• Communications for Statistical Applications and Methods
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• v.16 no.3
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• pp.495-500
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• 2009

Two diagnostic plots, added variable plot and partial residual plot, are proposed when a new explanatory variable is linearly added to constrained regressions. They are useful for investigating the effect of adding an explanatory variable to the constrained regression. They visually give an overall impression of the strength of linear relationship between response variable and added variable. A numerical example is provided for illustration.

• Radiation Oncology Journal
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• v.9 no.1
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• pp.59-63
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• 1991

Thirty-one patients with previously untreated and locally advanced nasopharyngeal cancer were retrospectively reviewed for comparing the effects of radical radiotherapy alone with that of combining chemotherapy and radiotherapy from 1983 to 1989 at Kangnam 51. Mavy's hospital.23/31 were evaluable for recurrence and suwival. There were 8 patients for stage III, and 15 patients for stage IV. Eleven patients were treated with radical radiation therapy done (arm I). Twelve patients were given 1~3 courses of cisplatin-5FU or cisplatin-bleomycin-vincristine prior to radiation therapy (arm II). The two arms were comparable in patient characteristics Of 11 radiotherapy Patients, complete response was 55%(6/11) and Partial response 45%(5/11). Among 12 patients after induction chemotherapy, complete response was 25%(3/12) and partial response 75%(9/12). After subsequent radiotherapy, complete response was increased to 83%(10/12) and partial response was 17%(2/12). Treatment failure was 30%(local recurrence; 3/11, and regional recurrence; 1/11) in arm 1 and 33% (local recurrence; 1/12, regional recurrence; 2/12 and distant metastasis; 1/12) in arm ll . There was no significant difference in survival between arm I and arm II (p> 0.05). The toxicities of treatment were acceptable. More controlled clinical trials must be completed before acceptance of chemotherapy as part of a standard radical treatment for locally advanced nasopharyngeal cancer.

• Radiation Oncology Journal
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• v.36 no.2
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• pp.153-162
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• 2018

Purpose: We aimed to evaluate clinical outcomes including progression-free survival (PFS), overall survival (OS), partial response, and complete response in patients who underwent radiation therapy (RT) for mycosis fungoides (MF). Also, we sought to find prognostic factors for clinical outcomes. Materials and Methods: Total 19 patients confirmed with MF between 1999-2015 were retrospectively reviewed. Clinical and treatment characteristics, clinical outcomes, and and toxicities were analyzed. Results: Eleven patients were treated with total skin electron beam radiotherapy (TSEBT) and 8 patients with involved field radiation therapy (IFRT) with median dose of 30 Gy, respectively. The median time interval from diagnosis to RT was 2.6 months (range, 0.4 to 87.3 months). The overall response rate was 100%; 11 patients (57.9%) had a complete response and 8 patients (42.1%) a partial response. The presence of positive lymph node at the time of consultation of RT was associated with lower OS (p = 0.043). In multivariate analysis, PFS was significantly lower for patients with increased previous therapies experienced following RT (p = 0.019) and for patients showing PR during RT (p = 0.044). There were no reported grade 3 or more skin toxicities related with RT. Conclusion: Both IFRT and TSEBT are effective treatment for MF patients. Patients with short disease course before RT or complete response during RT are expected to have longer PFS. Positive lymph node status at the initiation of RT was associated woth poor OS, suggesting other treatment modalities such as low-dose RT for patients with low life-expectancy.

• Childhood Kidney Diseases
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• v.26 no.2
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• pp.107-110
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• 2022

