• 디자인학연구
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• 제19권5호
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• pp.255-268
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• 2006

본 연구에서는 '제품에 대한 사용자의 심리적 가치의식이 디자인 평가에 어떠한 작용을 하는가'에 문제의식을 제기하여 14가지의 제품 샘플을 대상으로 평가를 실시하였다. 이에 따른 주요내용은 '제품평가의 단계별 사고', '제품에 대한 가치의식', '조형이미지 생성과 디자인 평가' 등 크게 3가지 영역을 주요 골자로 하여 분석을 실시하였다. 결론 도출을 위해 먼저 4개의 연구가설을 설정하였고, 이를 검증하기 위하여 '종결적 조사'의 일환으로 사례연구를 실시하였다. 표본은 데이터의 정확성을 높이기 위하여 제품디자인을 전공으로 하는 20대 대학생 120명을 대상으로 선정하였다. 수집된 데이터는 '단순집계'에 의하여 전체적인 흐름을 파악하였고, 이를 토대로 3개의 평가항목에 대한 구체적인 분석을 실시하였다. 분석방법은 '요인분석(factor analysis)', '클러스터분석(duster analysis)' 등 '다변량분석(multivariate analysis)'에 의한 '정량적 분석'에 중점을 두었다. 본 연구의 실증분석은 유의수준 p<.05에서 검증하였고, 통계처리는 'SPSSWIN 12.0' 프로그램을 사용하였다. 그 결과 '제품에 대한 사용자의 가치의식에 따른 디자인 평가의 유형'에 관해 4가지 결론을 얻었다.

• Journal of Pharmaceutical Investigation
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• 제23권3호spc1호
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• pp.9-18
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• 1993

Sugar spheres loaded with melatonin (MT) were coated with $Aquacoat^{\circledR}$ to control the release rate of MT over 8 hours. A zero-order release pattern over 8 hours was obtained with 20% coating on 8-10 mesh beads in USP basket dissolution studies. MT in 20% coated beads was quite stable at room temperature with less than 5% MT degraded during 6 months' storage. Dissolution profiles were also unchanged after 6 months. An oral preparation containing MT-loaded uncoated beads for immediate release and 20% coated beads with $Aquacoat^{\circledR}$ for controlled release over 8 hours was evaluated in six human subjects. When total 0.5 mg MT as low dose (immediate release portion of MT, 0.1 mg) was administered to four subjects, average peak plasma MT concentration was reached at about 600 pg/ml and maintained at about 10 pg/ml over 8 hours. Plasma MT concentration-time profiles were similar in shape to computer-simulated profiles. However, maximal plasma MT concentrations were three times greater compared to computer simulated curve. These results suggest that MT dose, ratio of immediate and controlled release MT, and pharmacokinetic parameters selected are adjusted to mimic endogenous MT concentration-time curve. In another study, 0.2 mg MT having 10% of immediate release portion and 80% controlled release portion produced plasma MT concentration-time curve which is more similar to endogenous profiles. A low bioavailability (<20%) may result from extensive first pass metabolism and remaining amounts of MT from controlled beads. A good correlation between plasma MT concentration and urinary excretion rate of 6-sulphatoxymelatonin (6-STMT), a major metabolite of MT was observed. As plasma MT concentration increased, urinary excretion rate of 6-STMT increased concomitantly. The linear relation between plasma MT and urinary excretion rate of 6-STMT was statistically significant. This result suggests that urinary 6-STMT may be used as an index of circadian rhythms of MT in humans.

• Journal of Pharmaceutical Investigation
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• 제15권2호
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• pp.53-62
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• 1985

Pivampicillin hydrochloride is a kind of broad spectrum antibiotics with bactericidal action, and is used in many countries, although it has bitter taste, unpleasant odour and side effects of irritating gastric mucosa, nausea, penicillin allergy, etc. For the improvement of such side effects of pivampicillin hydrochloride, microcapsules, with wall of ethylcellulose, have been prepared by coacervation method. The shape was observed through the scanning electron microscope, the release of the drug into an aqueous medium was studied and the effects of core: ethylcellulose ratio were interpreted as well as making sensory evaluation of taste and odour. There was decreasing trend in dissolution rate of the drug with the increase of core: ethylcellulose ratios, and the smaller microcapsules released their contents more rapidly. A linear relationship was established between the amount of ethylcellulose and the time for 60% release of the drug, and the release pattern was found to have similar characteristics to the release of the drug from an insoluble porous matrix. The release of the drug in the artificial intestinal fluids (pH 6.8) was found to be similar to that in water, while the release in the artificial gastric juice (pH 1.2) was slightly slower. Bioavailability of microcapsule was compared with that of pivampicillin hydrochloride in rabbits using serum concentration and urinary excretion measurements. Microcapsule gave showed slightly higher serum level than pivampicillin hydrochloride from 2 hours after administration, while no significant difference was observed in the accumulated urinary excretion rate between pivampicillin hydrochloride and microcapsule. The ulcer index of pivampicillin hydrochloride administered group was 2.6, and microcapsule administered group was 1.5, while control group was 0.8. Therefore it may be concluded that microencapsulation of pivampicillin hydrochloride is a useful pharmaceutical approach to protect the gastrointestinal tract from being injured by direct contact of pivampicillin hydrochloride without any significant difference of bioavailability.

