• Geomechanics and Engineering
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• 제13권6호
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• pp.1027-1044
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• 2017

Membrane penetration is the most important factor influencing the measurement of volume change for triaxial consolidated-drained shear test for coarse-grained soil. The effective pressure p, average particle size $d_{50}$, thickness $t_m$ and elastic modulus $E_m$ of membrane, contact area between membrane and soil $A_m$ as well as the initial void ratio e are the major factors influencing membrane penetration. According to the membrane deformation model given by Kramer and Sivaneswaran, an analytical solution of the membrane penetration considering the initial void ratio is deduced using the energy conservation law. The basic equations from theory of plates and shells and the elastic mechanics are employed during the derivation. To verify the presented solution, isotropic consolidation tests of a coarse-grained soil are performed by using the method of embedding different diameter of iron rods in the triaxial samples, and volume changes due to membrane penetration are obtained. The predictions from presented solution and previous analytical solutions are compared with the test results. It is found that the prediction from presented analytical solution agrees well with the test results.

• Journal of Pharmaceutical Investigation
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• 제36권6호
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• pp.385-392
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• 2006

Paclitaxel is an important chemotherapeutic agent for the treatment of human solid tumors. Multicellular resistance(MCR) is considered to be a major mechanism of resistance of human solid tumors to chemotherapeutic agent such as paclitaxel, which includes barriers to drug penetration through tumor tissues. Multicellular layers(MCL) cultures resemble in vivo tumor condition in terms of MCR and has been used successfully to produce clinically relevant data. In the present study, we evaluated the penetration characteristics and post-penetration anti-proliferative activity of paclitaxel using MCL of human colorectal cancer cells(DLD-1 and HT-29) grown in Transwell inserts. The penetration of $[^{14}C]-paclitaxel$ was slower than that of mannitol which penetrates via paracellular pathway in DLD-1 MCL. The penetration of $[^{14}C]-paclitaxel$ was faster in HT-29 MCL compared to DLD-1 MCL, i.e., at 10 ${\mu}M$ 100% and 40% penetration were observed after 48 hr incubation for HT-29 and DLD-1 cells, respectively. When calculated using anti-proliferative activity in the conditioned media of bottom chamber, the penetration after 24 hr was very limited(less than 50%) and concentration-dependent at the concentrations tested in both MCL's. These results suggest that limited and differential penetration of paclitaxel in tumor tissues may contribute to lower and differential efficacy against human solid tumors.

• 한국군사과학기술학회지
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• 제15권5호
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• pp.550-556
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• 2012

In this study, a series of ballistic experiments have been performed to investigate the protection mechanism of some inert reactive cassettes against shaped charge jet. Three kinds of material were tested as a core material of the inert cassettes, i.e. one of rubber materials, a high modulus and high strength composite material used for ballistic protection and a mixture of energetic materials. Parameters such as deformation of the cassettes, occurrence time of jet distortion, leading jet length and residual penetration depth were investigated from the experiments and they were compared to each other quantitatively according to the jet incidence angles. The results show that the increment of cassette deformation caused jet distortion to occur early and jet distortion brought decrease of the length of leading jet. Then the decrease of the length of leading jet accompanied the decrease of residual penetration depth.

• 한국정밀공학회지
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• 제23권5호
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• pp.170-176
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• 2006

Multi-layered laminate made of ceramic/composite have been developed to prevent penetration by high velocity impact. In this study, three-layered plates consisted of 1) cover layer (glass fiber reinforced polymer), 2) $Al_{2}O_{3}$, ceramic plate, and 3) backing plate (glass fiber reinforced polymer) were fabricated with various conditions and tested for their ballistic protection characteristic. The ceramic composite laminates, with thin backing plate, were completely penetrated by armor piercing projectile. The plate with inserted rubber between ceramic and backing plate showed excellent ballistic protection, though completely penetrated by the second shoot.

• Journal of Electrical Engineering and Technology
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• 제13권4호
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• pp.1407-1418
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• 2018

Novel mechanism of customized adequacy formulation is proposed in order to enhance micro grids system reliability. The mechanism accounts for 2-levles of load curtailment, and is mainly based on probabilistic load profile and hybrid Distributed Generation (DG) units modeling. The two load curtailments are needed in order to ensure adequate technical constraints at steady state condition during islanding mode of operation. The effectiveness of the proposed formulation has been verified using system independent analytical expressions for the evaluation of both reliability and Expected Energy Not Served (EENS) indices. The evaluation has examined the impact of different penetration levels of Hybrid DG Units in case study islands. Results show the enhancement of the overall distribution system reliability and the recommended conditions for successful islanding mode of operation.

