• Journal of Veterinary Clinics
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• v.30 no.3
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• pp.186-188
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• 2013

This study investigated the prevalence of ectoparasite infestations in the pet rabbits of Daejeon area, Korea. The authors used tape strip test, hair coat combing and otoscopy for diagnosis. Only three species were detected. Cheyletiella parasitovorax was found in 152/251 rabbits (60.6%), Psoroptes cuniculi was found in 7/251 rabbits (2.8%) and Ornithonyssus bacoti was found in 5/251 rabbits (1.9%). C parasitovorax is the highest prevalence among the three species. Co-infection of C. parasitovorax with P. cuniculi was found in 3/251(1.2%). Co-infection of C. parasitovorax with O. bacoti was found in 5/251(1.9%). This study is the first large scale survey of C. parasitovorax, P. cuniculi and O. bacoti in the pet rabbits of Daejeon area, Korea.

• Journal of Veterinary Clinics
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• v.26 no.6
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• pp.625-627
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• 2009

Treponematosis, called rabbit syphilis, is an infectious disease caused by Treponema cuniculi in rabbits. In this case report, five rabbits were presented with severe crusts in lips, genitalia and nose. Skin scrapings and fungal test were negative. Human syphilis antibody test was positive. The rabbits were treated with penicillin and chloramphenicol for 3 weeks and the crusts were significantly decreased from 5 to 7 days after treatment. No crusts were evident in the rabbits 3 weeks after treatment. These rabbits were cases of treponematosis which showed a favorable therapeutic response by penicillin and chloramphenicol.

• Journal of Radiopharmaceuticals and Molecular Probes
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• v.1 no.2
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• pp.123-129
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• 2015

$^{64}Cu$-labeled diacetyl-bis($N^4$-methylthiosemicarbazone) is a promising agent for internal radiation therapy and imaging of hypoxic tissues. In the study, we confirmed hypoxia regions in VX2 tumor implanted rabbits with injection $^{64}Cu$-ATSM and $^{18}F$-FDG using positron emission tomography (PET)/computed tomography (CT). PET images with $^{18}F$-FDG and $^{64}Cu$-ATSM were obtained for 40 min by dynamic scan and additional delayed PET images of $^{64}Cu$-ATSM the acquired up to 48 hours. Correlation between intratumoral $O_2$ level and $^{64}Cu$-ATSM PET image was analyzed. $^{64}Cu$-ATSM and $^{18}F$-FDG were intravenously co-injected and the tumor was dissected and cut into slices for a dual-tracer autoradiographic analysis. In the PET imaging, $^{64}Cu$-ATSM in VX2 tumors displayed a specific uptake in hypoxic region for48 h. The uptake pattern of $^{64}Cu$-ATSM in VX2 tumor at 24 and 48 h did not match to the $^{18}F$-FDG. Through ROI analysis, in the early phase (dynamic scan), $^{18}F$-FDG has positive correlation with $^{64}Cu$-ATSM but late phase (24 and 48 h) of the $^{64}Cu$-ATSM showed negative correlation with $^{18}F$-FDG. High uptake of $^{64}Cu$-ATSM in hypoxic region was responded with significant decrease of oxygen pressure, which confirmed by $^{64}Cu$-ATSM PET imaging and autoradiographic analysis. In conclusion, $^{64}Cu$-ATSM can utilize for specific targeting of hypoxic region in tumor, and discrimination between necrotic- and viable hypoxic tissue.

• Journal of Veterinary Clinics
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• v.26 no.6
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• pp.622-624
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• 2009

Psoroptic mites can cause severe pruritic otitis externa with crusts in rabbits. In this case report, three rabbits with a psoroptic mite infestation were treated with a formulation containing 10% imidacloprid and 50% permethrin at a dose of 0.4 ml regardless of body weight. One week after treatment, the rabbits showed mild pruritus with no crusts, mites or eggs. Four weeks after treatment, there were no clinical signs, mites or eggs observed in the rabbits. The rabbits were treated successfully with this combination without adverse reactions for 8 weeks after treatment. This case report suggests that a single topical application of a combination of imidacloprid and permethrin may be an effective and practical treatment for psoroptic mite infestations in pet rabbits.

• Journal of Veterinary Clinics
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• v.24 no.3
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• pp.312-314
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• 2007

Cheyletiellosis is a very common infestation in pet rabbits that causes dermatosis with pruritus and scale. In this study, thirty two rabbits with cheyletiellosis were treated with a single dermal application of a formulation containing imidacloprid 10% (w/v) and moxidectin 1% (w/v) at a dose 0.4 ml. The therapeutic effects of the formulation were 100% at 4, 8 and 12 weeks without adverse reactions. This suggests that a formulation containing imidacloprid and moxidectin is an effective treatment for cheyletiellosis in rabbits.

