• Journal of the Korean Institute of Illuminating and Electrical Installation Engineers
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• v.20 no.7
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• pp.38-45
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• 2006

The superconducting fault current limiters(SFCLs) provide the effect such as enhancement in power system reliability due to limiting the fault current within a few miliseconds. Among various SFCLs we have developed a flux-lock type SFCL and exploited a special design to effectively reduce the fault current according to properly adjustable magnetic field after the short-circuit test. This SFCL consists of two copper coils wound in parallel on the same iron core and a component using the YBCO thin film connected in series to the secondary copper coil. Meanwhile, operating characteristics can be controlled by adjusting the inductances and the winding directions of the coils. To analyze the operational characteristics, we compared closed-loop with open-loop iron core. When the applied voltage was 200[Vrms] in the additive polarity winding, the peak values of the line current the increased up to 30.71[A] in the closed-loop and 32.01[A] in the open-loop iron core, respectively. On the other hand, in the voltages generated at current limiting elements were 220.14[V] in the closed-loop and 142.73[V] in the opal-loop iron core during first-half cycle after fault instant under the same conditions. We confirmed that the open-loop iron core had lower power burden than in the closed-loop iron core. Consequently, we found that the structure of iron core enabled the flux-lock type SFCL at power system to have the flexibility.

• Journal of Oriental Neuropsychiatry
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• v.24 no.3
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• pp.293-308
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• 2013

Objectives : The Bambusae Caulis in Taeniam has been used in traditional oriental medicine to treat a variety of mental disorders including anxiety and depression. The purpose of present study is to observe the changes which take place in the body in stressful situations and to compare the anti-depressive, anxiolytic and anti-stress effect of Bambusae Caulis in Taeniam in different doses. Methods : This study was performed to evaluate the effects of Bambusae Caulis in Taeniam in the immobilization stress model in rats. Twenty-five rats were divided into 5 groups of 5: control, stress, low dose administration (75 mg/kg), medium dose administration (150 mg/kg) and high dose administration (225 mg/kg). The four groups other than the control group were placed in an immobilization stress test, and distilled water (control) or Bambusae Caulis in Taeniam extract was administration orally for 2 weeks. After treatment, the despair and anxiety behavior of rats were measured by open field test, forced swimming test, weight gain, contents of 5-HT in raphe nucleus and adrenal gland weight. Results & Conclusions : As a result of evaluation by measuring five aspects, FST, OFT, weight gain, 5-HT contents and adrenal gland weight, Bambusae Caulis in Taeniam has significant antidepressant, anxiolytic, anti-stress effects.

• CELLMED
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• v.2 no.4
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• pp.36.1-36.4
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• 2012

This study was carried out to investigate the neurobehavioural effects of the smoking of Carica papaya leaves based on ethnopharmacological information. Twenty -four rats used for the study were grouped into four groups namely; Groups 1 (Control, unexposed to any smoke) and Groups 2 - 4 (exposed to smoke from varying amount of pawpaw leaf powder). Groups 2, 3, and 4 were exposed to smoke from 6.25 g (low dose), 12.50 g (medium dose), and 18.75 g (high dose) of dry pawpaw leaves respectively in a smoking chamber twice daily for 21 one days with each exposure lasting 3 min. The spontaneous motor activities and locomotory behaviour of the animals were assessed using an open field maze and hole board maze test. The results showed that the smoking of Carica papaya leaves led to a significant (p < 0.05) increase in locomotory activities from $33.36{\pm}3.36$ (control) to $66.50{\pm}6.16$ (high dose), number of head dips (from $8.50{\pm}0.36$, to $12.83{\pm}0.87$) and rearing behaviour (from $14.83{\pm}0.74$, to $27.0{\pm}1.46$). However, the freezing durations as animals were introduced into the maze and grooming behaviour were significantly (p < 0.05) reduced in the treated groups. In conclusion, the increased ambulations and exploratory behaviours imply that the anxiety level is low in the treated groups compared to the control group which thus confirms that dry Carica papaya leaf may possibly contain psychoactive substance(s) that become active when smoked.

