• Journal of muscle and joint health
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• v.17 no.2
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• pp.212-221
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• 2010

Purpose: The purpose of this study was to determine the effects of music therapy (Jang-Gu) on depression, stress, pain and body discomfort in women with osteoarthritis. Methods: The study is designed using one group pretest-posttest experimental design. 31 arthritis patients, the subjects of the group participated in the music therapy program. The program was provided for 12 weeks (two times per week). The questionnaires were used to measure the outcome variables before and after the program. Data were analyzed with the SPSS 17.0 using descriptive statistics, paired t-test. Results: Depression, Stress, Pain did not decrease. But body discomfort decreased (p=0.001). Conclusion: Therefore this program was effective in body discomfort and can be a community based self-help management program for arthritis patient.

• Journal of Korean Clinical Nursing Research
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• v.16 no.1
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• pp.83-93
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• 2010

Purpose: This study identified effects of laughter therapy administered to mastectomy patients as an adaptive coping mechanism. Methods: The study design was a non-synchronized design with a non-equivalent control group. Participants were 40 patients admitted to S hospital in Busan from July 1 to October 10, 2008. The laughter therapy was provided to the experimental group for 20 minutes, four times per week for 2 weeks in each patient's room. Results: The experimental and control groups showed significant differences in Mood (t=-2.314, p=.032), and Stress (t=-2.535 p=.020). Pain and serum cortisol in the experimental and control groups did not show any significant difference. Conclusion: Based on the findings the laughter therapy has significant effects on mastectomy patients' mood and stress.

• The Journal of Korean Academy of Orthopedic Manual Physical Therapy
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• v.21 no.2
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• pp.53-62
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• 2015

Background: This study was to investigate the effect of 8-weeks medical exercise therapy on ankle pain, range of motion, stress symptom after traumatic injury, and depression, in a 51 years old stroke patient with right ankle joint inflammation. Method: The 8-weeks medical exercise therapy program was applied to 4 grades of Dosage 1 (1-3 weeks), Dosage 2 (4-5 weeks), Dosage 3 (6-7 weeks), and Dosage 4 (8 weeks) on right ankle joint inflammation in a female with right hemiplegia admitted to D hospital located in Gyeonggi-do. Result: The findings showed that visual analogue scale (VAS) scores improved from 8 to 0-1 scores, passive range of motion (ROM) increased to 5 degrees more than before, Korean-version impact of event scale-revised (IES-R-K) scores increased from 61 to 31 scores, and Korean-version beck depression inventory II (BDI-II-K) scores decreased from 51 to 17 scores. As such, the 8-week medical exercise therapy program may decrease the pain, increase ROM, improve stress after traumatic injury, and improve depression symptom. Conclusion: The presented evidence suggests that exercise and physical activity have beneficial effects on depression symptoms. It is possible to apply the medical exercise therapy for modulating pain experience and treating pain. Also, it may be effective methods to treat the psychological aspects of pain.

• The Korean Journal of Pain
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• v.35 no.3
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• pp.291-302
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• 2022

Background: Spinal cord injury (SCI) is one of the most debilitating disorders throughout the world, causing persistent sensory-motor dysfunction, with no effective treatment. Oxidative stress and inflammatory responses play key roles in the secondary phase of SCI. Naringenin (NAR) is a natural flavonoid with known anti-inflammatory and antioxidative properties. This study aims at evaluating the effects of intrathecal NAR administration on sensory-motor disability after SCI. Methods: Animals underwent a severe compression injury using an aneurysm clip. About 30 minutes after surgery, NAR was injected intrathecally at the doses of 5, 10, and 15 mM in 20 µL volumes. For the assessment of neuropathic pain and locomotor function, acetone drop, hot plate, inclined plane, and Basso, Beattie, Bresnahan tests were carried out weekly till day 28 post-SCI. Effects of NAR on matrix metalloproteinase (MMP)-2 and MMP-9 activity was appraised by gelatin zymography. Also, histopathological analyses and serum levels of glutathione (GSH), catalase and nitrite were measured in different groups. Results: NAR reduced neuropathic pain, improved locomotor function, and also attenuated SCI-induced weight loss weekly till day 28 post-SCI. Zymography analysis showed that NAR suppressed MMP-9 activity, whereas it increased that of MMP-2, indicating its anti-neuroinflammatory effects. Also, intrathecal NAR modified oxidative stress related markers GSH, catalase, and nitrite levels. Besides, the neuroprotective effect of NAR was corroborated through increased survival of sensory and motor neurons after SCI. Conclusions: These results suggest intrathecal NAR as a promising candidate for medical therapeutics for SCI-induced sensory and motor dysfunction.

