• Journal of Oral Medicine and Pain
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• v.44 no.3
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• pp.118-122
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• 2019

Paraneoplastic pemphigus (PNP) is a rare and often fatal autoimmune blistering disease accompanied by both benign and malignant neoplasms. Usually, oral, skin, and mucosal lesions are the earliest manifestations shown by PNP patients. Oral ulcers are initial lesions in various autoimmune diseases like pemphigus, bullous pemphigoid, erythema multiforme, graft-versus-host, lichen planus, it does not improved despite of high-dose steroid therapy. We report a-35-year-old female who presented oral ulceration, lip crust and skin lesions. By doing several examinations, such as enzyme-linked immunosorbent assay, incisional biopsy with indirect immunofluorescence, she was diagnosed PNP with non-Hodgkin's lymphoma on pancreas.

• Journal of Oral Medicine and Pain
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• v.45 no.3
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• pp.65-70
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• 2020

Myxomas in the orofacial regions are relatively uncommon tumors that occur in two different types: odontogenic myxomas and soft tissue myxomas. Odontogenic myxomas, derived from the mesenchymal cells such as papillae, dental follicles, or periodontal ligament, occur commonly in the maxilla and mandible. However, soft tissue myxomas in the oral cavity are rare and have been previously reported in only about 30 cases of unknown pathogenesis. The aim of this case report is to present a new case of oral soft tissue myxoma in a 37-year-old male patient who presented with a soft, exophytic round mass on the palate.

• Journal of Oral Medicine and Pain
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• v.41 no.2
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• pp.72-75
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• 2016

Lichen planus is a chronic disease characterized by bilateral and multiple lesions on the skin or oral mucosa. Lichen planus is caused by immune mediated degeneration along the border between epithelium and connective tissue. The incidence of oral squamous cell carcinoma in patients diagnosed with oral lichen planus (OLP) is reported to be between 0.4%-5.6% in different studies and the World Health Organization has categorized lichen planus as "a potentially malignant disorder". However, the correlation between OLP and oral cancer still remains controversial as some reported that the reason for increased incidence of squamous cell carcinoma in OLP patient is misdiagnosis of dysplastic lesion as OLP. This report aims to discuss the correlation between OLP and oral cancer through a case of middle aged woman diagnosed with OLP who was successfully treated but developed squamous cell carcinoma 8 years later.

• Journal of Oral Medicine and Pain
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• v.43 no.3
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• pp.70-76
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• 2018

The definition and application of disability are becoming more important as society becomes more complex. The precise criteria for the assessment and classification of disabilities are primarily focused on certain medical conditions with a lack of guidelines for dental conditions. This study provides an evaluation and comparison of the current tables available for the assessment of disabilities in the dental field with the aim of identifying areas to be improved.

• Journal of Oral Medicine and Pain
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• v.40 no.1
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• pp.17-27
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• 2015

Purpose: The purpose of this study was to investigate occupational distribution of temporomandibular disorders (TMD) patients and their diagnosis according to occupations and to evaluate the relationship between TMD and occupations. Work-related factors which might aggravate TMD symptoms were also evaluated. Methods: We investigated 316 TMD patients, aged from 13 to 65 years old, who had visited the Department of Oral Medicine in Pusan National University Dental Hospital. The subjects who have a job were assessed using TMD analysis examination and occupation questionnaire. The level of significance was p-value<0.05. Result: This study presented that the diagnoses according to occupations were not significant, but work-related factors such as verbal work and poor posture were related with TMD symptoms. Conclusions: Proper education is essential to prevent aggravation of TMD symptoms because TMD symptoms were more related to work environment than a specific occupation.

• Journal of Oral Medicine and Pain
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• v.47 no.3
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• pp.144-147
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• 2022

Chronic maxillary sinusitis is a common disease, with symptoms of dull, aching pain or pressure below the eyes and signs such as tenderness over the involved sinus, whereas trigeminal neuralgia is described as severe, paroxysmal, and lancinating brief pain limited in distributions of one or more divisions of trigeminal nerve. In cases where these two non-odontogenic toothache symptoms overlaps, the diagnostic process can be confusing. Here, we report a case of a 54-year-old male patient with chief complaints of intermittent, severe, and electric-like pain in the upper left premolar and first molar area, initially diagnosed with trigeminal neuralgia but finally with maxillary sinusitis after pain recurrence 2 years after that. Therefore, thorough history taking and precise imaging interpretation should be considered to make correct diagnose especially in case of a patient with newly developed or altered or atypical symptoms.

• Journal of Oral Medicine and Pain
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• v.46 no.4
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• pp.99-108
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• 2021

Sjögren's syndrome (SjS) is a common autoimmune disorder characterized by lymphocytic infiltration in the salivary and lacrimal glands, resulting in severe dry mouth or eyes. The symptoms are complex and heterogeneous. Several diagnostic criteria have been proposed for SjS and its subsets over the years. However, on the other hands, great efforts have been made searching for reliable biomarkers able to ameliorate the diagnostic algorithm and the prognostic stratification of SjS patients. The aim of this article is to review biomarkers and treatments related to SjS for oral medicine specialists.

• Journal of Oral Medicine and Pain
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• v.40 no.2
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• pp.82-87
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• 2015

Methotrexate (MTX) is a chemotherapeutic agent that is used to treat a host of malignancies. But recently, MTX has also been used as a therapeutic agent for chronic inflammatory disorders such as rheumatoid arthritis, psoriasis, and systemic lupus erythematosus. However, MTX is an antimetabolite that affects rapidly dividing normal cells such as oral mucosal epithelial cells, gastrointestinal epithelial cells, and bone marrow cells-which explains why oral mucositis is often an initial manifestation of MTX toxicity. Because oral lesions are frequently initially presented in dental clinics, dentists should consider the possibility of adverse drug reactions in the differential diagnoses of oral lesions through a meticulous collection of patients' medical histories. In this report, we examine patients who suffered from oral ulcerative lesions upon diagnosis of MTX-induced oral mucositis. Then, we suggest approaches for the diagnosis and treatment of MTX-induced oral mucositis through a review of literature.

• Journal of Oral Medicine and Pain
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• v.43 no.4
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• pp.136-141
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• 2018

Oral cancer is a malignant neoplasm of the lips or oral cavity. Surgery, radiotherapy and chemotherapy depending on the location and stage of the tumor can be considered as important treatment modalities of oral cancer. Unfortunately, all three treatments can have both acute and chronic complications. Among them, trismus and osteoradionecrosis (ORN), unique complications of radiotherapy in the orofacial region, are particularly difficult to treat once manifested. Therefore, these two complications of radiotherapy have devastating effects on the patient's oral health and furthermore, overall quality of life. In this study, we present a case of a patient showing trismus and ORN following radiotherapy for the treatment of maxillary squamous cell carcinoma and briefly discuss this matter of trismus and ORN in the perspective of a dentist.

• Journal of Oral Medicine and Pain
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• v.43 no.3
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• pp.87-91
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• 2018

Sialolithiasis is the most frequent disease of the salivary glands, causing swelling and/or pain of the affected site. We report a 44-year-old woman who presented with severe pain in the lower left second molar region without swelling. Sialoliths on her left submandibular gland were confirmed by radiographic examinations. After robot-assisted sialoadenectomy, the pain did not recur but remained facial paralysis and unaesthetic scar.