• Journal of the Korean Society of Physical Medicine
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• v.15 no.1
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• pp.11-18
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• 2020

PURPOSE: This study was to investigate examined the differences in the autonomic nervous functions of elite female judo athletes according to their performance by measuring the heart rate variability (HRV). METHODS: Sixteen elite female judo players participated in this study. The participants were divided into a high performance and low performance group according to the results of their competitions. The HRV (mean heart rate, SDNN, RMSSD, TP, LF, HF, LF/HF ratio) was measured in the resting status. A t-test was used to compare the two groups, and bivariate logistic regression analysis was performed to determine the HRV elements that affect performance. The data were analyzed using IBM SPSS Statistics ver. 24.0 (IBM Co., Armonk, NY, USA). RESULTS: The mean heart rate was higher in the high performance group (72.88) than in the low performance group (64.75) (p=.049). The LF/HF ratio was higher in the high performance group (3.43) than in the low performance group (0.83), and the results were significant (p=.038). No HRV elements having a significant effect on the performance were observed. CONCLUSION: This study showed that the activity of the sympathetic nervous system was dominant in the high performance group in the resting status than in the low performance. The high performance group is believed to be in the overtraining status who experience more stress.

• Journal of Acupuncture Research
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• v.26 no.6
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• pp.111-119
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• 2009

Objectives : To assess the characteristics of electropyography(EMG) and heart rate variability(HRV) values in idiopathic facial palsy inpatients of different Sasang constitutions. Methods : Medical records of 103 idiopathic facial palsy inpatients who underwent facial EMG testing and HRV testing were retrospectively reviewed. All subjects had been consulted to the department of Sasang constitution for constitution differentiation. The Sasang constitutional and age distribution were initially analyzed, and axonal loss percentage values on EMG were correlated with Sasang constitution and sex. HRV results were also correlated with Sasang constitution and sex. Results : 1. 24.4 percent of idiopathic facial palsy inpatients were of the Soyang constitution, 52.4 percent were of the Taeum, and 23.3 percent were of the Soeum. Patients in their fifties were most common in all constitutions(27.8%). 2. Mean axonal loss values for the temporal, zygomatic, and buccal branches were all statistically significantly lower in the Taeum constitution compared with Soyang or Soeum(p<0.05). 3. Mean axonal loss values for the temporal, zygomatic, and buccal branches were all statistically significantly lower in men than women(p<0.05). 4. The mean LF/HF ratio was significantly lower in idiopathic facial palsy inpatients of the Soeum constitution compared with Soyang and Taeum(p<0.05), but there was no statistically significant difference in mean MHRT, SDNN, TP, VLF, LF, and HF of different constitutions. 5. The mean SDNN was significantly lower in women inpatients compared with men(p<0.05), but there was no statistically significant difference in mean MHRT, TP, VLF, LF, HF, and LF/HF ratio. Conclusions : The Sasang constitutional composition of idiopathic facial palsy inpatients closely adheres to the composition proposed in Dong-eui-su-se-bo-won, but the Taeum and Soeum proportion is slightly larger and the Soyang proportion slightly smaller. Axonal loss value on EMG was significantly lower in the Taeum constitution, and in men(p<0.05, <0.05). Mean LF/HF ratio was significantly lower in the Soeum constitution compared with Soyang and Taeum(p<0.05), and mean SDNN was significantly lower in women(p<0.05).

• Journal of Microbiology and Biotechnology
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• v.12 no.5
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• pp.787-792
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• 2002

When developing a combined DTaP-HepB vaccine, toxicity and HBsAg immunogenicity are both important considerations. Thus, for a combined DTaP-HepB vaccine with a low toxicity, the effect of the DTaP content and $Al(OH)_3$, gel concentration on the vaccine toxicity was investigated. Within the range studied, the higher the concentrations, the higher the vaccine toxicity. The importance of the tetanus toxoid content in the combined DTaP-HepB vaccine was also revealed. A higher concentration of the tetanus toxoid was found to have a negative effect on the stability of the HBsAg immunogenicity in the combined vaccine. Accordingly, considering the factors affecting toxicity and HBsAg immunogenicity, a novel DTaP-HepB vaccine (30 Lf/ml of diphtheria toxoid, 5 Lf/ml of tetanus toxoid, 10 $\mu\textrm{g}$ PN/ml of acellular pertussis, 24 $\mu\textrm{g}$/ml of HBsAg, and 500 $\mu\textrm{g}$ Al/ml of $Al(OH)_3$ gel) was developed. It has a low toxicity and a stable HBsAg immunogenicity and also satisfies the potency criteria of K-FDA for a combined DTaP vaccine.

