• Journal of Radiopharmaceuticals and Molecular Probes
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• v.7 no.2
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• pp.93-98
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• 2021

meta-iodobenzylguanidine is one of the norepinephrine analogs and reuptakes together with norepinephrine with norepinephrine transporter. The radioiodinated ligand, ¹²³I-meta-iodobenzylguanidine, is the most widely used for single photon emission computed tomography imaging to diagnose functional abnormalities and tumors of the sympathetic nervous system. In this study, we performed cellular uptake studies of ¹²³I-meta-iodobenzylguanidine in positive- and negative-norepinephrine transporter cells in vitro to verify the uptake activity for norepinephrine transporter. After ¹²³I-meta-iodobenzylguanidine was injected via a tail vein into normal mice, Single photon emission computed tomography/computed tomography images were acquired at 1 h, 4 h, and 24 h post-injection, and quantified the distribution in each organ including the adrenal medulla as a norepinephrine transporter expressing organ. In vitro cell study showed that ¹²³I-meta-iodobenzylguanidine specifically uptaked via norepinephrine transporter, and significant uptake of ¹²³I-meta-iodobenzylguanidine in the adrenal medulla in vivo single photon emission computed tomography images. These results demonstrated that single photon emission computed tomography imaging with ¹²³I-meta-iodobenzylguanidine were able to quantify the biodistribution in vivo in the adrenal medulla in normal mice.

• Journal of Genetic Medicine
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• v.20 no.1
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• pp.6-14
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• 2023

Fabry disease (FD), a rare X-linked lysosomal storage disorder, is caused by mutations in the α-galactosidase A gene gene encoding α-galactosidase A (α-Gal A). The functional deficiency of α-Gal A results in progressive accumulation of neutral glycosphingolipids, causing multi-organ damages including cardiac, renal, cerebrovascular systems. The current treatment is comprised of enzyme replacement therapy (ERT), oral pharmacological chaperone therapy and adjunctive supportive therapy. ERT has been introduced 20 years ago, changing the outcome of FD patients with proven effectiveness. However, FD patients have many unmet needs. ERT needs a life-long intravenous therapy, inefficient bio-distribution, and generation of anti-drug antibodies. Migalastat, a pharmacological chaperone, augmenting α-Gal A enzyme activity only in patients with mutations amenable to the therapy, is now available for clinical practice. Furthermore, these therapies should be initiated before the organ damage becomes irreversible. Development of novel drugs aim at improving the clinical effectiveness and convenience of therapy. Clinical trial of next generation ERT is underway. Polyethylene glycolylated enzyme has a longer half-life and potentially reduced antigenicity, compared with standard preparations with longer dosing interval. Moss-derived enzyme has a higher affinity for mannose receptors, and seems to have more efficient access to podocytes of kidney which is relatively resistant to reach by conventional ERT. Substrate reduction therapy is currently under clinical trial. Gene therapy has now been started in several clinical trials using in vivo and ex vivo technologies. Early results are emerging. Other strategic approaches at preclinical research level are stem cell-based therapy with genome editing and systemic mRNA therapy.

• Korean Journal of Health Education and Promotion
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• v.8 no.1
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• pp.59-67
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• 1991

Cerebrovascular disease have been replaced by neoplasm as first cause of death on 1980's. So, many epidemiological studies on cancer have been reported. However, most of them were performed on beses of biopy data or of histological examination. We had reported that valuable results could be obtained from surgical data for cancer patients, previously. In this paper, 5,103 surgically treated cancer patients in Daegu-Kyungbuk area during 1985-1989 were analyzed in terms of sex, age and organ. Mean age on male cancer patients was increased, but in the case of female, the trend of age distribution is inverse to other reports. It is considered as regional specificity to cancer incidence and it is due to higher frequency of breast and uterine cervical cancer than other areas. Especially, in the case of breast cancer, the mean age of patients was 30's and be considered as most dangerous cancer to famale.

• Bulletin of the Korean Chemical Society
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• v.32 no.4
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• pp.1282-1292
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• 2011

The biotin-attached G8 molecular transporter (5) was synthesized and used together with quantum dots in preparing the complexes (QD-MT). The QD-MT complexes were studied in terms of the cellular uptake and the internalization mechanism in live HeLa cells with the aid of various known endocytosis inhibitors. It has been concluded that the QD-MT complex is internalized largely by macropinocytosis. The mouse tissue distribution of the QD-MT complex by i.p. and i.v. routes showed some organ selectivity and a good ability to cross the BBB.

