• 한국경영과학회지
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• 제25권4호
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• pp.1-14
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• 2000

The methods of sensitivity analysis for linear programming can be classified in two types: sensitivity analysis using an optimal solution, and sensitivity analysis using an approximate optimal solution. As the methods of sensitivity analysis using an optimal solution, there are three sensitivity analysis methods: sensitivity analysis using an optimal basis, positive sensitivity analysis, and optimal partition sensitivity analysis. Since they may provide different characteristic regions under degeneracy, it is not easy to understand and apply the results of the three methods. In this paper, we propose a generalized sensitivity analysis that can integrate the three existing methods of sensitivity analysis. When a right-hand side or a cost coefficient is perturbed, the generalized sensitivity analysis gives different characteristic regions according to the controlling index set that denotes the set of variables allowed to have positive values in optimal solutions to the perturbed problem. We show that the three existing sensitivity analysis methods are special cases of the generalized sensitivity analysis, and present some properties of the generalized sensitivity analysis.

• 한국식품영양학회지
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• 제24권4호
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• pp.617-621
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• 2011

황련은 염증, 항균, 고혈압 및 항암 작용을 지닌 중요한 전통 한약재이다. 황련 뿌리 메탄올 추출성분은 CPC와 HPLC 방법으로 정제하였다. CPC의 최적 용매 조건은 n-butanol:acetic acid:water(4:1:5)이었다. Berberine(16.8 mg)은 CPC와 HPLC 방법에 의하여 효과적으로 분리하였다. 이 물질의 화학적 구조는 $^1H$, $^{13}C$-NMR과 ESI-MS 데이터 분석에 의하여 확인되었다.

• 한국환경과학회지
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• 제14권9호
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• pp.827-835
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• 2005

A three-dimensional ecological model (EMT -3D) was applied to Nonylphenol in Tokyo Bay. EMT -3D was calibrated with data obtained in the study area. The simulated results of dissolved Nonylphenol were in good agreement with the observed values, with a correlation coefficient(R) of 0.7707 and a coefficient of determination (R2) of 0.5940. The results of sensitivity analysis showed that biodegradation rate and bioconcentration factor are most important factors for dissolved Nonylphenol and Nonylphenol in phytoplankton, respectively. In the case of Nonylphenol in particulate organic carbon, biodegradation rate and partition coefficient were important factors. Therefore, the parameters must be carefully considered in the modeling. The mass balance results showed that standing stocks of Nonylphenol in water, in particulate organic carbon and in phytoplankton are $8.60\times 10^5\;g,\;2.19\times 10^2\;g\;and\;3.78\times 10^0\;g$ respectively. With respect to the flux of dissolved Nonylphenol, biodegradation in the water column, effluent to the open sea and partition to particulate organic carbon were $6.02\times10^3\;g/day,\;6.02\times10^2\;g/day\;and\;1.02\times10^1\;g/day$, respectively.

• 한국지능시스템학회논문지
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• 제8권6호
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• pp.99-105
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• 1998

이 논문은 퍼지비선형회귀모형에 대한 것으로서 유전적 알고리즘을 이용한 퍼지회귀분석모형을 제안한다. 유전적 알고리즘이란 좀 더 나은 퍼지회귀분석을 위하여 입력데이터를 분류하는데 사용되어진다. 이 분할에서 각 데이터는 분류된 데이터그룹에 속하는 멤버쉽함수의 값을 가지게 된다. 데이터그룹은 각 변수의 영역을 최적으로 분할함에 따라 몇 개의 퍼지선형회귀모형에서 서로 다른 퍼지파라메타를 가지게 된다. 데이터에 대한 최종 퍼지수를 얻기 위하여 각 데이터그룹의 퍼지출력을 구성한다. 이 방법의 유효성은 사례연구에 의하여 보이고자 한다.

• Journal of Pharmaceutical Investigation
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• 제23권2호
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• pp.61-69
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• 1993

Prodrug of cefazolin (CFZ) was prepared with the objective of improving its oral bioavailability. Cefazolin phthalidyl ester (CFZ-PT) was synthesized and evaluated as potential prodrug form. The successful synthesis of CFZ-PT was identified by spectroscopic analysis. Partition coefficient studies showed that CFZ-PT is more lipophilic than CFZ and the ester was hydrolyzed enzymatically into the parent drug in blood, liver and intestinal homogenates. The pharmacokinetic characteristics of CFZ-PT and CFZ were compared following oral administrations to rabbits. Serum CFZ concentration was determined by HPLC method and the ester compound (prodrug) was not detected in serum following oral administration of CFZ-PT. CFZ-PT did not have antimicrobial activity in vitro against Bacillus subtilis ATCC 6633, whereas CFZ-PT in serum after oral administration to rabbits had antimicrobial activity. From above observations, it was noted that CFZ-PT is rapidly hydrolyzed to CFZ in the body and the bioavailability of CFZ-PT was increased by 3.5-fold than that of CFZ. From these results of this study, it was concluded that CFZ-PT may be a novel prodrug of CFZ which can improve the oral absorption of CFZ.

