• Korean Business Review
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• v.4
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• pp.355-383
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• 1991

1. The Purpose of This study research: The focus of marketing until recently has simply been on sales which means the transfer of goods from the producer to the consumer and on profits therefrom. However, the excess supply of goods due to the expansion of the economy and the resulting fierce competition between companies have changed the nature of marketing. Maximizing consumers' satisfaction and establishing marketing mix strategies for market subdivision and penetration into the target market are now significant roles of the marketing manager. In addition, with regard to company management, information within the company which had been collected, managed and processed sporadically indegrated manner. The purpose of this research on marketing information systems in connection with the above will be to seek ways enabling us to create an efficient and integrated information system for an entire company. 2. The Method and Scop of This Stdudy: Marketing information systems, as a part of management information systems, shall be examined based on relevant theoretical literature. The research process shall be generally developed as follows: 1) The basic structure of the marketing information systems, including its fundamental purpose and necessity, shall be examined. 2) The method for a specific plan shall be presented through fundamental marketing strategy concepts and marketing decision-making. 3) A general model shall be presented based on examinations of various mod els used for marketing information systems and on research of the models' relationship with management information systems. 4) The direction of development shall be presented as the basis for gradual development following examination of the scope, pertinent issues, and means of improvement of the marketing information systems. 3. Summary and Conclusion: As the competition among the enterprises has become keen and thus the management of the contemporary enterprises shows the tendencies of uncertainty as well as complexity, all the managers must make the correct and prompt decision of their mind. Otherwise, the danger which will lead to and failure in the failure in the business may befall to the enterprise. Though computer system and information related techniques have the endless potentiality for the improvement of the enterprise, those are granted only to the enterprise which will be able to manage the computer system and information related techniques. In the contemporary industrial society, the need to a managerial information system has been increasing because all the complicated information can be stored, disposed and managed by the efficient method. And the marketing information system is also the integrated system which has been formed and developed through the efficient mixture of all the constituent elements including the definition of marketing research as the definition of the information system has been enlarged due to the reason shown above. The common point of the two systems is the man machine system functioning to help the efficient decision of the mind by introducing the computer system on the basis of user manager centered thought in order to provide informations to be useful in operation and management of the organization and the function of the mind decision. The purpose for the marketing information system lies in making the utmost use of marketing information available in the course of the mind decision. The reason why the contemporary enterprises necessitate the marketing information system are as follows: 1) The stages of the business operation are expanded wide to the world. 2) As the living standards of the consumers have been on the rise, the enter prise has to satisfy the consumer's "wants" than simple "needs".

• Journal of Oral Medicine and Pain
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• v.20 no.2
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• pp.429-447
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• 1995

This study was designed to determine the most effective concentration of fluoride and levels of laser irradiation for the remineralization of decayed teeth. After irradiation with a pulsed Nd:YAG laser and the topical application of fluoride, phosphate and fluoride concentration in enamel were measured. And then the changes on surface enamel using an scanning electron microscope were observed. Samples by extraction healthy, permanent, mandibular bovine teeth with no caries were obtained. Among them 371 healthy samples were selected and artificial carious lesions were made. 20 samples were assigned to each experimental group. After irradiation with a pulsed Nd:YAG laser with total energy densities of 10J/$\textrm{cm}^2$, 20J/$\textrm{cm}^2$ for each group. On the teeth, 2% NaF, 1.9% NH4F, 1.6% TiF4 Elmex gel(amine fluoride) and 1.23% APF gel were applied. After pH circulatory procedures, concentrations of fluoride with and Ionalyzer (Orion Research, Model 901, USA) and phosphates with an Uv/V is spectrophotometer (Uvikon 860, Kontrom Co, Switzerland) were measured. By etching the teeth in layers and measuring fluoride concentrations, a profile of fluoride penetration according to depth could be developed. And also the changes on the surface of the enamel using an electron scanning microscope were observed. The comparative analysis yielded the following results : 1. Phosphate concentration was low in all groups compared with the control group except for teeth treated Elmex gel, irradiated with 10J/$\textrm{cm}^2$ and 30J/$\textrm{cm}^2$ energy densities. Teeth treated with APF gel and 30J/$\textrm{cm}^2$ irradiation gad the lowest phosphate concentration. 2. Among all groups, fluoride concentrations in tooth enamel were highest in APF gel and NaF groups irradiated at 30J/$\textrm{cm}^2$. The APF gel group had the highest fluoride concentrations across all energy densities. 3. In the APF gel group, and the NaF group, the greater the energy density of the laser, the higher the fluoride concentrations in the enamel. 4. In all groups, the concentration of fluoride in the enamel by depth tended to decrease with depth. 5. Under the scanning electron microscope, under the condition of irradiation with 20J/$\textrm{cm}^2$, enamel crack was detected for the first time. In the NH4F group, spherical deposits were found on the surface of the enamel, and in the TiF4 group the surface of enamel was covered with an irregular, thin membranous mass in places. In the APF gel and NaF groups irradiated with 10J/$\textrm{cm}^2$, spherical and irregular particles covered the teeth. When these groups were irradiated at 20J/cm2, they were covered with amorphous crystals. These results suggest that one could obtain more effective anticariogenic effects without damage to teeth when less than 20J/$\textrm{cm}^2$ energy densities and APF gel are used.