• 대한의용생체공학회:학술대회논문집
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• 대한의용생체공학회 1994년도 추계학술대회
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• pp.71-74
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• 1994

In cementless total hip arthroplasty(THA), an initial stability of the femoral component is mandatory to achieve bony ingrowth and secondary long term fixation. Bone ingrowth depends strongly on relative micromotion and stress distributions at the interface. Primary stability of the femoral component can be obtained by minimizing the magnitude of relative micromotions at bone-prosthesis interface, Hence an accurate evaluation of interface behavior and stress/strain fields in the bone implant system may be relevant for better understanding of clinical situations and improving THA design. However, complete evaluation of load transfer in the bone remains difficult to assess experimentally, Hence, recently finite element method (FEM) was introduced in orthopaedic research field to fill the gap due to its unique capacity to evaluate stress in structure of complex shape, loading and material behavior. The authors developed the 3-dimensional numerical finite element model which is composed of totally 1179 elements off and 8 node blick. We also analyzed the micromotions at the bone-stem interface and mechanical behavior of existing bone prosthesis for a loading condition simulating the single leg stance. The result indicates that the values of relative motion for this well fit Multilock stem were $150{\mu}m$ in maximum, $82{\mu}m$ in minimum, and the largest relative motion developed in medial region of proximal femur with anterior-posterior direction. The proximal region of the bone was much larger in motion than the distal region and the stress pattern shows high stress concentration on the cortex near the tip of the stem. These findings indicates that the loading in the proximal femoral bone in the early postoperative situation can produce micromotions on the interface and clinically cementless TEA patient should not be allowed weight bearing strictly early in the postoperative period.

• 보존과학회지
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• 제30권4호
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• pp.365-372
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• 2014

사찰의 단청 등 회화에 사용된 적색과 녹색안료에 대해 그 종류를 밝혀내고, 이들의 광물입자 특성을 관찰하여 서로 비교분석하고자 하였다. 성분분석 결과, 적색안료는 진사(Cinnabar)와 석간주(Hematite), 연단(Minium) 등 3가지 종류가 사용된 것으로 확인되었고, 녹색안료는 녹염동광(Atacamite)과 뇌록석(Celadonite) 그리고, 일부 석록(Malachite)이 확인되었다. 이는 사찰별로 독특한 안료를 사용하였다기 보다는 다양한 종류의 안료를 회화의 특성에 맞게 모두 이용하였음을 알 수 있다. 안료의 입자특성에서는 적색안료 중에서 같은 진사라 할지라도 매끄럽거나 길쭉하고 각진모양, 판상 등 자형(hedral) 또는 타형(anhedral)의 다양한 형태를 가지고 있으며, 이는 녹색안료에서도 유사한 패턴을 보였다. 특히 지금까지 안료의 성분과 결정구조분석을 통해 광물을 확인하는 방법이 주로 이용되어왔으나 이에 비해 입자의 형태적 특성을 이용하는 것이 색상과 종류가 유사한 안료 그룹내에서는 이들을 보다 세밀하게 구분할 수 있고, 인자화 하는데 유리한 방법일 수 있을 것으로 판단된다.

• 대한의용생체공학회:의공학회지
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• 제28권5호
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• pp.601-608
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• 2007

2 Dimensional Gel Electrophoresis(2DGE) is an essentialmethodology for analysis on the expression of various proteins. For example, information for the location, mass, expression, size and shape of the proteins obtained by 2DGE can be used for diagnosis, prognosis and biological progress by comparison of patients with the normal persons. Protein spot matching for this purpose is comparative analysis of protein expression pattern for the 2DGE images generated under different conditions. However, visual analysis of protein spots which are more than several hundreds included in a 2DGE image requires long time and heavy effort. Furthermore, geometrical distortion makes the spot matching for the same protein harder. In this paper, an iterative algorithm is introduced for more efficient spot matching. Proposed method is first performing global matching step, which reduces the geometrical difference between the landmarks and the spot to be matched. Thus, movement for a spot is defined by a weighted sum of the movement of the landmark spots. Weight for the summation is defined by the inverse of the distance from the spots to the landmarks. This movement is iteratively performed until the total sum of the difference between the corresponding landmarks is larger than a pre-selected value. Due to local distortion generally occurred in 2DGE images, there are many regions in whichmany spot pairs are miss-matched. In the second stage, the same spot matching algorithm is applied to such local regions with the additional landmarks for those regions. In other words, the same method is applied with the expanded landmark set to which additional landmarks are added. Our proposed algorithm for spot matching empirically proved reliable analysis of protein separation image by producing higher accuracy.