• 대한핵의학회지
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• 제4권1호
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• pp.51-60
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• 1970

1969년도 일년간 당연구실에서 합성한 방사성의약품의 양은 131mc이며 그 종류는 $Hippuran-^{131}I$의 4종에 달하였다. 이들 의약품의 품질 및 안정도를 Paper partition chromatography 및 thin-layer chromatography를 이용하여 시험하고 그 결과를 외국제품의 품질 및 안정도와 비교 검토하여 보았다. 그 결과 합성방식에 따라 품질에 차이가 있었다. 본 연구소제품이 품질 및 안정도면에서 우수하였다. 본 연구에서는 방사성의약품을 임상에 사용하는데 주의해야 할 품질관리 및 안정도 test에 관하여 그 시험방법을 아울러 기술하였다.

• IEIE Transactions on Smart Processing and Computing
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• 제6권4호
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• pp.299-304
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• 2017

A wireless passive sensor network is a network consisting of sink nodes, sensor nodes, and radio frequency (RF) sources, where an RF source transfers energy to sensor nodes by radiating RF waves, and a sensor node transmits data by consuming the received energy. Against theoretical expectations, a wireless passive sensor network suffers from many practical difficulties: scarcity of energy, non-simultaneity of energy reception and data transmission, and inefficiency in allocating time resources. Perceiving such difficulties, we propose a simple contending-type medium access control (MAC) scheme for many sensor nodes to deliver packets to a sink node. Then, we derive an approximate expression for the network-wide throughput attained by the proposed MAC scheme. Also, we present an approximate expression for the optimal partition, which maximizes the saturated network-wide throughput. Numerical examples confirm that each of the approximate expressions yields a highly precise value for network-wide throughput and finds an exactly optimal partition.

• 대한기계학회논문집B
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• 제24권3호
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• pp.426-434
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• 2000

This paper deals with a generalized similarity solution for the one-dimensional solidification of ternary or higher-order multicomponent alloys. The present approach not only retains the existing features of binary systems such as temperature- solute coupling, shrinkage-induced flow, solid-liquid property differences, and finite back diffusion, but also is capable of handling a multicomponent alloy without restrictions on the partition coefficient and microsegregation parameter. For an alloy of N-solute species, governing equations in the mushy region reduce to (N+2) nonlinear ordinary differential equations via similarity transformation, which are to be solved along with the closed-form solutions for the solid and liquid regions. A linearized correction scheme adopted in the solution procedure facilitates to determine the solidus and liquidus positions stably. The result for a sample ternary alloy agrees excellently with the numerical prediction as well as the reported similarity solution. Additional calculations are also presented to show the utility of this study. Finally, it is concluded that the present analysis includes the previous analytical approaches as subsets.

• 한국환경농학회지
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• 제29권3호
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• pp.247-256
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• 2010

A high-performance liquid chromatographic (HPLC) method was developed to determine buprofezin residues in hulled rice and fruits. The buprofezin residue was extracted with acetone and the extract was stepwise purified by liquid-liquid partition and Florisil column chromatography. For rice samples, acetonitrile/n-hexane partition was additionally employed to remove nonpolar lipids. Reversed phase HPLC using an octadecylsilyl column was successfully applied to separate buprofezin from sample co-extractives, as detected by ultraviolet absorption at 250 nm. Recovery experiment at the limit of quantitation validated that the proposed method could evidently determine the buprofezin residue at the level of 0.02 mg/kg. Mean recoveries from hulled rice, apple, pear, and persimmon samples fortified at three tenfold levels were in the range of 80.8~85.2%, 89.1~98.4%, 88.8~95.7% and 90.8~96.2%, respectively. Relative standard deviations of the analytical method were all less than 5%, irrespective of sample types. A selected-ion monitoring LC/mass spectrometry with positive electrospray ionization was also provided to sensitively confirm the suspected residue.

• 한국소음진동공학회논문집
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• 제26권3호
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• pp.315-322
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• 2016

Room acoustic properties of coupled rooms connected by an aperture has been analyzed using statistical acoustic model based on the diffused sound field assumption, which has limitation in dealing with the parameters such an room geometries and non uniform absorptivity of the boundary surfaces. In order to overcome these difficulties the acoustic diffusion model has been introduced, by which distribution of the acoustic energy density can be analyzed for various shapes and wall absorptivity. In this study acoustic properties of coupled rooms connected by an aperture(e.g. door) is analyzed using acoustic diffusion equation, which is solved numerically. The mean energy densities of two rooms obtained by the diffusion model are compared with those from the statistical model. The results show good agreement for various coupling aperture sizes and absorption coefficients. For a limiting case when the partition wall is substituted by an aperture and the two rooms eventually forms a single room, results of coupled room analysis using diffusion model show good agreement with those of a single room.