• Journal of Oral Medicine and Pain
• /
• 제45권3호
• /
• pp.71-78
• /
• 2020

While oral melanotic macule is regarded as the most frequent oral pigmented lesion without any harmful symptom, oral melanoma is a very rare and life-threatening disease among oral pigmented lesions. Oral melanotic macule has previously been described as benign, with no malignant potential. However, a few case reports have raised the question of malignant potential of oral melanotic macule. In this case report, we present a case of coexistence of oral melanotic macule and oral melanoma. A 66-year-old man with a chief complaint of black pigmentation on gingiva showed the lesion spread out on the right palatal gingiva, the right maxillary buccal gingiva and the right buccal mucosa, appearing to merge with one another. Biopsies were performed on the right palatal gingiva and the right buccal mucosa. While the lesion on the right palatal gingiva was diagnosed as an oral melanotic macule, the other lesion on the right buccal mucosa was diagnosed as an oral melanoma. The present case implied the possibility of malignant potential of oral melanotic macule. Therefore, oral melanotic macule needs careful periodic observation for early detection and prompt treatment of the transformed oral melanoma.

• Journal of the Korean Association of Oral and Maxillofacial Surgeons
• /
• 제34권6호
• /
• pp.611-615
• /
• 2008

The prognosis of oral malignant melanoma is poor compared with cutaneous melanoma. It may be related to the difficulty of wide enough resection, the early hematogenous matastases, higher stage at initial diagnosis, and tendency to growth vertically. In the view of histological differences between oral mucosa and skin, it is impossible use Clark's and Breslow's classifications for prognosis. The great problem is that there is still no consensus on the treatment due to rarity. Because data collection from case reports is considered to be the best source of information and should be pooled to analyze key determinants of outcome, We analysed 6 cases of primary malignant melanoma of the oral cavity which were diagnosed and treated in Pusan National University Hospital on recent 7 years and reviewed the literatures. Immunohistochemical study on S 100 Protein, GP 100 (HMB-45) with biopsy was usable to confirm the melanoma. Three patients who were treated by surgery, chemotherapy are alive, but a patients who couldn't received benefit care surgically due to poor condition was died of distant metastasis, and two patients who refused to surgery are still alive. Neck dissection including wide excision is recommended if lymph node involvement is suspected. Additionally, adjuvant chemotherapy could be considered as supporting therapy for malignant melanoma.

• Journal of the Korean Association of Oral and Maxillofacial Surgeons
• /
• 제44권2호
• /
• pp.66-72
• /
• 2018

Objectives: Desmoplastic melanoma of the oral cavity is an extremely rare condition that is often confused on initial diagnosis with non-melanotic benign lesion or spindle cell tumors. The purpose of this article was to raise awareness of the disease using a literature review. Materials and Methods: We analyzed 19 desmoplastic melanoma cases reported in the literature and added our experience. Data on clinical, histopathology, treatment, and survival were retrieved and analyzed. Survival analysis was by the Kaplan-Meier method. Results: Initial clinical and histopathological features were indistinctive, and a definite diagnosis of desmoplastic melanoma at initial assessment was possible in only 23.5% of cases. Among tests, immunohistochemical studies for S-100 and vimentin were all positive. The 5-year disease-free survival rate for oral desmoplastic melanoma was 0%, and the 5-year overall survival rate was 55.0%. Conclusion: Oral desmoplastic melanoma has a high percentage of initial misdiagnosis and propensity for local recurrence. Thus, careful initial diagnosis and adequate surgery may result in improved overall survival.

• International Journal of Oral Biology
• /
• 제37권4호
• /
• pp.189-195
• /
• 2012

Resistance to the induction of apoptosis is a possible mechanism by which tumor cells can survive anti-neoplastic treatments. Melanoma is notoriously resistant to anti-neoplastic therapy. Previous studies have demonstrated focal adhesion kinase (FAK) overexpression in melanoma cell lines. Given its probable role in mediating resistance to apoptosis, many researchers have sought to determine whether the downregulation of FAK in melanoma cells would confer a greater sensitivity to anti-neoplastic agents. Genistein is a known inhibitor of protein-tyrosine kinase (PTK), which may attenuate the growth of cancer cells by inhibiting the PTK-mediated signaling pathway. This present study was undertaken to investigate the effect of genistein on the expression of FAK and cell cycle related proteins in the G361 melanoma cell line. Genistein was found to have a preferential cytotoxic effect on G361 melanoma cells over HaCaT normal keratinocytes. Genistein decreased the expression of 125 kDa phosphotyrosine kinase and the FAK protein in particular. Genistein treatment did not affect the expression of p53 in G361 cells in which p21 is upregulated. The expression of cyclin B and cdc2 was downregulated by genistein treatment. Taken together, our data indicate that genistein induces the decreased proliferation of G361 melanoma cells via the inhibition of FAK expression and regulation of cell cycle genes. This suggests that the use of genistein may be a viable approach to future melanoma treatments.

