• Journal of Technology Innovation
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• v.2 no.1
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• pp.256-276
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• 1994

This paper aims at identifying the desirable R'||'&'||'D life cycle related to government-industry cooperative R'||'&'||'D. It is based on a case study associated with the relationship between cooperation and cooperation in information in information communications sector. It presents three types of R'||'&'||'D life cycle to achieve a technological enhancement as high as possible with limited resources. The first case of R'||'&'||'D project is of "advanced type". In the generic technology phase, government takes a leading role jointly in R'||'&'||'D activities, but, in after the applied research phase, the domestic firms take the lead. This kind of cooperation can be made when competition between domestic firms is highly intense, and the technological knowledges of participating firms are at internationally competitive levels. The second type of "less-advanced type"; the firms of a country(more often a small country) lag behind in technology level, and the penetration of foreign firms in the market is limited. In this case, government takes full charge of R'||'&'||'D activities up to the applied research phase, due to the low technology level and insufficient financial resources of private firms. Lastly, this paper presents and R'||'&'||'D life cycle of "strategic" type. This applies to the case in which domestic firm with less financial resources make an attempt to increase their technological knowledges while the government, in turn, contributes to strengthen the international competitiveness of domestic industry.

• Proceedings of the Korean Society of Propulsion Engineers Conference
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• 2012.05a
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• pp.378-385
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• 2012

Vent mixer can provide main flow directly into a recirculation region downstream of the mixer to enhance fuel-air mixing efficiency. Based on experimental results of three-dimensional velocity, vorticity and turbulent kinetic energy obtained by a stereoscopic PIV method, the performance of the vent mixer was compared with that of the step mixer which was used as a basic model. Thick shear layers of the vent mixer induced the increase of the penetration height. The turbulent kinetic energy mainly distributed along a boundary layer between the main flow and the jet plume. This turbulent field activates mass transfer in a mixing region, leading to the mixing enhancement.

• Korean journal of dermatology
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• v.56 no.10
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• pp.624-627
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• 2018

Allergic contact dermatitis is an inflammatory condition associated with periorbital erythema, edema, and pruritus. The periorbital skin is relatively thin compared with the skin over other facial areas; therefore, it is vulnerable to allergen penetration and may show a variety of cutaneous manifestations. Recently, vision enhancement surgery is a widely performed procedure, and the prevalence of senile cataract and glaucoma is increasing. The prevalence of periocular allergic contact dermatitis is increasing secondary to the growing use of topical ophthalmic medications. Several studies in Korea have reported periocular allergic contact dermatitis secondary to the use of topical ophthalmic medications including latanoprost ($Latano^{(R)}$), fluorometholone ($Tolon^{(R)}$), polymyxin B ($Terramycin^{(R)}$), atropine sulfate ($Atropine^{(R)}$), neomycin sulfate ($Cambison^{(R)}$), and befunolol hydrochloride ($Bentos^{(R)}$), among others. However, ofloxacin ($Effexin^{(R)})$-induced allergic contact dermatitis has not been reported in the domestic and/or foreign literature. We report a case of periocular allergic contact dermatitis secondary to the use of ofloxacin ophthalmic ointment.

• Korean Journal of Metals and Materials
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• v.49 no.9
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• pp.720-725
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• 2011

W-Ni-Fe heavy alloys have been used in various fields, such as kinetic energy penetrators and radiation shielding materials, due to their high density and good mechanical properties. In this study, the sintering of W-Ni-Fe alloys with various Ni/Fe ratios was demonstrated to improve the mechanical properties and penetration capabilities of heavy alloys by formation of interfacial phase. The microstructural changes and the mechanical properties of the W-Ni-Fe alloys after liquid-phase sintering were investigated. The Vickers hardness and tensile strength of the 95W1.3Ni3.7Fe sample, which had coated W grains by $Fe_7W_6$ phase (${\mu}$-phase), were 450 Hv and 1560 MPa, respectively. As a result, enhancement of the mechanical properties was considered to have uniformly generated ${\mu}$-phase around W grains.

