• Title/Summary/Keyword: pNET

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Altered expression of norepinephrine transporter and norepinephrine in human placenta cause pre-eclampsia through regulated trophoblast invasion

  • Na, Kyu-Hwan;Choi, Jong Ho;Kim, Chun-Hyung;Kim, Kwang-Soo;Kim, Gi Jin
    • Clinical and Experimental Reproductive Medicine
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    • v.40 no.1
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    • pp.12-22
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    • 2013
  • Objective: We investigated the norepinephrine transporter (NET) expression in normal and pre-eclamptic placentas and analyzed the invasion activity of trophoblastic cells based on norepinephrine (NE)-NET regulation. Methods: NET and NE expression levels were examined by western blot and enzyme-linked immunosorbent assay, respectively. Trophoblast invasion activity, depending on NE-NET regulation, was determined by NET-small interfering RNA (siRNA) and NET transfection into the human extravillous trophoblast cells with or without NE treatment and invasion rates were analyzed by zymography and an invasion assay. Results: NET mRNA was expressed at a low level in pre-eclamptic placentas compared with normal placentas and NE concentration in maternal plasma increased significantly in pre-eclamptic women compared to normal pregnant women (p<0.05). NET gene upregulation and NE treatment stimulated trophoblast cell invasion up to 2.5-fold (p<0.05) by stimulating matrix metalloproteinase-9 activity via the phosphoinositol-3-kinase/AKT signaling pathway, whereas NET-siRNA with NE treatment reduced invasion rates. Conclusion: NET expression is reduced by inadequate regulation of NE levels during placental development. This suggests that a complementary balance between NET and NE regulates trophoblast cell invasion activities during placental development.

Effects of improvement of fishing operating system on a coastal improved stow net fishing vessel on the work safety and workload of seafarers (연안개량안강망어선의 조업 시스템 개선이 선원들의 작업 안전과 작업부하에 미치는 영향)

  • Min-Son KIM;Ho-Young CHANG;Bo-Kyu HWANG
    • Journal of the Korean Society of Fisheries and Ocean Technology
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    • v.59 no.1
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    • pp.74-84
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    • 2023
  • This paper is the result of a comparative analysis of crew members' workloads using the EMG and OWAS methods according to the fishing process before and after the improvement of the operating system of the experimental vessel, with the aim of improving operational efficiency and safety work of coastal improved stow net fishing vessels. The target crew members were three people with at least five years of experience on board the same fishing vessel as the experimental vessel. After improving the operating system, such as installing a power block crane and two capstans, change the location of the ball-roller, the time required for setting and hauling work decreased (p < .01), and the evaluation results by OWAS showed that the overall workload for setting and hauling net work decreased. The results of muscle activity analysis showed a decrease in lashing anchor work (p < .01) in the case of hauling net and in anchor dropping work in the case of setting net (p < .001). It is judged that the use of ball rollers in net handling has been reduced; consequently, work safety has been improved.

The Hybrid LVQ Learning Algorithm for EMG Pattern Recognition (근전도 패턴인식을 위한 혼합형 LVQ 학습 알고리즘)

  • Lee Yong-gu;Choi Woo-Seung
    • Journal of the Korea Society of Computer and Information
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    • v.10 no.2 s.34
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    • pp.113-121
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    • 2005
  • In this paper, we design the hybrid learning algorithm of LVQ which is to perform EMG pattern recognition. The proposed hybrid LVQ learning algorithm is the modified Counter Propagation Networks(C.p Net. ) which is use SOM to learn initial reference vectors and out-star learning algorithm to determine the class of the output neurons of LVa. The weights of the proposed C.p. Net. which is between input layer and subclass layer can be learned to determine initial reference vectors by using SOM algorithm and to learn reference vectors by using LVd algorithm, and pattern vectors is classified into subclasses by neurons which is being in the subclass layer, and the weights which is between subclass layer and class layer of C.p. Net. is learned to classify the classified subclass. which is enclosed a class . To classify the pattern vectors of EMG. the proposed algorithm is simulated with ones of the conventional LVQ, and it was a confirmation that the proposed learning method is more successful classification than the conventional LVQ.

