• 통합자연과학논문집
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• 제7권1호
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• pp.45-49
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• 2014

The (c-Jun N-terminal kinase 3) JNK3 is a potential therapeutic target for various neurological disorders. Here, a three dimensional quantitative structure-activity relationship (3D-QSAR) study on phenoxypyridine as JNK3 inhibitors was performed to rationalize the structural requirements responsible for the inhibitory activity of these compounds. The comparative molecular field analysis (CoMFA) using different partial atomic charges, was employed to understand the structural factors affecting JNK3 inhibitory potency. The Gasteiger-Marsili yielded a CoMFA model with cross-validated correlation coefficient ($q^2$) of 0.54 and non-cross-validated correlation coefficient ($r^2$) of 0.93 with five components. Furthermore, contour maps suggested that bulky substitution with oxygen atom in $R^3$ position could enhance the activity considerably. The work suggests that further chemical modifications of the compounds could lead to enhanced activity and could assist in the design of novel JNK3 inhibitors.

• 한방재활의학과학회지
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• 제24권1호
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• pp.77-82
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• 2014

Objectives Adhesive capsulitis (AC) is a restricted shoulder range of motion. Rotator cuff disease (RCD) has been believed to be a major etiologic factor of AC, however, how soon is the development time from RCD to AC (DTRA) has not been elucidated. The purpose of our study was to evaluate the correlation between the ultrasonographic characteristics of RCD and the DTRA. Methods Total 40 patients who were diagnosed as AC were recruited. The clinical characteristics of RCD were diagnosed by ultrasonography and classified with the Southern California Orthopedic Institute for Rotator Cuff Classification. The correlation was analyzed with Mann-Whitney U test and one-way analysis of variance. Results 60% of full thickness tear and 40% of partial thickness tear patients (10 male and 30 female, mean age of $54.0{\pm}8.4$ years) and 38% of bursitis and 21% of neovascularization were observed. The mean value of DTRA was $74.8{\pm}131.3$ days. There were no correlation between DTRA and gender (p=0.63), location of the partial tear (p=0.63), the severity of the partial thickness tear (p=0.63), full thickness tear (p=0.66) and completeness of the tear (p=0.16). The presence of bursitis or neovascularization was not associated with DTRA (p=0.60, p=0.61). Conclusions Although RCD is a major etiologic factor of AC, the severity, the type of RCD and the presence of bursitis and neovascularization were not statistically correlated with the DTRA in our study. Comprehensive consideration about etiologic factor analysis of AC will be needed with prospective study design for future study.

• 대한치매학회지
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• 제22권4호
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• pp.139-147
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• 2023

Background and Purpose: Dual walking task such as crossing over an obstacle may serve as an excellent tool for predicting early cognitive decline. Thus, this study aimed to investigate correlation between walking while crossing over an obstacle and executive functions under different gait phases to validate the use of walking with an obstacle for predicting early cognitive decline. Methods: A cross-sectional study was conducted on 48 elderly individuals from 2 day-care centers and 3 welfare-centers in Seoul and Gyeonggi, Korea. Executive function tests (Trail Making Test, Stroop test) and dual walking tests (gait speed, cadence, stance time, gait cycle time) were performed and compared using partial correlation analysis. Results: There were significant correlations between executive function and most of the gait variables (stance time, cadence, and gait cycle time) (p<0.05) when crossing over an obstacle while walking. Especially, stance time exhibited significant correlations with most executive functions (p<0.05). Conclusions: When evaluating executive function during walking with an obstacle, post-obstacle-crossing phase and stance time need to be observed.

• 한국콘텐츠학회논문지
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• 제11권6호
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• pp.428-437
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• 2011

본 연구는 요양보호사 교육원에서 교육을 받고 있는 교육생들의 학습동기가 학습몰입에 미치는 영향을 알아보고자 하였다. 조사 대상자는 B시의 요양보호사 교육원의 교육생 230명이었다. 연구도구는 학습동기 척도와 몰입 상태 척도를 사용하였다. 학습동기가 학습몰입에 미치는 영향을 알아 본 결과 내재적, 외재적 학습동기가 학습몰입과 상관관계를 가지고 있었다. 또한, 학습과제에 대한 몰입은 학습동기가 증가될수록 높아지는 성향을 나타내었다. 그러나 외재적 학습동기보다 내재적 학습동기가 학습몰입과 더 높은 상관관계를 가지고 있는 것으로 나타났다. 따라서, 요양보호사 교육생들의 몰입정도는 내재적 동기에 가장 많은 영향을 받고, 외재적 동기에도 영향을 일부 받는 것으로 나타났다. 성공적인 요양보호사 인력 양성을 위하여 요양보호사 교육에 대한 다각적인 측면의 연구가 필요한 것으로 보인다.

• 아동학회지
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• 제26권4호
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• pp.55-70
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• 2005

The Teachers' Job Stress Scale(D'Arienzo, 1981) and the General Self-Efficacy Scale(Kim & Cho, 1996) were used to study 170 child care teachers. Data were analyzed by one-way ANOVA, Pearson's partial correlation, stepwise multiple regression(forward), path analysis, Internal consistency(Cronbach's $\alpha$), and factor analysis. Results showed that job stress was low for teachers of the national child care center, university graduates, higher salaried, and married teachers. Self-efficacy was high among teachers with more than 2 years experience, married status, and previous experience. Correlation between teacher's job stress and self-efficacy was -.19. Self-efficacy and demographic variables for job stress explained 8~22% of the variability. Self-efficacy intermediated between job stress and demographic variables. Monthly salary directly affected job stress.