• 대한의용생체공학회:의공학회지
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• 제33권4호
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• pp.169-176
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• 2012

Tumor cell morphology is closely related to its migratory behaviors. An active tumor cell has a highly irregular shape, whereas a spherical cell is inactive. Thus, quantitative analysis of cell features is crucial to determine tumor malignancy or to test the efficacy of anticancer treatment. We use 3D time-lapse phase-contrast microscopy to analyze single cell morphology because it enables to observe long-term activity of living cells without photobleaching and phototoxicity, which is common in other fluorescence-labeled microscopy. Despite this advantage, there are image-level drawbacks to phase-contrast microscopy, such as local light effect and contrast interference ring. Therefore, we first corrected for non-uniform illumination artifacts and then we use intensity distribution information to detect cell boundary. In phase contrast microscopy image, cell is normally appeared as dark region surrounded by bright halo ring. Due to halo artifact is minimal around the cell body and has non-symmetric diffusion pattern, we calculate cross sectional plane which intersects center of each cell and orthogonal to first principal axis. Then, we extract dark cell region by analyzing intensity profile curve considering local bright peak as halo area. Finally, we calculated the Fourier descriptor that morphological characteristics of cell to classify tumor cells into active and inactive groups. We validated classification accuracy by comparing our findings with manually obtained results.

• 한국산학기술학회논문지
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• 제14권8호
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• pp.3611-3616
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• 2013

MR 유체의 물리특성은 자기장에 의해 영향을 받는다. 본 연구에서는 MR 유체의 자기장에 의한 유동변화를 실험적으로 조사하고자, MR 유체의 밀도와 점도를 변경하면서 자기장에 의한 유동 가시화와 전단응력 변화를 측정하였다. 이를 위해 밀도 3종, 점도 3종에 대한 MR 유체를 제조하였고 MR 유체 가시화 실험장치를 제작하였다. 자기장이 인가되면, MR 유체 파우더의 유동흐름은 띠를 형성하면서 자기장이 인가되지 않은 경우와는 다른 유동흐름을 보여주었다. 또한 전단응력은 인가전류와 밀도가 높을수록 더 크게 증가하였으며, 인가전류 2.0A에서 MR 유체의 밀도가 $1300kg/m^3$에서 $1700kg/m^3$ 로 변하면 전단응력은 33% 정도 증가하였다.

• 한국생활과학회지
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• 제24권1호
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• pp.97-109
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• 2015

Recently, because the market for compression wear now includes all consumers, not just professionals, various items for recovery after exercising or for enhanced effects from exercise have been introduced. In this research, a systematic and stepwise design process was proposed to develop compression garment that has both functional area and appropriate pressure to protect the knee when exercising. The U-V format functional area that wraps underneath the knee was selected by considering the shape and change in the skin length when bending the knee. After the selection of the functional area, a total of seven knee design areas, including the existing product, were designed to determine the appropriate pressure. After various movements, the compression garment was ranked in terms of support of the knee, level of pressure, discomfort of seam line, and comfort of popliteal; the preferred design was selected using the quad method. Four compression wear garments were produced using two selected preferred designs; the wear evaluation was performed using a seven-point Likert scale. As a result, the optimal reduction rate of the pattern was calculated based on Ziegert and Keil's method. The applied percentage of the fabric stretch at the upper part of the crotch was 66% for the width and 50% for the length; for the lower part of the crotch, only 66% for the width was applied. Moreover, it was determined that the design of the U-V knee protection part was preferred when a 7 mm square was placed at a 1 mm distance because this not only supports the knee but also allows the fabric to accommodate various skin deformations.

• 한국콘텐츠학회논문지
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• 제4권4호
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• pp.21-32
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• 2004

본 연구는 우리나라의 역사와 문화 그리고 오랜 상상력이 담긴 시나리오 소재 개발에 기여할 한국 전통 몬스터의 원형 재현 및 복원을 목적으로 한다 연구방법은 역사서, 설화, 민화 등의 문헌조사와 전문가의 고증을 근거로 하였으며, 한국 전통 몬스터 50건을 디지털 복원하였다. 연구결과는 다음과 같다. 첫째, 신, 귀, 괴, 인간, 짐승을 포함한 한국 전통 몬스터의 범위를 규정하였다. 둘째, 한국 전통 몬스터의 유형을 위계와 출현 장소에 따라 5급 4부류로 분류하였다. 셋째, 소재 개발에 활용할 전통 몬스터 50종 각각을 디지털 그래픽 이미지와 플래쉬 애니메이션으로 제작하였다. 넷째, 각 몬스터의 스토리를 중심으로 게임, 캐릭터 등 문화콘텐츠 산업 소재개발을 위한 아이디어를 제안하였다. 본 연구에서 개발된 결과물이 앞으로 우리 문화전통에 대한 이해를 높여주는 자원으로 활용되고, 게임, 캐릭터, 만화, 영화 등의 문화콘텐츠 산업분야의 독창적 소재로서 활용될 수 있기를 기대한다.