• 대한의생명과학회지
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• 제14권3호
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• pp.157-165
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• 2008

Recently, the number of patients with prostate cancer has been increased gradually by both the change of living environment and the increase of aged population. In this study the serum prostate specific antigen (PSA) level was compared to the Gleason score known as a prognostic factor for the prostate cancer. In the Gleason score 6 and $9{\sim}10$, the average age was 69.68 years old and 69.52 years old, respectively and there was no statistically difference in both of age and Gleason score. the PSA serum consistency appeared <4 ng/mL as example 1, $4{\sim}20ng/mL$ as example 17 and ${\geq}20ng/mL$ as example 4 in the Gleason score 6, and In the Gleason score $9{\sim}10$, it appeared <4 ng/mL as example 1, $4{\sim}20ng/mL$ as example 6 and ${\geq}20ng/mL$ as example 15. PSA serum consistency in the Gleason score $9{\sim}10$ showed higher value than those of Gleason score 6 (P<0.05). Next, expression ratios of bcl-2, Ki-67 and p53 were examined in the Gleason score 6 and $9{\sim}10$. the p53 expression ratio, a tumor suppression gene, appeared the significance statistically by the classification of the Gleason score as example 7 (28%) in the Gleason score 6 and as example 16 (64%) in the Gleason score $9{\sim}10$ (P<0.05). but not different in the expression ratios of the Ki-67 and bcl-2. The expression ratio of p53 by the expression ratio of bcl-2 and the expression ratio of Ki-67 by the expression ratio of p53 had a positive relationship in all of the Gleason score 6 and the Gleason score $9{\sim}10$ (P<0.05). However, the expression ratio of Ki-67 by the expression ratio of bcl-2 did not show any significance in the Gleason score $9{\sim}10$ (P<0.05). Therefore, the results suggested that p53 expression could be used as an independent prognostic factor.

• Asian Pacific Journal of Cancer Prevention
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• 제15권10호
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• pp.4175-4179
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• 2014

Aims: To delineate the histopathological pattern of prostate diseases and to highlight age variations in prostate specific antigen (PSA) values and histopathological features. Materials and Methods: A retrospective review was made of all prostate biopsy reports seen between January 2006 and December 2013 at the King Fahad Hospital, Madinah, Saudi Arabia. Prostate lesions were tabulated and classified into benign and malignant groups. Histological scoring of adenocarcinomas was accomplished using the Gleason system. PSA values were correlated with Gleason scores. Results: Of 417 prostate lesions reviewed, 343 (82.3%) were benign and 74 (17.7%) were malignant, giving a benign to malignant ratio of 4.6:1. Benign prostatic hyperplasia (both with and without inflammation) was the commonest prostatic lesion and accounted for 80.3% of all cases and 97.6% of all benign cases. The age range was 20 to 97 years with a mean of 69.2 years and a peak age group at 70-79 years. Seventy one cases of adenocarcinoma accounted for 95.9% of the total of 74 malignant tumors. It showed an age range of 44 to 95 years, a mean age of 70.9 years and peak prevalence in the 80-89 year age group. Gleason score seven was the most frequent (39.4%) in occurrence. Most adenocarcinomas, 41 cases (57.7%), were moderately differentiated (Gleason score of 5-7). PSA values ranged widely between 16-1,865ng/ml with a mean of 363.4ng/ml. Elevated PSA (>100ng/ml) levels were found in 53 (81.6%) patients. There was a statistically significant positive correlation between serum PSA level and Gleason score (p=0.0304). Conclusions: Prostatic lesions constitute a significant source of morbidity among adult males in Madinah. Benign prostatic hyperplasia was the commonest benign prostatic lesion and adenocarcinoma was the commonest histological subtype of prostatic cancer.

• 대한영상의학회지
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• 제83권5호
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• pp.1059-1070
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• 2022

목적 계산형 확산강조영상 b2000과 실제 획득한 확산강조영상 b2000 사이에 전립선암 발견을 위한 민감도 및 관찰자 간 일치도를 비교하였다. 대상과 방법 근치적 전립선 절제술 및 확산강조영상(b, 0, 100, 1000, 2000 s/mm²)을 포함한 수술 전 3 Tesla 자기공명영상을 통해 전립선암으로 진단받은 총 88명의 환자가 연구에 포함되었다. 계산형 확산강조영상 b2000은 실제 획득한 확산강조영상 b0, 100, 1000으로부터 단일 지수 감쇠 모델에 의해 계산되었다. 두 명의 독립된 검토자가 4주 간격으로 무작위 순서로 두 영상 세트를 검토하여, 가장 큰 종양에 대해 관심 영역을 그렸고, Prostate Imaging-Reporting and Data System 2.1에 기반한 점수를 기록하였다. 전층 절편 조직 검사가 참고 기준으로 제공되었다. 결과 연구에 포함된 환자의 글리슨 점수는 6 (n = 16), 7 (n = 53), 8 (n = 9), 9 (n = 10)로 구성되었다. 두 명의 검토자 모두 계산형 확산강조영상 b2000과 실제 획득한 확산강조영상 b2000 간 전립선암 발견에 대한 민감도 차이는 없었다(검토자 1, 모두 94% [83/88]; 검토자 2, 모두 90% [79/88], 모두 p = 1.000). 관찰자 간 PI-RADS 점수에 대한 일치도는 계산형 확산강조영상에서 0.422 (95% 신뢰구간, 0.240-0.603), 실제 획득한 확산강조영상에서 0.495 (95% 신뢰구간, 0.308-0.683)였다. 결론 계산형 확산강조영상 b2000과 실제 획득한 확산강조영상 b2000은 전립선암 발견 민감도에 차이가 없고, 관찰자 간 일치도는 유지되었다.