Nephrogenic diabetes insipidus, decreased ability to concentrate urine, with production of large amounts of urine, is caused by the refractory response of renal tubules to the action of antidiuretic hormone. This rare disorder, known as X-linked nephrogenic diabetes insipidus, is caused by a mutation in the AVPR2 gene. Because it is hereditary, most patients are male. This report highlights a case of nephrogenic diabetes insipidus in a 3-year 5-month-old female; upon presentation to the hospital, her symptoms included frequent urinationand consumptionof a significant amount ofwater,which had begun2 years ago. The results of blood tests showed increased levels of serum antidiuretic hormone, and sellar magnetic resonance imaging showed no abnormality. The results of the water restriction test and the desmopressin administration test confirmed the diagnosis of nephrogenic diabetes insipidus showing a partial response to desmopressin. The results of genetic testing indicated the presence of an AVPR2 mutation, a heterozygous missense mutation (p.Val88Met), suggesting inheritance of X-linked nephrogenic diabetes insipidus. This report describes a significant case of symptomaticX-linked nephrogenic diabetes insipidus in a female patient who showed a partial response to desmopressin.

• Ocean Systems Engineering
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• v.1 no.4
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• pp.337-353
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• 2011

In the present study, an offshore platform having large partial porous cylindrical members, which are composed of permeable and impermeable cylinders, is suggested. In order to calculate the wave force on large partial porous cylindrical members, the fluid domain is divided into three regions: a single exterior region, N inner regions and N beneath regions, and the scattering wave in each fluid region is expressed by an Eigen-function expansion method. Applying Darcy's law to the porous boundary condition, the effect of porosity is simplified. Wave excitation forces and wave run up on the structures are presented for various wave conditions. For the idealized three-dimensional platform having large partial porous cylindrical members, the dynamic response evaluations of the platform due to wave forces are carried out through the modal analysis. In order to examine the effects of soil-structure interaction, the substructure method is also applied. The displacement and bending stress at the selective nodal points of the structure are computed using various input parameters, such as the shear-wave velocity of soil, the wave height and the wave period. Applying the Monte Carlo Simulation (MCS) method, the reliability evaluations at critical structure members, which contained uncertainties caused by dynamic forces and structural properties, are examined by the reliability index with the results obtained from MCS.

• Steel and Composite Structures
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• v.6 no.3
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• pp.237-255
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• 2006

This paper presents a novel analytical formulation for the analysis of composite beams with partial shear interaction stiffened by a bolted longitudinal plate accounting for time effects, such as creep and shrinkage. The model is derived by means of the principle of virtual work using a displacement-based formulation. The particularity of this approach is that the partial interaction behaviour is assumed to exist between the top slab and the joist as well as between the joist and the bolted longitudinal stiffening plate, therefore leading to a three-layered structural representation. For this purpose, a novel finite element is derived and presented. Its accuracy is validated based on short-and long-term analyses for the particular cases of full shear interaction and partial shear interaction of two layers for which solutions in closed form are available in the literature. A parametric study is carried out considering different stiffening arrangements to investigate the influence on the short-and long-term behaviour of the composite beam of the shear connection stiffness between the concrete slab and the steel joist, the stiffness of the plate-to-beam connection, the properties of the longitudinal plate and the concrete properties. The values of the deflection obtained from the finite element simulations are compared against those calculated using the effective flexural rigidity in accordance with EC5 guidelines for the behaviour of elastic multi-layered beams with flexible connection and it is shown how the latter well predicts the structural response. The proposed numerical examples highlight the ease of use of the proposed approach in determining the effectiveness of different retrofitting solutions at service conditions.

• Geomechanics and Engineering
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• v.6 no.2
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• pp.99-115
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• 2014

Uncertainties in design variables and design equations have a significant impact on the safety of geotechnical structures like retaining walls and slopes. This paper presents a possible framework for obtaining the partial safety factors based on reliability approach for different random variables affecting the stability of a reinforced concrete cantilever retaining wall and a slope under static loading conditions. Reliability analysis is carried out by Mean First Order Second Moment Method, Point Estimate Method, Monte Carlo Simulation and Response Surface Methodology. A target reliability index ${\beta}$ = 3 is set and partial safety factors for each random variable are calculated based on different coefficient of variations of the random variables. The study shows that although deterministic analysis reveals a safety factor greater than 1.5 which is considered to be safe in conventional approach, reliability analysis indicates quite high failure probability due to variation of soil properties. The results also reveal that a higher factor of safety is required for internal friction angle ${\varphi}$, while almost negligible values of safety factors are required for soil unit weight ${\gamma}$ in case of cantilever retaining wall and soil unit weight ${\gamma}$ and cohesion c in case of slope. Importance of partial safety factors is shown by analyzing two simple geotechnical structures. However, it can be applied for any complex system to achieve economization.

