• 한국근적외분광분석학회:학술대회논문집
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• 한국근적외분광분석학회 2001년도 NIR-2001
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• pp.4111-4111
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• 2001

When a drug is prepared in a tablet, the active component represents only a small portion of the dosage form. The other components of the formulation include materials to assist in the dissolution, antioxidants, coloring agents and bulk fillers. The tablets are tested using approved testing methods usually involving separation and subsequent quantification of the active component. Tablets may also be tested by near-Infrared Reflectance spectrometry (NIRS). In the present study, based on NIRS and multivariate calibration methods, a novel and precise method is developed for direct determination of ascorbic acid in vitamin C tablet. Two different tablet formulations were powdered in three different sizes, 63-125 ${\mu}{\textrm}{m}$, and examined. Spectral region of 4750-4950 $cm^{-1}$ / was used and optimized for quantitative operations. Partial least squares (PLS) and multiple linear regression (MLR) methods were performed for this spectral region. The results of optimized PLS and MLR methods showed that reproducibility increase with decreasing grain size and standard error of calibration (SEP) of less than 1% w/w of ascorbic acid and a correlation coefficient of 0.998 can be achieved. The PLS method showed better results than MLR. Seven overdose and underdose samples (prepared in the laboratory to match marketed products) were tested by proposed and iodometric standard methods. A correlation between NIRS predicted ascorbic acid values and iodomet.ic values was calculated ($R^2$=0.9950). Finally, the direct analysis of individual intact tablets in their unit-dose packages (Blistering in aluminum and PVC foils) obtained from market were also carried out and a correlation coefficient of 0.9989 and SEP of 0.931% w/w of ascorbic acid were achieved.

• Bulletin of the Korean Chemical Society
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• 제34권12호
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• pp.3553-3558
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• 2013

The three dimensional-quantitative structure activity relationship (3D-QSAR) studies on chemical features of pyridine-2-amines in the external region of c-Met active site (ER chemical features of pyridine-2-amines) were conducted by docking, comparative molecular field analysis (CoMFA), and topomer CoMFA methods. The CoMFA model obtained the partial least-squares (PLS) statistical results, cross-validated correlation coefficient ($q^2$) of 0.703, non cross-validated correlation coefficient ($r^2$) of 0.947 with standard error of estimate (SEE) of 0.23 and the topomer CoMFA obtained $q^2$ of 0.803, $r^2$ of 0.940, and SEE of 0.24. Further, the test set was applied to validate predictive abilities of models, where the predictive $r^2$ ($r{^2}_{pred}$) for CoMFA and topomer CoMFA models were 0.746 and 0.608, respectively. Each contribution of ER chemical features of pyridine-2-amines to the inhibitory potency showed correlation coefficients, $r^2$ of 0.670 and 0.913 for two core parts, 3-(benzo[d]oxazol-2-yl)pyridine-2-amine and 3-(1-(2,6-dichloro-3-fluorophenyl)ethoxy) pyridine-2-amine, respectively, with corresponding experimental $pIC_{50}$.

• Journal of Nutrition and Health
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• 제38권6호
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• pp.445-454
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• 2005

The purpose of this study was to compare the validity of obese index among body mass index (BMI), waist to hip ratio (WHR), and waist circumference (WC) and to determine which is the best in relation to cardiovascular disease (CVD) risk in Korean elderly more than 65 ages. Data from the 1998 Korean Health and Nutrition Survey were used (n=1017). Anthropometric indices and CVD risk factors were measured, and chi-square test, analysis of variance following duncan's multiple range test, partial correlation analysis, and Receiver Operator Characteristic (ROC) curves were used in the analysis. Anthropometric values were decreased in both male and female when ages were goes up. In female elderly, it specially showed the characteristics of upper body fat and systolic blood pressure risk (p<0.05). Among life style factors the current smokers were prevalent in obese male (p<0.05), but not prevalent in female having obese or upper body fat. Also, person with upper body obesity have more exercise than that of normal group (p<0.01). Mean BMI values of the current smoker was lower than that of normal group in both sexes (p<0.01). Mean BMI value of person with other risk factors were higher than that of normal groups (p<0.05). Among 7 CVD risk factors in partial correlation analysis, WC had the highest correlation coefficient in 5 in male, whereas BMI in 4 in female. In ROC analyses of 12 risk factors and health conditions, the largest area under curve of obese indices for risk factors were WC>WHR>BMI in male and BMI>WHR>WC in female. The optimal cutoff values of each index (BMI : WHR : WC) for one or more risk factors were 19.02 : 0.84 : 71.3 in male and 19.04 : 0.88 : 85.6 in female. In conclusion, Most Korean elderly showed non-obese and abdominal obesity likewise other Asians. Also CVD risk factors were prevalent in Korean elderly within normal limits of obese indices. Therefore the upper body fat indices reflected in the aged whose muscle mass is replaced by fat must be used as an indicator of CVD risk together with BMI. Although WHR was the worst index based on partial correlation analysis and so located between BMI and WC in ROC curve analysis in both sexes, it need to be use with WC to screen the cardiovascular risk group.

