• Molecules and Cells
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• v.37 no.5
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• pp.412-417
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• 2014

It has been reported that exogenously introduced micro-RNA (exo-miRNA) competes with endogenously expressed miRNAs (endo-miRNAs) in human cells, resulting in a detectable upregulation of mRNAs with endo-miRNA target sites (TSs). However, the detailed mechanisms of the competition between exo- and endo-miRNAs remain uninvestigated. In this study, using 74 microarrays that monitored the whole-transcriptome response after introducing miRNAs or siRNAs into HeLa cells, we systematically examined the derepression of mRNAs with exo- and/or endo-miRNA TSs. We quantitatively assessed the effect of the number of endo-miRNA TSs on the degree of mRNA derepression. As a result, we observed that the number of endo-miRNA TSs was significantly associated with the degree of derepression, supporting that the derepression resulted from the competition between exo- and endo-miRNAs. However, when we examined whether the site proficiency of exo-miRNA TSs could also influence mRNA derepression, to our surprise, we discovered a strong positive correlation. Our analysis indicates that site proficiencies of both exo- and endo-miRNA TSs are important determinants for the degree of mRNA derepression, implying that the derepression of mRNAs in response to exo-miRNA is more complex than that currently perceived. Our observations may lead to a more complete understanding of the detailed mechanisms of the competition between exo- and endo-miRNAs and to a more accurate prediction of miRNA targets. Our analysis also suggests an interesting hypothesis that long 3'-UTRs may function as molecular buffer against gene expression regulation by individual miRNAs.

• Journal of the Korean Home Economics Association
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• v.38 no.12
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• pp.29-45
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• 2000

The purposes of this study were to determine what factors influence risk perceptions of females and males for milk produced using food-related biotechnology, to test whether risk perceptions or other factors influence self-protection actions and to estimate milk demand response in light of self-protection actions and other economic and demographic factors. The expected utility model was applied to explain the way consumers would take self-protection actions regarding risk perceptions and to drive milk demand. Telephone interviews were conducted and the data were collected from households(females=1,029, males=437) nationwide in the U.S. And the data were analyzed by Heckman two-step method using the software package LIMDEP. Risk perceptions were found to be influenced not by demographic factors but by outrage factors as well as attitudinal factors in both females and males, although some factors were different. In addition, risk perceptions and labeling availability were found to significantly influence self-protection actions in both groups. Furthermore, as an important concern in this study, self-protection action was found to significantly influence milk demand in only male group, implying a consistent behavior of males. Also milk price and household size were found to significantly influence milk demand in both groups. In fact, the results did demonstrate that labeling availability significantly influenced self-protection actions. That is, in markets where labeled laternatives were present, concerned consumers were more likely to self protect by substituting to these products. A policy implication of this result is that labeling food products produced using biotechnology enhances consumer choice. Hence, consumer could express a more accurate demand response and reduce the perceived food safety risk. Furthermore, education for females might be necessary to have a consistent behavior because self-protection action did not significantly influence female's milk demand, though they have greater risk perceptions than males have.

• Journal of the Korean Society of Clothing and Textiles
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• v.15 no.2 s.38
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• pp.211-227
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• 1991

The purpose of this study was to investigate the effects of design modification, decoration and color scheme of traditional Korean women's clothing on impression formation by 2 age groups of women. The instruments developed for the study were 2 sets of stimuli and a response scale. Stimuli I (design stimuli) consisted of 6 line drawings of female figures in Korean clothing and modified Korean style clothing, whereas stimuli II (color stimuli) consisted of 6 colored drawings of female figures in different color schemes. The 7-point semantic differential scale of 14 bipolar adjectives were used for the response scales. 144 female college students and 144 middle·aged women subjects were randomly assigned to one of 6 drawings from each set of stimuli. The data were analyzed by factor analysis, ANOVA and t-test. 1) There factors emerged to account for dimensions of design and color scheme, respectively. The first factor was interpreted as Evaluation/prestige both in design (stimuli I) and color scheme (stimuli II), the second factor was Modernity for stimuli I, and the third factor for stimuli I was Practicality. On the other hand, the Luxuriousness/Individuality was factor 2 and Modernity was factor 3 for stimuli ll. 2) Modification had the largest effect on impressions regarding design and decorated designs had a partial effect on the impression of Modernity and Practicality. The female figures in modified Korean style clothing were perceived as more prestigious, modern and practical than those in traditional Korean clothing. 3) Color schemes had little effect on impressions, while perceiver's age had a larger effect. Middle·aged women formed more positive impressions toward Korean clothing of various color schemes than female college students.

