• International Journal of Oral Biology
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• 제43권1호
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• pp.37-42
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• 2018

It is noted that Streptococcus mutans (S. mutans) triggers dental caries establishment by two major factors: the synthesis of organic acids, which demineralize dental enamel, and the synthesis of glucans, which mediate the attachment of bacteria to the tooth surface. Therefore, it is noted that the development of a more effective, substantial and safe preventive agent that works against dental caries and periodontal disease is required at this time. For this reason, the present study was designed to investigate the effect of croton seed ethanol extracts on the growth, acid production, adhesion, and insoluble glucan synthesis of S. mutans. In this case, the ethanol extract of croton seed showed concentration dependent inhibitory activity against the growth, acid production and adhesion of S. mutans. Especially, it is important to note that it has produced significant inhibition at the concentration of 0.1 and 0.2 mg/ml as compared to the control group. Moreover, these results suggest that the application of croton seed extract may be considered to be a useful method for the prevention of dental caries.

• Journal of Chest Surgery
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• 제18권4호
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• pp.692-699
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• 1985

Fifty cases of Open Heart Surgery due to congenital and acquired heart disease were done using the cardiopulmonary bypass in the Department of Thoracic and Cardiovascular surgery, Chosun University Hospital from November, 1980 to June, 1985. 1. The age of the congenital heart disease was from 7 to 29 years, the mean age was 14.5 years. In the acquired heart disease, the age was from 14 to 48 years, and the mean age was 22.3 years. The ratio of male to female was about 1.8:1. 2. The number of congenital cyanotic heart disease were 7 patients, congenital acyanotic heart disease were 17 patients and acquired valvular heart disease were 26 patients. All of the acquired heart disease was one or more valve disease. 3. Preoperative symptoms of the congenital heart disease were exertional dyspnea [cyanotic 100%, acyanotic 70.6%] and palpitation [cyanotic 28.6%, acyanotic 76.1%], and the acquired heart diseases were exertional dyspnea [92.3%], palpitation [34.1 %], and chest discomfort [30.8%]. 4. The method of the myocardial protection during the cardiopulmonary bypass were mild or moderate hypothermia, intermittent coronary perfusion of the cardioplegic solution, topical myocardial hypothermia with 4oC Hartmann`s solution. 5. In the cases of the valve replacement, postoperative oral anticoagulant therapy was started at oral intake of food using the warfarin and persantin, and the prothrombin time was maintained 30-50% of control value during 3-6 months for tissue valve replacement and permanently for metal valve replacement. 6. The postoperative complications were appeared in 24 cases and the complications were wound infection, occipital alopecia, hemorrhage etc. 7. The mortality after open heart surgery was 8 percents and the cause of death was low cardiac output syndrome, right heart failure, DIC, and Left ventricle rupture.

• 구강회복응용과학지
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• 제31권4호
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• pp.371-377
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• 2015

편평태선은 피부, 점막에 양측성 또는 다발성의 병소가 만성으로 나타나는 흔한 질환이다. 편평태선을 발생시키는 원인으로는 구강 내 수복물, 전신질환, 약물, 스트레스 등 여러 가지 요인이 작용한다고 알려져 있다. 그 중 편평태선에 대한 구강 내 수복물과 위생관리의 영향은 치과 영역에서 큰 관심이 되어왔다. 본 증례는 형태가 불량하고 경계가 잘 맞지 않는 보철물이 수복되어 있는 편평태선 환자에 관한 것이다. 환자는 오랜 시간 동안 편평태선으로 치료받고 있었고 양측 구치부에 금속도재관을 수복한 이후 증상이 더욱 악화되어 있었다. 불량한 적합도와 외형을 보이는 금속도재관을 제거하고 치주치료를 동반하여 보철물의 형태와 변연 적합도를 개선시킴으로써 편평태선이 효과적으로 줄어들었기에 다음을 보고자 한다.

• 한국융합학회논문지
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• 제11권10호
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• pp.133-138
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• 2020

이 연구의 목적은 유방질환 중 악성 종양 관련인자를 알아보고 최근에 보고 되고 있는 경구 피임약은 우리나라 여성에 어떤 영향이 있는지 알아보고자 실시 하였다. 연구 방법은 질병관리본부에서 진행한 제 7기 국민건강영양조사 자료로 질병관리본부 홈페이지를 통해 안내한 이용절차에 따라 자료를 제공 받았다. 분석된 자료는 2016년 3341명, 2017년 3263명, 2018년 3377명 총 9981명을 연구 대상으로 하였다. 연구를 통한 결과는 연령, 흡연, 음주, 고지혈증과 미혼관련 변수의 유의성을 알 수 있었고 특히 경구피임약 관련 유의성은 알 수 없었다. 본 연구를 토대로 관련 인자의 적극적 예방과 암 유발 억제 정책에 기여할 수 있으며 특히 경구피임약 관련 복용 증가 추세이므로 향후 기간 및 복용량 등 복용대상자의 지속적인 융합 연구가 진행되어야 할 것으로 사료된다.