• 한국통신학회논문지
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• 제17권11호
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• pp.1320-1331
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• 1992

부분대역 간섭 환경하에서 m-분포 페이딩 채널을 통해 수신되는 반복다이버시티 방식의 FH/MFSK 신호에 대한 오율식을 유도하고 이를 수치계산하여 비트 에너지 대 잡음 전력 밀도 비 $(E_b/N_0)$, 비트에너지 대 간섭 전력 밀도 비 $(E_b/N_1)$, 페이딩 지수(m), 부분대역 간섭의 대역 점유율$(\rho)$, 반복 정송수(L), 신호와 간섭 사이의 전력 상관계수 값을 함수로 하여 그림으로 나타내고 이를 분석했다. 본 논문에서는 이동무선 채널에서 발생하는 페이딩에 대처하기 위해 송신기에서 반복 전송 다이버시티를 사용할 때를 생각했는데 다이버시티를 사용할 때와 사용하지 않을 때의 오율을 비교한 결과 반복 전송 다이버시티가 페이딩에 매우 효과적이라는 것을 알 수 있었으며 다이버 시티 기법에 의해 얻어지는 오율의 개선정도를 알아내었다. 얻어진 결과로 부터 부분대역 간섭의 대역 점유율인 $\rho$가 작아지면 작아질수록 오율이 열화되는 것으로 보아 전대역 간섭보다는 부분대역 간섭의 영향이 더 크다는 것을 알 수 있었다. 아울러 $E_b/N_1$가 작고 $\rho$가 작을때는 페이딩의 심도가 깊으면 깊을수록 반복다이버 시티를 도입하므로서 오율특성의 개선이 현저하다는 것도 알수 있었다.

• 한국식품과학회지
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• 제38권6호
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• pp.835-837
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• 2006

근적외선 분광광도법을 이용하여 송이버섯의 원산지 판별을 시험하였다. 259개의 국내산 시료중 256개는 국내산으로 판별하였고(98.84%) 수입산 81개중 60개는 수입산으로 판별하였으나(74.07%) 21개의 북한산은 판별하기가 모호하여 잘못 판정한 것으로 간주할 때 시료 판별의 전체정확도는 92.94%로 나타났다. MPLS에 따른 분석의 경우 상관계수는 0.84, 검량선의 표준오차는 15.10%, 예측 표준오차는 18.30% 이었다.

• 한국공작기계학회논문집
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• 제15권5호
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• pp.1-6
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• 2006

The purpose of this study is to develop to portable near infrared analyzer measuring the sugar content of the fruits on a tree before harvesting ones. The portable near infrared system consists of a tungsten lamp, a coaxial optical fiber bundle and a multi-channel detector, which has 256 pixels and a concave transmission grating. Reflectance NIR spectra of orange were recorded by using a coaxial optical fiber bundle. The spectra were collected over the spectral range $400{\sim}1100nm$. Partial least squares regression(PLSR) was applied for a calibration and validation for determination of sugar contents. The multiple correlation coefficient was 0.99 and standard errors of calibration(SEC) was 0.069 brix. The calibration model predicted the sugar content for validation set with standard errors of prediction(SEP) of 0.092 brix. The sugar content in fruits was successfully quantified using the portable near infrared analyzer.