• The Journal of The Korea Institute of Intelligent Transport Systems
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• v.17 no.5
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• pp.14-28
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• 2018

Thanks to technical improvement on the vehicle to vehicle communication and the intelligent transportation system, gradual introduction of the autonomous vehicles is expected soon in the market. The study analyzes the autonomous vehicles' impacts on the network efficiencies. In order to measure the network efficiencies, the study applies the sequential procedures that combines the microscopic and macroscopic simulations. The microscopic simulation attends to the capacity changes due to the autonomous vehicles' proportions on the roadway while the macroscopic simulation utilizes the simulation results in order to identify the network-wide improvement. As expected, the autonomous vehicles efficiently utilizes the existing capacity of the roadway than the human driving does. Particularly, the maximum capacity improvements are expected by the 190.5% on the expressway. The significant capacity change is observed when the autonomous vehicles' proportions are about 80% or more. These improvements are translated into the macroscopic model, which also yields overall network efficiency improvement by the autonomous vehicles' penetration. However, the study identifies that the market debut of the autonomous vehicles does not promise the free flow condition, which implies the possible needs of the system optimal routing scheme for the era of the autonomous vehicles.

• Korean Journal of Oriental Medicine
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• v.3 no.1
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• pp.67-83
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• 1997

In order to search for anti-influenza virus type A agents from Korean medicinal herbs, we selected 100 medicinal herbs, based on a review of the Korean traditional medicine books. Four of 100 Korean medicinal herbs, MM-40, MM-55, MM-63, MM-110, exhibited very strong anti-influenza virus activity. The fractions of four medicinal herbs, which had very strong anti-influenza virus activity, were tested for antiviral activity by means of Haemagglutination inhibition test(HTT), 40% MeOH fraction of MM-40, $H_2O$ fraction of MM-55, 20% fraction of MM-63 3nd $H_2O$ fraction of MM-110 had strong anti-influenza virus activity at the range of $78{\mu}g/ml$ to $156{\mu}g/ml$, 1.56mg/ml to 100mg/ml, 6.25mg/ml to 50mg/ml and $48.7{\mu}g/ml$ to $780{\mu}g/ml$, respectively. These results of HIT indicated that fractions of Korean medicinal herbs might inhibit either attachment of virus to cell surface receptor or penetration of virus into cell during the initial stage of infection. In the cytotoxicity of fractions against red blood cells, 40% MeOH fraction of MM-40, 20% fraction of MM-63 and $H_2O$ fraction of MM-110 showed cytotoxicity at the range of $78{\mu}g/ml$ to 10mg/ml, 50mg/ml to 100mg/ml and $195{\mu}g/ml$ to 100mg/ml, respectively, whereas $H_2O$ fraction of MM-55 did not show cytotoxicity. In order to establish influenza virus adapted animal model, influenza virus type A were passaged 3 and 4 times successively in Balb/c mouse. As a result, we had 4 HA unit titers on the 5 days of 3rd passages and 7 days of 4th passages after infection, respectively.

• Journal of the Korean GEO-environmental Society
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• v.21 no.4
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• pp.19-30
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• 2020

This numerical study is to investigate the seepage characteristics of the side of the structure in the event of leakage from the structural connection part of the drainage structure installed through the enlarged levee, and to analyze the effect of piping on the stabilization of the levee by the lateral penetration behavior. To take into account lateral seepage behavior, 2D and 3D numerical analyses were performed on the same model, and the effect of lateral seepage was analyzed to assess the validity of the numerical analysis. As a result, when leakage occurs and a lateral seepage is considered with the gate located on the riverside land, the maximum pore water pressure near the leakage point of the structure has been reduced by half compared to the normal seepage state where no leakage occurred. Excessive variation in the pore pressure was shown at the lower part of the structure, especially if lateral seepage is not considered. As a water level rises to the high water level, it shows the hydraulic gradient was larger than the critical hydraulic gradient, which will be vulnerable to long-term piping. If a gate is located in the inland and side seepage is not considered, the effect of the seepage water such as hydraulic gradient and seepage velocity is underestimated compared with the case of considering side seepage. The maximum hydraulic gradient is relatively small when lateral seepage is neglected if a gate is located in the riverside land and there was might be a risk of piping or loss of material. In addition, the period exceeding the critical hydraulic gradient was interpreted as a short time zone. As a result, it is considered that the possibility of piping can be underestimated if side seepage is ignored.

