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Alterations of Blood Cholinesterase Activity and Urinary Para-nitrophenol Excretion After Exposure to Organophosphorus Insecticides (유기인제 농약 폭로로 인한 혈중 Cholinesterase 활성치와 요중 P-nitrophenol의 배설량의 변동)

  • Lee, Byung-Kook;Chung, Kyou-Chull
    • Journal of Preventive Medicine and Public Health
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    • v.7 no.1
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    • pp.115-121
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    • 1974
  • In order to evaluate the health hazard due to exposure to organophosphorus insecticides, we measured the blood cholinesterase activity ana urinary para-nitrophenol among 56 exposed subjects. They are orchard workers, rice plant workers and smithion factory workers. The clinical symptoms were also checked by physicians. We also measured the blood cholinesterase activity and urinary para-nitrophenol excretion of 20 urban people and 15 rural people who had never been exposed to organophosphorus insecticides in order to compare them according to age, sex and geographical differences. And these results were also compared with those of exposed groups. The results obtained were as follows. 1. The normal plasma cholinesterase activity and cell cholinestrase activity were $0.861{\pm}0.148\;{\Delta}pH/hr$ and $0.822{\pm}0.154\;{\Delta}pH/hr$. And normal para-nitrophenol in urine was $1.21{\pm}0.52mg/liter$. 2. No significant difference was existed in blood cholinesterase activities and urinary para-nitrophenol excre tion according to sex, age and geographical difference. 3. The plasma cholinesterase activity and cell cholinesterase activity of orchard workers, rice plant workers and smithion factory workers were $0.682{\pm}0.189\;{\Delta}pH/hr,\;0.775{\pm}0.160\;{\Delta}pH/hr,\;0.754{\pm}0.123\;{\Delta}pH/hr,\;and\;0.691{\pm}0.082\;{\Delta}pH/hr,\;0.756{\pm}0.117\;{\Delta}pH/hr,\;0.739{\pm}0.117\;{\Delta}pH/hr$. And significant decreses in blood cholinesterase activities were existed among orchard workers and smithion factory workers compared with control group. 4, The urinary para-nitrophenol excretions of orchard workers, rice plant workers and smithion factory workers were $1.33{\pm}0.66mg/liter,\;1.19{\pm}0.88mg/liter\;and\;1.37{\pm}0.67mg/liter$ and there were no significant difference between exposed groups and control group. 5. The clinical symptoms complained during and after organophosphorus insecticides exposure were frequently ranked by headache (67.7%) and vertigo (64.5%) and muscular ataxia and weakness (51.6%).

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Studies on Manufacture of Busuge -I. Effect of Steeping Process on Viscosity and Raising Power of Glutinous Rice- (부수게 제조(製造)에 관한 연구 -제 1 보 : 수침공정(水浸工程)이 원료찹쌀의 점도(粘度)와 팽화력(膨化力)에 미치는 영향-)

  • Yang, Hee-Cheon;Hong, Jai-Sic;Kim, Joong-Man
    • Korean Journal of Food Science and Technology
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    • v.14 no.2
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    • pp.141-145
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    • 1982
  • Busuge is conventional snack food in Korea which is made from steeped glutinous rice. The effect of the steeping time on total acidity, viscosity, canons, phosphorus and raising power of glutinous rice was investigated. Total acidity was increased from 0.3 to 1.02% by steeping for 20 days at $10^{\circ}C$. Viscosity was increased from 25.5 to 32.4 cP after 14 days steeping and thereafter decreased to 23.5 cP. K, Na, Ca, Mg and P were leached 68, 67, 85 and 16% on 20 days steeping, respectively. K, Na and P were leached in the initial period, and Ca, Mg in the middle period of steeping. Raising power was increased according to the acidity increase and leaching of Ca, Mg and inorganic phosphorus during steeping. However, influence of the former on raising power was greater than the after.

