• Korean Journal of Community Nutrition
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• v.5 no.4
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• pp.608-614
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• 2000

The purpose of this study was to evaluate the relative importance among various biological and environmental factors on refractive errors. Various factors such as diseases, health related behavior such as drinking, smoking and exercise, as well as dietary factors were considered as a possible determinant. Surveys of 492 residents over 20 years of age in Kuri city were conducted during 1998. The survey included a refractive error test adopting a autokerato-refractometer, dietary survey using a 24 hour recall method, disease survey including blood and other diagnosis tests, and a health behavior survey using questionnaires with variables of smoking, drinking, and exercise. A stepwise logistic regression analysis was adopted to analyse the relative importance among independent variables of health behaviors, disease, and dietary factors on ametropias. As a result, in the case of myopia, liver dysfunction appeared to be the most important factors followed by the health related behavior of smoking and exercise as the second most important factors. Nutrient factors such as carotene and protein appeared to be the third most important factors. Similar results had been shown in the case of the hyperopia. In summary, liver dysfunction and the health related behaviors of drinking and smoking appeared to be more influential factors on abnormal eye sight of myopia and hyperopia than dietary factors.

• Journal of Korean Ophthalmic Optics Society
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• v.19 no.2
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• pp.231-237
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• 2014

Purpose: This study is research of the conditions which causes difference between the refractive power of the measurement of autorefractometer and the prescription using phoropter. Methods: Autorefractometer (SR-7000) and phoroptor (AV-9000) were used to measure 60 eyes of 30 participants who had no eye diseases and wore the corrective lens due to Ametropia. To prevent the dependence of the prescription value of the refractive power on the testers, two testers measured the refractive power of the eyes of the participants at the same measuring conditions. Results: Statistically, the prescribed values of the refractive power by two testers were not significantly different. Most of the prescribed values of the refractive power were smaller than the refractive power by autorefractometer In case of myopic eyes, the difference between refractive powers by the measurement of autorefractometer and the prescription using phoropter showed the trend of increase as the spherical refractive power became larger. The result was analyzed by the range of the different cylindrical refractive power for the myopic astigmatic eyes. In this case, the difference between refractive powers showed the trend of decrease as the cylindrical refractive power became larger. Conclusions: No difference between the prescribed value by two testers was observed. In case of myopic or myopic astigmatic eyes, the difference between refractive powers by autorefractometer and the prescription were measured to be approximately proportional to the refractive powers of ametropic eyes. As the this difference become larger for the participant who needs the lens of larger refractive power, additional caution is needed in the prescription of the refractive power of the corrective lens.

• Journal of Korean Ophthalmic Optics Society
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• v.15 no.1
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• pp.79-85
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• 2010

Purpose: We studied the relationship between subjective and objective deviating angle. Methods: Those who were diagnosed with strabismus among the patients who had no systemic diseases that fifty-one subjects (Male; 21, Female; 30) were measured between seven to sixty three years, evaluated to alternate cover test after AR/K (Canon RK-FI, Japan) and retinoscope measured refractive errors. Objective deviating angle was measured using prism bar; and subjective and objective deviating angles were measured and compared using the synoptophore. Results: For the correlation between subjective and objective deviating angles. The differences were $2.6{\pm}2.5{\Delta}$, between subjective deviating angle measured using synoptophore and objective deviating angles measured using synoptophore were $0.7{\pm}1.4{\Delta}$, the average with each other were $1.7{\pm}1.8{\Delta}$, with all the differences highly significant. Conclusions: We thought not only reduced angle of deviating errors and identified the significance in the correlation between subjective and objective deviating angles but also considered to be useful in determining deviating angle of patient with strabismus.

• Journal of Korean Ophthalmic Optics Society
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• v.20 no.4
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• pp.477-484
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• 2015

Purpose: This study was investigated to evaluate the effect of the variation of the face form angle(FFA) of spectacle frame on the visual acuity and the visual function. Methods: The visual acuity, the contrast sensitivity, the stereopsis, and the phoria were measured with the spectacle frame whose the FFA is at $5^{\circ}$ and $25^{\circ}$ and the surveys were conducted on subjective symptoms. Here, 30 adults (14 men and 16 women, average age:$25.46{\pm}3.9$), who did not have ocular diseases and were fully corrected in case of having had refractive error, were to act as experimental subjects for this measurement. Results: The visual acuity and the contrast sensitivity was decreased and the phoria was tended to increase to the esophoria direction at the FFA $25^{\circ}$ than at the FFA $5^{\circ}$. The stereopsis was significantly reduced at the FFA $25^{\circ}$ than at the FFA $5^{\circ}$. Also when the FFA was larger, the higher the degree of refractive error was, the more the increase of the subjective symptoms such as being blurred characters, being disturbed head, and having sore eyes was, which reveals a statistically significant correlation between them. Conclusions: If the FFA increases, the visual acuity, the contrast sensitivity and the stereopsis was found to decrease and the phoria to increase to the esophoria direction. Therefore it shows that the variation of the FFA of spectacle frame can influence the visual acuity and the visual function.