• Journal of Chest Surgery
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• 제26권4호
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• pp.249-254
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• 1993

Atrial fibrillation is commonly associated with organic mitral valve disease including rheumatic valvular heart diasease or mitral valve prolapse and so forth. Although spontaneous sinus reversion may occur in some patients after mitral valve operation, recurrence of atrial fibrillation is the rule in most of these patients. We have tried to maintain sinus rhythm after mital valve operation with oral quinidine therapy, and we will show the efficacy of this therapy in this report. From January 1986 to August 1992, 60 patients of mitral valvular heart disease, who had had atrial fibrillation preoperatively and gained sinus rhythm postoperatively, were selected for this study. These patients were divided into 2 groups: Control group [n=30] and Quinidine trial group [n=30]. The age,sex, duration of symptoms,left atrial size and other risk factors of the reversion to atrial fibrillation were adjusted to be similar between the two groups. The maintenance rate of sinus rhythm was calculated by Kaplan-Meier method, and the rate was significantly higher in quinidine trial group than in control group [ p=0.0001 ]. Univariate analysis was performed on the risk factors of reversion to atrial fibrillation, and the difference of maintenance rate between the two groups were corrected with this result: the difference was still statistically significant [ p=0.0205 ]. The quinidine levels were measured in postoperative days, and there were no difference of serum quinidine level between the quinidine success group and quinidine failure group. In conslusion, oral quinidine therapy was effective for the maintenance of sinus rhythm after mitral valve operation compared to control group, and there was no correlation between the serum quinidine level and clinical efficacy of quinidine therpy.

• Maxillofacial Plastic and Reconstructive Surgery
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• 제37권
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• pp.39.1-39.6
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• 2015

Skull-base osteomyelitis is a rare disease affecting the medulla of the temporal, sphenoid, and occipital bones. In general, it occurs due to external ear canal infections caused by malignant external otitis. Skull-base osteomyelitis usually affects elderly diabetic patients. The patient, a 58-year-old man, was referred for evaluation and management of the left jaw. Clinical examination of the patient revealed pain in the left jaw and mouth-opening deflection to the left. The maximum active mouth opening was measured to about 27 mm. Panoramic, CT, and CBCT revealed bone resorption patterns in the left condyle. Through control of diabetes, continued pharmacological treatment, arthrocentesis, and occlusal stabilization appliance therapy were carried out. The extent of active mouth opening was increased to 45 mm, and pain in the left jaw joint was alleviated. This was a case wherein complications caused by failure to control diabetes induced skull-base osteomyelitis. There is a need for continued discussion about the advantages and disadvantages of arthrocentesis with lavage for patients with skull-base osteomyelitis and other treatment options.

• Journal of Pharmaceutical Investigation
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• 제41권5호
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• pp.301-307
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• 2011

The aim of this study was to investigate the effects of kaempferol on the pharmacokinetics of nimodipine in rats. Nimodipine and kaempferol interact with cytochrome P450 (CYP) enzymes and P-glycoprotein (P-gp), and the increase in the use of health supplements may result in kaempferol being taken concomitantly with nimodipine as a combination therapy to treat orprevent cardiovascular disease. The effect of kaempferol on P-gp and CYP3A4 activity was evaluated and Pharmacokinetic parameters of nimodipine were determined in rats after an oral (12 mg/kg) and intravenous (3 mg/kg) administration of nimodipine to rats in the presence and absence of kaempferol (0.5, 2.5, and 10 mg/kg). Kaempferol inhibited CYP3A4 enzyme activity in a concentration-dependent manner with 50% inhibition concentration ($IC_{50}$) of $17.1{\mu}M$. In addition, kaempferol significantly enhanced the cellular accumulation of rhodamine-123 in MCF-7/ADR cells overexpressing P-gp. Compared to the oral control group, the area under the plasma concentration-time curve ($AUC_{0-\infty}$) and the peak plasma concentration ($C_{max}$) of nimodipine significantly increased, respectively. Consequently, the absolute bioavailability of nimodipine in the presence of kaempferol (2.5 and 10 mg/kg) was 29.1-33.3%, which was significantly enhanced compared to the oral control group (22.3%). Moreover, the relative bioavailability of nimodipine was 1.30- to 1.49-fold greater than that of the control group. The pharmacokinetics of intravenous nimodipine was not affected by kaempferol in contrast to those of oral nimodipine. Kaempferol significantly enhanced the oral bioavailability of nimodipine, which might be mainly due to inhibition of the CYP3A4-mediated metabolism of nimodipine in the small intestine and /or in the liver and to inhibition of the P-gp efflux transporter in the small intestine by kaempferol. The increase in oral bioavailability of nimodipine in the presence of kaempferol should be taken into consideration of potential drug interactions between nimodipine and kaempferol.

