• 한국응용약물학회:학술대회논문집
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• 한국응용약물학회 1994년도 춘계학술대회 and 제3회 신약개발 연구발표회
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• pp.318-318
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• 1994

Addition of AAF to murine splenocytes culture produced a dose-related suppression of lymphoproliferative response to lipopolysaccharide (LPS). The time course of the suppression showed that a significant inhibition was occured after a 18 hr AAF treatment. Total protein kinase C activity in splenocytes was decreased to 72% of control level after a 18 hr AAF treatment. Phosphorylation of a PKC specific 80 kDa protein was increased by LPS and AAF down-regulated LPS-induced PKC activity. LPS-induced phosphorylation of overall proteins in membrane and cytosolic fraction were also decreased by the treatment of AAF. A significant increase of PKC activity in membrane fraction was noticed within 10 min of AAF treatment compared to LPS alone and then gradually decreased to LPS level in 60 min. Meanwhile, PKC activity in cytosolic fraction was increased slightly in 10 min by the treatment of AAF and then decrease to 80% LPS level in 30 min. These results suggested that suppressive effect of AAF on LPS-induced lymphoproliferative response may be associated with the down-regulation of PKC and other susceptible kinases in spleen cells.

• Journal of the Korean Wood Science and Technology
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• 제49권6호
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• pp.566-573
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• 2021

We investigated color changes on the outer surfaces of Phyllostachys bambusoides bam-boo by heat treatment under three different temperatures (180℃, 200℃, and 220℃) for three different durations (60 min, 90 min, and 120 min). A method of predicting the bam-boo surface color change after heat treatment was developed to provide valuable information and increase the added value of domestic bamboo products. The three average color parameters L^*, a^*, and b^* decreased, and the overall color changes increased as the severity factor increased. The values of L^* × a^* × b^* were highly related to the severity factor, and the optimal duration time for the desired bamboo surface color with a certain heat-treatment temperature could be estimated.

• 대한한의학원전학회지
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• 제22권1호
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• pp.71-85
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• 2009

For having good therapeutic value, putting the ideal of diagnosis and treatment based on overall analysis of symptoms and signs[辨證施治] into practice is very important, so the Eastern Medicine's peculiar diagnosis without interference by the western medical diagnosis is very important. The peculiar method of Eastern Medicine's diagnosis is four methods of diagnosis(四診法), a joint term for inspection, auscultation and olfaction, interrogation, pulse feeling and palpation. In the process of interrogation[問診], from analyzing the perspiration phase, doctor can get various physical information. Especially perspiration from particular region can be a clue for founding focus or cause of disease. This thesis divide the phase of perspiration into eight bodily region, perspiration from all body, head, face, back, chest and armpit, stomach, pubic region and lower part, hands and feet, and inquire the possible causes and principles of these perspirations. In conclusion, the regional perspiration can be a clue point out the origin of fever and condition of Gi(氣) flow. Perspiration from head, back, chest and armpit, hands and feet means that certain fever cannot extend to the outside of body, and at the same time, means the Gi(氣) flow of outside is being intercepted. So the perspirations from that region become an object of medical treatment.

• 한국물환경학회지
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• 제28권1호
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• pp.121-128
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• 2012

The purpose of this study is to solve the problem of nutrient removal due to rapid hydraulic retention time (HRT) variation in small size private sewage treatment facility and to have better effluent quality by using natural zeolite as a coagulant aid. The experiments were conducted by applying different conditions of HRT, coagulant, and zeolite dosages. As an experimental result, $TBOD_{5}$, TSS, and TP removal efficiencies were 64.9%, 94.5%, and 98.8% at co-injection with zeolite. Overall removal efficiencies of $TBOD_{5}$, TSS, and TP have improved 15.7, 28.7, 6.1%, respectively. This result shows that zeolite addition could improve flocculation, increase setting velocity, and thus have better treatment. Therefore the use of zeolite as a coagulant aid can be useful in small size private sewage treatment facility, where especially extra nutrient removal is required to meet the legal standard for discharge.

