• 핵의학기술
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• 제27권1호
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• pp.47-54
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• 2023

Purpose PET-CT imaging require an appropriate quality assurance system to achieve high efficiency and reliability. Quality control is essential for improving the quality of care and patient safety. Currently, there are performance evaluation methods of UN2-1994 and UN2-2001 proposed by NEMA and IEC for PET-CT image evaluation. In this study, we compare phantom images with the same experiments before and after PET-CT 3D normalization and well counter correction and evaluate the usefulness of quality control. Materials and methods Discovery 690 (General Electric Healthcare, USA) PET-CT equiptment was used to perform 3D normalization and well counter correction as recommended by GE Healthcare. Based on the recovery coefficients for the six spheres of the NEMA IEC Body Phantom recommended by the EARL. 20kBq/㎖ of ¹⁸F was injected into the sphere of the phantom and 2kBq/㎖ of ¹⁸F was injected into the body of phantom. PET-CT scan was performed with a radioacitivity ratio of 10:1. Images were reconstructed by appliying TOF+PSF+TOF, OSEM+PSF, OSEM and Gaussian filter 4.0, 4.5, 5.0, 5.5, 6.0, 6,5 mm with matrix size 128×128, slice thickness 3.75 mm, iteration 2, subset 16 conditions. The PET image was attenuation corrected using the CT images and analyzed using software program AW 4.7 (General Electric Healthcare, USA). The ROI was set to fit 6 spheres in the CT image, RC (Recovery Coefficient) was measured after fusion of PET and CT. Statistical analysis was performed wilcoxon signed rank test using R. Results Overall, after the quality control items were performed, the recovery coefficient of the phantom image increased and measured. Recovery coefficient according to the image reconstruction increased in the order TOF+PSF, TOF, OSEM+PSF, before and after quality control, RCmax increased by OSEM 0.13, OSEM+PSF 0.16, TOF 0.16, TOF+PSF 0.15 and RCmean increased by OSEM 0.09, OSEM+PSF 0.09, TOF 0.106, TOF+PSF 0.10. Both groups showed a statistically significant difference in Wilcoxon signed rank test results (P value<0.001). Conclusion PET-CT system require quality assurance to achieve high efficiency and reliability. Standardized intervals and procedures should be followed for quality control. We hope that this study will be a good opportunity to think about the importance of quality control in PET-CT

• 한국자연치유학회지
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• 제8권2호
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• pp.53-62
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• 2019

목적: 만성질환인 요통, 오십견, 무릎관절염 환자 남녀 21명을 대상으로 수정기공을 주사해서 치유효과를 연구하는 것이 목적이었다. 방법: 대상자에게 수정기공 에너지를 손으로 주사해서 치유 연구를 하였다. 결과: 대상자는 요통환자는 10명 (47.6%), 오십견은 8명(38%), 무릎 관절염은 3명(14.3%)의 비율이었다. 기공치유 5회 후의 만족도는 정상으로 회복한 대상자가 72%, 호전된 대상자는 14%로 전체적으로 86%의 만족도를 나타내었다. 최대통증의 기준치를 5.0로 하였을 때에, 치유 전과 후의 차이는 관절염의 대상자는 3.33, 오십견 대상자는 3.75 그리고 요통의 경우도 3.80으로 높게 나타나서 모두 유의한 차이를 보이었다(p<.001). 전체적으로 치유 횟수의 증가에 따라서 통증정도가 현저히 감소하였다. 특히 첫 1회 치유를 한 후에도 대상자가 느끼는 통증의 감소는 관절염, 오십견, 요통에서 모두 높게 나왔다. 즉, 단 한 번의 치유만으로도 통증의 조절 가능성이 있었다. 결론: 상기 수정기공요법으로 관절염, 오십견, 그리고 요통 환자가 거의 정상 상태로 회복이 되었다. 그런고로 기공요법이 유용한 자연치유 요법중의 하나라고 평가한다.

