• Title/Summary/Keyword: opening ratio

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The Pharmacological Effects of KR-30450 , A Potassium Channel Opener on Coronary Artery Occlusion / Reperfusion-Induced Myocardial Infarction in the Rat (흰쥐에서의 관상동맥 결찰/재관류도 유도된 심근경색에 대한 칼륨통로 개방제 KR-30450의 약리학적 효과)

  • Lee, Jae-Heung;Kwon, Kwang-Il;Shin, Hwa-Sup
    • YAKHAK HOEJI
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    • v.41 no.1
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    • pp.117-125
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    • 1997
  • The pharmacological effects of benzopyran potassium channel openers (lemakalim, KR-30450 and KR-30818) on the occlusion/reperfusion-induced myocardial infarction were investigat ed. In anesthetized rats, subjected to 45-min occlusion of the left anterior descending coronary artery (LAD) followed by 90-min reperfusion, the infarct size was measured by calculating the ratio of infarct zone to area at risk (IZ/AAR) with the Evans blue/TTC technique. Rats were intravenously given vehicle (1% DMSO), lemakalim, KR-30450, and KR-30818 alone or in combination with a selective K$_{ATP}$ blacker glibenclamide, 30 min prior to coronary occlusion. Compared to vehicle, lemakalim (30 ${\mu}$g/kg i.v.), the active enantiomer of cromakalim, had a tendancy to decrease infarct size. KR-30450(30 ${\mu}$g/kg, i.v.). the newly synthetized potassium channel openers (PCOs), caused a reduction of infarct size (from 70${\pm}$4%to 57${\pm}$5%). but KR-30818 (30 ${\mu}$g/kg, i.v.), a metabolite of KR-30450. did not modify infarct size. It seem ed likely that glibenclamide (0.3mg/kg, i.v.), given in combination, reduced the effects of these PCOs, especially KR-30450 (30 ${\mu}$g/kg, i.v.) on the infarct size. These results indicate that. in the coronary occluded rat model of ischemia, lemakalim and KR-30450 may exert cardioprotective activity through a reduction of infarct size, the effect being considered related to the opening of K$_{ATP}$ channel.

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Polarization-Independent 2-Dimensional Photonic Crystal Structure for Maximum Bandgap (최대 광밴드갭을 위한 2차원 광결정 구조)

  • Sung, Jun-Ho;O, Beom-Hoan;Lee, Seung-Gol;Park, Se-Geun;Lee, El-Hang
    • Korean Journal of Optics and Photonics
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    • v.16 no.3
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    • pp.261-265
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    • 2005
  • The large and polarization-independent photonic bandgap (PBG) is very useful to the application to various optical devices. Until present, it has been known that the PBG for a triangular lattice remains the largest both in the E- and H-polarized modes. However, we proposed a new structure with a larger polarization-independent PBG, by analyzing and systemizing the PBG opening trends as the structural changes. This optimal structure for maximum bandgap has more increased gap-midgap ratio $(\Delta\omega/\omega)$ of about $30\%$ than the triangular lattice.

Taguchi's Robust Design Method for Optimization of Grinding Condition by Hammer Mill (다구치 방법을 활용한 해머밀 분쇄공정의 최적화 연구)

  • Choe, Hong-Il;Kim, Byoung-Gon;Park, Chong-Lyuck;Jeong, Soo-Bok;Jeon, Ho-Seok;Jang, Hee-Dong
    • Journal of the Mineralogical Society of Korea
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    • v.23 no.3
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    • pp.219-225
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    • 2010
  • Optimal grinding condition was examined by changing only the size of screen opening with fixing other factors to produce coal fines of particle sizes required for circulating fluidized bed gasifier. At least 85 wt% of the coal particles should fall into the size range of 0.045~1.0 mm for efficient gasification. In this study, hammer mill was used to grind Chinese low rank lignite coal following grinding condition designed by Taguchi method. The analysis of signal to noise ratio showed that optimum grinding condition for the gasifier was 3 mm in primary screen size and 1.3 mm in secondary screen size on the 95% level of significance.