• Journal of Veterinary Clinics
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• v.24 no.3
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• pp.392-399
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• 2007

Scutellaria baicalensis Georgi. (SBGE) is known to be antioxidant effect. In addition of the effects, we further investigated the SBGE on the antioxidant effect on a renal cortical slices cell and kidney protecting effects. The results were as follows. 1 When renal cortical slices separated from a rabbit's kidney were treated with 1mM tert-Butylhydroperoxide (t-BHP) in the presence of SBGE. SBGE significant prevented t-BHP induced increase in lactate dehydrogenase (LDH) release and lipid peroxidation. 2. When renal cortical slices separated from a rabbit's kidney were treated with oxidant $300{\mu}M$ cisplatin in the presence of SBGE. SBGE significant prevented cisplatin-induced increase in LDH release and lipid peroxidation. 3. Pretreatment with 0.1g/kg SBGE for seven day and treatment with 5 mg/kg cisplatin by the intraperitoneal injection The results were that the pretreatment group with SBGE showed a significant decrease in lipid peroxidation, increase in clearance rate of blood urea nitrogen (BUN) and creatinine in the kidney than the administering single agent group of cisplatin. and pretreatment group with SBGE showed intact microvillus of proximal tubule and no contraction of rumen, it was a similar result with normal group. With the results SBGE showed to be highly effective on antioxidant effect and cellular protection activity against cisplatin that was a toxic agent on a kidney. Therefore, SBGE is considered to have protective effective on a disordered kidney or kidney diseases such as nephritis or renal failure that cause tissue damages in a kidney.

• Journal of Veterinary Clinics
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• v.25 no.2
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• pp.112-114
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• 2008

The fur mite is a highly contagious zoonotic mite that causes skin disorders in rabbits. In this case report, four rabbits with a fur mite infestation were treated with a single dermal application of permethrin (65%) at a dose of 0.1 ml. All the rabbits were treated successfully with permethrin without any adverse reactions at 8 weeks after treatment. This suggests that permethrin is an effective treatment for fur mite infestations in rabbits.

• Korean Journal of Veterinary Research
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• v.32 no.4
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• pp.641-647
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• 1992

This study was conducted to determine the serum antibodies against toxoplasma in the artificially infected dogs, pet and street dogs by latex agglutination (LA) and indirect fluorescent antibody (IFA) test. LA test was carried out with commercial Toxo-MT kit (Eiken chemical Co.) and IFA test was carried out with rabbit-anti-dog IgG labelled with FITC (Cappel Co.) and toxo-antigen slides prepared in laboratory. The results obtained were as follows ; 1. Antibodies to Toxoplasma gondii in the artificially infected dogs were detected firstly at the Day 8 in IFA and Day 9 in LA test after inoculation. Positive antibody reactions by these tests were declined gradually afterward but maintained up to 12 weeks. 2. In LA test serum antibody titers in 310 test sera were shown as 10 cases(32%) in 1 : 32.5(1.0%) in 1 : 64, 4(1.3%) in 1 : 128 and 2(0.7%) in 1 : 256. In IFA test serum antibody titers 310 test sera were shown as 17 cases(5.5%) in 1 : 64, 8(2.6%) in 1 : 128 and 5(1.6%) in 1 : 256. 3. In the total of 310 sera from pet and street dogs toxoplasma antibody positive rates were 21 cases (6.8%) by LA and 30 cases (9.7%) by IFA test and the positive detection rates between these two groups by LA and IFA test were not significant(p<0.05). 4. In the total of 115 sera from pet dogs toxoplasma antibody positive rates were 12 cases(10.4%) by LA and 15(13.0%) by IFA test. And in the 195 street dogs the positive rates were 9 cases(4.6%) by LA and 15(7.7%) by IFA test. Also, the positive detection rates between these two groups by LA and IFA test were not significant(p<0.05). 5. Agreement of reactivity between LA and IFA test for 310 sera was 91.3% in total of 283 cases consisting of 12 cases(3.9%) of both LA and IFA positive and 271 cases(87.4%) of LA and IFA negative. 6. LA test was almostly equivalent to the IFA test in producibility and proved to be a simple tool for the screening of toxoplasma antibody in laboratory.

• Journal of Veterinary Clinics
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• v.31 no.1
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• pp.15-18
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• 2014

A total of 122 rabbits (40 males, 51 females, 25 castrated males and 6 spayed females; age range: 3 months to 11 years; weight range: 0.8-3.4 kg) were admitted to Veterinary Medical Teaching Hospital of Chungnam National University from January 2012 to February 2013. The syphilis rapid test was positive in 21.3% of rabbits, with a significant difference in the rates of positivity between male versus female rabbits and rabbits younger than 1 year versus older than 1 year of age (both p < 0.01). Skin lesions were detected around the lips (59.1%), nose (56.5%), genitalia (50.0%), anus (40.9%) and eyelids (18.2%). Coexisting skin lesions were found on the nose and lips (26.0%); anus and genitalia (21.8%); lips, anus and genitalia (17.4%) of rabbits. Twenty-two rabbits with skin lesions were subcutaneously treated with Penicillin G (48,000-84,000 IU/kg, Green cross, Korea) every 7 days for three or four weeks. All skin lesions were disappeared after Penicillin G treatment. In conclusion, a rabbits with skin lesions and serological test positive for syphilis should undergo prompt treatment and not be used for breeding.