• 제목/요약/키워드: pH Sensors

검색결과 256건 처리시간 0.03초

Cyclic olefin copolymer (COC) 폴리머 프리즘을 사용한 광섬유 기반 표면 플라즈몬 공명 (SPR) 바이오 센서 (A fiber optic surface plasmon resonance (SPR) sensorusing cyclic olefin copolymer (COC) polymer prism)

  • 윤성식;이수현;안종혁;이종현
    • 센서학회지
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    • 제17권5호
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    • pp.369-374
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    • 2008
  • A novel fiber optic surface plasmon resonance (SPR) sensor using cyclic olefin copolymer (COC) prism with the spectral modulation is presented. The SPR sensor chip is fabricated using the SU-8 photolithography, Ni-electroplating and COC injection molding process. The sidewall of the COC prism is partially deposited with Au/Cr (45/2.nm thickness) by e-beam evaporator, and the thermal bonding process is conducted for micro fluidic channels and optical fibers alignment. The SPR spectrum for a phosphate buffered saline (0.1.M PBS, pH.7.2) solution shows a distinctive dip at 1300.nm wavelength, which shifts toward longer wavelength with respect to the bovine serum albumin (BSA)concentrations. The sensitivity of the wavelength shift is $1.16\;nm{\cdot}{\mu}g^{-1}{\cdot}{\mu}l^{-1}$. From the wavelength of SPR dips, the refractive indices (RI) of the BSA solutions can be theoretically calculated using Kretchmann configuration, and the change rate of the RI was found to be $2.3{\times}10^{-5}RI{\cdot}{\mu}g^{-1}{\cdot}l^{-1}$. The realized fiber optic SPR sensor with a COC prism has clearly shown the feasibility of a new disposable, low cost and miniaturized SPR biosensor for biochemical molecular analyses.

세포 배양액의 연속 공급기 제작을 통한 심근세포의 성숙개선에 관한 연구 (A study on the maturation of cardiomyocytes by continuous supply of culture media)

  • 권우진;김근우;정운선;김종윤;이동원
    • 센서학회지
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    • 제30권2호
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    • pp.109-113
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    • 2021
  • In this study, an automated culture media replacement system was developed to analyze changes in the contraction characteristics of cardiomyocytes according to the state of the culture media. For the long-term storage of culture media, a Peltier refrigerator with a temperature of 5 to 8℃ was provided and a pH of 7.4 was maintained. The cell culture media of the cardiomyocytes was continuously replaced using interlocking pumps at a flow rate of 0.83 μl/h. The cardiomyocytes in which the culture media was replaced automatically demonstrated lower heartbeats per minute compared to samples in which there was no replacement. However, these cardiomyocytes moved more uniformly and produced greater displacement in one heartbeat cycle. It was observed that the sarcomere length of the cardiomyocytes increased due to the automated culture media replacement system. These cardiomyocytes were found to demonstrate better maturation compared to the control group. The maturation of cardiomyocytes was verified through staining images. The proposed automated culture media replacement system generates a uniform heart rate and improvements in contraction force. Based on the study, patient-specific drug toxicity assessments can be conducted using differentiated cardiomyocytes in induced pluripotent stem cells.

EEPROM을 이용한 전하센서 (EEPROM Charge Sensors)

  • 이동규;김해봉;양병도;김영석;이형규
    • 한국전기전자재료학회논문지
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    • 제23권8호
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    • pp.605-610
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    • 2010
  • The devices based on electrically erasable programmable read-only memory (EEPROM) structure are proposed for the detection of external electric charges. A large size charge contact window (CCW) extended from the floating gate is employed to immobilize external charges, and a control gate with stacked metal-insulator-metal (MIM) capacitor is adapted for a standard single polysilicon CMOS process. When positive voltage is applied to the capacitor of CCW of an n-channel EEPROM, the drain current increases due to the negative shift of its threshold voltage. Also when a pre-charged external capacitor is directly connected to the floating gate metal of CCW, the positive charges of the external capacitor make the drain current increase for n-channel, whereas the negative charges cause it to decrease. For an p-channel, however, the opposite behaviors are observed by the external voltage and charges. With the attachment of external charges to the CCW of EEPROM inverter, the characteristic inverter voltage behavior shifts from the reference curve dependent on external charge polarity. Therefore, we have demonstrated that the EEPROM inverter is capable of detecting external immobilized charges on the floating gate. and these devices are applicable to sensing the pH's or biomolecular reactions.

