• Pediatric Gastroenterology, Hepatology & Nutrition
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• v.22 no.4
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• pp.358-368
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• 2019

Purpose: Pediatric Crohn's disease (CD) is directly related to growth and has a high probability of requiring surgical intervention(s); therefore, more active treatment for CD is required for children. This study investigated the impact of biologics on growth and disease course associated with surgery. Methods: This was a retrospective cohort study involving patients diagnosed with CD at the Seoul National University Children's Hospital (Seoul, Korea) between January 2006 and October 2017. The aim was to determine the characteristics of pediatric patients with CD and whether biologics affected growth and the surgical disease course. Results: Among patients who underwent surgery for CD, the mean number of operations per patient was 1.89. The mean time from initial diagnosis to surgery was 19.3 months. The most common procedure was fistulectomy (34%), followed by incision and drainage (25%). In all patients, the use of biologics increased the height (p=0.002) and body mass index (BMI) (p=0.005). Among patients who underwent surgery, height (p=0.004) and BMI (p=0.048) were increased in the group using biologics. Patients who used biologics exhibited a low operation rate only within 2 years after diagnosis, with no differences thereafter (p=0.027). Conclusion: Although biologics could not mitigate the operation rate in pediatric patients who underwent surgery for CD, biological therapy delayed disease progression within 2 years of disease onset. Additionally, biologics conferred growth and BMI benefits in this window period. Therefore, it may be helpful to use biologics for optimal growth in pediatric patients with a high probability of undergoing future surgery.

• The Sea:JOURNAL OF THE KOREAN SOCIETY OF OCEANOGRAPHY
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• v.13 no.4
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• pp.342-347
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• 2008

Mortality and growth rate of the soft coral, Dendronephthya gigantea, from Jejudo Island on the southern coast of Korea were investigated from February 2003 to October 2004 using SCUBA diving. 48 individuals with variable sizes of D. gigantea of the depth of 15m were tagged with flagging tapes and plastic films, and then monitored with two month intervals. The average mortality of two-month term for the study period was 50.4%, with the peak of 84.6% during the summer storms in August - October 2003. About the size class mortality, individuals of size class I(${\leq}$10 cm) showed the highest mortality, followed by size class III(>20 cm) and size class II(10 cm-20 cm). Growth rate did not show a seasonal pattern. For growth in length, individuals of D. gigantea grew about 3cm in average for two-month period, with a maximum growth of 6.4 cm which occurred in August - October 2003. For growth in diameter, individuals grew about 0.3 cm for 2 month term, with a maximum of 1.4cm in April - June 2004. Individuals of size class I usually grew faster than those of larger size classes. D. gigantea population in Jejudo Island was strongly affected by summer storms, which was due to annual event of summer typhoon. Never the less, it appears that the local population can be maintained by fast growth of the juvenile stage and active recruitment to compensate the high mortality caused by the summer disturbance.

• Korean Journal of Environmental Agriculture
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• v.19 no.5
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• pp.375-381
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• 2000

Quantifying the changes of soil microbial biomass and activity of enzymes are important to understand the dynamics of active soil C and N pools. The dynamics of soil microbial biomass C and N and the activity of enzymes over entire growth period of soybean-(Glycine max (L) Merr.)-wheat (Triticum aestivum L.) sequence on a Typic Haplustert as influenced by organic manure and inorganic fertilizer N were investigated in a field experiment. The application of farmyard manure at 4 to 16 $Mg{\cdot}ha^{-1}\;y^{-1}r^{-1}$ along with fertilizer nitrogen at 50 or 180 $kg{\cdot}ha^{-1}$ increased the mean soil microbial biomass from 1.12 to 2.05 fold over unmanured soils under soybean-wheat system. Irrespective of organic and chemical fertilizer N application, the soil microbial biomass was maximum during the first two months at active growing stage of the crops and subsequently declined with crop maturity. The mean annual microbial activity was significantly increased when manure and chemical fertilizer at 8 $Mg{\cdot}ha^{-1}$ and 50/180 N $kg{\cdot}ha^{-1}$, respectively were applied. The C turnover rate decreased by 47 to 72 % when the level of farmyard manure was increased from 4 to 8 and 16 $Mg{\cdot}ha^{-1}$. There were significant correlations between biomass C, available N, dehydrogenase, phosphatase and yield of the crops.