• Animal Bioscience
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• 제36권10호
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• pp.1612-1618
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• 2023

Objective: In our previous study, we observed that the addition of waste cooking oil (WCO) reduced ammonia (NH₃) emissions during laboratory-scale composting of dairy cattle manure under low-aeration condition. Therefore, this study aimed to evaluate the effect of addition of WCO on NH₃ emissions reduction during pilot-scale composting of dairy cattle manure, which is close to the conditions of practical composting treatment. Methods: Composting tests were conducted using pilot-scale composting facilities (1.8 m³ of capacity). The composting mixtures were prepared from manure, sawdust, and WCO. Two treatments were set: without WCO (Control) and with WCO added to 3 wt% of manure (WCO3). Composting was conducted under continuous aeration at 40 L/min, corresponding to 22.2 L/(min·m³) of the mixture at the start of composting. The changes in temperatures, NH₃ concentrations in the exhaust gases, and contents of the composted mixtures were analyzed. Based on these analysis results, the effect of WCO addition on NH₃ emissions and nitrogen loss during composting was evaluated. Results: During composting, the temperature increase of the composting mixture became higher, and the decreases of weight and water content of the mixture became larger in WCO3 than in Control. In the decrease of weight, and the residual weight and water content of the mixture, significant differences (p<0.05) were detected between the two treatments at the end of composting. The NH₃ concentrations in the exhaust gases tended to be lower in WCO3 than in Control. Nitrogen loss was 21.5% lower in WCO3 than in Control. Conclusion: Reduction of NH₃ emissions by the addition of WCO under low aeration condition was observed in pilot-scale composting, as well as in laboratory-scale composting. This result suggests that this method is effective in reducing NH₃ emissions in practical-scale composting.

• 한국작물학회:학술대회논문집
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• 한국작물학회 2022년도 추계학술대회
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• pp.321-321
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• 2022

Wheat was brought to solve food scarcity with aid from the United States caused by the Korean War. The Korean government launched a campaign to encourage mixed rice and wheat meals due to shortage of rice production in the 1960s, Wheat consumption began in earnest. However, it is difficult to rebuild the domestic wheat production base devastated by the Korean War with the technology at the time. Thus, wheat was mainly consumed from imported in the past. Since then, as wheat consumption has increased due to westernization and diversification of dietary life, wheat became the second staple grain in Korea. In this situation, the government enacted the Wheat Industry Promotion Act to create a basis for sustainable production and consumption of wheat in Korea. This study sought to improve the self-sufficiency of domestic wheat by examining the possibility of using "Ariheuk", a variety of new Korean wheat, as a rice supplement in the same context as the govemment's policy. Wheat has been used as a raw material for the processed food, such as noodles and bread. However, we approached it by using whole wheat as a nutritional grain. Participants were recruited from the agri-food consumer panel conducted by Rural Development Administration. We set a final sample of 525 consumer panels based on the age of census household heads. The experiment was conducted in such a way that participants cooked and ate 100% rice meal and rice containing 20% whole wheat meal. Participants completed the sensory evaluation questionnaire with online. For this experiment, all participants were given same whole wheat product. The sensory evaluation questionnaire consisted of color, glossiness, stickiness, aroma, chewing, sweetness, nuttiness, chewiness, softness, bursting, flavor, texture and swallowability. The sensory evaluation results were analyzed by giving -3 points to +3 points. The former points were given to the response that 100% rice meal is very superior to the response that rice containing 20% whole wheat meal. The latter points were given vice versa. Zero point was given to the response that they are similar each other. As a result, rice with 20% whole wheat meal was better than 100% rice meal in terms of color, aroma, chewiness, bursting and flavor. In case of sweetness and glossiness, there didn't exist significantly different. On the other hands, 100% rice meal was better in terms of softness and swallowability. As a result of ANOVA by age groups, from 30s or younger to 60s or more, there was significant difference among the groups in terms of color, chewiness and bursting. As a result of post-hoc analysis with Duncan's multiple range test (p < 0.05), 50s were evaluated to be significantly superior in color, chewiness and bursting compared to other age groups. In conclusion, it is appropriate to use whole wheat as a supplement to rice in order to improve the self-sufficiency of domestic wheat. As a strategy to promote domestic wheat consumption, in case of Ariheuk, it is necessary to provide an experience through whole wheat tasting and to establish a marketing strategy segmented by age groups.

