• 대한의용생체공학회:의공학회지
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• 제41권1호
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• pp.48-54
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• 2020

In this paper, we deal with a liver fibrosis classification problem using ultrasound B-mode images. Commonly representative methods for classifying the stages of liver fibrosis include liver biopsy and diagnosis based on ultrasound images. The overall liver shape and the smoothness and roughness of speckle pattern represented in ultrasound images are used for determining the fibrosis stages. Although the ultrasound image based classification is used frequently as an alternative or complementary method of the invasive biopsy, it also has the limitations that liver fibrosis stage decision depends on the image quality and the doctor's experience. With the rapid development of deep learning algorithms, several studies using deep learning methods have been carried out for automated liver fibrosis classification and showed superior performance of high accuracy. The performance of those deep learning methods depends closely on the amount of datasets. We propose an enhanced U-net architecture to maximize the classification accuracy with limited small amount of image datasets. U-net is well known as a neural network for fast and precise segmentation of medical images. We design it newly for the purpose of classifying liver fibrosis stages. In order to assess the performance of the proposed architecture, numerical experiments are conducted on a total of 118 ultrasound B-mode images acquired from 78 patients with liver fibrosis symptoms of F0~F4 stages. The experimental results support that the performance of the proposed architecture is much better compared to the transfer learning using the pre-trained model of VGGNet.

• International Journal of Contents
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• 제5권1호
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• pp.33-36
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• 2009

Since the diagnosis of malignancy and benign of thyroid gland diseases is difficult only by using ultrasonogram opinions, the combination of fine needle aspiration (FNA) has been generalized trend for precise pathological diagnosis. Therefore, the current study aimed to know about its availability. The study subjected 500 patients who received the FNA along with the ultrasonogram screening for thyroid gland from October, 2007 to April, 2008. As the equipments for the study, Philips HDI-3500 and Philips UITRAMARKer-9 (UM-9) were used to conduct the comparative analysis of pathological results that were obtained through the inspection of ultrasonogram screening and through ultrasonogram guided FNA. Among the 464 patients who were found to be benign from the ultrasonogram screening inspection, II cases of the FNA diagnosis results judged to be malignancy, and 13 cases of the FNA diagnosis resulted to be benign among 36 patients who were diagnosed to be malignancy. The cases observed as solid from the opinions of ultrasonogram screening were often found to be malignancy, and most of the malignancy results were observed to show the hypoechoic pattern. Among the patients diagnosed with malignancy from the diagnosis of FNA, the 32 patients were found to have the papillary carcinoma, and the benign type was observed to be goiter and hyperplasia in 263 patients, which took up 52.6%. The ultrasonogram screening test that is performed for the purpose of diagnosing thyroid gland diseases, it is distinctively an useful inspection to diagnosis the presence, size and shape of nodules. However, the results of performing of FNA for those of nodules which were observed to be benign from the ultrasonogram were often came up with malignancy and there were cases that the nodules diagnosed with malignancy were diagnosed as benign from the FNA diagnosis.

• 식물분류학회지
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• 제35권4호
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• pp.287-294
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• 2005

제주도 오름의 동굴 입구에 생육하고 있는 줄고사리 (Nephrolepis cordifolia)와 제주도 해발 400-500 m의 붉가시나무림 내에 생육하는 산중개고사리 (Athyrium epirhachis) 그리고 전남북 및 서울 산지의 바위 틈새에서 자라는 거미꼬리고사리 (Asplenium castaneo-viride)를 국내 미기록 양치식물로 보고한다. 줄고사리는 외래식물로 알려져 왔으나 제주도 오름의 동굴 입구에 무리지어 생육하고 있다. 산중개고사리는 골개고사리와 유사하지만 대부분의 소우편 (최종열편)이 우축에 넓게 붙어 자루가 없고 또한 전열, 심열 혹은 중열하는 우편을 갖는 1회 우상복엽인 점에서 구분이 가능하다. 거미꼬리고사리는 거미고사리와 꼬리고사리의 교잡종으로 엽축 선단부의 무성아의 존재 유무, 엽신의 형태, 엽맥의 종류, 식물체의 크기, 잎의 질감 및 우편의 분열 유무 등으로 모종과 구분된다.