• Journal of mucopolysaccharidosis and rare diseases
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• v.4 no.1
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• pp.26-36
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• 2018

Mucopolysaccharidosis IIIA is a heritable neurodegenerative disorder resulting from the dysfunction of the lysosomal hydrolase sulphamidase. This leads to the primary accumulation of the complex carbohydrate heparan sulphate in a wide range of tissues and CNS degeneration. Characterization of animal model is the beginning point of the therapeutic clinical trial. Mouse model has a limitation in that it is not a human and does not have all of the disease phenotypes. Therefore, delineate of the phenotypic characteristics of MPS IIIA mouse model prerequisite for the enzyme replace treatment for the diseases. We designed 6-month duration of phenotypic characterization of MPS IIIA mouse biochemically, behaviorally and histologically. We compared height and weight of MPS IIIA mouse with wild type from 4 weeks to 6 months in both male and female. At 6 months, we measured GAG storage in urine kidney, heart, liver, lung and spleen. The brain GAG storage is presented with Alcian blue staining, immunohistochemistry, and electron-microscopy. The neurologic phenotype is evaluated by brain MRI and behavioral study including open field test, fear conditioning, T-maze test and Y-maze test. Especially behavioral tests were done serially at 4month and 6month. This study will show the result of the MPS IIIA mouse model phenotypic characterization. The MPS IIIA mouse provides an excellent model for evaluating pathogenic mechanisms of disease and for testing treatment strategies, including enzyme or cell replacement and gene therapy.

• Journal of Ginseng Research
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• v.41 no.2
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• pp.201-208
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• 2017

Background: Panax vietnamensis Ha et Grushv. or Vietnamese ginseng (VG) is a recently discovered ginseng species. Studies on its chemical constituents have shown that VG is remarkably rich in ginseng saponins, particularly ocotillol saponins. However, the psychopharmacological effects of VG have not been characterized. Thus, in the present study we screened the psychopharmacological activities of VG in mice. Methods: VG extract (VGE) was orally administered to mice at various dosages to evaluate its psychomotor (open-field and rota-rod tests), sedative-hypnotic (pentobarbital-induced sleeping test), anti-stress (cold swimming test), anxiolytic (elevated plus-maze test), and cognitive (Y-maze and passive-avoidance tests) effects. Results: VGE treatment increased the spontaneous locomotor activity, enhanced the endurance to stress, reduced the anxiety-like behavior, and ameliorated the scopolamine-induced memory impairments in mice. In addition, VGE treatment did not alter the motor balance and coordination of mice and did not potentiate pentobarbital-induced sleep, indicating that VGE has no sedative-hypnotic effects. The effects of VGE were comparable to those of the Korean Red Ginseng extract. Conclusion: VG, like other ginseng products, has significant and potentially useful psychopharmacological effects. This includes, but is not limited to, psychomotor stimulation, anxiolytic, antistress, and memory enhancing effects.

• Journal of Korean Ophthalmic Optics Society
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• v.20 no.2
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• pp.187-193
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• 2015

Purpose: This study was aimed to investigate effects of increased breath alcohol concentration (BrAC) which is the standard measurement of alcohol consumption in sobriety test under current laws on visual acuity and values of objective refraction. Methods: For twenty three males in 20s (average age $21.17{\pm}2.19$ years, body mass index (BMI) $22.09{\pm}2.16$) were selected. Distance and near visual test was performed at BrAC of 0%, 0.05% and 0.08%, and objective refraction with open-field auto-refractometer was also performed at different BrAC. Results: As breath alcohol concentration is increased, distance visual acuity was decreased, which was statistically significant, but near visual acuity was not changed. Also, values of objective refraction tended to be increased towards minus as breath alcohol concentration is increased. Conclusions: As breath alcohol concentration is increased, corrected visual acuity is decreased and refractive power is towards minus, it is necessary that visual acuity test and refraction measurement should be conducted under sober condition.