• Korean Journal of Radiology
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• 제24권4호
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• pp.294-304
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• 2023

Objective: We aimed to investigate whether image standardization using deep learning-based computed tomography (CT) image conversion would improve the performance of deep learning-based automated hepatic segmentation across various reconstruction methods. Materials and Methods: We collected contrast-enhanced dual-energy CT of the abdomen that was obtained using various reconstruction methods, including filtered back projection, iterative reconstruction, optimum contrast, and monoenergetic images with 40, 60, and 80 keV. A deep learning based image conversion algorithm was developed to standardize the CT images using 142 CT examinations (128 for training and 14 for tuning). A separate set of 43 CT examinations from 42 patients (mean age, 10.1 years) was used as the test data. A commercial software program (MEDIP PRO v2.0.0.0, MEDICALIP Co. Ltd.) based on 2D U-NET was used to create liver segmentation masks with liver volume. The original 80 keV images were used as the ground truth. We used the paired t-test to compare the segmentation performance in the Dice similarity coefficient (DSC) and difference ratio of the liver volume relative to the ground truth volume before and after image standardization. The concordance correlation coefficient (CCC) was used to assess the agreement between the segmented liver volume and ground-truth volume. Results: The original CT images showed variable and poor segmentation performances. The standardized images achieved significantly higher DSCs for liver segmentation than the original images (DSC [original, 5.40%-91.27%] vs. [standardized, 93.16%-96.74%], all P < 0.001). The difference ratio of liver volume also decreased significantly after image conversion (original, 9.84%-91.37% vs. standardized, 1.99%-4.41%). In all protocols, CCCs improved after image conversion (original, -0.006-0.964 vs. standardized, 0.990-0.998). Conclusion: Deep learning-based CT image standardization can improve the performance of automated hepatic segmentation using CT images reconstructed using various methods. Deep learning-based CT image conversion may have the potential to improve the generalizability of the segmentation network.

• Korean Journal of Radiology
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• 제24권3호
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• pp.190-203
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• 2023

Objective: We aimed to assess and validate the radiologic and clinical factors that were associated with recurrence and survival after curative surgery for heterogeneous targetoid primary liver malignancies in patients with chronic liver disease and to develop scoring systems for risk stratification. Materials and Methods: This multicenter retrospective study included 197 consecutive patients with chronic liver disease who had a single targetoid primary liver malignancy (142 hepatocellular carcinomas, 37 cholangiocarcinomas, 17 combined hepatocellular carcinoma-cholangiocarcinomas, and one neuroendocrine carcinoma) identified on preoperative gadoxetic acid-enhanced MRI and subsequently surgically removed between 2010 and 2017. Of these, 120 patients constituted the development cohort, and 77 patients from separate institution served as an external validation cohort. Factors associated with recurrence-free survival (RFS) and overall survival (OS) were identified using a Cox proportional hazards analysis, and risk scores were developed. The discriminatory power of the risk scores in the external validation cohort was evaluated using the Harrell C-index. The Kaplan-Meier curves were used to estimate RFS and OS for the different risk-score groups. Results: In RFS model 1, which eliminated features exclusively accessible on the hepatobiliary phase (HBP), tumor size of 2-5 cm or > 5 cm, and thin-rim arterial phase hyperenhancement (APHE) were included. In RFS model 2, tumors with a size of > 5 cm, tumor in vein (TIV), and HBP hypointense nodules without APHE were included. The OS model included a tumor size of > 5 cm, thin-rim APHE, TIV, and tumor vascular involvement other than TIV. The risk scores of the models showed good discriminatory performance in the external validation set (C-index, 0.62-0.76). The scoring system categorized the patients into three risk groups: favorable, intermediate, and poor, each with a distinct survival outcome (all log-rank p < 0.05). Conclusion: Risk scores based on rim arterial enhancement pattern, tumor size, HBP findings, and radiologic vascular invasion status may help predict postoperative RFS and OS in patients with targetoid primary liver malignancies.

• Animal Bioscience
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• 제37권6호
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• pp.982-992
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• 2024

