• Journal of Sensor Science and Technology
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• v.21 no.1
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• pp.68-74
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• 2012

In this paper, Frequency Domain Mode Locked(FDML) wavelength swept laser with 55.027 kHz sweeping speed and 125 nm sweeping range has realized, and also a new method for recalibrating a nonlinear frequency sweeping of a swept laser has proposed. The Swept Source-Optical Coherence Tomography system using the proposed method has performed. For a mirror surface, the system showed the very clean 2-dimensional image and the advanced image speed of 7 frames per sec compared to the previous recalibration method.

• Journal of the Optical Society of Korea
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• v.18 no.1
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• pp.55-59
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• 2014

Sarcopenia, or reduced muscle mass and volume, is due to various factors such as senile change, neuronal degeneration, drug, malignancy, and sepsis. Sarcopenia with the aging process has been evidenced by the decline in muscle mass by 0.5 to 1% per year with 3-5% reduction in muscle strength for 10 years between the ages of 40 and 50, and a 1-2% of decline of mass every year in people aged 60-70. Therefore, early diagnosis and understanding the mechanism of sarcopenia are crucial in the prevention of muscle loss. However, it is still difficult to image changes of muscle microstructure due to a lack of techniques. In this study, we developed an animal model using denervated rats to induce a rapid atrophy in the tibialis anterior (TA) and imaged its structural changes using optical coherence tomography (OCT) along with histologic and ultrasound analyses. Ultrasound showed changes of overall muscle size. Histology revealed that the atrophic TA muscle displayed an increased size variability of muscle fiber and inflammatory changes. Three dimensional OCT imaged the changes of perimysial grid and muscle fiber structure in real time without sacrifice. These observed advantages of multimodal imaging using OCT and ultrasound would provide clinical benefits in the diagnosis of sarcopenia.

• Journal of the Optical Society of Korea
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• v.11 no.1
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• pp.18-25
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• 2007

We present an ultrahigh-resolution full-field optical coherence tomography (FF-OCT) implemented with a white-light interference microscope and a detector array as an alternative OCT technique. The use of detector array allows the capture of two-dimensional en-face images in parallel without taking any lateral scanning process. The phase shifting interferometric technique with the sinusoidal phase modulation (SPM) is utilized to get the demodulated OCT images. The configuration of the system and the resolution of the obtained image are presented. The topographic images, taken with the implemented system, of a coin, an integrated circuit chip, and the tomographic images of an onion epithelium are demonstrated also. Axial and lateral spatial resolution of ${\sim}1.0{\mu}m$ and ${\sim}2.0{\mu}m$ are achieved with the system respectively.

• The Journal of Korean Institute of Electromagnetic Engineering and Science
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• v.30 no.1
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• pp.23-27
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• 2019

In this paper, we propose a micro vibro tomography(MVT) method, that can be used to visualize two-dimensional cross-sectional images and micro-vibration tomographic images in real time in a non-contact and non-destructive manner. The proposed method is based on the optical coherence tomography(OCT) technique, with an additionally customized image processing algorithm. The proposed method can detect the micro-motions or vibrations in sample structures by measuring the phase shift variations in the sample structures. In this study, we show the potential capabilities of the proposed MVT system for measuring the micro-vibrations generated when sound waves in a frequency range of 2~5 kHz are applied to an $80-{\mu}m$ thick latex phantom, which mimics the changes in physical structure of the human tympanic membrane while hearing. Additionally, three-dimensional volumetric images of the MVT method were recorded to observe the surface morphological changes in the surface of the phantom sample which mimics the human tympanic membrane while hearing.

• Proceedings of the KIEE Conference
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• 2002.07d
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• pp.2707-2709
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• 2002

In this paper, we suggest new optical eye-diagnosis medical equipment. First, we simulate light propagation in bio-tissue using MC method. Second, we propose the OCT design parameter using Michelson interferometer.

