• Computers and Concrete
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• 제2권3호
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• pp.203-214
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• 2005

In the Part 1 paper (Gawin, et al. 2005) some experimental results concerning micro-structural tests, permeability measurements and stress-strain tests of four types of High Performance Concrete, exposed to elevated temperatures (up to $700^{\circ}C$) are presented and discussed. On the basis of these experimental results parameters of the constitutive relationships describing influence of damage and temperature upon material intrinsic permeability at high temperature were determined. In this paper the effects of various formulations of damage-permeability coupling on results of computer simulations are analysed and compared with the results obtained by means of the previously proposed approach, that does not take into account the thermo-chemical concrete damage directly. Numerical solutions are obtained using the recently developed fully coupled model of hygro-thermal and damage phenomena in concrete at elevated temperatures. High temperature effects are considered by means of temperature and pressure dependence of several material parameters. Based on the mathematical model, the computer code HITECOSP was developed. Material parameters of the model were measured by several European laboratories, which participated in the "HITECO" research project. A model problem, concerning hygro-thermal behaviour and degradation of a HPC structure during fire, is solved. The influence of two different constitutive descriptions of the concrete permeability changes at high temperature, including thermo-chemical and mechanical damage effects, upon the results of computer simulations is analysed and discussed.

• 한국지반공학회지:지반
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• 제13권2호
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• pp.77-90
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• 1997

지하수 거동에 대한 불확실성을 극복하기 위해서 암반 지반의 투수계수를 예측할 수 있는 신뢰적이고 경제적인 방법이 필요하다. 이러한 목적을 위하여 암반의 투수계수 예측 방법에 대한 연구가 수행되어졌다. 인공 신경망 이론을 적용한 투수계수 예측 방법에 대한 일환으로 오차역 전파 학습알고리즘을 이용한 투수계수 예측 방법에 대하여 연구를 수행하였으며, 이 방법의 타당성 검토를 위하여 현장투수시험 결과와 지반물성치들에 적용하여 검증을 실시하였다. 검증결과 평균오차 범위가 작아 비교적 정착한 투수계수 예측방법임을 보여주었다.

• 한국암반공학회:학술대회논문집
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• 한국암반공학회 2000년도 암반공학문제의 수치해석(Numerical Analysis in Rock Engineering Problems)
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• pp.129-137
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• 2000

본 논문은 통계적 기법에 의한 균열망 해석 프로그램(NAPSAC)을 사용하여 암반의 수리특성을 평가하기 위해 시도되었다. 암반내 존재하는 절리의 방향성을 고려한 투수계수를 산정하기 위해 마북리 시험터널 주위의 시추자료와 막장 자료로부터 얻어진 균열에 대한 정보로부터 대상지역의 등가 투수계수를 추정하였다. 대상지역의 관찰자료(균열망에 대한 자료, 수리지질학적 자료)로부터 통계적 균열망 해석을 위한 입력자료를 결정하여 해석모델의 신뢰성을 확보하였다. 구현된 모델로부터 모델의 크기를증가함에 따라서 이방성 투수계수 및 투수계수의 변화를계산하였다. 해석결과대상지역의 투수성은 균열군의 방향성에 의해 강한 이방성을 보였다.

• 터널과지하공간
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• 제10권3호
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• pp.378-386
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• 2000

본 논문은 통계적 기법에 의한 균열망 해석 프로그램 (NAPSAC)을 사용하여 암반의 수리특성을 평가하기 위해 시도되었다. 암반내 존재하는 절리의 방향성을 고려한 투수계수를 산정하기 위해 마북리 시험터널 주위의 시추자료와 막장 자료로부터 얻어진 균열에 대한 정보로부터 대상지역의 등가 투수계수를 추정하였다. 대상지역의 관찰자료 (균열망에 대한 자료, 수리지질학적 자료 )로부터 통계적 균열망 해석을 위한 입력자료를 결정하여 해석모델의 신뢰성을 확보하였다. 구현된 모델로부터 모델의 크기를 증가함에 따라서 이방성 투수계수 및 투수계수의 변화를 계산하였다. 해석결과 대상지역의 투수성은 균열군의 방향성에 의해 강한 이방성을 보였다.

• Coupled systems mechanics
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• 제11권2호
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• pp.93-106
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• 2022

The total embankment settlement consists of three stages: the initial settlement, the primary consolidation settlement, and the secondary consolidation settlement. The total embankment settlement is largely controlled by the primary consolidation settlement, which is usually computed with numerical models that implement Biot's theory of consolidation. The key parameter that affects the primary consolidation time is the coefficient of permeability. Due to the complex stress and strain states in the foundation soil under the embankment, to be able to predict the consolidation time more precisely, aside from porosity-dependency, the strain-dependency of the coefficient of permeability should be also taken into account in numerical analyses. In this paper, we propose a two-dimensional plane strain numerical model of embankment primary consolidation, which implements Biot's theory of consolidation with both porosity-dependent and strain-dependent coefficient of permeability. We perform several numerical simulations. First, we demonstrate the influence of the strain-dependent coefficient of permeability on the computed results. Next, we validate our numerical model by comparing computed results against in-situ measurements for two road embankments: one near the city of Saga, and the other near the city of Boston. Finally, we give our concluding remarks.