• Journal of Korean Ophthalmic Optics Society
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• v.17 no.4
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• pp.403-410
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• 2012

Purpose: The purposes of this study are to investigate accommodative response among emmetropes, spectacle wearer and contact lens wearer, and correlation between refractive error and accommodative respons for each group. Methods: The 72 subjects(144 eyes) who do not have any ocular diseases were participate in this study. Subjects were categorized into emmetropes, spectacle wearer and contact lens wearer by refractive error using closed-field auto-refractometer. We measured dominant eye, naked/habitual visual acuity and refractive error of monocular/binocular vision of refractive error for far/near distance with open-field auto-refractometer and calculated accommodative lag. Results: There were no significant difference of accommodative lag between right and left eye dominant and non-dominant eye, monocular and binocular vision, and spectacle lens wearer and contact lens wearer, However the accommodative lag of binocular vision was severe than monocular vision at near. The lag of myopia was larger than emmetropes, and male was larger than female. Significant correlation was found between refractive error and accommodative lag in total subjects and the same result was found in emmetropes and contact lens wearer. However there were no significant correlation in the spectacle wearer. Conclusions: There were significant difference between emmetrops and myopes in terms of accommodative lag, however accommodative lag of spectacle wearer was not different with contact lens wearer in myopes. There were also significant correlation between refractive error and accommodative lag in emmetropes and contact lens wearer, but the accommodative lag of spectacle wearer was not significantly correlated with refractive error.

• Journal of Korean Ophthalmic Optics Society
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• v.14 no.3
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• pp.65-73
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• 2009

Purpose: This study was conducted to investigate the changes in distance refractive power and reading addition that occur after wearing corrective glasses for prebyopia. Methods: The subjects aged 42 to 75 years who had no ophthalmologic diseases and did not undergo cataract or retina surgery, had a corrected visual acuity of 20/20 and did not have a previous history of wearing corrective glasses for presbyopia. These subjects were divided into 3 groups: the control, reading spectacles and multifocals wearing group and they were measured for distance refractive power and reading addition at their visit. The maximum follow-up period was 73 months. Results: As for distance refractive power, the power tends to shift to hyperopia depending on age (r=0.486, p<.001) and 50.0% of the subjects increased plus power during this study period. Plus power Increments per year in distance refractive power in the reading spectacle wearing group were significantly different with control and multifocals wearing group (p<.05). On the other hand, the multifocals wearing group's increments were not different with control. Increments in reading addition were also increased in the reading spectacles group than in the control and multifocals wearing groups (p<.05). Conclusions: The age related hyperopic shift could be occurred in the elderly people, routine refraction is mandatory. And reading spectacles could induce an age related hyperopic shift and the additional need for reading addition that the prescription of multifocals may reduce changes in distance refractive power and reading addition.

• Journal of Korean Ophthalmic Optics Society
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• v.13 no.4
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• pp.51-58
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• 2008

Purpose: This study was assessed to investigate adverse effect induced by overuse of disposable soft contact lenses (CL). Methods: Three disposable lenses (etafilcon A, hilabilcon A, and nelfilcon A) were applied to 19 normal subjects free from any eye diseases for either a single day or variable periods by when subjects complained any discomforts. On the first and last days, localizations of lens' center on corneal surface and blink rates were recorded at every case. Results: Among CL wearers, 10.5% and 47.4% of total subjects quit wearing on the second day and third day, respectively. The case of stopping disposable lens wear was continuously increased with extended hour of lens application. On fourth day, 70.2% of CL wearers reported severe discomforts such as redness, dryness, irritation, pain and blurred vision. When subjects stopped CL wear, decentration of lens from the center of cornea was observed when it compared to the case of single usage of disposable CL. Also about 80% of total subjects showed increased blink rate when CL were worn for more than 2 days. These changes in lens centration and blink rate were consistantly shown regardless of lens types. Conclusions: Blurred vision and acute/chronic discomforts could occur to CL wearers by decentration of lens and increased blink rate when CL were overused more than 2 days even the numbers of two parameters measured in this study were variable by each subject or lens types. Therefore, consideration of individual characteristics and lens types is critical to prevent adverse effects may induced by overusage of disposable lens.