• BMB Reports
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• 제57권1호
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• pp.50-59
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• 2024

The application of gene engineering in livestock is necessary for various reasons, such as increasing productivity and producing disease resistance and biomedicine models. Overall, gene engineering provides benefits to the agricultural and research aspects, and humans. In particular, productivity can be increased by producing livestock with enhanced growth and improved feed conversion efficiency. In addition, the application of the disease resistance models prevents the spread of infectious diseases, which reduces the need for treatment, such as the use of antibiotics; consequently, it promotes the overall health of the herd and reduces unexpected economic losses. The application of biomedicine could be a valuable tool for understanding specific livestock diseases and improving human welfare through the development and testing of new vaccines, research on human physiology, such as human metabolism or immune response, and research and development of xenotransplantation models. Gene engineering technology has been evolving, from random, time-consuming, and laborious methods to specific, time-saving, convenient, and stable methods. This paper reviews the overall trend of genetic engineering technologies development and their application for efficient production of genetically engineered livestock, and provides examples of technologies approved by the United States (US) Food and Drug Administration (FDA) for application in humans.

• 한국약용작물학회지
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• 제21권5호
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• pp.394-400
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• 2013

This study was carried out in order to examine the germination characteristics of Atractylodes japonica seeds, and it was to develop the more efficient pre-treatment and production system of the seeds. Experiment was performed by two ways-temperature control (10, 15, 20, $25^{\circ}C$) and shading treatment (full sunlight, 35, 50, 75, 95% of full sunlight). Seed pre-treatment before the each experiment was carried out by temperature (with low temperature and wetting treatment (LTW) for 0, 15, 30, 45 and 60 days) and shading treatment (with drying at room temperature (DRT), drying at low temperature (DLT) and water soaking (WS) for 48 hours). Seeds of A. japonica were germinated well under temperature control (overall 85.3~100%), especially high temperature. And, the seeds pre-treated with LTW for 45 days germinated with a 100% success rate. Under the surveying shading treatment, the highest germination rate was 95.8% with DRT and overall 63.2~95.8%. Germination rate under seeds with WS was 63.2~7.8%. As a result of surveying the whole experiment, A. japonica seeds don't need to pre-treat cause of high germination, but if it is performed with LTW for a certain period of time, it would be more productive.

• 대한한방부인과학회지
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• 제35권4호
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• pp.105-120
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• 2022

Objectives: The purpose of this study is to investigate the perception of Korean Medicine (KM) doctors toward infertility treatment evaluation tools and develop a standard evaluation tool for mental and physical function improvement following Korean medicine treatment. Methods: An online survey (Moaform) was conducted, and responses were analyzed for members of the Society of Korean Medicine Obstetrics and Gynecology and KM doctors who participated in the 2021-2022 traditional Korean medicine treatment infertility support program in Gyeonggi-do. Results: In fertility treatment, the most effective indicators that KM doctors wanted to evaluate other than pregnancy and childbirth were reproductive health indicators, overall health improvement, and stress improvement (33.1%, 21.2%, 18.9%). Furthermore, 45.1% of the respondents had experience using the presented infertility stress evaluation tools. For each evaluation tool, 52.1% and 54.6% of the respondents answered that it 'does not reflect the changing circumstances of the times' and that there were 'too many questions'. As for the developing a standard evaluation tool for infertility treatment in KM, KM doctors expected a simple and clear tool focusing on the pregnancy rate. They also wanted the tool to include a reproductive health index, overall function improvement and stress improvements. Conclusions: The survey confirmed the need to evaluate indicators for reproductive health, mental health, and infertility stress in addition to pregnancy rate to assess the effectiveness of KM infertility treatment. It also confirms the necessity of developing an infertility stress evaluation tool with simplified questions that reflects the changing time.