• Tribology and Lubricants
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• v.36 no.6
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• pp.320-323
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• 2020

Thin film coatings are commonly exploited to minimize wear and optimize the frictional behavior of various precision mechanical systems. The enhancement of thin film durability is directly related to the performance maximization of the system. Therefore, a fine approach to analyze the thin film wear behavior is required. Archard's equation is a representative and well-developed law that defines the wear coefficient, which is the probability of creating wear particles. A ploughing model is a commonly used model to determine the friction force during the abrasive contact. The equations demonstrate that the friction force and wear coefficient are inversely proportional to the hardness of the material. In this study, Archard's equation and ploughing models are modified with an effective hardness to minimize the gap between the experimental and numerical results. It is noted that the effective hardness is the hardness variation with respect to the penetration depth owing to the substrate effect. The nanoindentation method is utilized to characterize the effective hardness of Cu film. The wear coefficient value considering the effective hardness is more than three times higher than that without considering the effective hardness. The friction force predicted with the effective hardness agreed better with the results obtained directly from the friction force detecting sensor. This outcome is expected to improve the accuracy of friction and wear amount predictions.

• Journal of Sensor Science and Technology
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• v.32 no.6
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• pp.418-424
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• 2023

Natural killer (NK) cells play a crucial role in combating infections and tumors. However, their therapeutic application in solid tumors is hindered by challenges, such as limited lifespan, tumor penetration, and delivery precision. Our research introduces a novel ultrasonic actuation technique to navigate NK cells more effectively in the vascular system, particularly at vessel bifurcations where targeted delivery is most problematic. We use a hemispherical ultrasonic transducer array that generates phase-modulated traveling waves, focusing on an ultrasound beam to steer NK cells using blood-flow dynamics and a focused acoustic field. This method enables the precise obstruction of non-target vessels and efficiently directs NK cells toward the tumor site. The simulation results offer insights into the behavior of NK cells under various conditions of cell size, radiation pressure, and fluid velocity, which inform the optimization of their trajectories and increase targeting efficiency. The experimental results demonstrate the feasibility of this ultrasonic approach for enhancing NK cell targeting, suggesting a potential leap forward in solid tumor immunotherapy. This study represents a significant step in NK cell therapeutic strategies, offering a viable solution to the existing limitations and promising enhancement of the efficacy of cancer treatments.

• Korean Journal of Animal Reproduction
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• v.25 no.4
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• pp.317-325
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• 2001

This study investigated the effect of ferrous sulfate (Fe$^{2+}$) and/or ascorbic acid (Asc) on fertilizing ability in vitro of frozen-thawed boar spermatozoa. Using chlortetracycline (CTC) fluorescence, the spermatozoa was treated in preincubation medium with control, Fe$^{2+}$(1 mM), Asc (0.5 mM) and Fe$^{2+}$Asc to assessed for acrosome reaction, and the oocyte penetration test to determine whether the Fe$^{2+}$ and/or Asc can promote the penetration ability in vitro. When frozen-thawed spermatozoa was washed with preincubation medium, there were significantly (P ＜ 0.05) more acrosome-reacted in medium with Fe$^{2+}$Asc (38%) than control (27%). The penetration rates were also significantly (P ＜ 0.05) higher in medium with Fe$^{2+}$Asc (76%) than control (55%). Next, the lipid peroxidation of sperm was evaluated on the basis of malondialdehyde production following same treatments. The addition of Fe$^{2+}$Asc to sperm suspension increases the formation of malondialdehyde. However, there were not significantly different under the all conditions. The sperm suspension were also treated with control, Fe$^{2+}$, Asc and Fe$^{2+}$/Asc and assayed for sulfhydry1(-SH) group content. In the Fe$^{2+}$/Asc group, sperm-SH group were higher than another groups. In spermatozoa treated with Fe$^{2+}$ and/or Asc, however, no changes in sperm -SH-groups were detected when compared to controls. In another experiment, the activity of sperm binding to zona pellucida was evaluated through binding to salt-stored porcine oocytes. In control and Asc treatment groups, sperm binding to zona pellucida were significantly (P ＜ 0.05) higher than in medium with Fe$^{2+}$. On the other hand, there is not a significant increase in binding to zona pellucida with spermatozoa treated by Fe$^{2+}$/Asc. In summary, the present study suggests that Fe$^{2+}$/Asc causes an enhancement in fertilizing ability that is associated with penetration rate increased without change of spermatozoa binding capacity to homologous zona pellucida.o homologous zona pellucida.