광반사를 이용한 한국 논 토양 특성 추정 (Estimation of Korean Paddy Field Soil Properties Using Optical Reflectance)

  • 정선옥;정기열
    • Journal of Biosystems Engineering
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    • 제36권1호
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    • pp.33-39
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    • 2011
  • An optical sensing approach based on diffuse reflectance has shown potential for rapid and reliable on-site estimation of soil properties. Important sensing ranges and the resulting regression models useful for soil property estimation have been reported. In this study, a similar approach was applied to investigate the potential of reflectance sensing in estimating soil properties for Korean paddy fields. Soil cores up to a 65-cm depth were collected from 42 paddy fields representing 14 distinct soil series that account for 74% of the total Korean paddy field area. These were analyzed in the laboratory for several important physical and chemical properties. Using air-dried, sieved soil samples, reflectance data were obtained from 350 to 2500 nm on a 3 nm sampling interval with a laboratory spectrometer. Calibrations were developed using partial least squares (PLS) regression, and wavelength bands important for estimating the measured soil properties were identified. PLS regression provided good estimations of Mg ($R^2$ = 0.80), Ca ($R^2$ = 0.77), and total C ($R^2$ = 0.92); fair estimations of pH, EC, $P_2O_5$, K, Na, sand, silt, and clay ($R^2$ = 0.59 to 0.72); and poor estimation of total N. Many wavelengths selected for estimation of the soil properties were identical or similar for multiple soil properties. More important wavelengths were selected in the visible-short NIR range (350-1000 nm) and the long NIR range (1800-2500 nm) than in the intermediate NIR range (1000-1800 nm). These results will be useful for design and application of in-situ close range sensors for paddy field soil properties.

당량점 예측 알고리듬에 의한 가성소다 처리 섬유감량 시스템용 자동적정 장치 설계 (Design of an Automatic Titration System for Caustic Soda Treatment System Using the Equivalent Point Estimation Algorithm)

  • 조진호;진경찬;유병희;구성모;김명남;이종현;이홍락
    • 센서학회지
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    • 제3권3호
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    • pp.28-35
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    • 1994
  • 폴리에스 섬유의 감량을 위한 가성소다 처리 시스템에서 감량정도를 알기 위해서는 가성소다의 농도 측정 장치가 필요하다. 감량공정에서는 여러번의 농도측정이 요구되므로 단위농도 측정 공정은 빠르고 정확하게 이루어져야 하며, 이에 따른 당량점 검출 알고리듬이 제시되어야 한다. 본 논문에서는 매 적정액 주입 후 측정되는 각 pH값들로써 적정곡선을 추정하였고, 정확한 당량점을 예측하기 위해서 카디날 스프라인 알고리듬을 사용하였다. 처리시간이 경과되는 동안의 여러 당량점들을 이용하여 섬유의 감량 직선을 자동적으로 추정하고 그래프로 나타낼 수 있게 하였으며 섬유감량 시스템의 감량종료 신호를 발생시킬 수 있는 자동적정 장치의 하드웨어와 소프트웨어를 설계하였다.

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0.85NaNbO3-0.15LiNbO3 세라믹스의 구조 및 전기적 특성 (Structure and Electrical Properties of 0.85NaNbO3-0.15LiNbO3 Ceramics)

  • 전창준;정영훈;윤지선;남중희;백종후;조정호
    • 센서학회지
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    • 제23권2호
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    • pp.105-109
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    • 2014
  • Structure and electrical properties of $0.85NaNbO_3-0.15LiNbO_3$ ($(Li_{0.15}Na_{0.85})NbO_3$) ceramics were investigated as a function of sintering temperature. $(Li_{0.15}Na_{0.85})NbO_3$ ceramics were prepared by conventional solid state processing. A main phase of the orthorhombic perovskite structure and secondary phase of $LiNbO_3$ were confirmed for all sintered specimens. Dense $(Li_{0.15}Na_{0.85})NbO_3$ ceramics were obtained at sintering temperature above $1050^{\circ}C$. With increasing sintering temperature, the electromechanical coupling factor ($k_p$), piezoelectric constant ($d_{33}$) and relative dielectric constant (${\varepsilon}_r$) of the sintered specimens increased, while the mechanical quality factor ($Q_m$) decreased. These results are due to the increase of grain size and crystallite size of orthorhombic perovskite structure. Based on the temperature dependence of ${\varepsilon}_r$, stable piezoelectric properties were expected because no phase transition found up to $300^{\circ}C$. Typically, kp of 18%, $d_{33}$ of 34.7 pC/N, ${\varepsilon}_r$ of 135, and $Q_m$ of 62.8 were obtained for the specimens sintered at $1200^{\circ}C$ for 5 h.