• Journal of Periodontal and Implant Science
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• 제49권4호
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• pp.206-214
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• 2019

Purpose: The purpose of this study was to examine the association between the intake of semi-solid yogurt and periodontitis in Korean adults using a national database. Methods: The data analyzed in this study are a subset of the sixth Korean National Health and Nutrition Examination Survey conducted in 2015 by the Korea Centers for Disease Control and Prevention. The sample size for this study was 4,727. We collected data on sociodemographic characteristics, oral health-related variables, oral and general health status, and intake of semi-solid yogurt. Semi-solid yogurt intake (YI) was calculated by multiplying the frequency of YI over the previous week by the average intake per serving. We assessed periodontal conditions using the Community Periodontal Index (CPI) and defined periodontitis as a CPI score ${\geq}3$. Multivariate logistic regression analyses were performed after adjusting for sociodemographic variables, and oral and general health behaviors and status. Results: The mean weekly YI among those without periodontitis ($1.03{\pm}0.06cups$) was significantly higher than among those with periodontitis ($0.77{\pm}0.08cups$) (P<0.001). Individuals who consumed more than 2 cups of yogurt per day were 76% less likely to have periodontitis than those who consumed less than 1 cup of yogurt per week after adjusting for all covariates (odds ratio, 0.24; 95% confidence interval, 0.10-0.60). Conclusions: We found a significant association between increased intake of semi-solid yogurt and periodontal health. We therefore recommend daily consumption of semi-solid yogurt as a probiotic to improve periodontal health. Further longitudinal studies are required to elucidate plausible mechanisms through which probiotics impact periodontal disease, considering both periodontal pathogens and clinical periodontal parameters.

• 한국콘텐츠학회논문지
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• 제20권12호
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• pp.454-459
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• 2020

구강질환의 주된 원인은 치면세균막 형성이며, 억제하는 방법의 하나로 화학제재로 된 구강세정제를 사용한다. 하지만 화학제재는 부작용이 발생할 염려가 있어 본 연구에서 천연물질인 대나무 추출물의 구강미생물에 대한 항균효과를 검증하고자 하였다. 대상자는 대구에 소재한 대학교 학생으로 대조군, 실험군 각 15명씩을 선정 후 대조군은 증류수 양치액, 실험군은 대나무 추출물의 사용 전, 후의 구강병원성 미생물의 변화를 비교하였다. 수집된 자료는 SPSS Windows ver. 20.0을 이용하여 분석하고, 통계적 유의수준은 p<0.05로 하였다. 그룹간의 양치액 사용 후 병원성 미생물의 변화차이를 알아보기 위해 Mann-Whitney test를 실시하였으며, 총 병원미생물수가 실험군은 -1.27±1.26, 대조군이 0.26±1.21로 높은 것으로 나타났고 이는 통계적으로 유의한 것으로 나타나 결과적으로 부작용이 적으면서 우수한 구강양치액의 개발에 기초자료를 제공할 것으로 기대된다.

• 대한통합의학회지
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• 제12권2호
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• pp.25-32
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• 2024

Purpose: This study utilizes big data from the 8th (2021) National Health and Nutrition Examination Survey to determine first, the relationship between chewing discomfort in the elderly and some systemic diseases and second, whether oral diseases and oral health problems are related to systemic diseases. Since this may have an impact, we aim to provide basic data to facilitate the expansion and emphasize the importance of integrated health management education. Methods: Original data from the 8th (2021) National Health and Nutrition Survey, conducted by the Korea Centers for Disease Control and Prevention, were analyzed using SPSS Version 21.0 (IBM). A complex sample frequency analysis was conducted to confirm the general and health-related characteristics of the study subjects, and a complex sample cross-analysis was conducted to determine chewing discomfort according to both general and health-related characteristics. Complex sample multiple logistic regression analysis was conducted to determine the effect on chewing discomfort. Results: In order to analyze the factors that affect chewing discomfort, the general characteristics that showed significant differences in chewing discomfort were adjusted for age, personal income, education level, basic livelihood security, high blood pressure, subjective health status, and subjective oral health. It was found that the condition had a statistically significant effect on chewing discomfort. Conclusion: The findings of this study demonstrate that high blood pressure, subjective health status, and subjective oral health status affect chewing discomfort; hence, measures such as developing and operating programs to improve national oral health are needed. We hope that our study will be used as basic data for research into chewing discomfort and systemic diseases in the elderly.