• The KIPS Transactions:PartD
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• v.16D no.1
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• pp.43-54
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• 2009

The purpose of this study is to explore variables that affect users' perceived value of mobile advertising and actual response intention and to analyze causal relationships among variables. In order to verify the relational significance, we built new research model and hypotheses based on the Ducoffe's model(1996). And we found out four independent variables such as entertainment, information usefulness, convenience, economical efficiency, and advertising impact's value as a mediating variable. Especially, we classified into four multi-age groups to investigate properly moderating effects through SEM(path analysis) and difference test. Therefore, it is academical and practical worth that we developed our model to appropriate on mobile advertising's unique property and that we verified our hypotheses and variables focused on age group, whereas previous research did not. For this, we surveyed 345 samples for conducting structural equation modeling in empirical approach. The results of this study supported the statistical significance of all hypotheses except but convenience.

• Safety and Health at Work
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• v.6 no.4
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• pp.305-311
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• 2015

Background: The purpose of this study was to examine the relationship nursing personal and workplace system factors (work disability) and work ability index scores in Ontario, Canada. Methods: A total of 111 registered nurses were randomly selected from the total number of registered nurses on staff in the labor, delivery, recovery, and postpartum areas of four northeastern Ontario hospitals. Using a stratified random design approach, 51 participants were randomly selected in four northeastern Ontario cities. Results: A total of 51 (45.9% response rate) online questionnaires were returned and another 60 (54.1% response rate) were completed using the paper format. The obstetric workforce in northeastern Ontario was predominately female (94.6%) with a mean age of 41.9 (standard deviation = 10.2). In the personal systems model, three variables: marital status (p = 0.025), respondent ethnicity (p = 0.026), and mean number of patients per shift (p = 0.049) were significantly contributed to the variance in work ability scores. In the workplace system model, job and career satisfaction (p = 0.026) had a positive influence on work ability scores, while work absenteeism (p = 0.023) demonstrated an inverse relationship with work ability scores. In the combined model, all the predictors were significantly related to work ability scores. Conclusion: Work ability is closely related to job and career satisfaction, and perceived control at work among obstetric nursing. In order to improve work ability, nurses need to work in environments that support them and allow them to be engaged in the decision-making processes.

• Journal of Fisheries and Marine Sciences Education
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• v.24 no.4
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• pp.543-558
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• 2012

This is a qualitative study of pre-service teachers' experiences in a teaching practicum course which attempted to identify the characteristics of the course that has been recently revised as professional education course. Data were collected from college students who took the professional education courses including the teaching practicum course by using both a survey on the opinions and suggestions of the students on the teaching practicum and a in-depth interview with 12 students of them. The results are as follows. First, pre-service teachers' perception of a teaching practicum course was divided into two sides : functional side and sociocultural side. The formal is that the professional education courses significantly handed to discipline practical jobs related to educational administration. The latter is that the professional education courses significantly handed to deal for teachers like pay step, extra pay, vacation, and leave of absence. Second, the pre-service teachers had suggestions that were divided into the 'curriculum content' and the 'instructional method'. For instance, regarding the 'curriculum content' they suggested such things needed as 'lessening and differentiation of content, sensitive about the scene, and lesson hands-on', and as for the 'instructional method' they suggested such things needed as actively 'doing, participating, assessing, coursework participating'. Based on these results, I have comprehended the pre-service teachers' positive response. Untill now, we have perceived that the professional education courses is excessively theory-oriented one. But a teaching practicum course is different. Meanwhile, It is not identify what the teaching practicum course as teaching refinement education course is. Due to this cause, I have comprehended that 'curriculum content' and the 'instructional method' is plunged in confusion. As pointed out this, I did concrete proposals in response to such a confusion. This proposals have helped decided on a direction of a teaching practicum course.