• Child Health Nursing Research
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• 제24권1호
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• pp.9-17
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• 2018

Purpose: The purpose of this descriptive survey study was to characterize the relationship between clinical decision-making and job satisfaction among pediatric nurses and to elucidate the mediating effects of the nurse-parent partnership on that relationship. Methods: The subjects of the study were 174 nurses who had worked in a pediatric ward in a university hospital, general hospital, or children's hospital. Data were collected from June 20, 2016 to August 10, 2016 and analysed using descriptive statistics, the t-test, analysis of variance, the Pearson correlation coefficient, and three-step mediated regression analysis in SPSS version 22.0 for Windows. Results: The nurse-parent partnership had significant effects on clinical decision-making and job satisfaction, with an explanatory power of 19% and 26%, respectively. The nurse-parent partnership had a partial mediating effect on the relationship between clinical decision-making and job satisfaction (Sobel test: Z=4.31, p<.001). Conclusion: The nurse-parent partnership had a partial mediating effect on the relationship between clinical decision-making and job satisfaction among pediatric nurses. Therefore, in order to improve the job satisfaction of pediatric nurses, it is necessary to develop effective educational programs and strategies to address their clinical decision-making and their experiences of the nurse-parent partnership.

• 전력전자학회논문지
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• 제26권1호
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• pp.38-45
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• 2021

The photovoltaic module has the characteristic of changing its output characteristics depending on the amount of radiation and temperature, where the arrays that connect them in series and parallel also have the same characteristics. These characteristics require the MPPT technique to find the maximum power point. Existing P&O and IncCond cannot find the global maximum power point (GMPP) for partial shading. Moreover, in the case of Improved-GMPPT and Enhanced Search-Skip-Judge-GMPPT, GMPP due to partial shading can be found, but the variation in the open voltage during temperature fluctuations will affect the operation of the Skip and will not be able to perform accurate MPPT operation. In this study, we analyzed the correlation between voltage, current, and power under solar module and array conditions. We also proposed a technique to find the maximum power point even for temperature fluctuations using not only the amount of radiation but also the temperature coefficient. The proposed control technique was verified through simulations and experiments by constructing a 2.5 kW single-phase solar power generation system.

• Asian-Australasian Journal of Animal Sciences
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• 제17권12호
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• pp.1736-1740
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• 2004

Since the application of relatively high levels of heavy metals in the compost poses a potential hazard to plants and animals, the content of heavy metals in the compost with animal manure is important to know if it is as a fertilizer. Measurement of heavy metals content in the compost by chemical methods usually requires numerous reagents, skilled labor and expensive analytical equipment. The objective of this study, therefore, was to explore the application of near-infrared reflectance spectroscopy (NIRS), a nondestructive, cost-effective and rapid method, for the prediction of heavy metals contents in compost. One hundred and seventy two diverse compost samples were collected from forty-seven compost facilities located along the Han river in Korea, and were analyzed for Cr, As, Cd, Cu, Zn and Pb levels using inductively coupled plasma spectrometry. The samples were scanned using a Foss NIRSystem Model 6500 scanning monochromator from 400 to 2,500 nm at 2 nm intervals. The modified partial least squares (MPLS), the partial least squares (PLS) and the principal component regression (PCR) analysis were applied to develop the most reliable calibration model, between the NIR spectral data and the sample sets for calibration. The best fit calibration model for measurement of heavy metals content in compost, MPLS, was used to validate calibration equations with a similar sample set (n=30). Coefficient of simple correlation (r) and standard error of prediction (SEP) were Cr (0.82, 3.13 ppm), As (0.71, 3.74 ppm), Cd (0.76, 0.26 ppm), Cu (0.88, 26.47 ppm), Zn (0.84, 52.84 ppm) and Pb (0.60, 2.85 ppm), respectively. This study showed that NIRS is a feasible analytical method for prediction of heavy metals contents in compost.

• 한국공간구조학회논문집
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• 제21권2호
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• pp.99-110
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• 2021

This study presents the estimation of crack depth by analyzing temperatures extracted from thermal images and environmental parameters such as air temperature, air humidity, illumination. The statistics of all acquired features and the correlation coefficient among thermal images and environmental parameters are presented. The concrete crack depths were predicted by four different machine learning models: Multi-Layer Perceptron (MLP), Random Forest (RF), Gradient Boosting (GB), and AdaBoost (AB). The machine learning algorithms are validated by the coefficient of determination, accuracy, and Mean Absolute Percentage Error (MAPE). The AB model had a great performance among the four models due to the non-linearity of features and weak learner aggregation with weights on misclassified data. The maximum depth 11 of the base estimator in the AB model is efficient with high performance with 97.6% of accuracy and 0.07% of MAPE. Feature importances, permutation importance, and partial dependence are analyzed in the AB model. The results show that the marginal effect of air humidity, crack depth, and crack temperature in order is higher than that of the others.