• Korean Journal of Oriental Medicine
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• v.13 no.3
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• pp.97-103
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• 2007

The object of this study is to evaluate confounding effect of sleeping behavior on heart rate variability (HRV) in healthy volunteers during a randomized clinical trial. From 6 healthy volunteer, we acquired circadian electrocardiography(ECG) with a Holter monitoring device(DigiTrak Plus, Philips). The compatible analytical program, Zymed, was used for calculation of RR intervals of 24h ECG signal. Then, we generated HRV signals and calculated 9 HRV parameters in time domain and frequency domain for every 30 minute with Matlab 6.x software. We also encoded participants' activities as follows; stable condition(1), sleeping behavior(2), eating behavior(3), and undefined condition(4). Using SPSS 12.0, we tested if there was any difference between HRV parameters of day-time and night-time and between those of a subject in stable condition and in sleeping behavior. As a result, one of the most important parameter-LF/HF ratio, which indicates the autonomic balance between sympathetic and parasympathetic nervous systems, as same the other parameters, showed large inter-individual variations in circadian profiles. And, the mean LF/HF ratio of each participant was different between in stable condition and in sleeping behavior (p<.05). Consequently, the effect of sleeping behavior must be considered when one or more of HRV parameters, especially LF/HF ratio, are used as assessment index in clinical studies.

• Clinical and Experimental Pediatrics
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• v.46 no.10
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• pp.996-1002
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• 2003

Purpose : In Rett syndrome patients, the incidence of sudden death is greater than that of the general population, and cardiac electrical instability including fatal cardiac arrhythmia is a main suspected cause. In this study, we are going to find out the possible cause of the higher risk of sudden death in Rett patients by the evaluation of heart rate variability, a marker of cardiac autonomic activity and corrected QT intervals. Methods : Diagnosis of Rett syndrome was made by molecular genetic study of Rett syndrome (MECP2 gene) or clinical diagnostic criteria of Rett syndrome. Heart rate variability and corrected QT intervals were measured by 24 h-Holter study in 12 Rett patients, and in 30 age-matched healthy children with chief complaints of chest pain or suspected heart murmurs. The were compared with the normal age-matched control. Results : Patients with total Rett syndrome, classic Rett syndrome, and Rett variants had significantly lower heart rate variability(especially rMSSD)(P<0.05) and longer corrected QT intervals than age-matched healthy children(P<0.05). Sympathovagal balance expressed by the ratio of high to low frequency(LF/HF ratio) also showed statistically significant differences between the three groups considered(P<0.05). Conclusion : A significant reduction of heart rate variability, a marker of autonomic disarray, suggests a possible explanation of cardiac dysfunction in sudden death associated with Rett syndrome.

• Maxillofacial Plastic and Reconstructive Surgery
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• v.42
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• pp.33.1-33.8
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• 2020

Background: We investigated the efficacy of a maxillary Jackson-Pratt (J-P) suction drain for preventing maxillary sinus hematoma and facial swelling after maxillary Le Fort I osteotomy (LF1). Methods: We retrospectively evaluated 66 patients who underwent LF1 at a single institution. Of these, 41 had a J-P suction tube inserted in the mandible and maxilla (maxillary insertion), and 25 had a J-P drain inserted in the mandible only (no maxillary insertion). Facial CT was obtained before and 4 days after surgery. We compared mean midfacial swelling and maxillary sinus haziness by t test and examined correlations between bleeding amount and body mass index (BMI). Results: For the maxillary-insertion group, the ratio of total maxillary sinus volume to haziness (57.5 ± 24.2%) was significantly lower than in the group without maxillary drain insertion (65.5% ± 20.3; P = .043). This latter group, however, did not have a significantly greater midfacial soft tissue volume (7575 mm³) than the maxillary-insertion group (7250 mm³; P = .728). BMI did not correlate significantly with bleeding amount or facial swelling. Conclusions: Suction drainage in the maxilla reduced maxillary sinus haziness after orthognathic surgery but did not significantly reduce midfacial swelling.

