• Journal of Korean Ophthalmic Optics Society
• /
• v.19 no.1
• /
• pp.51-57
• /
• 2014

Purpose: The present study was conducted to establish the experimental condition for the proper evaluation of protein removal efficacy when developing protein removal agents. Its protein removal efficacy was further analyzed and compared with the result from protein removal efficacy against protein deposition on contact lens to suggest the evaluation method for efficacy of protein removal agents. Methods: Protein digestibility assay presented in the Korean pharmacopoeia was selected to establish the evaluation method for efficacy of papain, pancreatin, subtilisin A and protease itself as a ingredient and protein removal tablets or solution containing those enzymes and find a suitable test conditions. Furthermore, the cleaning efficacy of commercially available protein removal tablets and solution on balafilcon A lens deposited with protein artificially was measured and the correlation between two evaluation methods was further analyzed. Results: When pancreatin itself and the product containing pancreatin was evaluated by protein digestibility assay, both reached 28 IU/mg, the standard value of protein digestibility suggested by the Korean pharmacopoeia. In case of protease and subtilisin A tested with trichloroacetic acid B solution, both of them met the enzyme activity level proposed by the manufacturers when they were evaluated by protein digestibility assay however, papain and subtilisin A tested with trichloroacetic acid A solution were not reached the enzyme activity level. Among protein removal agents, three products except a product containing pancreatin did not meet the enzyme activity value specified by the manufacturer when they were evaluated by protein digestibility assay. However, actual protein removal efficacy of three products except a papain-containing product on the lens was greater than 90% protein removal. In the case of papain-containing protein removal product, its effect was not measured by protein digestibility assay however, its actual protein removal efficacy on the lens reached 73.72%. Conclusions: From the results, it was confirmed that the efficacy of protein removal agents for contact lens should be evaluated by different method according to the type of proteolytic enzyme contained. That is, the protein removal agents containing pancreatin, protease and subtilisin A can be evaluated by protein digestibility assay and protein removal efficiency evaluation and the products containing papain can be effectively evaluated by only the evaluation method for protein removal efficiency employing the lens.

• Journal of Korean Ophthalmic Optics Society
• /
• v.13 no.2
• /
• pp.1-7
• /
• 2008

Purpose: This study was performed to evaluate the changes of lens morphology and tear stability during wearing soft contact lenses (SCLs) which were kept in drying condition like dry eye or became to be dried due to heedless care. Method: SCLs having different water content, thickness or material were rehydrated after being dehydrated artificially 2 or 4 times, and estimated their diameter and radius. Furthermore, the changes of tear film break-up time (TBUT) during SCL wearing were also measured. Result: Due to the dryness, the diameter of both 70% water content SCL and 59% water content SCL decreased, but the decrement was larger in 59% water content SCL. The more 59% water content SCL was dehydrated, the more its radius changed. However, the radius of 70% water content SCL did not change by 2 times dehydration and increased greatly by 4 times dehydration. The reduction of diameter of -1.00 D SCL was greater than that of -9.00 D SCL. Moreover, the radius of -1.00 D SCL increased depending on the frequency of dehydration but that of -9.00 D SCL did not changed. The diameter and radius changes of lotrafilcon B, silicone hydrogel lens, were less than those of hilafilcon B, copolymer of HEMA and N-vinyl pyrrolidone. TBUT during wearing SCLs decreased by wearing dehydrated SCLs. Conclusion: The diameter and radius of dehydrated SCLs as well as TBUT during wearing them were changed in spite of rehydration, which would be the important cause of uncomfortable feeling when people wore dehydrated SCL. The changes of SCL morphology and TBUT differed according to the water content, lens thickness and material.

• Journal of Korean Ophthalmic Optics Society
• /
• v.8 no.2
• /
• pp.13-18
• /
• 2003

We did the comparison research about three different methods of measuring horizontal phoria and vertical phoria which are Von Graefe test, Maddox Rod test and polarizing lens test. The inspection was don with the subjective method of refraction about normal 63 subjects aged from 20 to 28 years old. The analysis of date resulted in as follows : 1. Using Von Graefe Horizontal phoria Measurement, they were measured 5% for orthpharia, 51% for exophoria and 44% for esophoria. 2. Using Von Graefe vertical phoria Measurement, they were measured 68% for orthphoria, 20% for left hypophoria against the right and 12% for left hyperphoria against the right. 3. Using Maddox Rod Horizontal phoria Measurement, they were measured 7% for orthphoria, 49% for exophoria and 44% for esophoria. 4. Using Maddox Rod vertical phoria Measurement, they were measured 70% for orthphoria, 19% for left hypophoria against the right and 11% for left hyperphoria against the right. 5. Using Polarizing Horizontal phoria Measurement, they were measured 10% for orthphoria, 49% for exophoria and 41% for esophoria. 6. Using Polarizing vertical phoria Measurement, they were measured 92% for orthpharia, 5% for left hypophoria against the right and 3% for left hyperphoria against the right.