Statistical analysis and probabilistic modeling of WIM monitoring data of an instrumented arch bridge

  • Ye, X.W.;Su, Y.H.;Xi, P.S.;Chen, B.;Han, J.P.
    • Smart Structures and Systems
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    • 제17권6호
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    • pp.1087-1105
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    • 2016
  • Traffic load and volume is one of the most important physical quantities for bridge safety evaluation and maintenance strategies formulation. This paper aims to conduct the statistical analysis of traffic volume information and the multimodal modeling of gross vehicle weight (GVW) based on the monitoring data obtained from the weigh-in-motion (WIM) system instrumented on the arch Jiubao Bridge located in Hangzhou, China. A genetic algorithm (GA)-based mixture parameter estimation approach is developed for derivation of the unknown mixture parameters in mixed distribution models. The statistical analysis of one-year WIM data is firstly performed according to the vehicle type, single axle weight, and GVW. The probability density function (PDF) and cumulative distribution function (CDF) of the GVW data of selected vehicle types are then formulated by use of three kinds of finite mixed distributions (normal, lognormal and Weibull). The mixture parameters are determined by use of the proposed GA-based method. The results indicate that the stochastic properties of the GVW data acquired from the field-instrumented WIM sensors are effectively characterized by the method of finite mixture distributions in conjunction with the proposed GA-based mixture parameter identification algorithm. Moreover, it is revealed that the Weibull mixture distribution is relatively superior in modeling of the WIM data on the basis of the calculated Akaike's information criterion (AIC) values.

졸-침투와 감광성 직접-패턴 기술을 이용하여 스크린인쇄된 Pb(Zr,Ti)O3 후막의 하이브리드 제작 (Hybrid Fabrication of Screen-printed Pb(Zr,Ti)O3 Thick Films Using a Sol-infiltration and Photosensitive Direct-patterning Technique)

  • 이진형;김태송;박형호
    • 마이크로전자및패키징학회지
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    • 제22권4호
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    • pp.83-89
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    • 2015
  • 본 논문에서는 졸-침투와 직접-패턴 공정을 이용하여 향상된 압전 후막의 전기적 특성과 우수한 패터닝 특성을 동시에 만족할 수 있는 제작 방법을 제시한다. 저온(< $850^{\circ}C$) 공정 후 후막의 고밀도 및 직접-패턴의 목적을 달성하기 위해서, 감광성 티탄산 지르콘산 연 ($Pb(Zr,Ti)O_3$, PZT) 졸을 스크린인쇄된 PZT 후막 내부로 침투시켰다. 직접-패턴된 PZT막은 포토크롬마스크와 UV 조사에 의해서 일정한 간격으로 인쇄된 후막 위에 성공적으로 형성되었다. 스크린인쇄된 후막은 분말형태의 기공성 구조를 갖고 있어 조사된 UV빛이 산란되기 때문에, 감광성 졸-침투 공정을 할 때 PZT 후막의 특성을 증가시키기 위한 공정의 최적화가 필요하다. 침투된 감광성 PZT 졸의 농도, 조사된 UV 시간 및 용매 현상 시간을 최적화한 결과, 0.35 M의 PZT 농도, 4 분의 UV 조사시간과 15 초의 용매 현상시간으로 졸-침투된 PZT 후막은 $800^{\circ}C$ 소결 온도에서 입자들의 성장에 의해 치밀화 정도가 증가되었다. 또한 PZT후막의 강유전 특성(잔류분극 및 항복 전압)도 향상되었다. 특히 잔류분극값은 스크린인쇄된 후막보다 약 4배정도 증가되었다. 이렇게 제작된 후막은 어레이타입의 압전형 마이크로미터크기의 센서 및 액츄에이터 등에 응용 가능성을 제시할 수 있었다.