• The Journal of Korean Medical History
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• v.36 no.1
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• pp.31-50
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• 2023

Through this paper, all the provisions of the enforcement statutes stipulated in the Joseon's law code were investigated and major medical issues and interests in the Joseon Dynasty were analyzed. The characteristics of each period reviewed in the text are as follows. The early Joseon Dynasty is divided into three periods. First of all, Joseon filled the gap in the law with the active acceptance of the Ming Dynasty's law code, Daemyeongrul, which conformed to Confucian virtue. Next, the completion of Gyeonggukdaejeon was an opportunity to prepare the basis for Joseon's medical laws. Lastly, from the late 15th century to the 16th century, the existing medicine promotion measures and emphasis on hyangyak(domestic herb) continued. it can be said that Joseon's politicians needed a medical policy based on Confucian virtues and maintained state-led promotion policies, but on the other hand, there was no other alternative to try newly by reflecting the limitations and failures of the policy. The late Joseon Dynasty is also divided into three periods. First of all, the period from the late 16th century to the early 18th century was marked by the growth of families in technical positions. The era of King Yeongjo can be said to be the period of reorganization of medical related laws. Finally, the period after the late 18th century is a period of passive regulation and supplementation. Lastly, the revision of the actual medical law was not made or reflected in era of King Jeongjo. In the case of the early Joseon Dynasty, the policy shifted from state-led to families in technical positions. However, in the 19th century, the weakening of the royal authority led to the weakening of the overall administrative system of the country, and the pharmaceutical policy had to be limited.

• The Journal of Korean Academic Society of Nursing Education
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• v.6 no.2
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• pp.303-326
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• 2000

Only one hundred years of history in nursing education in Korea is not enough to develop the subject fully as a science. However, the development of Korean nursing education is a great historical event, because Korean nursing education has been accepted by a male-oriented Korean society and has led to a new paradigm in the new millenium. These results are largely due to the Korean people's high enthusiasm for education, as well as Korean women's diligence. I think these 100 years of history can be divided into five periods: (1) the Sunlight period (1900-1911) (2) the New born period (1912-1945) (3) the Settle-down period (1946-1960) (4) the Marked Growth period (1961-1980) (5) the Jumping Period (1981-2000) These classifications are characterized by changes in the educational system, a changed nursing curriculum, educational goals, educational outcomes, and implications. The characteristics of historical development of Korean nursing education was evaluated in three dimensions: structures, contents, and outcome. The structure of Korean nursing education consists of a 3-year program and a 4-year program. Most nursing leaders in Korea hope that these two programs will converge into one system. Secondly, the contents of nursing education in Korea underwent very active changes, according to historical development. These changes in the nursing curriculum have been developed to provide a professional education and develop nursing education as a modern science. Lastly, as to the results of nursing education in Korea, the education was needed to turn out advanced specialists in nursing. In the new millenium, knowledge and information will be the driving forces behind social development. A nation's level of development and creativity in nursing education is the most potent determinant of the future of Korean nursing. The best way to prepare for future challenges will be to create the backbone of a nursing education system. Hence, well-educated nurses in graduate programs should be turned into advanced specialists in nursing. These groups will upgrade the image of Korean nurses, and will have strong influence to improve patient care and the health situation in Korea.

