• The Journal of Korean Physical Therapy
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• 제23권6호
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• pp.77-84
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• 2011

Purpose: The objectives of this study were to determine the enhancing effect of iontophoresis method as it transdermally deliver methylene blue (MB) using visual examination, in terms of penetration depth and tissue distribution in the skin, and to determine the effect of application duration on the efficacy of iontophoresis. Methods: Twenty-four male Sprague-Dawley rats were randomly divided into 5-, 10-, 20-, and 40-minute groups. These rats were exposed to either topical or anodic iontophoresis of 1% MB using a direct current of $0.5mA/cm^2$ for 5, 10, 20, and 40 minutes. Using cryosections of rat tissues, the penetration depth of MB was measured using light microscopy. Results: Significant differences in the penetration depth (F=54.20, p<0.001) were detected among the four groups. Post hoc comparisons of the penetration depth of MB data pooled across groups showed no significant difference between all topical application groups and 5-minute iontophoresis group, but did reveal a significant difference in the penetration depth between all topical application groups and 5-minute iontophoresis group versus 10-minute group, between the 10-minute and 20-minute group, and between the 20-minute and 40-minute iontophoresis group (p<0.05). Conclusion: The results demonstrate that iontophoresis enhances transdermal delivery of MB across stratum corneum of skin barrier by visual examination. Furthermore, the penetration depth of iontophoretic transdermal delivery of MB was dependent on the application duration. The duration of iontophoresis is one of the important factor in the efficacy of iontophoresis application.

• 대한기계학회:학술대회논문집
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• 대한기계학회 2008년도 추계학술대회A
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• pp.1518-1520
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• 2008

Recent clinical studies have shown that computer navigation for total knee arthroplasty (TKA) provides improved component alignment accuracy. However, femoral stress fracture after computernavigated TKA have been reported due to the pin hole and we hypothesized that osteoporosis would be one of the key factors in pin hole fracture after computer-navigated TKA. We investigated the von-Mises stress around the femoral pin-hole for different elastic modulli and ultimate stresses and four different pin penetration modes to understand the aging effect on femoral stress fracture risk after computer-navigated TKA by finite element analysis. In this study, aging effect was shown to increase the femoral stress fracture risk for all pin penetration modes. Especially, aging effect was shown dramatically in the transcortical pin penetration mode.

• 한국자동차공학회논문집
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• 제9권6호
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• pp.16-23
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• 2001

Spray dispersion in high pressure diesel engines have been simulated experimentally with a special emphasis on the effect of swirl by using a liquid injection technique. A constant volume chamber was designed to be rotatable in order to generate a continuous swirl and to have the flow field closely resembling a solid body rotation. Emulsified fuel was injected into the chamber and the developing process of fuel sprays was visualized. The effect of swirl on the spray dispersion was quantified by calculating non-dimensionalized dispersion area according to the spray tip penetration length. The results show that the effect of swirl on the spray dispersion is different between short and long spray penetrations. For short range of spray tip penetration, the effect of swirl on spray dispersion is quite small. However, as the spray tip is penetrated into longer distance in spray chamber, the effect of swirl on spray dispersion becomes larger. These results can be used as a basic data for designing combustion chamber and injection system of direct injection diesel engine.

• 대한소아치과학회지
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• 제26권2호
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• pp.416-426
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• 1999

본 연구의 목적은 치면열구전색제 수복시에 상아질 접착제의 primer 도포의 치면열구전색제 열구 침투도 향상 효과를 확인하는 것으로, 발거된 영구 구치상에서 통상적으로 치면열구전색제를 도포한 대조군과 $Scotchbond^{TM}$ Multi-Purpose system과 $All-Bond^{(R)}$ 2 system의 primer 도포 후에 치면열구전색제를 도포한 실험군들의 열구 기저부까지 전색제 침투 성공율을 비교하여 다음과 같은 결론을 얻었다. 1. $Scotchbond^{TM}$ Multi-Purpose system과 $All-Bond^{(R)}$ 2 system의 primer 를 사용한 군의 열구 기저부까지 치면열구전색제 침투 성공율은 primer를 사용하지 않은 대조군보다 높았으나 통계학적으로 유의성 있는 차이는 없었다(p>0.05). 2. 열구 깊이와 폭 및 '깊이/폭' 값은 열구 기저부까지 전색제 침투성공률에 대하여 통계학적으로 유의성 있는 효과를 나타내었다(p<0.05). 3. 열구 기저부까지 전색제 침투 성공률은 열구 깊이가 $25{\mu}m$ 증가할 때마다 약 0.9배로 감소하였고, 열구 입구의 폭이 $25{\mu}m$ 증가할 때마다 약 1.1배로 증가하였으며, 열구의 '깊이/폭' 비율이 1 증가할 때마다 약 0.6배로 감소하였다.