• 한국컴퓨터그래픽스학회논문지
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• 제21권5호
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• pp.1-10
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• 2015

본 연구는 가상 조경을 구성하는 다양한 종류의 디지털 잎을 쉽고 직관적으로 제작할 수 있는 저작도구 개발방법을 제안한다. 제안하는 저작도구의 핵심 시스템은 영상 워핑기반의 잎몸 윤곽선 변형 방법, 잎맥의 절차적 모델링 그리고 잎의 색과 명암 등을 표현하기 위한 수리모델기반 시각화 방법으로 구성된다. 우선 잎 영상을 입력으로 받아 잎몸에 대한 윤곽선 정보를 찾고, 특징기반 영상 워핑을 활용하여 다양한 잎몸 형상을 직관적인 구조에서 쉽게 생성할 수 있는 잎몸 변형 방법을 설계한다. 그리고 계산된 잎몸 윤곽선을 기반으로 잎몸 형상에 적합한 자연스러운 잎맥 패턴을 생성하는 일반화된 절차적 모델링 방법을 저작도구에 맞게 구현한다. 마지막으로 약수 함수의 합성 기반의 수리모델을 활용하여 잎의 색, 명암 그리고 시간에 따른 변화를 표현할 수 있는 시각화 기능을 적용한다. 제안한 저작도구를 활용하여 제작된 디지털 잎이 다양한 3차원 디지털 콘텐츠 분야에 활용 가능하도록 텍스쳐 지원 기능을 제공한다.

• 한국의상디자인학회지
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• 제17권4호
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• pp.41-54
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• 2015

The purpose of this study is to research on status of physical discomfort and clothing life including clothing inconvenience for enhancing self-reliance of elderly women, newly emerging consumer. The subject of research were 346 elderly women who aged 60 or older in Seoul and Seoul Suburbs. Survey consisted of questions about body discomfort, satisfaction and purchasing criteria of ready-to-wear, the inconvenience of clothing. The results of this study are as follows: Physical discomforts were generally associated with the ability to regulate body temperature. The biggest complaint of ready-to-wear was the price, and the next were the size and activity. In purchasing criteria, 'clothes to fit my body shape', 'clothes easy to put on and take off', 'comfortable clothes to work' showed high score. In clothing inconvenience, 'feel inconvenience due to several layers of clothing to avoid chilliness', 'feel heaviness in the waist due to tightness', 'feel chilliness even when wearing several layers of clothing in the winter' were the most uncomfortable parts. Subjects over the age of 80 years and needed the help of others in activities experienced more inconvenience in clothing life. It seems that body discomfort such as dulness of movement and loss of body temperature regulation capability due to aging had a influence on their clothing life. This problem could be improved by the adjustment of pattern allowance, the selection of the fastener, and the proper use of functional fabric. The results of this study will be used as a basis for development of the elderly women's clothing to increase convenience and mobility in everyday life.

• Journal of the Korean Data and Information Science Society
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• 제27권5호
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• pp.1193-1201
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• 2016

공간 또는 시공간 데이터에서 다른 지역에 비해 유난히 높은 위험률을 보이는 소위 핫 스팟 (hot spot)으로 불리는 클러스터 (cluster)를 찾으려고 하는 경우가 많다. 기존의 많은 방법들은 이러한 클러스터 패턴이 존재하는지에 대한 해답만 주었지만, 최근의 많은 방법들은 클러스터의 위치, 모양, 크기뿐만 아니라 찾아진 클러스터가 통계적으로 유의한지까지 검정해준다. 본 논문에서는 이러한 다양한 방법 중 가장 많이 사용되는 클러스터 탐색 방법 중 하나인 스캔 통계량을 이용한 방법을 소개하고 그 방법이 구현된 무료 소프트웨어 SaTScan을 이용한 결과를 보여주고 장단점을 논하고자 한다. 미국 국립암센터의 SEER 프로그램에서 제공하는 미국의 각 카운티별 암 사망자 자료 중 2006년 여성 폐암 사망자 데이터를 예시 데이터로 사용하여 스캔 통계량을 이용하여 구한 클러스터 탐색 결과를 제시하고 비슷한 연구를 하고자는 연구자에게 도움을 주고자 한다.

• 치과방사선
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• 제25권2호
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• pp.409-422
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• 1995

The purpose of this study was to investigate the effects of radiation on the formation of rat molar enamel at the developmental stage. The experimental animals were divided into five groups and were irradiated single dose of 396cGy ; 1 st group on 14th day of gestation, 2nd group on 19th day of gestation, 3rd group on 3 days after birth, 4th group on 8 days after birth, 5th group on 28 days after birth. The control and 1, 2, 3, and 4th experimental groups were sacrificed on 2, 4, and 6 weeks and the 5th groups were sacrificed on 1 day and 2 weeks after irradiation. Distal 1/2 and occlusal 1/3 enamel surface of lingual side of lingual cusp, and fractured surface of lingual side of lingual cusp in a longitudinal direction of the mandibular first molar were examined using scanning electron microscope. The following results were obtained. 1. The roughness of enamel surface and enamel hypoplasia were increased in a sequence of 4th, 1st, 2nd, and 3rd experimental group, and the enamel cracks were increased in the 1st and 2nd experimental group. 2. The pattern of enamel hypoplasia had a network form on the 1st and 2nd experimental group, and appeared a linear shape on the 3rd experimental group, and then the crator-like enamel defects were observed in all experimental groups (especially 1st and 2nd experimental group) except 5th. 3. Dentinoenamel junction showed the clear-cut and straight appearance except 5th experimental group. 4. There was no significant difference between 5th experimental and control group.