• Journal of Environmental Impact Assessment
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• v.25 no.6
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• pp.477-486
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• 2016

We investigated the growth pattern of Red-tongued viper snakes (Gloydius ussuriensis), which were captured from the islet of the Jeju Island, Gapado between April, 2006 and November, 2009. The results indicated that there were some snakes that grew relatively fast, but most snakes either almost did not grow or grew around 10mm in snout-vent length during one year period. High growth rates was April and June. Since the growth rate of snakes is highly correlated with their foods, these results implied that the feeding activity of Red-tongued viper snakes is high during this period compared to other months. In female, difference in body condition between good-conditioned and bad-conditioned snakes became large as time elapsed from April to June. The body condition of the male Red-tongued viper snakes improved with the progression of time from April till June. Many of the Red-tongued viper snakes were captured between April and June, while they were rarely captured between July and September. Some of the Red-tongued viper snakes were captured during the autumn season. This tendency was because snakes were rarely active during hibernation and peak summer seasons. Thus, Red-tongued viper snakes are active between April and June and between September and November. They then go into hibernation as the temperature dropped in November. Furthermore, the limitation of the movement period of the Red-tongued viper snakes restricted their feeding activities while foods became scarce, which ultimately restricted their overall growth rate. The growth rate of the snakes decreased with age. The snout-vent length of the Red-tongued viper snakes and growth rate showed a negative correlation (r = -0.591), however, it was not statistically significant due to small sample size. The findings from this study could provide meaningful information in the further study of the life cycle of Red-tongued viper snakes.

• YAKHAK HOEJI
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• v.4 no.1
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• pp.53-55
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• 1959

In order to confirm on production of vitamin $B_{12}$ during the kimchi fermentation period, the variation of its content is studied in this paper As a sample of kimchi for this fermentation study due to the seasonal condition, nabakkimchi which is aseasonal one in early spring, is prepared by author. The content of vitamin $B_{12}$ is estimated by the microbiological assay method using lactobacillus leichmannii A Tee 7830. Details for assay are indicated in the original part. And the pseudo-vitamin $B_{12}$ substances as thymidine which is active to the growth of lactobacillus leichmannii, are eliminated by the alkali treatment method of sample solution, According to the results shown in table 2 and 3 and figures 1 to 4, the following conclusions are summerized; 1. Vitamin $B_{12}$ produced during the fermentation period of kimchi. And the content of this vitamin during its optimum fermentation period, is much higher content compared with the theoretically calculated amount from its materials, This has been confirmed at the repeated experiment. The trend of variation during its period is indicated at the figures. 2. The sterilized kimchi inhibited the fermentation by sterilization at the preparation, did not increased its content showing only its theoretically calculated amount.

• Journal of Forest and Environmental Science
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• v.34 no.6
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• pp.435-450
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• 2018

Phenological events of four Rhododendron tree species (viz. R. arboreum, R. arboreum ssp. delavayi var. delavayi, R. barbatum and R. kesangiae) was monitored in temperate mixed broad-leaved forests of Arunachal Pradesh, India. Phenological events like flower bud formation, flowering, fruit setting, fruit maturing, seed dispersal, leaf bud formation, leaf flushing, and leaf shedding were recorded. Indices i.e., phenophase sequence index (PSI), active phenophasic period of the species (APS) and index of reproductive/vegetative activity (RVA) were also calculated. Present study revealed that bark consistency, growth form and leaf pattern of the studied species have showed variations among the species. Rhododendron species exhibited the phenological events overlapping with other phenophases. The peak flower bud formation was observed during the winter; R. arboreum ssp. delavayi var. delavayi start flowering from December, while the flowering in rest three species exhibited during February to April. Fruit setting occurred during summer to autumn while fruit maturation revealed peak during November. Leaf bud formation illustrated two peaks in April and May, leaf flushing exhibited peak in June, while leaf shedding peaked during October to November. Active phenophasic period of the species were found 12 months, which revealed that species engage in various phenophase activities throughout the year. Phenophase sequence index ranged between 0.8 to 0.9 (PSI ${\geq}0.6$), signifies that species have a sequential arrangement of phenophases. Index of reproductive/vegetative activity of the species exemplified >1, indicate that the reproductive phenophases were dominance over vegetative phenophases. The study have provided substantial insight on the life cycle events of Rhododendron species and ecological approaches for further scientific study with recent climate change and effective management and conservation.