휘발성 질소화합물 감응형 색변환 센서를 활용한 연어 신선도 모니터링 (Freshness Monitoring of Raw Salmon Filet Using a Colorimetric Sensor that is Sensitive to Volatile Nitrogen Compounds)

  • 김재만;이현지;현정호;박준식;김용신
    • 센서학회지
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    • 제29권2호
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    • pp.93-99
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    • 2020
  • A colorimetric paper sensor was used to detect volatile nitrogen-containing compounds emitted from spoiled salmon filets to determine their freshness. The sensing mechanism was based on acid-base reactions between acidic pH-indicating dyes and basic volatile ammonia and amines. A sensing layer was simply fabricated by drop-casting a dye solution of bromocresol green (BCG) on a polyvinylidene fluoride substrate, and its color-change response was enhanced by optimizing the amounts of additive chemicals, such as polyethylene glycol, p-toluene sulfonic acid, and graphene oxide in the dye solution. To avoid the adverse effects of water vapor, both faces of the sensing layer were enclosed by using a polyethylene terephthalate film and a gas-permeable microporous polytetrafluoroethylene sheet, respectively. When exposed to basic gas analytes, the paper-like sensor distinctly exhibited a color change from initially yellow, then to green, and finally to blue due to the deprotonation of BCG via the Brønsted acid-base reaction. The use of ammonia analyte as a test gas confirmed that the sensing performance of the optimized sensor was reversible and excellent (detection time of < 15 min, sensitive naked-eye detection at 0.25 ppm, good selectivity to common volatile organic gases, and good stability against thermal stress). Finally, the coloration intensity of the sensor was quantified as a function of the storage time of the salmon filet at 28℃ to evaluate its usefulness in monitoring of the food freshness with the measurement of the total viable count (TVC) of microorganisms in the food. The TVC value increased from 3.2 × 105 to 3.1 × 109 cfu/g in 28 h and then became stable, whereas the sensor response abruptly changed in the first 8 h and slightly increased thereafter. This result suggests that the colorimetric response could be used as an indicator for evaluating the degree of decay of salmon induced by microorganisms.

전류센서가 없는 열전모듈의 최대전력점 추적방식 (Maximum Power Point Tracking operation of Thermoelectric Module without Current Sensor)

  • 김태경;박대수;오성철
    • 한국산학기술학회논문지
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    • 제18권9호
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    • pp.436-443
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    • 2017
  • 최근, 지구온난화 등의 문제로 인해 새로운 에너지 기술의 개발이 화제가 되고 있다. 중규모 이상의 출력을 얻도록 최적화된 태양광 및 태양열, 풍력 발전과 같은 신재생에너지 기술과 다르게 에너지 하베스팅기술은 출력전력이 매우 작아 크게 주목받지 못하고 있다. 하지만 최근 모바일 산업이 활성화 되면서 에너지 하베스팅기술의 활용가치가 재평가 받고 있다. 또한, 최대전력점 추적방식기술 역시 활발히 연구가 이루어지고 있다. 본 논문에서는 일정한 저항부하를 위한 열전모듈의 새로운 최대전력점추적 제어방식을 제안한다. 열전 모듈(이하 TEM: Thermoelectric Module)의 V-I곡선특성과 내부저항을 분석하고. 기존의 MPPT제어방식을 비교하였다. P&O(Perturbation and Observation)제어방식은 전압, 전류를 측정하기위한 센서 2개를 사용해야하기 때문에 CV제어방식보다 경제성이 떨어지지만 보다 정확히 MPP를 찾는다는 장점을 가진다. CV(Constant Voltage)제어방식은 전압센서 1개만 사용하기 때문에 경제적인 측면에서는 P&O제어방식보다 뛰어나지만, MPP가 정확히 못하다는 단점을 가지고 있다. 본 논문에서는 두 제어방식의 장점만을 가지고 TEM의 최대전력점(MPP)을 추적하도록 설계하였다. 제안된 MPPT 제어 방식은 PSIM 프로그램을 이용한 모의실험으로 확인하였으며, 하드웨어제작을 통해 제안된 MPPT제어 방식을 검증하였다.