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Development of Water Reusing System by Using Net3FM (Net Fit Fiber Filter Module) (그물망 압착식 섬유여과장치를 이용한 물 재이용 시스템 개발)

  • Kim, Jeongsook;Kim, Mi-Ran;Jo, Myung-Chan;Jang, Jeong-Gook
    • Journal of Environmental Science International
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    • v.21 no.12
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    • pp.1523-1528
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    • 2012
  • This study was carried out to develop pilot plant Net3FM(Net Fit Fiber Filter Module) system and to suggest optimum operating condition for municipal wastewater reuse. SS concentration of biologically treated sewage effluent was reduced from 1.5~5.4mg/L to 0.4~1.0mg/L without coagulant injection in Net3FM system, and the SS removal efficiency was average 84.7%. And also, the removal efficiencies of COD and T-P were decreased slightly due to the SS removal by filtration. Coagulation-Filtration test was conducted to enhance the removal efficiencies of SS and T-P. The optimum dosage of coagulant was injected automatically by auto-controlling system, which is controlled by detecting value of turbidity of secondary sewage effluent. SS, COD and T-P concentrations in filtrated effluent were 0.21~0.57, 1.6~6.2 and 0.137~0.392mg/L with coagulant injection by in-line mixer in Net3FM system, respectively. The removal efficiencies of SS and T-P were highly increased to 92.8% and 89.8%, respectively. It was due to the combined the processes of coagulation and filtration. Net3FM system was evaluated that the removal efficiency of pollutants in secondary sewage effluent and the utilization potential as reclaimed water technology were very high.

Effects on Net Photosynthesis in Field-Grown Hot Peppers Responding to the Increased CO2 and Temperature

  • Yun, Sung-Chul;Ahn, Mun-Il
    • Korean Journal of Environmental Agriculture
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    • v.28 no.2
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    • pp.106-112
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    • 2009
  • The increased $CO_2$ and temperature (700 ${\mu}$mol.$mol^{-1}$ $CO_2$ and $30^{\circ}C$) was compared with ambient growth conditions (400 ${\mu}$mol.$mol^{-1}$ $CO_2$ and $25^{\circ}C$) in hot pepper. Gas exchange measurements, including net photosynthesis ($P_{net}$) and stomatal conductance ($g_s$), were taken according to treatment in fields of peppers grown in Suwon and Asan during 2008. The increased treatment $P_{net}$ by 35-45% throughout the season and was statistically significant in t-tests (p < 0.001); however, it did not significantly affect $g_s$. In addition, the gas exchange parameters in sun and shade leaves were measured. The difference between the sun and shade leaves was much greater than that between the elevated and ambient treatments, especially at harvest. Four commercial cultivars of hot pepper, Chunhasangsa, Ryukang, Manitta, and Olympic, were also compared by ANOVA. Chunhasangsa had the highest $P_{net}$, which decreased by 30% from the vegetative to the harvest stage. Based on a factorial design, the effect of the increased $CO_2$ and temperature was assessed based on the temperature, $CO_2$, and their interaction effects. Orthogonal contrasts showed that the effects of temperature on $P_{net}$ and $g_s$ were significant, whereas $CO_2$ and their interactions were not.

Fundamental Studies on the Net-Shape of the Drag Net-II On the Section Shape of the Simplified Model of the Bag Net in Four-Point Suspension (저예망의 어구형상에 관한 기초적 연구-II 단순화모형에 의한 4폭짜리 자루그물의 단면형상)

  • Lee, Ju-Hee
    • Journal of the Korean Society of Fisheries and Ocean Technology
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    • v.20 no.2
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    • pp.65-71
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    • 1984
  • As a primary step in studying the relationship between the arrangement of netting and the section shape of the bag net in the four-seam trawling net, a series of experiments were performed with the simplified model of the bag net made of vinyl film. This model was suspended horizontally in circularly flowing water, with two pairs of suspending threads to four points of symetry at the border of the bag mouth in place of both wing nets. And then, the area distribution of each panel in the bag net was arranged by the portion of the length of the side panel, q to that of the lower or upper panel, p at the border of bag mouth. In the experiments, the section shape of the bag mouth photographed and the tensions on both pairs of suspending threads were measured with two loadcells in circularly flowing water. From the results that the section shape of the bag mouth in circularly flowing water is controlled by the area distribution of panels in the bag net, the author estimated an experimental equation. h/w=k sub(1) e super(k) 2 super(q/p)+C, where h is the central height of the bag mouth, and w is the lateral width of that.

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Effect of Combining Wood Flakes and Polypropylene-net Flakes on Thickness Swelling and Bending Properties of Sawdust Board (목질(木質)플레이크와 폴리프로필렌망(網)플레이크 구성(構成)이 톱밥보오드의 팽창성(膨脹性)과 휨성질(性質)에 미치는 영향(影響))