• 한국응급구조학회지
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• 제27권2호
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• pp.65-78
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• 2023

Purpose: This study aimed to examine the mediating effect of self-efficacy between loneliness and life satisfaction among university students during the COVID-19 pandemic. Methods: This study administered a questionnaire survey of 282 college students enrolled in universities located in K area. Structural equation modeling analysis was utilized to examine the relationships of variables. The questionnaire included the life satisfaction, loneliness, and self-efficacy scales. Results: The results showed that loneliness had a negative correlation with life satisfaction and self-efficacy. Self-efficacy had a positive correlation with life satisfaction. The study confirmed that loneliness had a partial mediating effect on life satisfaction through self-efficacy. Conclusion: The study discussed ways of enhancing the life satisfaction of university students, the implications of the study findings, and suggestions for future research.

• 한국소음진동공학회논문집
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• 제17권11호
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• pp.1056-1063
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• 2007

Recently, there has been a growing consumer interest in the amount of noise produced by household electrical appliances. The designer of the product must identify the source of the noise, in order to reduce the noise. In the case of a household electric appliance such as the washing machine, there is consumer's complaint about the noise that is generated during the dehydrating condition. Because of several noise sources combined each other. It is difficult to identify the noise sources that contribute to the noise output. Multi-Dimensional Spectral Analysis (MDSA) is a method that can remove the correlation between different noise sources, and it expresses the key contributing factor as a unique output. This study utilized MDSA to analyze the contribution of each input in the noise output during the dehydrating condition.

• Food Science and Biotechnology
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• 제18권1호
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• pp.60-65
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• 2009

Near infrared reflectance spectroscopy (NIRS) was used as a rapid and non-destructive method to determine the protein content in intact and ground seeds of pea (Pisum sativum L.) germplasms grown in Korea. A total of 115 samples were scanned in the reflectance mode of a scanning monochromator at intact seed and flour condition, and the reference values for the protein content was measured by auto-Kjeldahl system. In the developed ground and intact NIRS equations for analysis of protein, the most accurate equation were obtained at 2, 8, 6, 1 math treatment conditions with standard normal variate and detrend scatter correction method and entire spectrum (400-2,500 nm) by using modified partial least squares regression (n=78). External validation (n=34) of these NIRS equations showed significant correlation between reference values and NIRS estimated values based on the standard error of prediction (SEP), $R^2$, and the ratio of standard deviation of reference data to SEP. Therefore, these ground and intact NIRS equations can be applicable and reliable for determination of protein content in pea seeds, and non-destructive NIRS method could be used as a mass analysis technique for selection of high protein pea in breeding program and for quality control in food industry.

• 농업생명과학연구
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• 제50권2호
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• pp.117-124
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• 2016

본 연구에는 경남의 혈통등록우 경매시장 A, B 지역에서 2014년도부터 2015년도에 경매된 한우송아지 중에서 경매가격이 있는 19,592두의 경매가격자료를 이용하였고 경매가격에 미치는 환경요인 및 요인별 기여도를 추정하였다. 연구의 결과를 살펴보면 송아지경매가격에 대한 모든 효과에서 고도의 유의적인 차이(p<0.01)를 나타내었고, 준부분 상관제곱(semi-partial correlation)값을 이용한 요인별 기여도 분석에서 회귀식의 수정모형 적합도(Adj R-Square)가 0.701로 나타났으며, 성, 경매체중, 출품개월령, 경매년도, 경매계절 및 경매지역의 준부분상관값은 각각 0.11563, 0.20013, 0.02823, 0.10727, 0.00330 및 0.02963으로 나타났다. 요인별 기여도에서 송아지 체중의 기여도가 가장 높은 것으로 나타났으며, 성, 경매년도, 경매지역 및 출품개월령 순으로 영향을 미치는 것으로 나타났다. 송아지 생산농가에서 경매가격을 잘 받기 위해서는 송아지의 발육정도를 측정할 수 있는 체중의 개량 및 적절한 사양 관리가 매우 중요할 것으로 사료된다. 또한 향후에는 개량방향과 맞는 우수한 유전자의 생산 및 확보가 농가 경쟁력 및 소득증대에 이바지할 것으로 사료된다. 송아지경매가격 및 요인별 기여도에 대한 연구는 아직 많이 부족한 상황으로 더 많은 연구가 이루어져야 할 것으로 사료된다.

• 한국연초학회지
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• 제27권1호
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• pp.141-152
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• 2005

This study focused on the relationships among leaf and smoke components and sensory properties following tobacco leaf blending. A completely randomized experimental design was used to evaluate components of leaf and smoke and sensory properties for sample cigarettes with four mixtures of flue cured and burley tobacco (40:60, 60:40, 80:20 and 100:0). Eleven leaf components, six smoke components, and eight sensory properties of smoking taste were analyzed. A sensory evaluation method known as quantitative descriptive analysis was used to evaluate perceptual strength on a fifteen score scale. Raw data from ten trained panelists were obtained and statistically analyzed. Based on the MANOVA, clustering analysis, correlation matrix and partial least square (PLS) method were applied to find out which smoke component most affected sensory properties. The PLS method was used to remove the influence between explanatory variables in the leaf, smoke components derived from the results. High correlations (p<0.0l) were found among ten specific leaf and smoke components and sensory attributes. Total nitrogen, ammonia, total volatile base, and nitrate in the leaf were significantly correlated (p<0.05) with impact, bitterness, tobacco taste, irritation, smoke volume, and smoke pungency. From the results of PLS analysis, influence variables are used to explain about the correlation. In terms of bitterness, with only two explanatory variables, Leaf $NO_3$ and Leaf crude fiber were enough for guessing their correlation. In the distance weighted least square fitting analysis, carbon monoxide highly influenced bitterness, hay like taste, and smoke volume.