• Archives of Pharmacal Research
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• v.13 no.2
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• pp.151-160
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• 1990

In order to develop a controlled-release oral drug delivery system (DDS) which sustains the plasma acetaminophen (AAP) concentration for a certain period of time, microporous membrane-coated tablets were prepared and evaluated in vitro. Firstly, highly water-soluble core tablet of AAP were prepared with various formulations by wet granulation and compression technique. Then the core tablets were coated with polyvinychloride (PVC) in which micronized sucrose particles were dispersed. Effect of formula compositions of core tablets and coating suspensions on the pharmaceutical characteristics such as drug release kinetics and membrane stability of the coated tablets was investigated in vitro. AAP was released from the coated tablets as a zero-order rate in a pH-independent manner. This independency of AAP release to pH change from 1.2 to 7.2 is favorable for the controlled oral drug delivery, since it will produce a constant drug release in the stomach and intestine regardless of the pH change in the GI tract. Drug release could be extended upto 10 h according to the coating condition. The release rate could be controlled by changing the formula compositions of the core tablets and coating suspensions, coat weight per each tablet, and especially PVC/sucrose ratio and particle size of the sucrose in the coating suspension. The coated tablets prepared in this study had a fairly good pharmaceutical characteristics in vitro, however, overall evaluation of the coated tablet should await in vivo absorption study in man.

• Archives of Pharmacal Research
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• v.8 no.1
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• pp.7-14
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• 1985

Membrane-coated tablet of isonicotinic acid hydrazide (INAH) which releases INAH at the zero-order kinetics was deveoped. It consisted of a soluble tablet core surrounded by a porous membrane which controls the diffusion rate. Tablet cores were prepared by compressing granules of INAH and polyvinyl chloride (PVC) dissolved in methyl ethyl ketone in which micronized sucrose were suspended. Diffusion rate of INAH from the tablet through the membrane was constant until the loaded INAH in the core was almost released. The rate was independent of pH of the dissolution medium. Water-soluble sucrose particles behaved as a poreproducing material in the water-insoluble PVC film coat. The pH independency of the rate was probably due to the high solubility of INAH in the water of wide pH range. The diffusion rate of INAH could be controlled by chnaging the composition of the membrane or the coat weight. This membrane-coated INAH tablet seemed to be a powerful candidate for the controlled release drug delivery system (DDS) of INAH or other highly watersoluble drugs.

• Journal of Korean Society of Steel Construction
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• v.24 no.1
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• pp.23-34
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• 2012

In this study, stub columns subjected to concentrical and eccentrical loads were tested to check the applicability of the current local stability criteria (KBC2009, AISC2005) to 800MPa high-strength steel (HSA800). The key test variables in the concentrically loaded tests included the plate-edge restraints and the width-to-thickness ratio normalized by the yield strength of steel. Specimens made of ordinary steel (SM490) were also tested for comparative purposes. Eccentrically loaded stub column tests were conducted for a range of the P-M combinations by controlling the loading eccentricity. All the concentrically loaded specimens with non-compact and slender sections developed sufficient strengths according to the current local stability criteria. All the eccentrically loaded specimens with non-compact H sections also exhibited a sufficient P-M interaction strength that was even higher than that of compact H- section counterparts. Residual stresses were also measured by using the non-destructive indentation method to demonstrate their dependency or independency on the steel material's yield strength. The measured results of this study also indicated that the magnitude of residual stresses bears no strong relation to the yield strength of the steel material.