• Proceedings of the Optical Society of Korea Conference
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• 2009.02a
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• pp.171-172
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• 2009

• Journal of the Korean Society for Nondestructive Testing
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• v.31 no.5
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• pp.466-471
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• 2011

Optical coherence tomography(OCT) is an emerging medical diagnostic tool that draws great attention in medical and biological fields. It has a 10-100 times higher spatial resolution than that of the clinical ultrasound but lower imaging depth such as 1-2 mm. In order to image internal organs, OCT needs an endoscopic probe. In this paper, the principle of Fourier-domain optical coherence tomography with high-speed imaging capability was introduced. An OCT endoscope based on MEMS technology was developed. It was attached to the Fourier-domain OCT system to acquire three-dimensional tomographic images of gastrointestinal tract of New Zealand white rabbit. The endoscope had a two-axis scanning mirror that was driven by electrostatic force. The mirror stirred an incident light to sweep two-dimensional plane by scanning. The outer diameter of the endoscope was 6 mm and the mirror diameter was 1.2 mm. A three-dimensional image rendered by 200 two-dimensional tomographs with $200{\times}500$ pixels was displayed within 3.5 seconds. The spatial resolution of the OCT system was 8 ${\mu}m$ in air.

• Proceedings of the Korea Information Processing Society Conference
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• 2022.11a
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• pp.541-543
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• 2022

In recent years, retinal disorders have become a serious health concern. Retinal disorders develop slowly and without obvious signs. To avoid vision deterioration, early detection and treatment are critical. Optical coherence tomography (OCT) is a non-invasive and non-contact medical imaging technique used to acquire informative and high-resolution image of retinal area and underlying layers. Disease signs are difficult to detect because OCT images have many areas which are not related to any disease. In this paper, we present a deep learning-based method to perform multi-label classification on a long-tailed OCT dataset. Our method first extracts the region of interest and then performs the classification task. We achieve 98% accuracy, 92% sensitivity, and 99% specificity on our private OCT dataset. Using the heatmap generated from trained convolutional neural network, our method is more robust and explainable than previous approaches because it focuses on areas that contain disease signs.

• Proceedings of the Optical Society of Korea Conference
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• 2009.02a
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• pp.169-170
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• 2009

We present a quantification protocol to get the alignment factors of a custom-made spectrometer and the nonlinear fitting function between the measured CCD pixel domain and the wavelength domain to apply the spectral-domain optical coherence tomography using fiber Bragg gratings. We have used 4 different center wavelength gratings with a narrow spectral bandwidth (<0.05 nm) and the same reflectivity (>92 %) to calibrate and align the custom-made spectrometer.

• Journal of Veterinary Science
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• v.24 no.4
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• pp.34.1-34.12
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• 2023

Background: There has not been a thoroughly reported study of the comparison between spectral domain-optical coherence tomography (SD-OCT) with both ultrasound biomicroscopy (UBM) and gonioscopy on the evaluation of the iridocorneal angle (ICA) in dogs. Objectives: To investigate the diagnostic value of SD-OCT for the early detection of narrowing ICA by comparing and assessing inter-device agreement in anterior chamber angle (ACA) measurements obtained by SD-OCT and UBM, and ICA evaluations by gonioscopy. Methods: A total of 28 eyes from 28 client-owned dogs with normal intraocular pressure were included for examination. The ACA and angle opening distance (AOD) were measured from the SD-OCT and UBM images, and gonioscopy images were analyzed using the ICA grade and ZibWest angle index. Results: The mean ACA and AOD for SD-OCT were 28.31° ± 5.37° and 658.42 ± 219.90 ㎛, and for UBM, 28.34° ± 5.82° and 859.29 ± 221.80 ㎛, respectively. The mean difference in ACA between the average values of SD-OCT and UBM measurements was 0.03° with a 95% limit of agreement (LoA) span of 16.2°, indicating positive agreement; that in AOD was 200.85 ㎛ with a 95% LoA span of 1,110.95 ㎛, indicating poor agreement. The Pearson correlation coefficient of the ACA of SD-OCT and ZibWest indices of gonioscopy was 0.624, indicating strong agreement; that of UBM and gonioscopy was 0.43, indicating moderate agreement. Conclusions: SD-OCT is well tolerated by canine patients due to its non-contact method and might be an alternative option for early screening of ICA narrowing in clinical settings.