• Radiation Oncology Journal
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• v.29 no.3
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• pp.174-180
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• 2011

Purpose: To evaluate the radiotherapy treatment outcome of patients in stage IE and IIE nasal natural killer/T-cell lymphoma. Materials and Methods: From August 1999 to August 2009, 46 patients with stage IE and IIE nasal natural killer/T-cell lymphoma were treated by definitive radiotherapy and chemotherapy. 33 patients were treated with chemotherapy followed by radiotherapy (CT + RT) and they received 50.4 Gy in 28 fractions. 13 patients were treated with concurrent chemoradiotherapy (CCRT) and they received 40 Gy in 20 fractions. Results: The median follow-up period was 4.6-137.6 months (median, 50.2 months) for all patients. The 4-year overall survival was 68.6% and 4-year disease free survival (DFS) was 61.9%. The 4-year locoregional recurrence free survival was 65.0%, and 4-year distant metastasis free survival (DMFS) was 66.2%. For patients treated with CT + RT, 15 patients (45.5%) achieved complete response after chemotherapy, and 13 patients (39.4%) achieved partial response. 13 patients (81.8%) achieved complete response after radiotherapy, and 6 patients (18.2%) achieved partial response. For patients treated with CCRT, 11 patients (84.6%) achieved complete response, and one patient (7.7%) achieved partial response. In univariate analysis, presence of cervical lymph node metastasis was only significant prognostic factor for DFS and DMFS. Conclusion: This study did not show satisfactory overall survival rate and disease free survival rate of definitive radiotherapy and chemotherapy for stage IE and IIE nasal natural killer/T-cell lymphoma. For patients with cervical lymph node metastasis, further investigation of new chemotherapy regimens is necessary to reduce the distant metastasis.

• Structural Engineering and Mechanics
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• v.56 no.4
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• pp.549-567
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• 2015

A first-order moment method (FORM) reliability analysis is commonly used for structural stability analysis. It requires the values and partial derivatives of the performance to function with respect to the random variables for the design. These calculations can be cumbersome when the performance functions are implicit. A Gaussian process (GP)-based response surface is adopted in this study to approximate the limit state function. By using a trained GP model, a large number of values and partial derivatives of the performance functions can be obtained for conventional reliability analysis with a FORM, thereby reducing the number of stability analysis calculations. This dynamic renewed knowledge source can provide great assistance in improving the predictive capacity of GP during the iterative process, particularly from the view of machine learning. An iterative algorithm is therefore proposed to improve the precision of GP approximation around the design point by constantly adding new design points to the initial training set. Examples are provided to illustrate the GP-based response surface for both structural and non-structural reliability analyses. The results show that the proposed approach is applicable to structural reliability analyses that involve implicit performance functions and structural response evaluations that entail time-consuming finite element analyses.

• Structural Engineering and Mechanics
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• v.75 no.3
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• pp.357-367
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• 2020

The objective of this article is investigation of dynamic response of thick multilayer functionally graded (FG) beam under generalized dynamic forces. The plane stress problem is exploited to describe the constitutive equation of thick FG beam to get realistic and accurate response. Applied dynamic forces are assumed to be sinusoidal harmonic, sinusoidal pulse or triangle in time domain and point load. Equations of motion of deep FG beam are derived based on the Hamilton principle from kinematic relations and constitutive equations of plane stress problem. The numerical finite element procedure is adopted to discretize the space domain of structure and transform partial differential equations of motion to ordinary differential equations in time domain. Numerical time integration method is used to solve the system of equations in time domain and find the time responses. Numerical parametric studies are performed to illustrate effects of force type, graduation parameter, geometrical and stacking sequence of layers on the time response of deep multilayer FG beams.