• Bulletin of the Korean Chemical Society
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• v.32 no.5
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• pp.1709-1714
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• 2011

KIST301135 was semi-synthetically prepared by the reaction of Staurosporine with triphosgene in anhydrous dichloromethane. The structure of KIST301135 was confirmed by $^1H$ NMR, $^{13}C$ NMR, and high resolution mass spectrum. KIST301135 was initially tested in a single dose duplicate mode at a concentration of 20 nM over a panel of 53 kinases against Staurosporine as a positive control. KIST301135 has showed inhibitions above 75% in only 2 kinases (FLT3 and JAK3 kinases) of the 53 tested kinases, while Staurosporine has showed inhibitions above 80% in about 62% of the tested kinases. KIST301135 was retested at a 5-dose testing mode over the 9 kinases inhibited by percentages over 20 at the single dose testing in order to determine its $IC_{50}$ values. KIST301135 has shown much improved kinase inhibitory selectivity relative to Staurosporine in its potency at JAK3 kinase and CAMK2b kinase.

• Journal of the Computational Structural Engineering Institute of Korea
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• v.28 no.6
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• pp.645-657
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• 2015

In this study floor impact noise and structure acceleration response of bare concrete slabs were predicted by using Finite Element Analysis(FEA). Prediction results were compared with experimental results to prove the accuracy of numerical model. Acoustic absorption were addressed by using panel impedance coefficients with frequency characteristics and structural modal damping of numerical model were applied by modal testing results and analysis of prediction and test results. By using frequency response function, the floor acceleration and acoustic pressure responses for various impact sources were calculated at the same time. In the FEA, the natural frequencies and the shapes of vibration and acoustic modes can be estimated through the eigen-value analysis, and it can be visually seen the vibration and sound pressure field and the contribution of major modes.

• Proceedings of the Korean Vacuum Society Conference
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• 2016.02a
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• pp.289.2-289.2
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• 2016

In-Ga-Zn-O(IGZO) receive great attention as a channel material for thin film transistors(TFTs) as next-generation display panel backplanes due to its superior electrical and physical properties such as a high mobility, low off-current, high sub-threshold slope, flexibility, and optical transparency. For the purpose of fabricating high performance IGZO TFTs, a thermal recovery process above a temperature of $300^{\circ}C$ is required for recovery or rearrangement of the ionic bonding structure. However diffused metal atoms from source/drain(S/D) electrodes increase the channel conductivity through the oxidation of diffused atoms and reduction of $In_2O_3$ during the thermal recovery process. Threshold voltage ($V_{TH}$) shift, one of the electrical instability, restricts actual applications of IGZO TFTs. Therefore, additional investigation of the electrical stability of IGZO TFTs is required. In this paper, we demonstrate the effect of Ti diffusion and modulation of interface traps by carrying out an annealing process on IGZO. In order to investigate the effect of diffused Ti atoms from the S/D electrode, we use secondary ion mass spectroscopy (SIMS), X-ray photoelectron spectroscopy, HSC chemistry simulation, and electrical measurements. By thermal annealing process, we demonstrate VTH shift as a function of the channel length and the gate stress. Furthermore, we enhance the electrical stability of the IGZO TFTs through a second thermal annealing process performed at temperature $50^{\circ}C$ lower than the first annealing step to diffuse Ti atoms in the lateral direction with minimal effects on the channel conductivity.

• International Journal of Aeronautical and Space Sciences
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• v.16 no.2
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• pp.206-222
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• 2015

This work uses different finite element approaches to the free vibration analysis of reinforced shell structures, and a simplified model of a typical launcher with two boosters is used as an example. The results obtained using a refined one-dimensional (1D) beam model are compared to those obtained with commercial finite element software. The 1D models that are used in the present work are based on the Carrera Unified Formulation (CUF), which assumes a variable kinematic displacement field over the cross-sections of the beam. Two different sets of polynomials that correspond to Taylor (TE) or Lagrange (LE) expansions were used. The analyses focused on three reinforced structures: a stiffened panel, a reinforced cylinder and the complete structure of the launcher. The frequencies and natural modes obtained using one-dimensional models are compared to those obtained from classical finite element analysis. The classical FE models were built using a beam-shell or solid elements, and the results indicate that the refined beam models can in fact be used to investigate the behavior of very complex reinforced structures. These models can predict the shell-like modes that are typical of thin-walled structures that cannot be detected using classical beam models. The refined 1D models used in the present work provide results that are as accurate as those from solid FE models, but the 1D models have a much lower computational cost.