• Geomechanics and Engineering
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• 제37권2호
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• pp.179-187
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• 2024

In this paper, a unified time-dependent constitutive model of Darcy flow and non-Darcy flow is proposed. The influencing factors of flow velocity are discussed, which demonstrates that permeability coefficient is the most significant factor. Based on this, the dynamic evolution characteristics of water inrush during tunneling through fault fracture zone is analyzed under the constant permeability coefficient condition (CPCC). It indicates that the curves of flow velocity and hydrostatic pressure can be divided into typical three stages: approximate high-velocity zone inside the fault fracture zone, velocity-rising zone near the tunnel excavation face and attenuation-low velocity zone in the tunnel. Furthermore, given the variation of permeability coefficient of the fault fracture zone with depth and time, the dynamic evolution of water flow in the fault fracture zone under the variable permeability coefficient condition (VPCC) is also studied. The results show that the time-related factor (α) affects the dynamic evolution distribution of flow velocity with time, the depth-related factor (A) is the key factor to the dynamic evolution of hydrostatic pressure.

• Journal of Pharmaceutical Investigation
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• 제38권3호
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• pp.183-189
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• 2008

The present study compared the feasibility of Caco-2 and MDCK cells as an efficient in-vitro model for the drug classification based on Biopharmaceutics Classification System (BCS) as well as an in-vitro model for drug interactions mediated by P-gp inhibition or P-gp induction. Thirteen model drugs were selected to cover BCS Class I{\sim}IV$ and their membrane permeability values were evaluated in both Caco-2 and MDCK cells. P-gp inhibition studies were conducted by using vinblastine and verapamil in MDCK cells. P-gp induction studies were also performed in MDCK cells using rifampin and the P-gp expression level was determined by western blot analysis. Compared to Caco-2 cells, MDCK cells required shorter period of time to culture cells before running the transport study. Both Caco-2 and MDCK cells exhibited the same rank order relationship between in-vitro permeability values and human permeability values of all tested model compounds, implying that those in-vitro models may be useful in the prediction of human permeability (rank order) of new chemical entities at the early drug discovery stage. However, in the case of BCS drug classification, Caco-2 cells appeared to be more suitable than MDCK cells. P-gp induction by rifampin was negligible in MDCK-cells while MDCK cells appeared to be feasible for P-gp inhibition studies. Taken all together, the present study suggests that Caco-2 cells might be more applicable to the BCS drug classification than MDCK-cells, although MDCK cells may provide some advantage in terms of capacity and speed in early ADME screening process.

• Computers and Concrete
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• 제24권6호
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• pp.571-578
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• 2019

This study aimed to investigate the permeable nature of pervious concretes (PC) through the moving particle simulation (MPS) method. In the simulation, the complex structure of a pervious concrete was virtually demonstrated as a lattice model (LM) of spherical beads, where the test of permeability was conducted. Results of the simulation were compared with the experimental ones for validation. As a result, MPS results showed the permeability index of the LM as almost twice as big as the actual PCs. A proposed virtual model was created to prevent the stuck of water flow in the MPS simulation of PC or LM. Successful simulation results were demonstrated with the model.

• 한국가스학회지
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• 제23권3호
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• pp.7-19
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• 2019

본 연구에서는 석탄층 메탄가스전에서의 영향반경 내 저류층 압력에 따라 변화하는 투과도를 고려한 저류층 생산성을 산출하고 그 저류층의 생산특성을 반영한 물질평형법을 사용하여 향후 생산거동을 예측하는 모델을 개발 하였다. 석탄층 메탄가스전을 대상으로 개발한 방법과 전통적인 방법의 저류층 생산성을 유정시험 측정치를 기준으로 비교하였다. 그 결과, 전자의 경우 결정계수($R^2$)가 약 0.76, 후자의 경우 0.69이었다. 이를 통해 석탄층 메탄가스전의 생산성을 대표할 때, 영향반경 내 저류층 압력과 압력 의존 투과도를 고려한 저류층 생산성이 더 적합함을 확인하였다. 이 과정을 통해 유정시험 측정치가 존재할 때, 압력 의존 투과도를 계산하기 위한 영향반경 내 저류층 압력을 산정하는 방법을 제안하였다. 산출한 저류층 생산성과 물질평형법을 이용하여 31개 가스정의 향후 15년간의 생산거동을 예측하여 압력 의존투과도를 고려하지 않은 문헌의 시뮬레이션 결과와 비교하였다. 적용된 현장의 압력 의존 투과도는 최대 1.17배 상승하여 각 가스정당 일일 생산량이 문헌의 결과 대비, 최대 약 15% 증가하는 결과가 도출되었다. 문헌들에 따르면, 석탄층 메탄가스전의 투과도는 저류층 압력에 따라 6~25배 증가하기도 한다. 그 경우, 생산거동은 전통적인 가스 전과 큰 차이가 나타날 것으로 사료된다.

• 한국막학회:학술대회논문집
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• 한국막학회 2004년도 Proceedings of the second conference of aseanian membrane society
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• pp.33-38
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• 2004

Molecular modeling of gas permeation through zeolite membranes with/without intercrystalline region was carried out. Molecular dynamics (MD) and Monte Carlo (MC) simulations were performed to estimate the diffusion coefficient and adsorption parameters respectively, and our proposed combined method of molecular simulation techniques with a permeation theory (CMP) was used to estimate gas permeability. The calculated permeability of gases (Ar, He, Ne, $N_2$, $0_2$, $CH_4$) at 301 K for the single crystal membrane model was about one order of magnitude larger than the experiential values, although the dependence on the molecular weight of the permeating species agreed with experiments. On the other hand, the estimated permeability using the diffusivity and adsorption parameters of the intercrystalline region model was in good agreement with the experiments. The consistency between experiments and the estimated values means the importance of considering the intercrystalline region and the validity of CMP method to predict the performance of zeolite membranes.