• 터널과지하공간
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• 제13권6호
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• pp.444-454
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• 2003

최근 TBM등의 기계식 터널 굴착에 널리 사용되는 커터 디스크 관입에 의한 암석 파쇄 기술은 커터디스크 관입에 따라 국부적으로 높은 응력이 발생하고 미소균열이 생성 및 전파되는 과정이며, 이러한 현상은 암석의 불균질성에 기인한다. 따라서 본 연구에서는 수치해석적으로 TBM에 의한 파괴 메카니즘을 규명하기 위하여. Weibull 분포함수를 이용하여 암석의 불균질 강도 물성을 고려하였으며, 파괴후 물성 저하를 고려하기 위하여 저감지수를 도입하였다. 본 연구결과로부터 단일 커터 디스크 관입시 측압이 매우 중요한 영향을 미치며, 측압이 작을수록 관입에 저항하는 강도는 약하여 커터 디스크와 접촉하는 면과 수직한 방향으로 파괴가 잘 발생하고 측압이 클수록 암석 표면을 따라 chipping 현상이 잘 나타났다. 또한 두 개의 커터 디스크가 작용하는 경우 파괴영역이 전파되고 상호 연합되어 최종적으로 파괴가 발생하는데, 커터 디스크 간격이 70 mm인 경우가 40 mm와 100 mm인 경우 비해 좋은 파쇄효율을 나타내었다. 이상의 결과로부터 커터 디스크 관입에 의한 암석의 chipping 과정 및 메카니즘의 이해와 TBM 터널 설계를 위한 다양한 검토를 해석적 기법으로서 제시할 수 있을 것으로 기대된다.

• Geomechanics and Engineering
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• 제29권3호
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• pp.359-368
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• 2022

Undercutting using an actuated disc cutter (ADC) involves more complex cutting mechanism than traditional rock cutting does, requiring the application of various new cutting parameters, such as eccentricity, cutter inclination angle, and axis rotational speed. This study presents cutting-edge laboratory-scale testing equipment that allows performing ADC tests. ADC tests were carried out on a concrete block with a specified strength of 20 MPa, using a variety of cutting settings that included penetration depth (p), eccentricity (e), and linear velocity (v). ADC, unlike pick and disc cutting, has a non-linear cutting path with a dynamic cutting direction, requiring the development of a new method for predicting cutting force and specific energy. The influence of cutting parameters to the cutter forces were discussed. The ratio of eccentricity to the penetration depth (e/p) was proposed to evaluate the optimal cutting condition. Specific energy varies with e/p ratio, and exhibits optimum values in particular cases. In general, actuated undercutting may potentially give a more efficient cutting than conventional pick and disc cutting by demonstrating reasonably lower specific energy in a comparable cutting environment.

• 한국군사과학기술학회지
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• 제11권6호
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• pp.164-171
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• 2008

A modified generalized particle algorithm, MGPA, was suggested to improve the computational efficiency of standard SPH method in numerical analysis of high speed impact behavior. This method uses a numerical failure mechanism than material failure models to describe the target penetration. MGPA algorithm was more effective to describe the impact phenomena and new boundaries produced during the calculation process were well recognized and treated in the target penetration problem of a bullet. When bullet perforation problems were analyzed by this method, MGPA algorithm calculation gives the stable numerical solution and stress oscillation or particle penetration phenomena were not shown. The error range in ballistic velocity limit is less than $2{\sim}13%$ for various target thickness.

• 한국콘크리트학회:학술대회논문집
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• 한국콘크리트학회 1999년도 봄 학술발표회 논문집(I)
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• pp.411-414
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• 1999

In this study, the characteristics of concrete strength according to age/curing condition and the penetration mechanism of seawater into the concrete has been studied. To this end, a comprehensive experimental program has been setup. The major test variables include the type of cement and the type of mineral admixture. The strength test as well as corrosion test have been conducted to explore the effects of chloride ion penetration on the properties of concrete. The experimental results and the developed theory in the present study can be efficiently used to analyze the chloride ion penetration and to estimate the durability of concrete structures.

• 한국포장학회지
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• 제13권2호
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• pp.59-65
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• 2007

Packaged food products often undergo retort processing, a thermal processing in a pressurized vessel called a retort, to ensure their microbiological safety or shelf-stability under normal non-refrigerated conditions of storage and distribution. Retort processing is generally aimed to accomplish commercial sterility of packaged foods with acceptable nutritional and sensorial qualities. Fundamental principles on retort processing, such as thermal resistance kinetics of target microorganism, heat penetration theory, and methods for evaluating process sterility and food quality loss, were reviewed. Factors affecting process severity, heat transfer mechanism, and heat penetration efficiency were summarized. General features of retortable packaging formats including metal cans, glass jars, and plastic packages were also briefly reviewed.