• Journal of Korean Society of Occupational and Environmental Hygiene
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• v.22 no.2
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• pp.107-118
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• 2012

Objectives: This study examines the occurrence of disease resulting from low back pain and factors of working environment meaningfully influencing the occurrence of lumbago as well as analyzes '2nd Korean Working Condition Survey (KWCS)' conducted in 2010 so as to establish the prevention and improvement measures. Methods: The analysis method is that it is to compare the prevalence rate of low back pain according to working environment via odds ratio and to implement the test about the factors having the difference in working environment between low back pain group and normal group through weighted t-test. Results: As a result, it indicates that there is a meaningful difference for prevalence rate of low back pain according to age, status in employment and education level which are socio-demographical factors. The analysis in working hours shows that the period of work is a factor raising the prevalence rate of low back pain rather than weekly working hours. The analysis in the work risk factor indicates that the increase in prevalence rate of low back pain takes place to either workers with repetitive movement and continuously standing posture or those with heavy stress and emotional labour. Conclusions: Workers with low back pain have suffered from accident, depression, anxiety disorder and sleep. The factors in which the prevalence rate of low back pain decrease are to provide information on health and safety and working speed, and enough rest.

• Journal of the Korean Society of Physical Medicine
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• v.7 no.4
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• pp.515-524
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• 2012

PURPOSE: It is known that work stress was linked to WRMDs in workplace. The purpose of this study was to identify the characteristics of work related musculoskeletal disorders (WRMDs) related to job stress among prosthetists and orthotists. METHODS: Eighty-six self-reported symptoms of discomfort (SRSD) and job stress were collected by questionnaire and analyzed. RESULTS: The results were as follows: Over 70% of respondents had WRMDs. The shoulder was the most painful region and each of "within 15 minutes", "once a week" and "severe moving or doing exercise" items were main characteristics in the SRSD. Finally, the "repetition of simple work" item in job stress ranked as resulting in "often discomfort" in over 43% of respondents. Additionally, there was a statistically significant correlation between job stress and pain intensity (p<.05, $r_s$=.36). CONCLUSION: Further studies are needed to identify the factors affecting musculoskeletal symptoms and job stress of prosthetists and orthotists in Korea.

• Proceedings of the Korean Society of Precision Engineering Conference
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• 2006.10a
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• pp.207-208
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• 2006

• Clinical and Experimental Pediatrics
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• v.49 no.2
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• pp.129-135
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• 2006

Chronic recurrent abdominal pain is a common manifestation in children. Functional abdominal pain is the most common cause of chronic abdominal pain and can be diagnosed properly by the physician without the requirement of specific evaluation when there are no alarm symptoms or signs. Functional abdominal pain is categorized as functional dyspepsia, irritable bowel syndrome, functional abdominal pain, abdominal migraine, and aerophagia, according to the Rome II criteria for pediatric functional gastrointestinal disorders. New concepts on the pathogenesis of functional abdominal pain include brain-gut interaction, visceral hypersensitivity, gastrointestinal dysmotility, inflammation, autonomic dysfunction, genetic predisposition, and triggering factors including psycho-social stress.

• Journal of Yeungnam Medical Science
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• v.40 no.2
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• pp.115-122
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• 2023

Hepatic ischemia-reperfusion injury is a major complication of liver transplantation, trauma, and shock. This pathological condition can lead to graft dysfunction and rejection in the field of liver transplantation and clinical hepatic dysfunction with increased mortality. Although the pathological mechanisms of hepatic ischemia-reperfusion injury are very complex, and several intermediators and cells are involved in this phenomenon, oxidative stress and inflammatory responses are the key processes that aggravate hepatic injury. This review summarizes the current understanding of oxidative stress and inflammatory responses and, in that respect, addresses the therapeutic approaches to attenuate hepatic ischemia-reperfusion injury.

• The Korean Journal of Pain
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• v.10 no.2
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• pp.170-178
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• 1997

Background: The analgesic efficacy and safety of propacetamol, an injectable prodrug of acetoaminophen, in combination with intravenous morphine PCA were studied in 40 patients after gynecological surgery requiring lower abdominal incision. Methods: Using a double-blind, randomized, parallel-group design, the effects of four(every 6 hr) intravenous injections of 2 g propacetamol(=1 g acetoaminophen) were compared with four injections of placebo(PL) immediately after surgery. Efficacy of cumulative dose of morphine and number of boluses requested was assessed over 24 hours by automated recording on the PCA device. It was assessed on pain scores rated on a ten-point verbal scale along with vital signs, $K^+$, glucose, BUN, creatinine, PT and PTT were measured along with stress hormones(epinephrine, norepinephrine and cortisol). Results: There were no differences in demographic data between two groups. Propacetamol group demonstrated approximately 21% morphine sparing effect compared to placebo group($33.1{\pm}10.4$ mg vs $41.4{\pm}8.0$ mg). No significant differences noted in $K^+$, glucose, BUN, Creatinine, PT and PTT levels. There were significant increases in norepinephrine and cortisol in placebo group postoperatively, compared to preoperative values. At the same time, propacetamol group also showed significant changes in these hormones. Both group revealed high degree of patient satisfaction. Conclusion: Propacetamol showed significant morphine sparing effect to some degree. Side effects were much less in propacetamol group with subsequently high patient satisfaction. The secretion of stress hormone were not blocked by postoperative propacetamol injections. Authors concluded that propacetamol should be considered as an excellent adjuvant analgesics in postoperative pain control in opioid patient controlled analgesia.