Objective: Jining Grey goat is a local Chinese goat breed that is well known for its high fertility and excellent meat quality but shows low meat production performance. Numerous studies have focused on revealing the genetic mechanism of its high fertility, but its highlighting meat quality and muscle growth mechanism still need to be studied. Methods: In this research, an integrative analysis of the genomics and transcriptomics of Jining Grey goats compared with Boer goats was performed to identify candidate genes and pathways related to the mechanisms of meat quality and muscle development. Results: Our results overlap among five genes (ABHD2, FN1, PGM2L1, PRKAG3, RAVER2) and detected a set of candidate genes associated with fatty acid metabolism (PRKAG3, HADHB, FASN, ACADM), amino acid metabolism (KMT2C, PLOD3, NSD2, SETDB1, STT3B, MAN1A2, BCKDHB, NAT8L, P4HA3) and muscle development (MSTN, PPARGC1A, ANKRD2). Several pathways have also been detected, such as the FoxO signaling pathway and Apelin signaling pathway that play roles in lipid metabolism, lysine degradation, N-glycan biosynthesis, valine, leucine and isoleucine degradation that involving with amino acid metabolism. Conclusion: The comparative genomic and transcriptomic analysis of Jining Grey goat and Boer goat revealed the mechanisms underlying the meat quality and meat productive performance of goats. These results provide valuable information for future breeding of goats.

• 핵의학기술
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• 제13권1호
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• pp.51-56
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• 2009

목적 : Small-scalled PACS, Pc-based PACS로 표현되는 MicroPACS 시스템 구축에 대한 관심도가 급격하게 증가하고 있는 추세이다. MicroPACS 시스템은 PACS를 작은 규모에서 사용할 수 있도록 구성해놓은 것이고, 이 시스템을 구성하기 위해서는 DICOM viewer나 연결프로그램 등이 필요하다. 이것은 공개소스프로그램(Open Source Program)을 통해서 어느 누구나 쉽게 무료로 다운로드를 받을 수 있게 되어있다. 본 논문은 Open source program으로 MicroPACS를 직접 구성해보았고, 저장매체로서의 활용가치를 측정하기위하여 성능, 안정성 측면에서 기존의 광 저장매체(CD, DVDRAM)와 비교 분석하였다. 실험재료 및 방법 : 1. 소형 PACS를 구축하기 위해서 먼저 다음 기준에 맞는 DICOM Server Software를 검색한다. (1) 윈도우체제에서 사용가능할 것. (2) Free ware일 것. (3) PET/CT scanner와 호환되어야 할 것. (4) 사용하기 쉬워야 할 것. (5) 저장의 한계가 없어야 할 것. 2. (1) MicroPACS의 성능을 평가하기 위해 환자 1명의 Data ($^{18}F$-FDG Torso PET/CT)를 현재 Back-up장치로 쓰이는 광 저장매체(CD, DVD-RAM)와 MicroPACS에 저장하는데 소요되는 시간(Back up time)과 workstation으로 복구되기까지의 시간(Retrieval time)을 비교해 보았다. (2) PET/CT 검사를 시행했던 환자 1명의 병록번호와 검사 시행날짜를 핵의학과 직원 7명을 대상으로 알려주고 Data를 찾는데 소요되는 시간을 MicroPACS와 광 저장매체(CD, DVD-RAM)에서 각각 측정하여 비교하였다. 3. 기존의 백업장치로 쓰였던 CD들 중에서 2004년부터 2006년까지 500장을 무작위로 뽑아서 loading을 하였고 그중에서 얼마만큼의 에러가 발생하였는지를 측정하여 MicroPACS의 안정성을 비교평가하였다. 결과 : 1. Server와 DICOM viewer 기능을 갖춘 11개의 open source software 중에서 Conquest DICOM Server를 선택하였다. 2. (1) Backup과 Retrieval 시간 비교(단위 : 분)는 다음과 같다; DVD-RAM(5.13,2.26)/Conquest DICOM Server (1.49,1.19) by GE DSTE (p<0.001), CD (6.12,3.61)/Conquest (0.82,2.23) by GE DLS (p<0.001), CD (5.88,3.25)/Conquest (1.05,2.06) by SIEMENS. (2) CD ($156{\pm}46$초), DVD-RAM ($115{\pm}21$초) and Conquest DICOM Server ($13{\pm}6$초). 3. 1년간 MicroPACS에서의 데이터손실은 없었으며(0%), 500장의 CD 중에서 14개(2.8%)가 Loading하는데 실패하였다. 결론 : 현재 많은 병원에서 도입되고 있는 Full PACS를 open source software를 통하여 소규모의 PACS로 재현해 보았고, 그 결과 가능하다는 결론이 나왔다. 데이터 저장의 유용성을 평가한 결과에서 MicroPACS를 이용하는 것이 기존의 광저장매체를 사용하는 것보다 효율적이고 작업속도가 향상 된다는 것을 확인할 수 있다.