A Study on Exhaust Gas Characteristics and Engine Performance of EGR Valve Installed Engine for Development of EGR Valve Test System (EGR 밸브 평가 장치 개발을 위한 EGR 장착 엔진 성능 및 배출 가스 특성 연구)

  • Na, D.H.;Ko, C.S.;Seo, H.J.;Lee, C.E.
    • Journal of Drive and Control
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    • v.9 no.4
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    • pp.52-57
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    • 2012
  • In this study, in order to understand contents and ranges of design for the EGR Valve test system for improving quality and performance of EGR Valve, engine performance and exhaust gas characteristic of 3L-class diesel engine was analyzed. Experimental operation of engine performance test was performed with 50% engine load and 20% and 100% opening ratio of EGR Valve. From test of performance and exhaust gas characteristic of engine, torque output of engine and temperature and pressure of inlet and outlet of EGR Valve were measured. As a result, for design of EGR Valve test system, input fluid flow of EGR Valve must be set the same amount with exhaust gas flow that was below of engine speed of 2,500 rpm, and temperature of inlet of EGR Valve must be set under about $510^{\circ}C$. And the difference of temperature between inlet and outlet of EGR Valve must be over than about $200^{\circ}C$. Exhaust gas of inlet and outlet of EGR Valve were under 1 bar that was not considerable, and the difference of pressure between inlet and outlet of EGR Valve were under 1 bar that could not effect on mechanical operation of EGR Valve.

Calculation of Hydrodynamic Characteristics of Weis-Fogh Type Water Turbine Using the Advanced Vortex Method (개선 와법을 이용한 Weis-Fogh형 수차의 유체역학적 특성계산)

  • Ro, Ki Deok
    • Transactions of the Korean Society of Mechanical Engineers B
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    • v.38 no.3
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    • pp.203-210
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    • 2014
  • In this study, the hydrodynamic characteristics of Weis-Fogh type water turbine were calculated by the advanced vortex method. The wing (NACA0010 airfoil) and both channel walls were approximated by source and vortex panels, and free vortices are introduced away from the body surfaces. The distance from the trailing edge of the wing to the wing axis, the width of the water channel and the maximum opening angle were selected as the calculation parameters, the important design factors. The maximum efficiency and the power coefficient for one wing of this water turbine were 26% and 0.4 at velocity ratio U/V=2.0 respectively. The flow field of this water turbine is very complex because the wing moves unsteadily in the channel. However, using the advanced vortex method, it could be calculated accurately.

Effects of Abscisic Acid on Some Physiological Responses of the Leaves in Nicotiana tabacum L. (담배(Nicotiana tabacum L.) 잎의 몇가지 생리적 반응에 미치는 Abscisic Acid의 영향)

  • 김진성
    • Journal of Plant Biology
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    • v.29 no.1
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    • pp.41-51
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    • 1986
  • The plants of Nicotiana tabacum L. cv. NC2326 were germinated in 10 cm D$\times$20 cm H polyethylene pot, and sand-cultured with Hoagland solution near by the window of laboratory room(26$\pm$5$^{\circ}C$). The growing plants were sprayed with various concentrations of ABA around 9 : 00 a.m. once in every two days for 12 weeks in summer. As the results, frequency of stomatal number, stomatal opening, chlorophyll content, respiration rate, and protein content in the leaves were decreased with the increasing of concentrations of ABA, respectively. The plant growth was inhibited by exogenous ABA, but leaf abscission was not found during the experimental period. The ratio of three to one in chlorophyll a to b was not altered by exogenous ABA. All the stomata were closed within three minutes by 100 $\mu\textrm{g}$ ml-1 ABA and within seven minutes by 1-10 $\mu\textrm{g}$ ml-1 ABA after the spraying of ABA, and then reopended after a few hours in 1-10 $\mu\textrm{g}$ ml-1 ABA and after 24 hours in 100 $\mu\textrm{g}$ ml-1 ABA. The polar movement of chloroplast within the guard cells was found in the higher concentrations of 10 and 100 $\mu\textrm{g}$ ml-1 ABA, but not found in the lower concentrations than 1 $\mu\textrm{g}$ ml-1 ABA. During the night and weak light, it was fond that the inhibition of respiration rate by the higher concentration of ABA was owing to firstly the stomatal closure by the spraying of ABA and secondly the decrease of stomatal frequency by the inhibition of stomatal development with exogenous ABA for the long period of 12 weeks. In the band number of leaf protein by the electrophoresis, most of the protein bands were disappeared by the higher concentration of 100 $\mu\textrm{g}$ ml-1 ABA, but were not altered by the lower concentration of ABA in comparison with control.

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Nonlocal strain gradient-based vibration analysis of embedded curved porous piezoelectric nano-beams in thermal environment