• Journal of The Korea Institute of Healthcare Architecture
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• v.25 no.1
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• pp.17-27
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• 2019

Purpose: Clinical laboratory in hospital has taken a great role in protection of chronic disease. as well as diagnosis and treatment, And laboratory layout has been considered by the management and laboratory section more than the function and workflow. Methods: So this study figures out the workflows of laboratory sections in the recently upgraded Laboratory Medicine, and searches the functional relationships and spatial block diagram between each disciplines as follows. Literature review and expert adviser has been conducted. Results: 1) Laboratory type of Laboratory Medicine is divided into routine and specialized laboratory according to the workflow by automated or specialized test. 2) The general workflow consists of specimen collection, specimen classification, test by discipline, test report, and specimen disposal. 3) Though the function of each laboratory section is very complicated and specific, the characteristics and the workflow can be shown in detail by each lab through [Figure 4], [Figure 5], [Figure 6], [Figure 7], and [Figure 8]. 4) Functional relationship diagram can be displayed to the adjacency and relation between each laboratory and support spaces. 5) The spatial block diagram could be presented as shown in [Figure 10], in which the emergency lab lay in front side, routine lab in the central open area, and specialized lab in the behind side. Implications: This study can be used as a useful data in planning and designing a Laboratory Medicine Department.

• Biomolecules & Therapeutics
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• v.27 no.2
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• pp.160-167
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• 2019

Depression is a major mood disorder. Abnormal expression of glial glutamate transporter-1 (GLT-1) is associated with depression. Schisantherin B (STB) is one bioactive of lignans isolated from Schisandra chinensis (Turcz.) Baill which has been commonly used as a traditional herbal medicine for thousands of years. This paper was designed to investigate the effects of STB on depressive mice induced by forced swimming test (FST). Additionally, we also assessed the impairment of FST on cognitive function in mice with different ages. FST and open field test (OFT) were used for assessing depressive symptoms, and Y-maze was used for evaluating cognition processes. Our study showed that STB acting as an antidepressant, which increased GLT-1 levels by promoting PI3K/AKT/mTOR pathway. Although the damage is reversible, short-term learning and memory impairment caused by FST test is more serious in the aged mice, and STB also exerts cognition improvement ability in the meanwhile. Our findings suggested that STB might be a promising therapeutic agent of depression by regulating the GLT-1 restoration as well as activating PI3K/AKT/mTOR pathway.

• Asian-Australasian Journal of Animal Sciences
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• v.32 no.7
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• pp.1062-1068
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• 2019

Objective: For many generations, most species of farm animals have been subjected to intense and strictly targeted selection for improvement of their performance traits. This has led to substantial changes in animal anatomy and physiology, which resulted in considerable differences between the current animal breeds and their wild ancestors. The aim of the study was to determine whether there is breed-specific variability in behaviour as well as differences in emotional reactivity and preferences of laying hens. Methods: The investigations involved 50 Green-legged Partridge, 50 Polbar, and 50 Leghorn hens. All birds were kept in the same conditions, and the behavioural tests were carried out at 30 weeks of age. We used the tonic immobility test and a modified open-field test including such objects as water, commercial feed, feed enriched with cereal grains, finely cut straw, and insect larvae, a sandpit, a mirror, and a shelter imitating a hen nest. Results: The research results demonstrate that the birds of the analysed breeds differ not only in the excitability and emotional reactivity but, importantly, also in the preferences for environment-enriching elements. Ensuring hens' well-being should therefore be based on environmental modifications that will facilitate acquisition of essential elements of chickens' behaviour. The greatest emotional reactivity was found in the Leghorn breed, which may be a result of correlated selection aimed at an increase in chicken productivity. Conclusion: The differences in the behaviour of the birds from the analysed breeds indicate that laying hens cannot be regarded as one group of animals with the same environmental requirements.

• Journal of the Society of Disaster Information
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• v.15 no.1
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• pp.98-108
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• 2019

Purpose: The purpose of this study is to test the sprinkler performance to protect the wall and ceiling joints of the sandwich panel warehouse in case of fire. Method: Based on the field surveys, test was setup and combustibles were prepared. The sprinkler discharge tests were performed at the corner of the wall and right under the sprinkler head. Results: It has been found that operation of the K-80 closed sprinkler head prevents the ignition of the sandwich panel and therefore no damage to the joints of sandwich panels. To prevent skipping phenomenon, it is necessary to install the sprinkler head from the corner of the wall and to keep a minimum distance of 2.4m and a maximum distance of 3m. Conclution: A Standard Operation Procedure should be prepared to suppress and rescue of fire brigade for a sandwich panel warehouse protected by perimeter sprinklers preventing a ignition of core materials and control fire.