• Journal of the Korea Academia-Industrial cooperation Society
• /
• v.10 no.7
• /
• pp.1635-1641
• /
• 2009

In this study, we have prepared plastic lenses with both photochromic and hard properties by hard coating, and evaluated their optical properties and surface characteristics. Photochromic effects could be observed on the UV spectra of the closed forms and the visible spectra of the open forms. Visible light transmittance of photochromic lenses was from 83.44% for graphite(GP) to 85.15% for blue(BL) in colourless state and from 71.10% for red(RE) to 79.98% for yellow(YE) in colour state. Red photochromic lens was higher in optical density(${\Delta}$OD) and color difference(${\Delta}$$E^{\ast}_\;{ab}$) than the others. Photochromic lenses applied by hard coating showed good adhesion, hot water resistance, chemical resistance and surface appearance. Also, compared to the uncoated lens, hardness and abrasion resistance were increased. Consequently, this coating system could impart functional properties such as photochromic and hard coating property onto ophthalmic lenses.

• Journal of Korean Ophthalmic Optics Society
• /
• v.19 no.3
• /
• pp.305-313
• /
• 2014

Purpose: A correlation between the rotating direction and rotation amount according to the eccentricity was analyzed in the present study when fitting the toric soft contact lens. Methods: One hundred fourteen eyes of with-the-rule astigmatism in 20s and 30s were appropriately applied toric soft contact lens by the guideline of manufacturer and fitting evaluations and analyzed the rotating direction and rotation amount when fixating at primary position and 8 different directions of gaze. The speed of reorientation and the correlation between the rotation amount and cornea eccentricity were also analyzed when rotating $45^{\circ}$ each toward the temporal and nasal direction. Results: The cornea eccentricity and rotation amount was shown positive correlation. For the gaze of direction, it was identified that the gaze of directions other than the gaze of direction towards the nasal and temporal had correlation, and among them, the gaze of directions to superior and the superior-temporal showed the tendency of decreasing rotation amount as the cornea eccentricity increased. On the contrary, the gaze of direction towards the inferior, inferior-temporal, superior-nasal, and inferior-nasal showed tendency of increasing rotation amount as the cornea eccentricity increased thus, it was identified that the cornea eccentricity showed different correlation according to the gaze of direction. For the case of re-orientational speed, the speed of lens reorientation in the group having the smallest corneal eccentricity was fastest in both direction but was not significantly different. Conclusions: Considering cornea eccentricity to current method of prescribing toric soft contact lens which is based on total astigmatism, it will be helpful to establish the optimal axis stabilization.

• Journal of Korean Ophthalmic Optics Society
• /
• v.20 no.2
• /
• pp.237-246
• /
• 2015

Purpose: The present study was conducted to reveal the correlation of structural denaturation and decrease of enzyme activity when the antioxidative enzymes, superoxide dismutase (SOD) and catalase (CAT) were repeatedly exposed to UV-B, and further investigate whether the denaturation and inactivation of those enzymes can be effectively blocked by using UV-inhibitory RGP lens. Methods: Each enzyme solution was prepared from the standardized SOD and CAT, and repeatedly exposed to UV-B of 312 nm for 30 minutes, 1 hour and 2 hours a day over 1, 2, 3, 4 and 5 days. Structural denaturation of SOD and CAT induced by repeat UV-B irradiation was confirmed by the electrophoretic analysis, and their enzyme activity was determined by the colorimetric assay using the proper assay kit. At that time, the change in structure and activity of the antioxidant enzymes directly exposed to UV-B was compared to the case that UV-B was blocked by UV-inhibitory RGP lens. Results: SOD exposed repeatedly to UV-B showed the polymerization pattern in the electrophoretic analysis when it repeatedly exposed for 30 min a day, however, the change of its activity was less than 10%. On the other hand, CAT repeatedly exposed to UV-B reduced size and density of the electrophoretic band which indicated a structure denaturation, and its activity was significantly decreased. In the case that the repeat exposure time was longer, CAT activity was completely lost even though some enzyme band occurred in the electrphoretic analysis. In addition, the degeneration of CAT due to UV-B irradiation was inhibited to some extent by using RGP lens with a UV-B blocking of 63.7%, however, it was not completely inhibited. Conclusions: From these results, it was revealed that the structural denaturation of antioxidative enzymes was not perfectly correlated with the reduction in enzyme activity according to the type of enzyme. It is recommended to minimize the exposure time to UV when wearing contact lens, or wear the contact lenses having UV blocking rate of the FDA Class I blocker or the sunglasses having equivalent UV-blocking rate for reducing the damage of antioxidative enzymes induced by UV.