• Journal of the Korean Applied Science and Technology
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• v.36 no.3
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• pp.685-699
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• 2019

Antioxidant, antibacterial, and skin penetration tests were conducted to investigate the skin absorption of Pyrus serotina var leaf extracts using polymer micelles and their applicability to cosmetic ingredients. Total polyphenol content was found to be $118.83{\pm}9.39mg/g$ in Pyrus serotina var leaf ethanol extract and $106.89{\pm}4.45mg/g$ in Pyrus serotina var leaf hydrothermal extract. The DPPH radical scavenging activity was found to be the highest radical scavenging activity of $74.39{\pm}7.48%$ of the Pyrus serotina var leaf ethanol extract at the concentration of 500 mg/L. The SOD-like activity was $91.62{\pm}0.43%$, the highest value at the concentration of 1,000 mg/L in the hydrothermal extract. After the experiment, antioxidation, wrinkle improvement and whitening activity were confirmed, and the Pyrus serotina var leaf extract was highly likely to be realized as antioxidant and antibacterial material. In the skin penetration experiment with the Pyrus serotina var leaf ethanol extract, the permeation amount of total accumulated tannic acid was found to be Formulation 2 ($55.45{\mu}g/cm^2$), Formulation 1 ($46.43{\mu}g/cm^2$), Formulation 0 ($34.36{\mu}g/cm^2$). In the liposome's skin penetration experiment containing pear leaf hydrothemal extract, the total amount of accumulated tannic acid permeation was found to be Formulation 5 ($75.01{\mu}g/cm^2$), Formulation 4 ($64.01{\mu}g/cm^2$) and Formulation 3 ($36.60{\mu}g/cm^2$). Through this study, we confirmed the possibility of antioxidant and wrinkle effects of Pyrus serotina var leaf extract. In addition, as a result of skin penetration through the production of polymer micelles and liposome containing Pyrus serotina var leaf extract, It will be more usable in cosmetic industry.

• Journal of the Korea Concrete Institute
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• v.18 no.2 s.92
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• pp.239-248
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• 2006

Recently, a variety of researches has been carried out to obtain a more controlled durability and long-term performance of concrete structures under chloride attack environments. In particular, new procedures for probability-based durability analysis/design have been noticed to be very valuable for the enhancement of service life of concrete structures. Although there is still a lack of relevant data, this approach has been successfully applied to some new concrete structures. In this paper, the diffusion equation based on Fick's second law has been solved with a time dependent diffusion coefficient and the probabilistic analysis of the durability performance has been carried out by using a Monte Carlo Simulation. From the results, the influence of each parameter on the durability of concrete structures was investigated and the new procedure for durability analysis was demonstrated in terms of chloride penetration data from various concrete structures. The new procedure might be very useful in designing important concrete structures and help to predict the remaining service life of existing concrete structures under chloride attack environments.

• Journal of the Korea institute for structural maintenance and inspection
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• v.19 no.5
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• pp.83-91
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• 2015

With varying conditions of concrete surface, induced chloride contents are changed and this is a key parameter for steel corrosion and service life in RC (Reinforced Concrete) structures. Many surface enhancement techniques using impregnation have been developed, however the evaluation techniques for chloride behavior through doubly layered media and time-dependent diffusion are rarely proposed. This paper presents an analysis technique considering double-layer concrete and time-dependent diffusion behavior, and the results are compared with those from the previous test results through reverse analysis. The chloride profiles from the surface-impregnated concrete exposed to atmospheric, tidal, submerged zone for 2 years are adopted. Furthermore surface chloride contents and diffusion coefficients are obtained, and are compared with those from Life365. Through consideration of time effect, the relative error decreases from 0.28 to 0.20 in atmospheric, 0.29 to 0.11 in tidal, and 0.54 to 0.40 in submerged zone, respectively, which shows more reasonable results. Utilizing the diffusion coefficients from Life365, relative errors increases and it needs deeper penetration depth (e) and lower diffusion coefficient ratio ($D_1/D_2$) due to higher diffusion coefficient.