  • Ebrahimi, Farzad;Daman, Mohsen;Jafari, Ali
    • Smart Structures and Systems
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    • v.20 no.6
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    • pp.709-728
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    • 2017
  • This disquisition proposes a nonlocal strain gradient beam theory for thermo-mechanical dynamic characteristics of embedded smart shear deformable curved piezoelectric nanobeams made of porous electro-elastic functionally graded materials by using an analytical method. Electro-elastic properties of embedded curved porous FG nanobeam are assumed to be temperature-dependent and vary through the thickness direction of beam according to the power-law which is modified to approximate material properties for even distributions of porosities. It is perceived that during manufacturing of functionally graded materials (FGMs) porosities and micro-voids can be occurred inside the material. Since variation of pores along the thickness direction influences the mechanical and physical properties, so in this study thermo-mechanical vibration analysis of curve FG piezoelectric nanobeam by considering the effect of these imperfections is performed. Nonlocal strain gradient elasticity theory is utilized to consider the size effects in which the stress for not only the nonlocal stress field but also the strain gradients stress field. The governing equations and related boundary condition of embedded smart curved porous FG nanobeam subjected to thermal and electric field are derived via the energy method based on Timoshenko beam theory. An analytical Navier solution procedure is utilized to achieve the natural frequencies of porous FG curved piezoelectric nanobeam resting on Winkler and Pasternak foundation. The results for simpler states are confirmed with known data in the literature. The effects of various parameters such as nonlocality parameter, electric voltage, coefficient of porosity, elastic foundation parameters, thermal effect, gradient index, strain gradient, elastic opening angle and slenderness ratio on the natural frequency of embedded curved FG porous piezoelectric nanobeam are successfully discussed. It is concluded that these parameters play important roles on the dynamic behavior of porous FG curved nanobeam. Presented numerical results can serve as benchmarks for future analyses of curve FG nanobeam with porosity phases.

Numerical Analysis of Reflection Characteristics of Perforated Breakwater with a Resonant Channel (공진수로 내장형 유공방파제의 반사특성에 관한 수치해석 연구)

  • Kim, Jeong-Seok;Seo, Ji-Hye;Lee, Joong-Woo;Park, Woo-Sun
    • Journal of Navigation and Port Research
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    • v.38 no.5
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    • pp.503-509
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    • 2014
  • In this study, a new concept perforated breakwater is proposed, which is having resonant channels. In the channel, perforated plate is installed for dissipating wave energy induced by flow separations. The breakwater has two advantages compared with conventional perforated breakwater having wave chamber with slotted walls. One is easy to control the target wave condition for dissipating wave energy, and the other is having the high structural safety because the structural members are not exposed to impact waves, directly. To evaluate wave reflection characteristics of the proposed breakwater, numerical experiment was carried out by using Galerkin's finite element model based on the linear potential theory. The results indicated that considerable energy dissipation occurs near the resonant period of channel, and wave reflection characteristics are affected by channel shape, location and opening ratio.

A Numerical Study on the Effect of Volume Change in a Closed Compartment on Maximum Heat Release Rate (밀폐된 구획실의 체적변화가 최대 열발생률에 미치는 영향에 관한 수치해석 연구)

  • Yun, Hong-Seok;Nam, Dong-Gun;Hwang, Cheol-Hong
    • Fire Science and Engineering
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    • v.31 no.5
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    • pp.19-27
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    • 2017
  • The effects of changes in area and location of fire source, fire growth rate, and volume of compartment on the major fire characteristics, including heat release rate, in closed compartment fires were examined. To this end, a fire simulation using Fire Dynamics Simulator (FDS) was performed for ISO 9705 room with a closed opening. As main result, it was found that the changes in the area and location of fire source did not significantly affect the thermal and chemical characteristics inside the compartment, such as maximum heat release rate, total heat release, maximum temperature at upper layeras well as species concentrations. However, increasinthe fire growth rate and volume of compartment resulted in increase of the maximum heat release rate and total heat release, decrease in the limiting oxygen concentration and increase in the maximum CO concentration. Finally, a methodology for the application of fire growth curves to closed compartment fires was proposed by deriving the correlation of the maximum heat release rate expressed as a function of the fire growth rate and the volume ratio of compartment based on the ISO 9705 room.

Analysis of Dynamic Characteristics and Performance of Solenoid Valve for Pressurization Propellant Tank (추진제탱크 가압용 솔레노이드밸브의 작동특성 분석 및 해석)

  • Jang, Jesun;Kim, Byunghun;Han, Sangyeop
    • Journal of the Korean Society of Propulsion Engineers
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    • v.17 no.2
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    • pp.128-134
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    • 2013
  • A 2-way solenoid valve regulates to maintain the pressure of ullage volume of propellant tanks when the command is given by control system for the liquid-propellant feeding system of space launch vehicle. The simulation model of solenoid valve for pressurization is designed with AMESim to verify the designs and evaluate the dynamic characteristics and pneumatic behaviors of valve. To improve the accuracy of the model, numerical flow analysis by using FLUNET code. The simulation results of their operating durations of valve by AMESim analysis are matched up with the results of experiments and validate valve model. Using the model, we analyze performance of valve; opening/closing pressure, operating time on various design factors of basic valve and control valve; geometrical size of valve seat, ratio of basic valve and sealing area.