• 한국정보디스플레이학회:학술대회논문집
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• 2004.08a
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• pp.1058-1061
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• 2004

Recently, According to companies of TFT LCD are making large sized products more and more. In the vortex of Products with a monitor and LCD TV is applied in a technique of a high viewing angle(FFS, IPS, VA). Also, as a high luminance, high speed response time, high degree of a color purity, and so on are continuing to develop a high performance, it is necessary to improve a specific character of high luminance that apply to LCD TV as a LCD BLU. Because a LCD panel for TV usually has a lower resolution that compare to a monitor, the structure of present backlight system can't put out its power even though it has a merit in transmission. Therefore, the examination of improvement about the high luminance direct typed BLU for LCD TV that presupposes several uses of CCFL(Cold Cathode Fluorescent Lamp) or EEFL(External Electrode Fluorescent Lamp)is actively being progressed. Although it is necessary to increase the number of lamps for applying high performance by the direct type, in this case, because we can design the character of luminance for adoption of high performance. We can satisfy with a level of luminance for LCD TV. Accordingly, we analyzed a change of the number of CCFL, mechanical and optical character to produce the direct typed backlight in 32inches spec. Consequently, we achieved luminance of 6597nit,which was including polarization film, and secured the standard for LCD TV.

• Proceedings of the Computational Structural Engineering Institute Conference
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• 1991.10a
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• pp.133-138
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• 1991

The aim of the present paper is to develop a computer program predicting ultimate fracture strength of initially cracked structure under monotonically increasing external loads. For this purpose, two kinds of 3-D isoparametric solid elements, one 6-node wedge element and another 8-node brick element are formulated along the small deformation theory. Plasticity in the element is checked using von Mises' yield criterion. Elasto-plastic stiffness matrix of the element is calculated taking account of strain hardening effect. If the principal strain at crack tip which is one nodal point exceeds the critical strain dependin on the material property, crack tip is supposed to be opened and the crack tip node which was previously constrained in the direction perpendicular to the crack line is released. After that, the crack lay be propagated to the adjacent node. Once a crack tip node is fractured, the energy of the newly fractured node should be released which is to be absorbed by the remaining part. The accumulated reaction force which was carried by the newly fractured node so far is then applied in the opposite direction. During the action of crack tip relief force, since unloading may be occured in the plastic element, unloading check should be made. If a plastic element unloads, elastic stress-strain equation is used in the calculation of the stiffness matrix of the element, while for a loading element, elasto-plastic stress-strain equation is continuously used. Verification of the computer program is made comparing with the experimental results for center cracked panel subjected to uniform tensile load. Also some factors affecting ultimate fracture strength of initially cracked plate are investigated. It is concluded that the computer program developed here gives an accurate solution and becomes useful tool for predicting ultimate fracture load of initially cracked structural system under monotonically increasing external loads.

• Journal of the Korean housing association
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• v.13 no.5
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• pp.77-88
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• 2002

This article deals the investigations how to solve the social deficiencies of deteriorate apartments, which is a half cycle of a building and it goes slum clearance and redevelopment. And this proposes an active remodeling and design strategy, management, and housing policies for extending the usage of the resource. Most of apartment housing in Korea is built by the panel wall and slab structure system fur economic price. To remake is possible, even though not designed in flexibility and variation. The remodeling strategies are dwelling unification, transformation of two units to one or three units, addition of a room, changing into commercial and community required spaces, and reshaping of a envelop and facade by addition of a dwelling or dwellings, roof floors, change of materials and colors, and so on. And, all activities in structural aspect are proposed removal in upper part and addition in lower part of an apartment housing. Active remodeling cost a great deal compare to new construction, so any remodeling activities should be based on a minimal interfere and budgets to enhancing the quality in existing building. The final aim of an active remodeling is to enhance the quality in economic values, and to keep original state and to put on the new one in a small part. To promote the active and careful management and rehabilitation, it is necessary to give the positive incentive in terms of architectural law, bank loan, and any redevelopment project should get the remodeling record in national resources.