• 대한두개안면성형외과학회지
• /
• 제21권2호
• /
• pp.132-136
• /
• 2020

Oral mucosal melanoma is a very rare type of malignant melanoma, the characteristics of which differ from those of cutaneous melanoma. Primary amelanotic melanoma of the mandibular gingiva, which can invade the mandibular bone, is very rare worldwide. Here, we report a case in which we performed a reconstruction of the mandible and gingiva using the fibula osteocutaneous free flap procedure to treat a patient diagnosed with a primary amelanotic melanoma of the mandibular gingiva. The procedure was successful, and no recurrence was observed 10 months after surgery. Oral mucosal melanoma has a much poorer prognosis and a lower 5-year survival rate than cutaneous melanoma. However, recently, immunomodulatory therapies for mutations in melanocytic lesions have been used effectively to treat the increasing number of patients developing this type of melanoma, thus improving the prognosis of patients with oral mucosal melanoma.

• 한국임상수의학회지
• /
• 제40권5호
• /
• pp.370-374
• /
• 2023

Oral melanoma is the most common type of oral tumor in dogs. In this report, computed tomography (CT) and magnetic resonance imaging (MRI) were performed to diagnose a right oral pigmented mass in an 8-year-old dog. The oral mass appeared as a homogeneous soft tissue density parenchyma on pre-contrast CT images, and with heterogeneous enhancement on post-contrast images. Bone destruction of the right mandibular body around the mass and mild enlargement of the right mandibular lymph node were also found. On MRI, the bulky oral mass showed mixed hyperintensity and isointensity compared to the adjacent muscle, where irregular hyperintensity on T1-weighted images corresponded to hypointensity on the T2-weighted images. Based on the physical examinations and imaging results, melanoma was suspected and confirmed via fine-needle aspiration. These unique MRI signals were due to the high paramagnetic melanin content in the tumor, therefore MRI examination could be useful for diagnosis of melanoma.

• Radiation Oncology Journal
• /
• 제16권1호
• /
• pp.87-90
• /
• 1998

구강내에서 발생하는 악성 흑색종은 비교적 드문 종양으로 원인에 대해서는 정확히 알려져 있지는 않으나 방사선치료 후에 발생된 양성 흑색종이 악성으로 전환된 보고가 있다. 본원에서 구강내 편평상피세포암으로 국소방사선치료 후 동일한 부위에 6년 후에 악성 흑색종이 발생하였기에 문헌고찰과 함께 보고하는 바이다.

• Journal of the Korean Association of Oral and Maxillofacial Surgeons
• /
• 제44권1호
• /
• pp.29-33
• /
• 2018

Sinonasal mucosal melanoma (SNMM) in the maxillary sinus is a rare disease condition. Compared to oral mucosal melanoma, SNMM has a bulky, exophytic, and polypoid appearance, is weakly pigmented, and associated with unspecific symptoms. Due to these features, SNMM in the maxillary sinus has been misdiagnosed as nasal polyps and chronic sinusitis. In this case report, we described SNMM occurring in the right maxillary sinus simulated as a cystic or benign lesion. Cortical bone thinning and expansion were observed around the mass. The excised soft mass was encapsulated and weakly pigmented. The mass was clearly excised and covered with a pedicled buccal fat pad graft. Diagnosis using immunohistochemistry with S-100 and homatropine methylbromide-45 (HMB-45) is critical for proper treatment.

• Maxillofacial Plastic and Reconstructive Surgery
• /
• 제12권1호
• /
• pp.135-141
• /
• 1990

저자등은 구강내 흑색병소를 가진 2명의 환자를 이학적 검사, 임상검사, 방사선 검사, 조직검사를 하여 악성흑색종(증례 I : Level IV, Stage II A, 증례 II : Level V, Stage II B)으로 진단하고 증례 I은 경부곽청술을 시행하지 않고 외과적 절제술만 시행하였는바, 술후 약 6주후에 악하임파결절이 증대되어 조직검사를 시행한 결과 전이성 악성흑색종으로 나와 DTIC를 이용한 전신적인 화학요법을 5회 시행하였다. 술후 22개월동안 관찰한 결과 재발은 없었다. 증례 II는 병소의 크기가 작았기 때문에 경부곽청술은 시행하지 않고 외과적 절제술만을 시행하였다. 8개월 동안 관찰한 결과 재발이나 전이는 발생하지 않았다.

• 치과방사선
• /
• 제23권2호
• /
• pp.347-355
• /
• 1993

악성 흑색종은 멜라닌모세포로부터 유래되는 종양으로서, 이의 병인에 대하여서는 현재까지 확실히 구명된 바 없으나, 외상이나 만성 자극 등에 의하여 발생되는 것으로 알려져 있다. 이는 전체 악성 종양의 1.2%를 차지하는 발생빈도가 매우 낮은 질환으로서, 대부분 피부에서 발생되고, 점막에서의 발생은 매우 드물다. 특히 비강과 부비동에서 원발되는 경우는 전체 악성 흑색종의 0.6%-0.7%에 불과하며, 예후가 극히 불량하다. 비강과 부비동의 원발성 악성 흑색종은 50세-70세 사이에서 호발되고, 사춘기 이전에는 거의 발생되지 않으며, 남녀 성 차는 없는 것으로 알려져 있다. 또한 비폐색과 비출혈이 가장 흔한 증상이며, 간혹 비루, 안모종창, 두통등을 호소하기도 하나, 종물이 상당한 크기로 성장되기 전에는 특이한 임상증상을 보이지 않으므로 이의 조기발견 및 적절한 치료가 요구된다. 저자들은 최근 안모종창과 동통을 주소로 내원한 36세 여자 환자의 비강과 부비동에 원발된 악성 흑색종 1예를 경험하였기에 문헌고찰과 함꼐 이를 보고하는 바이다.