildenafil are mainly metabolized by cytochrome P450 enzyme CYP 3A4. In this study. we compared the metabolism of DA-8159 with sildenafil in vitro and in vivo. First, we quantified the remaining gatio of original compound, DA-8159 and sidenafil., after we incubated drugs for 30 minutes with human liver microsome cytochrome P 450 3A4. (omitted)

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