• Korean Journal of Medicinal Crop Science
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• v.18 no.4
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• pp.255-265
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• 2010

The extent of growth L. plantarum (LP), L. delbrueckii subsp. bulgaricus (LD), L. fermentum (LF), S. thermophilus (ST), B. longum (BI) and S. cerevisiae (SA) was generally good with the lower concentration of the ginseng extract. Total sapogenin content was slightly different with kinds of a fermentation microorganism and the time of fermentation process, and generally reduced compare to before fermentation. The content of ginsenoside Rb1, Rb2, Rb3, Re and Rf were decreased with the fermentation but ginsenoside Rd was increased by the E, LF and SA fermented extract. The content of compound K increased in the order of not-fermented extrac < enzyme fermented extract < enzyme and microorganism fermented extract, and as the fermented time get longer, the content of compound K was sightly increased. Especially, the content of compound K of the SA fermented extract was the most increased, also it of the BI, LD and LF fermented extract was increased, so these extract were considered a high valuable. Polyphenol content of the BI, LD, LP and ST fermented extract indicated $9.18{\pm}0.39{\sim}15.68{\pm}0.54$ mg/10 g which was lower than it of a not-fermented extract ($11.92{\pm}0.26{\sim}28.41{\pm}0.39$ mg/10 g). Flavonoid content of a ginseng fermented extract indicated $26.93{\pm}0.17{\sim}156.45{\pm}1.29$ mg/10 g, it was higher than a not-fermented extract ($18.06{\pm}0.90$ mg/10 g). As the fermented time get longer, the flavonoid content tendency to increase. DPPH radical scavenging activity of a fermented ginseng extract was $24.11{\pm}1.41{\sim}55.62{\pm}0.33%$, it was slightly lower compared to a natural antioxidant, vitamin C. But it of the LF and ST fermented extract was similar to a natural antioxidant, vitamin C. It has not a concerned in a fermentation. Nitrite scavenging ability of a 24 hr fermented extract was above 80% at pH 2.5 and 4.2, it was similar to an artificial antioxidant, BHT ($84.76{\pm}0.13%$; pH2.5, $84.98{\pm}0.11%$; pH 4.2). It has not a concerned in a fermentation. SOD-like activity of a fermented extract was lower than that of a not-fermented extract ($19.22{\pm}0.51%$), but it of the E and LP-fermented extract was a very highly notable value. As the fermented time get longer, the SOD-like activity tendency to increase.

• Science of Emotion and Sensibility
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• v.20 no.3
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• pp.61-70
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• 2017

Physiological responses have been measured to recognize emotion. Although physiological responses have been interrelated between organs, their connectivities have been less considered for emotion recognizing. The connectivities have been assumed to enhance emotion recognition. Specially, autonomic nervous system is physiologically modulated by the interrelated functioning. Therefore, this study has been tried to analyze connectivities between heart and respiration and to find the significantly connected variables for emotion recognition. The eighteen subjects(10 male, age $24.72{\pm}2.47$) participated in the experiment. The participants were asked to listen to predetermined sound stimuli (arousal, relaxation, negative, positive) for evoking emotion. The bio-signals of heart and respiration were measured according to sound stimuli. HRV (heart rate variability) and BRV (breathing rate variability) spectrum were obtained from spectrum analysis of ECG (electrocardiogram) and RSP (respiration). The synchronization of HRV and BRV spectrum was analyzed according to each emotion. Statistical significance of relationship between them was tested by one-way ANOVA. There were significant relation of synchronization between HRV and BRV spectrum (synchronization of HF: F(3, 68) = 3.605, p = 0.018, ${\eta}^2_p=0.1372$, synchronization of LF: F(3, 68) = 5.075, p = 0.003, ${\eta}^2_p=0.1823$). HF difference of synchronization between ECG and RSP has been able to classify arousal from relaxation (p = 0.008, d = 1.4274) and LF's has negative from positive (p = 0.002, d = 1.7377). Therefore, it was confirmed that the heart and respiration to recognize the dimensional emotion by connectivity.

