• The Journal of Korean Medicine
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• v.30 no.1
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• pp.150-162
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• 2009

Objectives: Inflammatory mediators, such as nitric oxide (NO), prostaglandin E2 ($PGE_2$) and pro-inflammatory cytokines, TNF-${\alpha}$ and IL-$1{\beta}$ playa critical role in inflammatory immune response. Therefore, intervention of inflammatory mediator production promises therapeutic benefit for treatment of many chronic inflammatory diseases, such as allergic asthma, rheumatoid arthritis, multiple sclerosis, septic shock and neurodegenerative diseases. In this study, the pharmacological effects of the flower MeOH extract Panax notoginseng (Notoginseng Flos; NF) on inflammation were investigated to address potential therapeutic or toxic effects. Methods: RA W264.7 cells were treated with different concentrations of NF methanol (NF-M) extract in the presence or absence of LPS ($1{\mu}g/m{\ell}$). Results: NF-M extract significantly inhibited LPS-induced production of NO, $PGE_2$ and pro-inflammatory cytokines, TNF-${\alpha}$ and IL-$1{\beta}$ in a dose-dependent manner. In addition, NF-M extract suppressed mRNA expressions and protein levels of iNOS, COX-2 and pro-inflammatory cytokines in LPS-stimulated RA W264.7 cells. Conclusion: These results indicated that NF-M extract inhibits LPS-induced production of inflammatory mediators in macrophages and demonstrated that NF-M extract possesses anti-inflammatory properties in vitro.

• Journal of Acupuncture Research
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• v.19 no.1
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• pp.65-75
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• 2002

Objective : Since ancient times venepuncture has been widely used as a useful treatment for low back pain. This study is made in order to objectively evaluate the therapeutic effect of Weizhong(BL40) on low back pain. Methods : Total 46 cases of low back pain patients were divided into 2 groups; one group took only acupuncture therapy, and the other group took acupuncture and venepuncture therapy together. Each patient's pain was evaluated before the treatment and the 3 or 4 days later after the treatment. Pain rating score(PRS) was used to assess the pain for its intensity, frequency, duration, and aggravating factors. Results : Both acupuncture therapy group and acupuncture & venepuncture group showed good effect on low back pain. Though the latter group showed better pain release effect than the former, there was no statistical significance between pain rating score of two groups. Sciatica group showed no significant difference from non-sciatica group in pain rating score. Palpation on Weizhong(BL40) group showed significant difference only in pain duration from non-palpation group. Exposed vessel around Weizhong(BL40) group showed significant difference in pain rating score from non-exposed vessel group. Conclusion : Weizhong(BL40) venepuncture can be highly recommended as a useful therapy for low back pain patients especially who show exposed vessels on the popliteal area.

• The Journal of Internal Korean Medicine
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• v.27 no.3
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• pp.770-775
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• 2006

Objectives : This study was designed to evaluate the effects of oriental treatment on cancer patients. Methods : We retrospectively analyzed the medical record of a distal cholangiocarcinoma patient who had been treated with oriental medicine for 150 days. He complained of anorexia, dyspepsia, fatigue, weight loss, constipation, abdominal discomfort and pain. etc. We prescribed him Samchulkunbi-tang and other oriental medicines, in order to treat symptoms and improve long term survival. Results and Conclusion : For 150 days, he was treated with oriental medicine and the symptoms mostly disappeared. We had a worthwhile improvement of long term survival. When it comes to therapeutic effects, it could be suggested that oriental medicine has significant effects on improving symptoms, survival and quality of lifes.

• CELLMED
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• v.2 no.3
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• pp.24.1-24.5
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• 2012

Obesity is psychological and socioeconomic problems as well as health problems related to physical disease and disorder. The obesity epidemic, including a marked increase in the prevalence of obesity among pregnant women, represents a critical public health problem throughout the world. Gung-Gui-Tang (GGT), a prescription of traditional Korean medicine, has been used to treat dizziness due to loss of blood as well as static blood after childbirth. However, the therapeutic potential of GGT on postpartum obesity has not been fully elucidated in an experimental model. In our research, GGT inhibited the increases of body weight and adipose tissues in postpartum mice fed a high-fat diet. GGT also inhibited the elevations of plasma lipid profiles such as triglyceride, low-density lipoprotein cholesterol, total cholesterol, and glutamate pyruvate transaminase. Overall, these results provide evidence that GGT can help to inhibit postpartum obesity and open new perspective to recover the shape of mother into the moment of conception.

• Microbiology and Biotechnology Letters
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• v.21 no.2
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• pp.171-175
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• 1993

The antioxidant in the oriental drug, NP-S, traditionally used as a therapeutic agent for Hepatitis B was identified. The NP-S was divided into two fractions at molecular weight cut-off of 1000 by ultrafiltration and the fraction having molecular weight less than 1000 was named as NP-S(l)10. Both NP-S and NP-S(l)10 had antioxidant activity. An antioxidant that was extracted by chloroform from water-insoluble fraction in lyophilized NP-S(l)10 had a little smaller activity than NP-S(l)10 and identified as cyclooctasulfur(S8) by mass spectrum.