  • Lee, Phil Woo;Eom, Young Geun;Oh, Sei Chang;Chung, In Ju
    • Journal of Korean Society of Forest Science
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    • v.77 no.2
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    • pp.252-257
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    • 1988
  • This study was carried out to investigate the physical and mechanical properties of sawdust boards combined with sycamore and polypropylene-net flakes. Both the sycamore and polypropylene-net flakes were adjusted to the sizes of $1.0{\times}1.0$, $1.0{\times}2.0$, and $1.5{\times}1.5cm^2$ and these flakes were mixed at 1, 2, 3, and 4% levels based on ovendry weights of sawdusts, respectively. The results obtained in this study were summarized as follows : 1. Thickness swellings of sawdust boards combined with sycamore flakes decreased with the increase of mixture levels and similar effects were also recognized in combination with polypropylene-net flakes. 2. Moduli of rupture both in sawdust boards combined with sycamore and polypropylene-net flakes increased with the increase of their mixture levels, and sawdust boards combined with sycamore flakes of $1.0{\times}2.0cm^2$ size and polypropylene-net flakes of $1.5{\times}1.5cm^2$ size showed higher moduli of rupture than control boards. 3. Moduli of elasticity both in sawdust hoards combined with sycamore and polypropylene-net flakes increased with the increase of their mixture levels as in moduli of rupture. 4. The physical and mechanical properties of sawdust boards combined with sycamore and polypropylene-net flakes were mainly dependent on aspect ratio of sycamore flakes and size of polypropylene-net flakes respectively, and these properties were improved with the respective increase of aspect ratio and size.

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Seasonal Variations in Tannin Profile of Tree Leaves

  • Rana, K.K.;Wadhwa, M.;Bakshi, M.P.S.
    • Asian-Australasian Journal of Animal Sciences
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    • v.19 no.8
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    • pp.1134-1138
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    • 2006
  • Forest tree leaves (12 different species) of semi hilly arid region of Punjab State were collected at 30-day interval throughout the year to assess the seasonal variations in tannin profile. Tannins were extracted and fractionated from fat free samples and data were analyzed statistically by $12{\times}12$ factorial design. The leaves of Anogeissus latifolia had the highest (p<0.05) concentration of total phenols (17.4%), net (15.9%) and hydrolysable (16.9%) tannins, followed by leaves of Acacia nilotica. Majority of the tree leaves selected had moderate levels (2-5%) of net tannins. Leaves of Carrisa had the highest (p<0.05) concentration of condensed tannins (CT), whereas the leaves of Anogeissus had the lowest (p<0.05) concentration of condensed tannins. The protein precipitable phenols (PPP) corresponded well with the net tannin content present in different tree leaves. Seasonal variation data revealed that in summer, net tannins and PPP decline in leaves of Bauhinia and Zizyphus whereas the net tannin content of Anogeissus and that of Carrisa increased during summer. The CT and PPP content in the leaves of Pheonix, Leucaena, Zizyphus and Ougenia increased in winter till spring season. Tree leaves generally had higher concentration of HT during summer months. It was concluded that leaves of leaves of A. nilotica, A. latifolia and L. leucocephala could serve as an excellent alternate feed stuffs for ruminants. However, leaves of Phoenix, Carrisa, Bauhinia and Dodonea should be avoided.

A Study on the Improvement Plan and Issue of Network Neutrality Regulations (망 중립성 규제의 쟁점과 개선방안에 관한 연구)

  • Jin, Ho-Un;Shin, Jin-Sik;Choi, Seong-Jhin
    • Journal of Satellite, Information and Communications
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    • v.12 no.2
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    • pp.71-78
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    • 2017
  • A network neutrality is the concept that ISP assures users non-discrimination, interconnection, accessibility for ensuring users without control or interference of equal services in the network. But today a network traffic is growing rapidly in sensitive buffering services as P2P service diffusion and mass video stream service. To manage this problem, ISP violates a net neutrality by control, change and interfere with service. And then the debate about net neutrality is happening. Therefore in this paper, we compare and analyze net neutrality principles, concepts, and legislative policy in the native and foreign. Based on this, we suggested the issues and improvement plan of net neutrality guard line.

Capital Structure Decisions Following Credit Rating Changes: Evidence from Japan

  • FAIRCHILD, Lisa;HAN, Seung Hun;SHIN, Yoon S.
    • The Journal of Asian Finance, Economics and Business
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    • v.9 no.4
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    • pp.1-12
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    • 2022
  • Our study adds to the body of knowledge about the relationship between credit ratings and the capital structure of bond issuers. Using Bloomberg and Datastream databases and employing panel regression models, we study the capital structure changes of Japanese enterprises after credit rating changes by global rating agencies (S&P and Moody's) as well as their local counterparts (R&I and JCR) from 1998 to 2016. We find that after rating downgrades, Japanese enterprises considerably reduce net debt or net debt relative to net equity, similar to the findings of Kisgen (2009), who focused on U.S. industrial firms. They do not, however, make adjustments to their financial structure as a result of rating improvements. In comparison to downgrades by S&P and Moody's, Japanese corporations issue 1.89 percent less net debt and 1.50 percent less net debt relative to net equity after R&I and JCR rating downgrades. To put it another way, Japanese companies consider rating adjustments made by local agencies to be more significant than those made by global rating organizations. Our findings contradict earlier research that suggests S&P and Moody's are more prominent in the investment community than R&I and JCR in Japan.