• 한국농공학회지
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• 제17권1호
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• pp.3642-3654
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• 1975

The purpose of this thesis is to derive a unit hydrograph which may be applied to the ungaged watershed area from the relations between directly measurable unitgraph properties such as peak discharge(qp), time to peak discharge (Tp), and lag time (Lg) and watershed characteristics such as river length(L) from the given station to the upstream limits of the watershed area in km, river length from station to centroid of gravity of the watershed area in km (Lca), and main stream slope in meter per km (S). Other procedure based on routing a time-area diagram through catchment storage named Instantaneous Unit Hydrograph(IUH). Dimensionless unitgraph also analysed in brief. The basic data (1969 to 1973) used in these studies are 9 recording level gages and rating curves, 41 rain gages and pluviographs, and 40 observed unitgraphs through the 9 sub watersheds in Nak Oong River basin. The results summarized in these studies are as follows; 1. Time in hour from start of rise to peak rate (Tp) generally occured at the position of 0.3Tb (time base of hydrograph) with some indication of higher values for larger watershed. The base flow is comparelatively higher than the other small watershed area. 2. Te losses from rainfall were divided into initial loss and continuing loss. Initial loss may be defined as that portion of storm rainfall which is intercepted by vegetation, held in deppression storage or infiltrated at a high rate early in the storm and continuing loss is defined as the loss which continues at a constant rate throughout the duration of the storm after the initial loss has been satisfied. Tis continuing loss approximates the nearly constant rate of infiltration (${\Phi}$-index method). The loss rate from this analysis was estimated 50 Per cent to the rainfall excess approximately during the surface runoff occured. 3. Stream slope seems approximate, as is usual, to consider the mainstreamonly, not giving any specific consideration to tributary. It is desirable to develop a single measure of slope that is representative of the who1e stream. The mean slope of channel increment in 1 meter per 200 meters and 1 meter per 1400 meters were defined at Gazang and Jindong respectively. It is considered that the slopes are low slightly in the light of other river studies. Flood concentration rate might slightly be low in the Nak Dong river basin. 4. It found that the watershed lag (Lg, hrs) could be expressed by Lg=0.253 (L.Lca)0.4171 The product L.Lca is a measure of the size and shape of the watershed. For the logarithms, the correlation coefficient for Lg was 0.97 which defined that Lg is closely related with the watershed characteristics, L and Lca. 5. Expression for basin might be expected to take form containing theslope as {{{{ { L}_{g }=0.545 {( { L. { L}_{ca } } over { SQRT {s} } ) }^{0.346 } }}}} For the logarithms, the correlation coefficient for Lg was 0.97 which defined that Lg is closely related with the basin characteristics too. It should be needed to take care of analysis which relating to the mean slopes 6. Peak discharge per unit area of unitgraph for standard duration tr, ㎥/sec/$\textrm{km}^2$, was given by qp=10-0.52-0.0184Lg with a indication of lower values for watershed contrary to the higher lag time. For the logarithms, the correlation coefficient qp was 0.998 which defined high sign ificance. The peak discharge of the unitgraph for an area could therefore be expected to take the from Qp=qp. A(㎥/sec). 7. Using the unitgraph parameter Lg, the base length of the unitgraph, in days, was adopted as {{{{ {T}_{b } =0.73+2.073( { { L}_{g } } over {24 } )}}}} with high significant correlation coefficient, 0.92. The constant of the above equation are fixed by the procedure used to separate base flow from direct runoff. 8. The width W75 of the unitgraph at discharge equal to 75 per cent of the peak discharge, in hours and the width W50 at discharge equal to 50 Per cent of the peak discharge in hours, can be estimated from {{{{ { W}_{75 }= { 1.61} over { { q}_{b } ^{1.05 } } }}}} and {{{{ { W}_{50 }= { 2.5} over { { q}_{b } ^{1.05 } } }}}} respectively. This provides supplementary guide for sketching the unitgraph. 9. Above equations define the three factors necessary to construct the unitgraph for duration tr. For the duration tR, the lag is LgR=Lg+0.2(tR-tr) and this modified lag, LgRis used in qp and Tb It the tr happens to be equal to or close to tR, further assume qpR=qp. 10. Triangular hydrograph is a dimensionless unitgraph prepared from the 40 unitgraphs. The equation is shown as {{{{ { q}_{p } = { K.A.Q} over { { T}_{p } } }}}} or {{{{ { q}_{p } = { 0.21A.Q} over { { T}_{p } } }}}} The constant 0.21 is defined to Nak Dong River basin. 11. The base length of the time-area diagram for the IUH routing is {{{{C=0.9 {( { L. { L}_{ca } } over { SQRT { s} } ) }^{1/3 } }}}}. Correlation coefficient for C was 0.983 which defined a high significance. The base length of the T-AD was set to equal the time from the midpoint of rain fall excess to the point of contraflexure. The constant K, derived in this studies is K=8.32+0.0213 {{{{ { L} over { SQRT { s} } }}}} with correlation coefficient, 0.964. 12. In the light of the results analysed in these studies, average errors in the peak discharge of the Synthetic unitgraph, Triangular unitgraph, and IUH were estimated as 2.2, 7.7 and 6.4 per cent respectively to the peak of observed average unitgraph. Each ordinate of the Synthetic unitgraph was approached closely to the observed one.