• Journal of Sericultural and Entomological Science
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• v.13 no.1
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• pp.23-29
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• 1971

As a result of analyzing the change of material substance of all sorts biochemically and comparing the control with ${\gamma}$-ray irradiation (800${\gamma}$, 40 Min), incubating the silkworm eggs (Bombyx mori L.) as the objective in the process of growth of embyro shortly before hatching, the following conclusion has been found. 1. Ascorbic acid has shown the maximum increase of 319 r/g in the Byong B embyro stage and in other words it has increased during the period of vigorous metabolism of the materials in eggs but it has decreased before hatching after that period. 2. Triglyceride has shown the increase of 27.54 mg/g in the Byong A stage, the early period of incubation and in other words it has increased in the period of activation of cells in eggs but it has gradually decreased during the growth of embyro after that period. Great change of either total cholesterol or free cholesterol has not been shown from the early period till shortly before hatching. 3. Free fatty acid has shown the minimum decrease of 257.4$\mu$ mole/g in the Byong A stage in which triglyceride increases greatly. On the contrary, it has shown the increase of 1, 020.0$\mu$ mole/g in Ki A stage in which triglyceride decreases. As a whole, the fact that free fatty acid increases according to the growth of embyro in eggs has been found. 4. Glucose has shown the increase of 281.2 mg/g in control during tile Pigment stage and it has shown the increase of 179.6 mg/g in ${\gamma}$-ray irradiation during the same period. The difference in quantity between the former and the latter is due to the fact that the growth of embyro has been influenced by the radio active. Glucose has changed with free fatty acid and phosphorus the other way round. 5. Control organic phosphorus has shewh the increase of 5.23mg/g during the Byong B or Ki A in which organ and tissue in the emhyro has been formed. Organic phosphorus in ${\gamma}$-ray irradiation has shown the increase of 5.73mg/g during Ki B. Inorganic phosphorus has shown only a little change in the control and ${\gamma}$-ray irradiation. The phosphorus in both has shown a little quantity in the ${\gamma}$-ray irradiation in the early period of incubation. After the Ki A embyro, it has increased rapidly and it has increased till the hatching more continually than in control. The about results of the research will be helpful and instructive to the betterment and improvement, breeding and management of animals and plants.

• Journal of Ginseng Research
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• v.48 no.1
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• pp.103-111
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• 2024

Background: Ginseng (Panax ginseng Mayer) is an important natural medicine. However, a long culture period and challenging quality control requirements limit its further use. Although artificial cultivation can yield a sustainable medicinal supply, research on the association between the transplantation and chaining of metabolic networks, especially the regulation of ginsenoside biosynthetic pathways, is limited. Methods: Herein, we performed Liquid chromatography tandem mass spectrometry based metabolomic measurements to evaluate ginsenoside accumulation and categorise differentially abundant metabolites (DAMs). Transcriptome measurements using an Illumina Platform were then conducted to probe the landscape of genetic alterations in ginseng at various ages in transplantation mode. Using pathway data and crosstalk DAMs obtained by MapMan, we constructed a metabolic profile of transplantation Ginseng. Results: Accumulation of active ingredients was not obvious during the first 4 years (in the field), but following transplantation, the ginsenoside content increased significantly from 6-8 years (in the wild). Glycerolipid metabolism and Glycerophospholipid metabolism were the most significant metabolic pathways, as Lipids and lipid-like molecule affected the yield of ginsenosides. Starch and sucrose were the most active metabolic pathways during transplantation Ginseng growth. Conclusion: This study expands our understanding of metabolic network features and the accumulation of specific compounds during different growth stages of this perennial herbaceous plant when growing in transplantation mode. The findings provide a basis for selecting the optimal transplanting time.