• The Korea Journal of Herbology
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• v.20 no.2
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• pp.149-157
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• 2005

Objectives : Each 2 types of Bangkeehwangkeetang(BHT) and Bangkeebok-ryeongtang(BBT) was prescribed to examined the therapeutic effects on hyperlipidemia. BHT-1 and BBT-1 were composed of Bunbangkee(粉防己, Stephaniae Radix) for Bangkee with other drugs, but BHT-2 and BBT-2 were composed of Cheongpungdeung(淸風藤, Sinomenii acuti Lignum). Methods : Four decoctions prepared from the prescriptions were respectively administrated to animal models in rats such as hyperlipidemic model induced by high cholesterol diet. Results : On the hyperlipidemic model, BHT-2 and BBT-2 would decrease the levels of total cholesterol(Tc) and triglyceride(TG) in blood, on the other hand, BHT-1 and BBT-1, despite little change of Tc, decrease TG but also HDL-cholesterol(HDLc). Conclusion : BBT, especially composed of Cheongpungdeung(Sinomenii acuti Lignum) for Bangkee, could be used more effectively than the others(Stephaniae Radix) on hyperlipidemia.

• The Journal of Internal Korean Medicine
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• v.41 no.5
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• pp.717-723
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• 2020

Objectives: The purpose of this study was to address a case of a Parkinson's disease with anorexia and nausea. Methods: A patient diagnosed with Parkinson's disease with anorexia and nausea was treated with Korean medicine therapies including herbal medication (Hyangsayukgunja-tang), acupuncture, electro-acupuncture, and moxibustion for 7days. To evaluate the therapeutic effect, we used a visual analogue scale(VAS). Results: After the treatment, the VAS score for anorexia and nausea had decreased. Conclusion: These results suggested that Korean medicine therapies with Hyangsayukgunja-tang have a beneficial effect on the gastrointestinal symptoms of Parkinson's disease.

• Korean Journal of Pharmacognosy
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• v.3 no.4
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• pp.187-197
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• 1972

In spite of the fact that the system of oriental medicine still remains in the realm of 'unproven-method of treatment', no one can deny that the oriental medicine is a rich source of idea and motivation for the discovery of new drug from natural sources. However, non-scientific, mystic hypothetical system of oriental medicine refuses to be revealed scientifically. For the purpose of drawing useful parameters for inductive reasoning of the system, a new approach which comprises statistical analyses of prescription was attempted in this study. One hundred and thirty two ginseng-compounds prescription in 'Bang-Yak-Hap-Pyon', one of the most popular formularies of oriental medicine in Korea, were analysed by multivariate analysis technique. The results revealed ginseng from many points of view, e.g., therapeutic indications, dose, and compatibility, etc. Among these, the most striking coincidence with scientific achievements of modern pharmacology, is the fact that the oriental medicine has characterized ginseng already from remote ancient times as neither a specific curative nor an aphrodisiac, but a non-specific adaptogenic drug for general infirmity.

• The Journal of Korean Medicine
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• v.26 no.4
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• pp.87-97
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• 2005

Backgrounds: Intracerebral hemon-hage is one of the most devastating types of stroke. Ginseng radix, the root of Panax Ginseng, C. A. MEYER (Araliaceae), is one of the most famous medicinal herbs with various therapeutic applications. Objectives: In the present study, the effect of aqueous extract of Ginseng radix on intracerebral hemorrhage-induced neuronal cell death in rats was investigated. Materials and Methods: Step-down avoidance task, Nissl staining, immunohistochemistry for caspase-3 and terminal deoxynucleotidyl transferase-mediated dUTP nick end labeling (TUNEL) assay were used for this study. Results: The present results show that hemorrhage-induced lesion volume and apoptotic neuronal cell death in the striatum were significantly suppressed by treatment with Ginseng radix, resulting in enhancement of short-ten-n memory. Conclusions: We have shown that Ginseng radix has a neuroprotective effect on stroke, and aids the recovery from central nervous system sequelae following stroke.

• Journal of the Korean Institute of Oriental Medical Informatics
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• v.19 no.2
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• pp.29-37
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• 2013

Objectives: This case report presents a 29-years-old male patient. His chief complaint was insomnia, anxiety and chest discomfort. We diagnosed him with sleep disorder. During the therapeutic period, he experienced temporary improvement. Methods: We treated him with emotional freedom techniques(EFT), giungoren-therapy. Also, acupuncture and chuna therapy were accessorily practiced. The effects of treatment were measured by Beck depression inventory(BDI), state-trait anxiety inventory(STAI), insomnia severity index(ISI). Results: After treatment, the chief complaint have been subsided and improved. But, BDI, STAI, ISI score were not remarkably decreased. Conclusions: This result suggests that EFT and giungoren-therapy might be effective for sleep disorder patient with anxiety.