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Fatty Acid Composition of Domestic and Foreign Margarine for Home Use (국내 및 국외 가정용 마아가린의 지방산(脂肪酸) 조성(組成)에 대한 연구(硏究))

  • Choi, Chun-Un;Kim, Hyean-Wee
    • Korean Journal of Food Science and Technology
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    • v.18 no.4
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    • pp.301-305
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    • 1986
  • Fatty acid composition of domestic margarines (summer 12, winter 12 kinds) and foreign margarines (U.S.A. 4, Japan 8, Denmark 2 kinds) for home use were determined. The major fatty acids were palmitic acid (16:0), stearic acid (18:0), oleic acid (18:1), linoleic acid (18:2) and linolenic acid (18:3) in all of the margarines. P/S ratios of winter products were $0.40{\sim}l.74$, those of summer products were $0.21{\sim}l.82$ in domestic margarines. Therefore degree of polyunsaturate in winter product was higher than that in summer product. P/S ratios of foreign margarines were $0.82{\sim}2.91$ irrespective of type.P/Sratios of stick and soft type in foreign margarines were similar as $0.82{\sim}2.59,\;0.90{\sim}2.67$, respectively Those of PUFA (polyunsaturated fatty acid) type and LFS (low fat spread) were 2.91, 2.70, respectively.

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Relationship between Satisfaction with Foodservice and Customer Loyalty of University Students in Busan (부산지역 대학교 급식소의 급식서비스 만족도와 고객충성도와의 관계)

  • Lee, Kyung-A;Lyu, Eun-Soon
    • Korean journal of food and cookery science
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    • v.26 no.4
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    • pp.413-421
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    • 2010
  • The purpose of this study was to improve the satisfaction of college foodservice customers by analyzing the correlation between college student satisfaction with foodservice and customer loyalty. The questionnaire was distributed to 480 customers at six universities in Busan. The average customer satisfaction score was 2.76, and customer satisfaction was highest with food, followed by sanitation, environment, and service (in decreasing order). Customers reported the frequency with which they were satisfied when using university foodservice operations (on an increasing scale from "almost never" to "more than five times") in four areas: food (p<0.001), service (p<0.01), sanitation (p<0.05), and environment (p<0.001). The average scores of customer loyalty, intent to purchase again, intent to advertise by word-of-mouth, and intent to switch were 2.67, 2.83, 2.52, and 2.67, respectively, and these scores demonstrated differences according to frequency of foodservice use (p<0.001). Food, service, sanitation, and environment correlated significantly (+) with customer loyalty. Intent to repeat purchase showed the highest correlation with food quality (p<0.05), and intent to advertise by word-of-mouth and to continue patronizing foodservice demonstrated the highest correlations with service (p<0.01). After classifying customers into four groups according to customer satisfaction and loyalty, a comparison was done to determine satisfaction and loyalty by each customer strata. In the "loyalist" group, satisfaction with environment and the intent to advertise by repurchase were significantly higher than in the other groups (p<0.001). In "defectors" group, satisfaction with service and the intent to advertise by word-of-mouth were significantly lower than in the other groups (p<0.001).

Characteristic of Flotation for Recovery of Copper from Copper Slag in Kazakhstan (카자흐스탄 구리제련소 슬래그 내 구리회수를 위한 선별 특성)

  • Park, Jayhyun;Choi, Uikyu;Choe, Hongil;Shin, Shunghan
    • Resources Recycling
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    • v.24 no.4
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    • pp.12-21
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    • 2015
  • Almost all copper slags contain a considerable amount of Cu (0.5 - 3.7%) close to or even higher than copper ores. A number of methods for metal recovery from copper slag were reported These methods can be classified into three categories, flotation, leaching and roasting. Sulfide flotation method for the recovery of copper from Kazahstan copper furnace slag is discussed in this investigation. 50% of copper from the slag was recovered by sulfide flotation at pH 4. meanwhile 67% of copper from the slag was recovered at pH 11. Higher copper recovery result at pH 11 rather than that at pH 4 was caused by the fact that copper sulfides were floated in particle size fraction over $100{\mu}m$ in concentrates at pH 11. When the slag were ground below $74{\mu}m$by ball milling, the recovery of copper by floation in slag improved to 78 - 83% because of copper liberation effect.