• 대한기계학회:학술대회논문집
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• 대한기계학회 2001년도 춘계학술대회논문집D
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• pp.127-132
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• 2001

An experimental study on penetration integrity of the reactor vessel has been performed under external vessel cooling during a core melt accident. In this study a series of experiments are performed for the verification of the effects of coolant in the annulus between the ICI(In-Core Instrumentation) nozzle and the thimble tube and also the effects of external vessel cooling on the integrity of the penetration using the test section including only one penetration and $Al_{2}O_{3}$ melt as a corium simulant. The experimental results have shown that penetration is more damaged in the case of no external vessel cooling compared with the case of external vessel cooling. It is preliminarily concluded that the external vessel cooling is very effective measure for the improvement of the penetration integrity. Also it is confirmed from the experimental results that the coolant in the annulus reduces the melt penetration distance through the annulus and enhance the integrity of the reactor vessel penetration in the end.

• 한국레이저가공학회지
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• 제5권1호
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• pp.33-42
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• 2002

In order to investigate the characteristics of the plasma induced by lap-joint CO$_2$ laser welding of automotive steel sheets, the effects of welding speed, shield gas flow rate, gap size, and laser beam defocus to plasma intensity emitted from keyhole have been investigated. The plasma light is measured by fiber and photodiode. Also, the plasma images were captured by the high speed digital camera in 1000frames/sec in order to correlate the plasma light signal with plasma pattern. From the results, it is observed that the difference of the plasma intensity for between the deep penetration and partial penetration exists from 1.2 to 2 times. The plasma light intensity decreased in case of the deep penetration Is observed due to the exhausting of the plasma gas under the sheet. On the other hand, under the conditions of the deep penetration, the plasma intensity is significantly increased by controling the conditions decreasing the penetration depth. It was specially founded that the effect of 0.3mm gap size at partial penetration condition is approximately similar to deep penetration in 0mm gap. It is concluded that the plasma intensity is able to evaluate the penetration depth in lap-joint welding and appears to offer the most straightforward correlation to the welding process.

• Restorative Dentistry and Endodontics
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• 제40권2호
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• pp.143-148
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• 2015

Objectives: This study evaluated the maximum depth and percentage of irrigant penetration into dentinal tubules by passive ultrasonic irrigation (PUI). Materials and Methods: Thirty extracted human teeth were instrumented and divided into three groups. According to final irrigation regimen, 5.25% sodium hypochlorite (Group A, NaOCl), 2% chlorhexidine (Group B, CHX) and saline solution (Group C, control group) were applied with Irrisafe 20 tips (Acteon) and PUI. Irrigant was mixed with 0.1% rhodamine B. Sections at 2 mm, 5 mm, and 8 mm from the apex were examined with confocal laser scanning microscopy (CLSM). The percentage and maximum depth of irrigant penetration were measured. Kruskal-Wallis test and Mann-Whitney test were performed for overall comparison between groups at each level and for pairwise comparison, respectively. Within a group, Wilcoxon test was performed among different levels. p values less than 0.05 were considered significant. Results: In all groups, highest penetration depth and percentage of penetration were observed at the 8 mm level. At 2 mm level, Groups A and B had significantly greater depths and percentages in penetration than Group C (p < 0.05), but there were no significant differences between Groups A and B. At 5 mm level, penetration depths and percentage of penetration was not significantly different among the groups. Conclusions: NaOCl and CHX applied by PUI showed similar depth and percentage of penetration at all evaluated levels.

• Journal of Pharmaceutical Investigation
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• 제22권2호
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• pp.163-166
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• 1992

The effect of Tween 20 on the penetration of ketoprofen in aqueous vehicles through excised rat skin has been evaluated. The addition of Tween 20, up to 2%, in water containing ketoprofen decreased the penetration of ketoprofen through the skin compared with the reference vehicle without this surfactant. However, the addition of Tween 20 in ketoprofen aqueous vehicle increased diffusion parameter significantly which was compensated with the lowered partition parameter.

• Ocean and Polar Research
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• 제26권1호
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• pp.43-50
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• 2004

The diffusion model, which considers diffusion and sorption, is proposed. The FEM program developed on the basis of the diffusion model provides the estimation of chloride concentration according to cyclic humidity and sorption. After the humidity diffusion analysis is carried out, the chloride ion diffusion and sorption analysis are conducted on the basis of the preestimated humidity data in each element. Each element has different analysis variables at different ages and locations. At early ages, the difference between inner and outer relative humidity causes the chloride ion penetration by sorption. As the humidity diffusion reduces the difference with age, the effect of sorption on the chloride ion penetration decreases. By the way, the cyclic humidity increases the effect of sorption on the chloride ion penetration at early ages, and the quantity of chloride ion around steel at later ages. Therefore, the in situ analysis of chloride ion penetration for marine concrete structures must be performed considering the cyclic humidity condition and the long term sorption.

• 대한전자공학회:학술대회논문집
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• 대한전자공학회 2002년도 하계종합학술대회 논문집(2)
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• pp.193-196
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• 2002

This paper presents the improvement of the boron penetration and the reverse short channel effect (RSCE) in the 130nm W/WNx/Poly-Si dual gate PMOSFET for a high performance embedded DRAM. In order to suppress the boron penetration, we studied a range in the process heat budget. It has shown that the process heat budget reduction results in suppression of the boron penetration. To suppress the RSCE, we experimented with the halo (large tilt implantation of the same type of impurities as those in the device well) implant condition near the source/drain. It has shown that the low angle of the halo implant results in the suppression of the RSCE. The experiment was supported from two-dimensional(2-D) simulation, TSUPREM4 and MEDICI.