• 디지털콘텐츠학회 논문지
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• 제14권2호
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• pp.275-282
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• 2013

의료 영상처리 분야에서의 일반적인 객체 인식 방법은 픽셀들의 밝기 정보, 형태 정보, 패턴 정보 등 다양한 컴퓨팅 처리 방법으로 수행되어 진다. 그러나 컴퓨팅 방법에 사용되는 다양한 정보들이 의미가 없을 경우 객체인식에 많은 제약이 따르게 된다. 따라서 본 논문은 이러한 컴퓨팅 처리의 근본적인 제약사항을 해결하고자, MR 의료 영상에서의 물리적인 이론에 기반한 영상처리 방법을 전처리에 활용하고자 한다. 제안된 방법은 대비 개선 작업을 주된 목적으로 하는 SWI(Susceptibility Weighted Imaging) 처리를 통해 의미 있는 전처리 작업을 수행하고, 이에 대한 결과를 텍스처 분석을 통해 MR 뇌 영상의 회백질을 효과적으로 검출하는 과정으로 구성된다. 실험결과 제안 방법은 평균 영역차이가 5.2%로 기존의 대표적인 영역분할 방법에 비해 보다 효율적임을 증명하였다.

• BMB Reports
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• 제28권6호
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• pp.499-503
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• 1995

In our previous studies (Chae et al., 1990; Chae et a1., 1993), we found that a phytochrome signal was clearly connected with the change in cytosolic free $Ca^{2+}$ concentration ($[Ca^{2+}]_i$) in oat cells. It was determined that the $[Ca^{2+}]_i$ change occured both by mobilization out of the intracellular $Ca^{2+}$ store and by influx from the medium. The specific aim of this work is to elucidate the processes connecting $Ca^{2+}$ mobilization and influx. The cells treated with thapsigargin (increasing $[Ca^{2+}]_i$ by inhibition of the $Ca^{2+}$-ATPase in the calcium pool) in the presence of external $Ca^{2+}$ showed the same increasing pattern (sustained increasing shape) of $[Ca^{2+}]_i$ as that measured in animal cells. Red light irradiation after thapsigargin treatment did not increase $[Ca^{2+}]_i$ These results suggest that thapsigargin also acts specifically in the processes of mobilization and influx of $Ca^{2+}$ in oat cells. When the cells were treated with TEA ($K^+$ channel blocker), changes in $[Ca^{2+}]_i$ were drastically reduced in comparison with that measured in the absence of TEA. The results suggest that the change in $[Ca^{2+}]_i$ due to red light irradiation is somehow related with $K^+$ channel opening to change membrane potential. The membrane potential change due to $K^+$ influx might be the critical factor in opening a voltage-dependent calcium channel for $Ca^{2+}$ influx.

• 복식
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• 제63권6호
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• pp.113-126
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• 2013

The purpose of this study is to analyze the current use of mannequins that are designed to display Hanbok and put forward suggestions for improvement. In order to carry out the study, an analysis on the mannequins that are currently in the market was conducted along with a survey with professionals who are in charge of the display. The significance of the study is that it has gathered the opinions of professionals who are currently participating in the displays of Hanbok to lay the foundation for improvements. As Hanbok is a flat-pattern costume unlike the Western ones, the most prominent way to display is to lay them on the floor or hang them on the wall. Nevertheless, the mannequin displays are needed to show the beauty of Hanbok as the silhouette can only be completed when it is put on a body. A new type of mannequins that can portray the distinctive features of Korean beauty more effectively need to be developed. Although the museum and enterprise slightly differ in their preferences and requirements for the mannequins, both agree on the following criteria; the shape should be adjusted: the protruding breasts of the mannequin are not suitable for Hanbok, the body should be disassembled: all parts of the body should be separable and it should be flexible at the joints so that it can produce various poses, the face should represent the "koreaness" and the material should be soft. Based on these findings, we put forth the suggestion that a more suitable mannequin should be developed to portray the beauty of Hanbok.