• Proceedings of the Korean Society of Applied Pharmacology
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• 1996.04a
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• pp.287-287
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• 1996

Long-circulating liposomes have prompted interests in using them as a drug delivery system. This improvements in delivery has been thought to be the results from sustained action of liposomes in plasma without RES uptake. Although methotrexate(MTX) has been one of the most widely used antineoplastc drug, its use was limited by prompt RES uptake. The purpose of this study was to prepare long-circulating liposomes for MTX using highly water-soluble polymer (PEG-PE). In vitro, release of MTX from liposomes in phosphate buffer (pH 7.4), rat liver homogenate, and rat plasma was investigated. The pharmacokinetics and organ distribution of fee drug, conventional and long-circulating liposomes were also compared with one another after intravenous administration to rats.

• Proceedings of the Korean Society of Medical Physics Conference
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• 2006.08a
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• pp.97-97
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• 2006

• Korean Journal of Veterinary Research
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• v.48 no.2
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• pp.235-238
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• 2008

This study describes thoracic radiographic features of normal premature minipigs at the age of 4, 8, 12 and 20 weeks. The evaluation for appearance, shape, contour, location and extent of distribution of thoracic organs was recorded through right lateral and ventrodorsal thoracic radiographs. The size of the tracheal diameter, cranial mediastinum, and the heart were measured, and information about the correlation of each organ in their thoracic conformation could be obtained. Although there were limitations with plain thoracic radiographs, basic characteristics and data for thoracic radiographs of normal premature minipigs according to each age were useful.

• Journal of Chest Surgery
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• v.19 no.4
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• pp.736-743
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• 1986

Thymus gland is a kind of endocrine organ which secretes thymosin and thymoprotein. There can be developed variable lesions like thymoma, thymic hyperplasia, thymic cyst, thymolipoma, and carcinoid tumor of the thymus gland. We have experienced 25 patients of thymic disease: thymoma 12, thymic hyperplasia 11, thymic cyst 1, carcinoid tumor 1. The age distribution were ranged from 3 to 66 years and the sex ratio was 1:1.8 [male to female]. Thymectomy was performed in all cases, but 3 cases with deep infiltration to the adjacent structures were not resectable completely. Malignancy [all thymoma] were 5 and the rest were benign. Two cases were died of recurrence after tumor resection. Myasthenia gravis occurred in 10 cases. Among them, 2 were thymoma and 8 were thymic hyperplasia. We could obtained the result that thymectomized cases reached 2 remission and 5 improvement. Myasthenia gravis treated medically [18 cases] had no remission and only 2 clinical improvement. In the light of these results, early radical thymectomy would be most favorable treatment in not only thymic tumor, but generalized myasthenia gravis.

• Journal of Chest Surgery
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• v.27 no.12
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• pp.1023-1026
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• 1994

We reviewed 10 cases of traumatic diaphragmatic injuries at Soonchunhyang University Gumi Hospital from January 1990 through April 1993. seven patients were male and three patients were female. The age distribution was ranged from 25 to 79 years, predominant 4th decades occurred in male. The traumatic diaphragmatic injuries were due to blunt trauma in 9 cases (traffic accident 7 and crash injury 2) and penetrating wound in 1 case (stab wound). The common symptom were dyspnea (60%), chest pain and abdominal pain in order frequency. In the blunt trauma and crash injury, te rupture site was all located in the left(9 cases). In the penetrating wound, the rupture site was located in the right(1 case). The surgical repair of 10 cases were performed with transthoracic approach in 9 cases and thoracoabodominal approach in 1 case. The postoperative mortality was 10% (1/10). The cause of death was multiple organ failure with pulmonary edema.

• Journal of Chest Surgery
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• v.27 no.12
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• pp.1027-1030
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• 1994

We reviewed 10 cases of traumatic diaphragmatic injuries at Soonchunhyang University Gumi Hospital from January 1990 through April 1993. Seven patients were male and three patients were female. The age distribution was ranged from 25 to 79 years, predominant 4th decades occurred in male. The traumatic diaphragmatic injuries were due to blunt trauma in 9 cases[traffic accident 7 and crash injury 2] and penetrating wound in 1 case[stab wound]. The common symptoms were dyspnea[60%], chest pain and abdominal pain in order frequency. In the blunt trauma and crash injury, the rupture site was all located in the left[ 9 cases ]. In the penetrating wound, the rupture site was located in the right[1 case]. The surgical repair of 10 cases were performed with transthoracic approach in 9 cases and thoracoabdominal approach in 1 case. The postoperative mortality was 10%[1/10]. The cause of death was multiple organ failure with pulmonary edema.