• Journal of Yeungnam Medical Science
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• v.24 no.2
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• pp.216-231
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• 2007

Background : An acceleration or deceleration of the heart rate (HR), which reflects autonomic effects, is observed before the onset of paroxysmal atrial fibrillation (PAF). The purpose of this study was to assess the discrepancy in the autonomic interactions before the onset of PAF for different patterns of change in the HR. Materials and Methods : From 105 Holter tapes with the PAF recorded, 55 episodes (42 patients, 34 men, $58{\pm}12$ years) of PAF (>5 min), preceded by a sinus rhythm for more than 1 hour, were selected and submitted to time-domain and frequency-domain HR variability analyses. Fifty-five episodes were divided into 2 groups: group A PAF (n=30) with acceleration of the HR during the last 2 minutes before the PAF and group B (n=25) with deceleration of the HR. Results : A significant linear decrease in the mean R-R interval was observed in group A ($924{\pm}30$ to $835{\pm}28ms$, $P$=0.001) and an increase from $831{\pm}32$ to $866{\pm}31ms$ in group B PAF episodes ($P$=0.046). In the frequency-domain analyses, the LF/HF ratio exhibited a progressive linear increase before the PAF in group A ($P$=0.005). The HF normalized units (HFnu) and natural logarithm-transformed HF ($In$HF) values decreased from $30.8{\pm}4.0$ to $16.1{\pm}1.8$ ($P$=0.003) and $4.49{\pm}0.25$ to $4.07{\pm}0.22$ ($P$=0.001), respectively. Contrary to the results in group A, a significant increase in the HF components (HFnu and $In$HF) (from $22.6{\pm}3.2$ to $30.2{\pm}4.0$, $P$=0.005, and $4.27{\pm}0.27$ to 4.75 0.33, $P$=0.001, respectively) and a resultant decrease in the LF/HF ratio were observed in group B PAF episodes. No significant changes were observed in the LF components in either PAF group. Conclusion : Autonomic stimuli leading to an acceleration or deceleration of the HR before the onset of AF are due to parasympathetic modulation. Parasympathetic modulation plays a key role in the initiation of PAF.

• Journal of the korean academy of Pediatric Dentistry
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• v.24 no.3
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• pp.660-677
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• 1997

The purpose of this study was to examine the morphological characteristics and combined effects of fluoride application and laser irradiation on artificial caries-like lesion formation in bovine enamel. Enamel specimens were divided into five experiment group and placed in no-treatment(group C), APF application alone(group F), laser irradiation alone(group L), APF application before laser irradiation (group FL), and APF application after laser irradiation(group LF) on artificial caries-like lesion. Sound enamel was used as a control group. The ultrastructural changes and physical effects of the fluorided and lased enamel has been investigated by using SEM, enamel solubility and microhardness test as well as distributions of calcium, phosphorus and fluoride in internal enamel by using EPMA. The following results were obtained. 1. In the all experiment groups, the amounts of dissolved calcium of enamel surfaces significantly decreased according to increasing exposure time of acid solution than control group(P<0.001). Group L showed higher than that group FL and LF in 30 and 60min(P<0.05). 2. The microhardness values of enamel surface in the control group was highest than that in the other experiment groups. Group F, L, FL and LF were significantly increased than group C(P<0.001). The enamel surface treated with APF produced deposites of numerous small globules and lased enamel showed a cracker-like appearance with microcrack and small pore. Numerous deposits were infiltrated in the fissured portion of enamel treated with APF after laser irradiation. 4. In the case of APF application alone, the elevation of the fluoride profile can be seen within $5{\mu}m$ of the outermost layer and a similar profile observed in the specimen treated with APF before laser irradiation. However, the specimen treated with APF after laser Irradiation showed a large elevation within $10{\mu}m$ of the outermost layer of the enamel. 5. The higher Ca/P ratios were observed in $10{\mu}m$ depth of lased and fluorided enamel when compared to the sound and carious enamel. The fluoride content decreased rapidly with distance from enamel surface, in the group F, fluoride concentration was significantly higher than that in the group C, L, FL, LF and control group according to increasing enamel depth (P<0.05).