• Clinical and Experimental Pediatrics
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• 제50권6호
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• pp.549-555
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• 2007

목 적 : 성인에서 맥파 속도와 발목 상완 동맥압 지수는 동맥 경직도를 측정할 수 있는 비침습적 방법이며 혈압, 고지혈증 등의 심혈관계 위험 인자와 연관성이 있어 심혈관계 질환과 관련이 있음이 알려져 있다. 본 연구는 우리나라 청소년에서 신장, 체중, 체질량 지수와 혈압, 맥파 속도, 발목 상완 동맥압 지수를 측정하였고 이들 사이의 상관성을 알아보고 정상 기준값를 확립하고자 하였다. 방 법 : 서울 시내 3개 고등학교에 재학 중인 15-16세 사이의 청소년 392명(남자 213명, 여자 179명)을 대상으로 신장, 체중, 체질량지수, 좌우 상완 및 발목의 수축기, 이완기, 평균 혈압과 양측 맥파 속도, 발목 상완 동맥압 지수, 박출 시간, 전구출기를 VP-1000(Colin사, Komaki, Japan)을 이용하여 측정하였다. 결 과 : 사지의 수축기, 이완기 평균 혈압은 남자에서 여자보다 유의하게 높은 값을 보였다(P<0.05). 우측 상완-발목 맥파 속도는 남자에서 $1,015.4{\pm}130.0cm/sec$, 여자에서 $947.6{\pm}105.1cm/sec$로서 남자에서 유의하게 높은 값을 보였다. 좌측 상완 발목 맥파 속도도 마찬가지로 남자에서 $1,023.4{\pm}132.5cm/sec$, 여자에서 $954.6{\pm}102.4cm/sec$로 남자에서 유의하게(P<0.05) 높은 값을 보였다. 발목 상완 동맥압 지수는 남녀 간에 유의한 차이를 보이지 않았다. 우측 상완-발목 맥파 속도의 기준값는 남자에서 1,032.4 cm/sec, 여자에서 963.1 cm/sec이었고, 좌측 상완-발목 맥파 속도는 남자에서 1,041.3 cm/sec, 여자에서 969.7 cm/sec이었다. 우측 발목 상완 동맥압 지수의 기준값은 남자에서 1.06, 여자에서 1.06이었으며, 좌측 발목 상완 동맥압지수의 기준값은 남자에서 1.05, 여자에서 1.06이었다. 맥파 속도는 사지 모두에서 혈압이 높아질수록, 유의한 양의 상관관계를 보였다. 또한 신장이 커질수록, 체중이 증가할수록, 체질량지수가 커질수록 사지의 혈압이 증가하는 유의한 양의 상관관계를 보였다. 반면, 발목 상완 동맥압 지수는 남녀 사이에 유의한 차이가 없었으며, 체중, 신장, 체질량지수 어느 것과도 유의한 상관관계가 없었다. 결 론 : 혈압은 신장, 체중, 체질량지수에 따라 높아지며 맥파 속도와 혈압 사이에도 유의한 양의 상관관계가 있다. 정상 청소년에서 측정한 맥파 속도의 기준값을 바탕으로 심혈관계 질환의 위험도를 조기 발견하고 예측하는데 유용하게 사용할 수 있을 것으로 생각한다.