• Asian Pacific Journal of Cancer Prevention
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• 제14권12호
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• pp.7193-7196
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• 2013

Ovarian cancer patients need a surveillance program for the detection of tumor progression after completion of treatment. The methods generally consist of history taking, physical examination, tumor marker monitoring and imaging. However, the details of recurrence detection with each method are not well defined. To clarify this issue, ovarian cancer patients who achieved complete or partial responses and developed tumor progression at the follow up time between January 2004 and December 2010 in University Hospital Chiang Mai, Thailand, were reviewed. Clinical data, CA 125 level and imaging results at the tumor progression time were recorded and analyzed. There were 144 ovarian cancer patients meeting the inclusion criteria with the mean age of 51 years and 62.5% of them were in an advanced stage. Complete response was achieved in 89 patients (61.8%) after primary treatment. The median progression free survival and overall survival were 15.5 months and 37.5 months, respectively. Abnormal symptoms presented in 49.3% of the studied patients and 59.7% developed physical examination abnormalities. In addition, CA 125 was elevated in 89.6% while in 74.3% of tumor progression was identified by CT-scan. Short treatment time period and a high level of CA 125 were significant independent prognostic factors in these patients. In conclusion, careful history taking, physical examination and monitoring of CA 125 levels are important methods for tumor progression detection in a surveillance program for epithelial ovarian cancer patients.

• Radiation Oncology Journal
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• 제16권3호
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• pp.303-310
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• 1998

목적 : 국소적으로 진행된 직장암의 방사선치료에 있어 전통적인 치료방법으로 알려져 있는 근치적 수술 및 보조 방사선 및 항암치료의 성적을 알아보고 이에 영향을 미치는 예후 인자를 알아보기 위함이다. 대상 및 방법 : 1989년 7월 부터 1993년 12월 까지 항문상방 15 cm 이내에 존재하는 직장암으로 진단받고 근치적 수술을 받은 71명의 환자를 대상으로 후향적 분석을 시행하였다. 방사선치료는 6 MeV 선형가속기를 사용하여 주5회씩 5040 cGy 까지 조사되였고 수술후 21일에서 94일 사이에 시작되었고 5-FU와 ACNU chemotherapy가 4주 간격으로 시행되었다. 결과 : 전체환자의 5년 생존율과 5년 무병생존율은 각각 58.8$\%$및 57$\%$였다. 대상환자들의 2년 국소제어율은 76.6$\%$였다. 생존기간 및 무병생존기간의 중앙값은 각각 30개월 및 27개월이었다. 단변량 및 다변량분석시 무병생존율에 의미있게 예후인자로 작용했던 요인은 국소림프절로의 전이여부, 4개 이상의 임파선 전이, 6주이상의 수술과 방사선치료 시작 사이의 간격 및 7일 이상 지속되는 방사선치료 도중의 휴식기간 등이었다. 결론 : 국소적으로 진행된 직장암의 경우 근치적 수술 및 방사선치료 및 5-FU/ACNU를 기본으로 한 항암제를 시행하였을 때 B3 이상의 병기에서는 아직도 생존율이 저조하며 bowel wall penetration이 있거나 국소 림프절전이가 있을 때는 국소제어율도 환자의 절반 정도에서 밖에 얻을 수 없을 뿐만이 아니라 림프절전이가 없는 경우라도 원격전이율이 치료실패의 많은 부분을 차지함을 알 수 있었다. 이는 좀더 효과적인 항암치료제의 선택과 투여 방법이 방사선치료와 병행될 필요가 있음을 시사하며 수술 후 보조적인 방사선치료를 시행함에 있어서 방사선치료가 시작되는 기간이 지연될 때, 또 방사선치료가 7일 이상 중단될 때 치료결과에 영향을 줄 수 있음을 보여준다. 직장선암의 경우 수술과 방사선치료시작까지의 기간이 필요이상으로 연장되거나 치료중 휴식기간이 생겨 전체치료기간이 길어지지 않게 하여야 할 것이다.

• 한국물환경학회지
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• 제30권1호
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• pp.95-101
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• 2014

Overall studies for the N-nitrosodimethylamine (NDMA) formation and treatment methods were conducted. In this study, occurrence in several countries and emerging treatment technologies of NDMA were generally reviewed. The NDMA formation was dependent on pH, contact time, and molar ratio (monochloramine/dimethylamine). The formation was rapidly increased when the molar ratio was greater than 1. It was likely that monochloramine could be related to stimulate NDMA formation. NDMA concentrations in water supply and wastewater plants after disinfection were approximately 10 ng/L and 100 ng/L, respectively. UV oxidation and adsorption processes are regarded as effective technologies for the NDMA removal. It is suggested that the UV oxidation with proper lamps is applied in water supply system.