• Convergence Security Journal
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• v.18 no.1
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• pp.69-84
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• 2018

This study examines antecedents of the intention of compliance with information security policies based on Ajzen's Theory of Planned Behavior. The study conducted the following: Verification of casual relations between role of management and protection motivation and the antecedents of planned behavior as parameters to determine the effect on the intention of compliance with information security policy, and comparative analysis between the research model and a competition model. The result of the study disclosed that, in the research model, attitude and subjective norm took an intermediary role on management beliefs, response efficacy, response cost, self-efficacy, and compliance intention, and perceived behavior control on management beliefs, self-efficacy and compliance intention.

• The Korean Journal of Franchise Management
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• v.12 no.1
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• pp.45-55
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• 2021

Purpose: How to build the positive emotion of customer is very important, because it affects the positive attitude. Brand evidence has a significant impact on consumer behavior in terms of reinforcing consumers' perception of food service companies and differentiating them from competing brands. Thus, this study examines the effect of brand evidence on emotion (positive emotion and negative emotion), and attitude in restaurant industry. Research design, data, and methodology: This study examines the structural relationship among brand evidence, emotion, and attitude. Brand evidence divide into three sub-dimensions such as physical evidence, core service, and employee service. In order to test the purposes of this study, research model and hypotheses were developed. The questionnaire items were modified and used according to the content of this study based on previous studies. All constructs were measured by multiple items tested and developed in the previous research. The data were collected from 439 restaurant users from Seoul area were analyzed using SPSS 22.0 and SmartPLS 3.0 program. A total of 460 questionnaires were distributed and a survey was conducted for 4 weeks, and a total of 439 were used for analysis, excluding non-response data and 21 unusable response data among the collected questionnaires. Frequency analysis was conducted to identify the general characteristics of the survey subjects. To measure the reliability and validity of the measurement tools, confirmatory factor analysis was conducted. Structural model analysis was conducted to verify the research model. Result: The findings demonstrate that physical evidence, core service, employee service had positive effects on positive emotion. And core service and employee service had negative effects on negative emotion while physical evidence did not have. Also, positive emotion had positive effect on attitude and negative emotion had negative effect on attitude. Conclusions: The findings of this study provide guidelines on how to enhance competitiveness in restaurant industry through understanding brand evidence's effects on raising perceived consumer's emotion and attitude. Therefore, food service companies should establish a marketing strategy that can stimulate positive emotions through brand evidence, which is all factors related to service brands that influence consumers' evaluation of service products and purchase decision-making process.

• Journal of Korea Game Society
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• v.21 no.4
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• pp.25-42
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• 2021

This study investigated motivation factors of mods and their influence on user response to analyze IS Continuance. The data of 610 players of who used mods was analyzed by a Post Acceptance Model of IS Continuance, followed by empirical results. As a result of SEM, the motive factor was divided into the 'Media characteristic', 'Content characteristic', and 'Situational characteristic'. The motive factors significantly affected user response of 'Perceived Usefulness', 'Satisfaction', and 'IS Continuance'; each motivation factors have different influence and 'Content characteristic' significantly affected the IS Continuance.

• Management & Information Systems Review
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• v.39 no.1
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• pp.75-91
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• 2020

The purpose of this study is to examine the application of in-depth interviews in terms of exploration on the basis of the theoretical basis of various aspects of consumer empathy, and the question of whether the consumer can expand to the process of self empathy. Most studies related to consumer empathy divide the responsive dimension of consumer empathy into rational and emotional dimension based on empathy theory, and look at the empathic response perceived by consumers to the stimulus presented from the current point of view. In this study, however, we want to go one step further and confirm that the consumers themselves can ultimately go to the self-empathy stage by forming a creative street of reproduction and redevelopment. As a result of exploratory research through in-depth interviews, it was indirectly confirmed that consumer's empathetic response to specific marketing stimulus exists at the level of creative and self-empathetic as well as the emphasis of previous studies. Based on these findings, this study confirmed that consumer empathetic responses could go beyond a single dimension to form a multidimensional structure and move toward an expanded structure of empathic self-creation. This suggests that consumers' empathic responses should be grasped in terms of continuity of empathic responses rather than explained in a specific dimension. Although this study is meaningful as an early research of exploratory nature, it is necessary to supplement various content validity and refine the research method through subsequent studies. This study is expected to expand the understanding that consumer's empathy can be extended to other people's empathy and to be self-empathy.