• Journal of Acupuncture Research
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• v.19 no.2
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• pp.39-50
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• 2002

Objective : The aim of this study was to investigate the effect of CMM oral administration and herbal acupuncture at BL13 LU4 on Asthma induced by ovalbumin in rats Methods : Several experimental items were measured and compared each other ; that is body weight change, oxygen consumption rate, Albumin change, white blood corpuscle change, Erythrocyte change, IgE change. Results : 1. Body weight was significantly increased in herbal acupuncture group after its administration while there was no such a response in oral administration group. 2. Oxygen Consumption rate was significantly increased in oral administration group and herbal acupuncture group. 3. Albumin in serum was significantly increased in oral administration group after its administration while there was no such a response in herbal acupuncture group. 4. White blood corpuscle in blood was significantly increased in oral administration group after its administration while there was no such a response in herbal acupuncture group. 5. Erythrocyte in blood was significantly increased in oral administration group after its administration while there was no such a response in herbal acupuncture group. 6. IgE in blood was decreased in oral administration group and herbal acupuncture group but there was no significance in oral administration group and herbal acupuncture group. Conclusion : Based on the above results it is assumed that CMM oral administration and CMM herbal acupuncture can help the treatment of Asthma induced by ovalbumin in rats.

• Korean Journal of Acupuncture
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• v.24 no.4
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• pp.151-162
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• 2007

Objectives : The purpose of this study was to examine the anti-allergic effect in vivo, and to observe single toxicity in mice of Armeniacae Semen herbal acupuncture solution (ASHA). Methods : We investigated anti DNP IgE-mediated passive cutaneous anaphylaxis in rodents and compound 48/80-induced active systemic anaphylatic shock in mice after treatment at both BL13 with ASHA of 25 ${\mu}{\ell}$(mice) or 50 ${\mu}{\ell}$(rats) 3 times for 5 days. To ascertain safety and toxicity of ASHA, we examined single toxicity test. In single test, three groups were treated with different dosages of ASHA (ASHA250, ASHA500 and ASHA1000) according to on Korean Food and Drug Administration, respectively. We observed attentively motality, abnormal clinical sign, body weight change, and organ weight of mice after ASHA treatment. Results : ASHA inhibited passive cutaneous anaphylaxis and active systemic anaphylatic shock by oral administration. During toxicity experiment period, there was no difference in body weight change, and organ weight among different dose groups. Death were not found in single test i.p. group. (ASHA250, ASHA500 and ASHA1000). Several individuals of single test i.p. group were observed yellow brown discharge around anus in early period after administration. Conclusions : These results indicate that ASHA have inhibition effects on passive cutaneous anaphylaxis and active systemic anaphylatic shock, and suggest that has some toxicity in high dosage.