• Transactions of the Korean Society of Mechanical Engineers B
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• v.34 no.9
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• pp.875-883
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• 2010

The thermal performance of LNG fuel tanks of vehicles is determined by the time for non-venting storage of fuel and the amount of fuel supplied to the engine. In this study, we selected a double-walled vacuum-insulated fuel tank with a volume of 450 liter, and the properties of the fuel contained in it were assumed to be the same as those of the methane($CH_4$). For the increasing the non-venting fuel storage time, we propose the use of shielded penetration pipes in the tank. We compared the storage times of the tank used in our study with those of the conventional fuel tank. Further, the additional heat input required to maintain the fuel pressure necessary for an appropriate fuel supply rate was predicted. For these parameters, we derived a thermodynamic relationship that can be used to estimate the rate of increase in pressure for a known heat input, and we obtained equations for estimating the rate of heat leaked by using the established heat transfer model. From the results of numerical computation, we found the non-venting storage time of the tank with shielded pipes to be 25-30% higher than that of the tank with unshielded pipes. Further, we determined the appropriate operation conditions by taking into consideration the transfer rate of additional heat provided to the fuel tank.

• Korean Journal of Environmental Agriculture
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• v.26 no.1
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• pp.69-76
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• 2007

The accumulation curves of phenol in the flesh of apples were measured at $5^{\circ}C$, $25^{\circ}C$ and $40^{\circ}C$ when they were exposed to phenol vapor, The effective diffusivities of phenol at the rind and flesh were determined by comparing its experimentally obtained accumulation curves with simulated ones. The simulation was carried out by the non-steady state diffusion rate equation. The diffusion model assumed the consecutive diffusion of phenol at the rind and flesh of apples. The detection time of phenol in the flesh of apples was shortened with increasing temperature, and it accumulated amount also increased rapidly. The estimated effective diffusivity of phenol at the rind of apples increased with temperature as like $1.1{\times}10^{-13}\;m^2/s$ at $5^{\circ}C$, $1.4{\times}10^{-13}\;m^2/s$ at $25^{\circ}C$ and $2.2{\times}10^{-13}\;m^2/s$ at $40^{\circ}C$, but those at the flesh of apples were invariant as $1.5{\times}10^{-10}\;m^2/s$ at this temperature range. The effect of temperature on the diffusivity of phenol was small, but the increase of the vapor pressure of phenol with temperature accelerated the penetration of phenol at the rind, resulting in the rapid accumulation at the flesh of apple.

• Knowledge Management Research
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• v.21 no.3
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• pp.105-121
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• 2020

With regard to the development of new drugs, what is most important for a Korean Biotech, where no global sales network has been established, is decision-making related to out-licensing of new drugs. The probability of success for each clinical phase is different, and the licensing amount and its royalty vary depending on which clinical phase the licensing contract is made. Due to the nature of such a licensing contract and Biotech's weak financial status, it is a very important decision-making issue for a Biotech to determine when to license out to a Big Pharma. This study defined a model called 'optimal timing for out-licensing of new drugs' and the results were derived from the decision tree analysis. As a case study, we applied to a Biotech in Korea, which is conducting FDA global clinical trials for a first-in-class new drug. Assuming that the market size and expected market penetration rate of the target disease are known, it has been shown that out-licensing after phase 1 or phase 2 of clinical trials is a best alternative that maximizes Biotech's profits. This study can provide a conceptual framework for the use of management science methodologies in pharmaceutical fields, thus laying the foundation for knowledge and research on out-licensing of new drugs.

• Journal of Wetlands Research
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• v.22 no.2
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• pp.130-138
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• 2020

As of 2017, the sewerage penetration rate of Seoul and metropolitan cities is more than 90%, and the number of domestic sewage treatment plants increased by 25% from 3,064 in 2010 to 4,072 in 2017. Among them, sewage treatment plant operated by SBR system is 585, which is 17% higher than 2010. In order to improve the water quality of the water source and improve the operation of the small sewage facilities, the improvement of the process was studied by applying the modelling to 49 facilities of the sewage treatment plant in Andong Imha dam area with more than 500㎥/day 3 places and 46 places less than 500㎥/day. As an improvement plan for modelling, candidate data were derived by reviewing operation data for 5 years. 49 facilities are operated by 12 types of operating processes. Among them, 1 place mort than 500㎥/day with SBR method and 9 facilities with less than 500㎥/day were selected by dividing 46 sites into 3 types. As a result of applying modelling to more than 500㎥/day, it was possible to improve the quality of discharged water through SRT control and it was found that applying model to sites of small scale treatment plants can improve the removal efficiency of TP by up to 14.4%. As a result, the data of this study could be used to improve and improve the operation of sewage treatment plants and RCSTP(Rural Community Sewage Tratment Plant).

• Journal of the Korean Geosynthetics Society
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• v.13 no.3
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• pp.1-10
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• 2014

Several types of methods such as resistivity survey, ground penetration radar, etc are used for detection of levee leakage and according to the river design guidelines detection of levee leakage is performed by measuring the hydraulic conductivity of levee soil. But, the former can not verify the leakage point and degree of saturation, the latter is an after treatment method. Movable sensor, which is a high-tech TDR system developed since 2000, can obtain directly the dielectric constant profile covering the whole depth of levee. In this study, laboratory and field model experiments were carried out using movable TDR sensor in order to evaluate the applicability as detection system of levee leakage, As the result, movable TDR system has proven to be 3 times more sensitive to water contents than dry unit weight, and the results conclude that the dielectric constant, water contents and density of the ground proved to have a correlation among them, and the dielectric constant is expected to be a basic data on detection of levee leakage.