• Journal of Genetic Medicine
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• v.18 no.2
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• pp.142-146
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• 2021

Alagille syndrome (AGS) is a rare autosomal dominant inherited disorder, with major clinical manifestations of bile duct paucity, cholestasis, cardiovascular anomaly, ophthalmic abnormalities, butterfly vertebrae, and dysmorphic facial appearance. It is caused by heterozygous mutations in JAG1 or NOTCH of the Notch signaling pathway presenting with variable phenotypic penetrance and involving multiple organ systems. The following case report describes a unique case of a 16-year-old female with AGS who presented with the primary complaint of renovascular hypertension. She had a medical history of ventricular septal defect and polycystic ovary syndrome. The patient had a dysmorphic facial appearance including frontal bossing, bulbous tip of the nose, a pointed chin with prognathism, and deeply set eyes with mild hypertelorism. Stenoocclusive changes of both renal arteries, celiac artery, lower part of the abdominal aorta, and left intracranial artery, along with absence of the left internal carotid artery were found on examination. Whole exome sequencing was performed and revealed a pathologic mutation of JAG1, leading to the diagnosis of AGS. Reverse phenotyping detected butterfly vertebrae and normal structure and function of the liver and gallbladder. While the representative symptom of AGS in most scenarios is a hepatic problem, in this case, the presenting clinical features were the vascular anomalies. Clinical manifestations of AGS are diverse, and this case demonstrates that renovascular hypertension might be in some cases a presenting symptom of AGS.

• The Journal of Korean Medicine Ophthalmology and Otolaryngology and Dermatology
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• v.34 no.3
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• pp.13-26
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• 2021

Objectives : This study was planned to help clinical treatment by examining the efficacy and frequency of use of medicines with removing nebula and improving vision action, centering on historical literature. Methods : Chinese literature centered on CNKI published after 2000 and ophthalmic books of the Beijing University of Chinese Medicine Library, regardless of the publication period. Domestic literature was searched using NDSL and OASIS, and literature published after 2000 was referenced. Results : According to traditional medical classics, as medicine with removing nebula and improving vision action, medicine with dispelling wind and clearing heat action accounted for the majority. However, it is desirable to use these medicine in the early stages of the disease. Conclusions : 1. Among the external contacts that induce corneal opacity, the wind-heat pattern was the most common. Among the visceral manifestation patterns that induce corneal opacity, liver or spleen was the most common. Cold-tempered medicine which is dispelling wind, clearing heat and bottling up the liver were most commonly used as therapeutic medicine. 2. As removing nebula and improving vision medicine, Cassiae Semen, Chrysanthmi Flos, Eriocauli Flos, and Buddlejae Flos have been widely used. 3. It has been investigated that removing nebula and improving vision medicine can be effectively used in the early stages of various diseases that cause corneal opacity.

• The Korean Journal of Physiology and Pharmacology
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• v.28 no.1
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• pp.39-48
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• 2024

Wogonin, extracted from the roots of Scutellaria baicalensis Georgi, has been shown to suppress collagen deposition in spontaneously hypertensive rats (SHRs). This study was performed to investigate the role and mechanism of wogonin underlying vascular remodeling in SHRs. After injection of SHRs with 40 mg/kg of wogonin, blood pressure in rats was measured once a week. Masson's trichrome staining was conducted to observe the changes in aortas and mesenteric arteries. Vascular smooth muscle cells (VSMCs) isolated from rat thoracic aortas were treated with Angiotensin II (Ang II; 100 nM) in the presence or absence of varying concentrations of wogonin. The viability and proliferation of VSMCs were examined using Cell Counting Kit-8 assay and 5-ethynyl-2'-deoxyuridine assay, respectively. The migration of VSMCs was examined using wound healing assay and transwell assay. We found that wogonin administration alleviated hypertension, increased lumen diameter, and reduced the thickness of the arterial media in SHRs. Ang II treatment enhanced the viability of VSMCs, which was inhibited by wogonin in a concentration-dependent manner. Wogonin reversed Ang II-induced increases in the viability, proliferation, and migration of VSMCs. Moreover, wogonin inhibited Ang II-induced activation of mitogen-activated protein kinase (MAPK) signaling in VSMCs. Overall, wogonin repressed the proliferative and migratory capacity of VSMCs by regulating the MAPK signaling pathway, thereby attenuating vascular remodeling in hypertensive rats, indicating that wogonin might be a therapeutic agent for the treatment of vascular diseases.