• Transactions of the Korean Society of Mechanical Engineers B
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• v.26 no.6
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• pp.893-901
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• 2002

Effect of boundary layer thickness on the flow characteristics around a rectangular prism has been investigated by using a PIV(Particle Image Velocimetry) technique. Three different boundary layers(thick, medium and thin)were generated in the Atmospheric Boundary Layer Wind Tunnel at Pusan National University. The thick boundary layer having 670 mm thickness was generated by using spires and roughness elements. The medium thickness of boundary layer($\delta$=270 mm) was the natural turbulent boundary layer at the test section floor with fairly long developing length(18 m). The thin boundary layer($\delta$=36.5 mm) was generated on the smooth panel elevated 70cm from the wind tunnel floor. The Reynolds number based on the free stream velocity(3 ㎧) and the height of the model(40 mm) was 7.9$\times$10$^3$. The mean velocity vector fields and turbulent kinetic energy distributions were measured and compared. The effect of boundary layer thickness was clearly observed not only in the length of separation bubble but also in the location of reattachment point. The thinner the boundary layer thickness, the higher the turbulent kinetic energy Peak around the model roofbecame. It is strongly recommended that the height ratio between the model and the approaching boundary layer thickness should be encountered as a major parameter.

• Progress in Medical Physics
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• v.28 no.3
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• pp.83-91
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• 2017

In this work, we investigated the recently proposed phase-contrast x-ray imaging (PCXI) technique, the so-called single grid-based PCXI, which has great simplicity and minimal requirements on the setup alignment. It allows for imaging of smaller features and variations in the examined sample than conventional attenuation-based x-ray imaging with lower x-ray dose. We performed a systematic simulation using a simulation platform developed by us to investigate the image characteristics. We also performed a preliminary PCXI experiment using an established a table-top setup to demonstrate the performance of the simulation platform. The system consists of an x-ray tube ($50kV_p$, 5 mAs), a focused-linear grid (200-lines/inch), and a flat-panel detector ($48-{\mu}m$ pixel size). According to our results, the simulated contrast of phase images was much enhanced, compared to that of the absorption images. The scattering length scale estimated for a given simulation condition was about 117 nm. It was very similar, at least qualitatively, to the experimental contrast, which demonstrates the performance of the simulation platform. We also found that the level of the phase gradient of oriented structures strongly depended on the orientation of the structure relative to that of linear grids.

• Journal of the Korean Society of Food Culture
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• v.2 no.2
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• pp.169-179
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• 1987

In the life style of the neolithic age, cooking and sleeping space was in one room dugout without differentiation of spaces, so to say one room system. Ro(a kind of primitive fire place) was used for both cooking and heating. However, in the early part of the Iron Age, the uses of Ro were separated into two major uses of cooking and heating. Especially, L-shaped Kudle(an unique under floor heating structure of Korea) was invented for the new system of heating, extending to Koguryo Period. The life style of Koguryo Dynasty could be seen through the mural paintings of tombs. For these mural paintings contain of cooking space(Kitchen), meat storage, and mill house drawing, we can recognize that houses were specialized many quaters according to their function. Also a kitchen fuel hole for preparing food was built without relation to L-shaped Kudle. But during Koryo Period, Kudle could be set up all over the room, the so-called Ondol(the unique Korean panel heating system) settled down. From this development of heating system, room could be adjacent to kitchen, and kitchen fuel hole and heating fuel hole be onething. This system was developed with variety, extending to Chosun Dynasty. In the period of Chosun Dynasty, a kitchen was made close to an Anbang(Woman's living room), and Anbangs Ondol was heated by the warmth of a cooking fireplace. Therefore Handae Puok, outer kitchen was used in summer. As for its storage space, it was seen that there were a pantry near the kitchen and a store house constructed as an independant building. In the latter, it was devided into a firewood storage, a Kimchi storage, and a rice storage, etc. Especially it is a unique feature that 'Handae-Duyju', an outer rice chest which keeps rice, was constructed as an isolated small building.