Scutellaria baicalensis Inhibits Coxsackievirus B3-Induced Myocarditis Via AKT and p38 Pathways

  • Fu, Qiang;Gao, Lu;Fu, Xiao;Meng, Qinghua;Lu, Zhihong
    • Journal of Microbiology and Biotechnology
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    • v.29 no.8
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    • pp.1230-1239
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    • 2019
  • Scutellaria baicalensis Georgi has been widely used in China for treatment of various diseases. This study investigated the effect of Scutellaria baicalensis Georgi extracts (SBE) against Coxsackievirus B3 (CVB3)-induced myocarditis in vitro and in vivo. In vitro, Hela cells and primary myocardial cells were infected with CVB3 and treated with SBE ($50-800{\mu}g/ml$) and ribavirin ($200{\mu}M$) for 48 h and then determined by CCK8 assay. Real-time PCR and western blotting assays were performed. In vivo, a myocarditis model was induced in male BALB/c mice by injecting CVB3 suspension intraperitoneally for three times, followed by treatment with SBE (400 and 200 mg/kg) and ribavirin (100 mg/kg) for 28 days. SBE ameliorated the cytotoxicity of CVB3 in Hela cells, especially at $400{\mu}g/ml$ (39.93% vs 65.67%, p < 0.05) without influencing cell growth and also significantly reduced CVB3 replication in primary myocardial cells. The levels of AKT, ERK, and p38 were increased after CVB3 infection. SBE could downregulate the expressions of AKT and p38. In vivo, the mortality rate from CVB3 reached to 66.67%, while 10.00% and 23.33% of this came after 400 and 200 mg/kg SBE treatment, respectively (p < 0.05). The CVB3 replication was obviously reduced after SBE administration from day 5. Similarly, the levels of AKT, ERK, and p38 mRNAs and proteins were increased, and SBE suppressed the expression of AKT and p38. Our study indicates that SBE is a promising potent antiviral agent against CVB3-induced myocarditis by inhibition of virus replication via depressing AKT and p38 expressions.

Immunohistochemical Characteristics of Primary and Recurrent Pleomorphic Adenoma (원발성 다형선종과 재발성 다형선종의 면역조직화학적 특성)

  • Suh Myung-Whan;Hah J.Hun;Lee Kyung-Bun;Jung Young-Ho;Kwon Seong-Keun;Kim Kwang-Hyun;Sung Myung-Whun
    • Korean Journal of Head & Neck Oncology
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    • v.21 no.2
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    • pp.146-150
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    • 2005
  • Background and Objectives: When the pleomorphic adenoma(PA) recures, the tumor tends to become a multinodular mass that infiltrates into the normal tissue which is not a common condition for a benign tumor. This manifestation is probably due to the difference in cell biology of the recurrent tumor compared to that of the primary PA. The aim of this study is to assay the immunhistochemical characteristics of the recurrent PA compared to the primary PA and to evaluate whether this property can be used for developing a method that can select the patients who have higher risk to recur. Materials and Methods: Thirteen patients were enrolled in the primary PA group and 15 patients who had a recurrent PA were enrolled in the recurrent PA group. To evaluate the cell biology of the tumor, immunohistochemical stainings of Ki-67, bcl-2 and p53 were performed. Results: There was no difference in the expression of Ki-67 (p=0.117, p=.208) and p53 (p=.430, p=.328). The extent stained by bcl-2 was significantly larger in the recurrent PA group (p=.033, p=.014). The expression of bcl-2 did not increase while time passed. Conclusion: The high expression of bcl-2 seems to be a property of the recurrent PA group which can be found even during first operation before recurrence. By this immunhistochemical characteristic, we would be able to sort out the patients who have higher risk to recur.