• Journal of Korean Ophthalmic Optics Society
• /
• v.14 no.2
• /
• pp.31-34
• /
• 2009

Purpose: We are to analyze optically how to affect the eye related with movement of the iris. Methods: Using the schematic eye to have the crystalline lens of the radial GRIN and the spherical GRIN forms that come to be planned in existing, the iris centre was moved 0.5 mm with nasal direction in order to be identical with the real eye. Also, considering that the iris centre move according to increase of the pupil size, the iris centre was moved 0.4 mm with temporal direction to analyze the optical performance change of the eye respectively. Results: Because of decrease in the spherical aberration, the schematic eye with nasal direction 0.5 mm eccentricity of the iris showed a different consequence plentifully compared with the performance of the real eye. Besides, the schematic eye with temporal direction 0.4 mm eccentricity of the iris showed that the spherical aberration somewhat increased. Conclusions: In case of design of the schematic eye with the similar real eye performance which the iris centre was moved 0.5 mm with nasal direction, we need to research about aspheric coefficient of optical constants of each refracting surface considering the performance change of a spherical aberration, a peripheral power error and astigmatism etc, owing to change of the real eye hence to be affected by the iris movement.

• Journal of Korean Ophthalmic Optics Society
• /
• v.15 no.3
• /
• pp.213-217
• /
• 2010

Purpose: To emphasize the necessity of post-fitting by follow-up test, the mis-alignment was analyzed after initial wearing of toric soft contact lenses (TSCL). Methods: After trial contact lenses were worn to 87 eyes with myopic astigmatism for 1 week, we observed the alignment of axis mark on trial contact lenses using slit lamp and corrected the rotated axis by method of LARS. After final fitting, rotation ratio, rotation degree and rotation position were analyzed compared to initial prescription divided to amount of cylinderical and spherical powers. Results: Rotation ratio of TSCL's axis was increased as increment of both cylinderical powers and (-)spherical powers. An average of rotation degree was $10^{\circ}{\sim}13^{\circ}$ which was not related to amount of their powers. Rotation position of TSCL's axis was more to temporal than to nasal. Conclusions: Because mis-alignment of axis after TSCL wearing induce the poor sight, adjustment of axial alignment as a result of follow-up must be performed.

• Journal of Korean Ophthalmic Optics Society
• /
• v.15 no.2
• /
• pp.151-154
• /
• 2010

Purpose: We investigated how the movement of iris and visual axis affects the finite schematic eye Methods: Using the schematic eye with the crystalline lens in the existing forms of the radial GRIN and the spherical GRIN, the iris centre was moved 0.5 mm in nasal direction and visual axis was tilted $5^{\circ}$ in same direction, with the additional degree of 2.5 down to locate the focal point in fovea. This study analyzed performance change of the optical system, designing it same as the real eye. Results: The whole aberration distribution showed a considerable difference in performance in comparison with the real eye; the biggest difference shown at the central field of optical system. The spherical aberration showed the biggest difference, and a peripheral power error and field curvature leaned toward (+) direction in aberration distribution. Conclusions: When designing the schematic eye with the performance similar with that of the real eye by taking into consideration the iris centre and visual axis, the aberration at the center field of optical system in particular should be corrected. Spherical aberration which showed the biggest difference should be corrected in the first place. In addition, a peripheral power error and field curvature that leaned toward (+) direction should be moved toward (-) direction.

• Journal of Korean Ophthalmic Optics Society
• /
• v.14 no.1
• /
• pp.47-56
• /
• 2009

Purpose: To find optimized luminosity factor of color from light transmission filter. Methods: To make $Y_{1-x}G_{x}$, $Y_{1-x}P_{x}$ by using CR-39 compound within dipping method, mixing up Y(Yellow), G(green) and P(pink) for optimize eye sensitivity. Modeling for relative luminous efficiency(relative sensitivity) curves in Luminose transmission, it could be resolved by Multiplying sensitivity of eye within transmission rate of Lens ($P_f({\lambda}=T({\lambda}){\cdot}P({\lambda}).)$.). To evaluate Wavelength between 400~700 nm, relative luminous efficiency curve in Area and Height value is being used. Results: In color filter of $Y_{1-x}G_{x}$ position of x equals to 0.04, 0.1, 0.08, 0.12, 0.14, 0.5 at ${\beta}=S_1/S_0{\cdot}100$ each consist value of 76.1, 77.9, 80.7, 81.6, 80.2, 18.6 In color filter of $Y_{1-x}P_{x}$ position of x equals to 1.00, 0.2, 0.6, 0.8 at ${\beta}=S_1/S_0{\cdot}100$ each consist value of 74.3, 74.0, 70.5, 33.0 The result from experiment $Y_{1-x}P_{x}$ value less than $Y_{1-x}G_{x}$, from evaluating luminous efficiency curve and test was successfully optimized. Conclusions: Optimized relative luminous efficiency curve result have value of X=0.12-0.14 at $Y_{1-x}G_{x}$.