• 대한약학회:학술대회논문집
• /
• 대한약학회 2004년도 Proceedings of the Convention of the Pharmaceutical Society of Korea Vol.2
• /
• pp.98-98
• /
• 2004

• 대한약학회:학술대회논문집
• /
• 대한약학회 2004년도 Proceedings of the Convention of the Pharmaceutical Society of Korea Vol.2
• /
• pp.102-102
• /
• 2004

• 대한약학회:학술대회논문집
• /
• 대한약학회 2004년도 Proceedings of the Convention of the Pharmaceutical Society of Korea Vol.2
• /
• pp.104-104
• /
• 2004

• BMB Reports
• /
• 제28권4호
• /
• pp.368-373
• /
• 1995

The upstream regulatory region (URR) of bovine papillomavirus type 1 (BPV) contains promoters and a conditional transcriptional enhancer that is trans-activated by the viral E2 protein. After deleting the 5' and 3' ends of BPV URR, BamHI linkers were inserted into several positions of BPV URR without causing an addition or a deletion of URR sequences. Most linker scanning mutations did not show any effects on the transcription of P7940 and P89 promoters in BPV URR. However, several mutants showed reduced transcriptional activities. Based on our results we found that the AP-2 and Sp1 binding sites were important for basal level transcription of BPV URR in the absence of the E2 protein and that the CTF/NF-1 site is dispensable for E2 transactivation of BPV URR transcription.

• Asian Pacific Journal of Cancer Prevention
• /
• 제13권12호
• /
• pp.6083-6086
• /
• 2012

Background: The aim of this study was to screen for human papillomavirus (HPV) infections in head and neck squamous cell carcinomas (HNSCCs) using P16 immunostaining. Materials and Methods: A retrospective study was performed on 150 samples from patients diagnosed with HNSCCs. HPV status was determined using $p16^{INK4A}$. Results: 31 of the 150 (20.7%) HNSCCs were HPV positive. Conclusions: A large proportion of HNSCCs in Sudan are associated with HPV infection. The fact that the prevalence of HPV is high among Sudanese patients with head and neck cancers (HNC) has obvious implications for vaccine therapy.

• 종양간호연구
• /
• 제11권3호
• /
• pp.193-199
• /
• 2011

Purpose: This study was aimed to examine mothers'knowledge about human papillomavirus (HPV)vaccination to prevent cervical cancer in Korea. Methods: From September 20 to October 10 2011, 101 mothers who have adolescent girls were surveyed with questionnaires about their general characteristics, the knowledge of HPV vaccine, inoculation rate and vaccination-related factors of their daughters. Results: The percentage of correct answers for HPV vaccine knowledge was 24.2% and the HPV vaccination rate was only 5.9%. HPV vaccine knowledge score of the vaccination group was significantly higher than that of the non-vaccinated group. Mothers said that the reasons why they didn't vaccinate their daughters against the HPV was the financial burden, the lack of HPV knowledge, and worries about possible side effects. The participants addressed that they understood the appropriate age for vaccination was sixteen. Conclusion: We recommend that more educational and promotional efforts need to be given for mothers in order to improve their knowledge of HPV vaccination and to increase the performance rates of HPV immunization against cervical cancer for their daughters.

• 대한기관식도과학회:학술대회논문집
• /
• 대한기관식도과학회 1991년도 제25차 학술대회 연제순서 및 초록
• /
• pp.18-18
• /
• 1991

후두유두종은 호흡기계에 발생하는 양성종양중 가장 흔한 질환으로 연령에 따라 소아형과 성인형으로 분류하는데 다발성 병변이 흔하고 재발율이 높다고 알려져 있다. 후두유두종의 원인으로는 human papillomavirus의 감염으로 생각되며 잠복 감염으로 인하여 후두유두종이 재발된다고 알려져 있다. Gissman등에 의해 HPV 11이 발견되었음이 보고된 이래 최근까지 HPV 6와 11이 후두유두종의 원인이 된다고 알려져 있다. HPV의 검출에는 Southern blotting이나 in-situ hybridization 방법이 알려져 있는데 저자들은 현재까지의 바이러스 검색방법 중 가장 예민한 방법인 PCR을 이용하여 후두유두종의 HPV DNA를 조사하여 보고자 한다. 저자들은 1989년 10월부터 1900년 12월까지 서울대병원 이비인후과에서 수술을 시행받은 후두유두종 환자 15예를 대상으로 하였으며 이중 소아형은 9예이었고 성인형은 6예였으며 대부분 다발성 병변이었다. HPV 6는 15예중 10예에서 HPV 11은 15예중 6예에서 발견되었으며 두가지 형이 같이 발견된 경우는 1예가 있었다. 소아형의 경우에는 HPV 6와 11이 각각 5예로 비슷한 비율로 검출된 반면 성인형에서는 HPV 6가 주로 검출되었다.

• 대한기관식도과학회:학술대회논문집
• /
• 대한기관식도과학회 1991년도 제25차 학술대회 연제순서 및 초록
• /
• pp.19-19
• /
• 1991

성인의 후두유두종은 Human Papillonavirus에 의해 발생하는 것으로 알려져 있다. 저자들은 1985년 4월부터 1989년 12월까지 충남대학교병원 이비인후과에서 후두유두종으로 수술받은 19예중 보관된 Paraffin block의 이용이 가능하였던 14예에서 Human Papillomavirus type 6, 11, 16 및 18에 대해 In situ hybridization 방법으로 DNA typing을 시행하여 다음과 같은 결과를 얻었다. 14예중 10예에서 type 6에 양성을 보였고 type 6에 양성을 보인 10예중 6예에서 type 11에 대해서도 양성을 보였다. Type 11 단독으로 양성을 보인 예는 없었다. 또한, type 16 및 18에 대해서는 모두 음성을 보였다. 이상의 결과로 성인의 후두유두종은 Human Papillomavirus type 6 및 11과 밀접한 관계가 있을 것으로 사료된다.

• 대한후두음성언어의학회지
• /
• 제31권1호
• /
• pp.7-12
• /
• 2020

Recurrent respiratory papillomatosis (RRP) is characterized by repeated recurrence in the respiratory system, such as the pharynx, larynx, and trachea, caused by the human papilloma virus. The main treatment is surgical removal of the papilloma. However repeated recurrence of RRP in multiple areas is burdened for the surgeon. In addition to the surgery, various adjuvant therapies have been studied to reduce the recurrence. Literature review was conducted with a focus on the adjuvant treatments for RRP.

• 대한두경부종양학회지
• /
• 제34권2호
• /
• pp.1-9
• /
• 2018

With the emerging knowledge about tumor biology specific for human papillomavirus (HPV)-related head and neck cancers, the classical understanding about the curative surgery in head and neck cancers are starting to progress, customized for their HPV-associations and ultimately specific for tumor biologic characteristics. The common rule for surgery should reflect the biologic characteristics of target tumors, but still, multi-institutional large-scale data could be scarce, due to the subjective feature of surgical treatment itself. However, the impact of HPV for margin determination is now being questioned by multiple groups, and typical example is European Cooperative Oncology Group (ECOG)-3311 study. Here, we review the impact of viral association for surgical decision and its biological background and implications.