Impact of Collateral Circulation on Futile Endovascular Thrombectomy in Acute Anterior Circulation Ischemic Stroke

  • Yoo Sung Jeon;Hyun Jeong Kim;Hong Gee Roh;Taek-Jun Lee;Jeong Jin Park;Sang Bong Lee;Hyung Jin Lee;Jin Tae Kwak;Ji Sung Lee;Hee Jong Ki
    • Journal of Korean Neurosurgical Society
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    • v.67 no.1
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    • pp.31-41
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    • 2024
  • Objective : Collateral circulation is associated with the differential treatment effect of endovascular thrombectomy (EVT) in acute ischemic stroke. We aimed to verify the ability of the collateral map to predict futile EVT in patients with acute anterior circulation ischemic stroke. Methods : This secondary analysis of a prospective observational study included data from participants underwent EVT for acute ischemic stroke due to occlusion of the internal carotid artery and/or the middle cerebral artery within 8 hours of symptom onset. Multiple logistic regression analyses were conducted to identify independent predictors of futile recanalization (modified Rankin scale score at 90 days of 4-6 despite of successful reperfusion). Results : In a total of 214 participants, older age (odds ratio [OR], 2.40; 95% confidence interval [CI], 1.56 to 3.67; p<0.001), higher baseline National Institutes of Health Stroke Scale (NIHSS) scores (OR, 1.12; 95% CI, 1.04 to 1.21; p=0.004), very poor collateral perfusion grade (OR, 35.09; 95% CI, 3.50 to 351.33; p=0.002), longer door-to-puncture time (OR, 1.08; 95% CI, 1.02 to 1.14; p=0.009), and failed reperfusion (OR, 3.73; 95% CI, 1.30 to 10.76; p=0.015) were associated with unfavorable functional outcomes. In 184 participants who achieved successful reperfusion, older age (OR, 2.30; 95% CI, 1.44 to 3.67; p<0.001), higher baseline NIHSS scores (OR, 1.12; 95% CI, 1.03 to 1.22; p=0.006), very poor collateral perfusion grade (OR, 4.96; 95% CI, 1.42 to 17.37; p=0.012), and longer door-to-reperfusion time (OR, 1.09; 95% CI, 1.03 to 1.15; p=0.003) were associated with unfavorable functional outcomes. Conclusion : The assessment of collateral perfusion status using the collateral map can predict futile EVT, which may help select ineligible patients for EVT, thereby potentially reducing the rate of futile EVT.

A study on dye wastewater treatment using the electrolysis (전기분해에 의한 염색폐수 처리공정에 관한 연구)

  • 김성국;박상원;홍대일
    • Journal of Environmental Science International
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    • v.8 no.4
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    • pp.539-545
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    • 1999
  • Dye wastewater was treated by using an electrochemical oxidation process. Various combinations of electrodes such as carbon, Al and Fe were investigated. In this study, electrode material, electrolyte concentration, electrode distance, current density, and pH value were found to have significant effect on both pollutant removal efficiency and current efficiency in electrochemical oxidation process. After electrolysis for 40min with carbon/Al, it was observed that COD, $T-N, NH_{4}^{+}-N$ and color of treated wastwater were reduced from 580mg/$\ell$ to 145mg/$\ell$, 67.2mg/$\ell$ to 26.8mg/$\ell$, 46.8mg/$\ell$ to 1.4mg/$\ell$, and 4200 Pt-Co units to 336 Pt-Co units, respectively. The optimal conditions of the electrooxidation process to treat the wastewater for this study were found to be such : current density ; 16.67mA/$cm^2$, electrode distance ; 2.5cm, pH value ; 5.0 and carbon/Al electrode.

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