• 제목/요약/키워드: open-field test

검색결과 340건 처리시간 0.026초

C57BL/6 쥐 외상성 뇌손상 모델에서 뇌 손상 정도에 따른 조직병리학적 변화 및 신경행동학적 특징 (Histopathological and Neurobehavioral Characterization in Adult Mice Exposed to Traumatic Brain Injury)

  • 오기영;최동원;장문순;이지한;김상철;박정수;이석우;김훈
    • 대한응급의학회지
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    • 제28권5호
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    • pp.457-466
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    • 2017
  • Purpose: Traumatic brain injury (TBI) is a significant cause of morbidity and mortality worldwide. Severity of the initial insult is one of the most significant factors affecting outcome following TBI. In order to investigate the mechanisms of cellular injury and develop novel therapeutic strategies for TBI, we designed a standardized animal TBI model and evaluated histological and functional outcomes according to the degree of impact severity. Methods: Male adult C57Bl/6 mice underwent controlled cortical impact (CCI) at varying depths of deflection (1.0-2.0 mm). We performed hematoxylin and eosin staining at 7 days after recovery from TBI. Neurobehavioral characterization after TBI was analyzed by the Barnes maze test, passive avoidance test, open field test, rotarod test, tail suspension test, and light/dark test. Results: We observed a graded injury response according to the degree of deflection depths tested (diameter, 3 mm; velocity, 3 m/s; and duration, 500 ms) compared to sham controls. In the Barnes maze test, the severe TBI (2 mm depth) group showed reduced spatial memory as compared with the sham and mild TBI (1 mm depth) groups at 7 days after TBI. There was a significant difference in the results of the open field test and light/dark test among the three groups. Conclusion: Our findings demonstrate that the graded injury responses following TBI resulted in differential histopathological and behavioral outcomes in a mouse experimental CCI model. Thus, a model of CCI with histologic/behavioral outcome analysis may offer a reliable and convenient design for preclinical TBI research involving mice.

RANS법을 이용한 선박 프로펠러 날개 끝 보오텍스 유동 해석 (RANS ANALYSES OF THE TIP VORTEX FLOW OF A MARINE PROPELLER)

  • 박일룡
    • 한국전산유체공학회지
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    • 제21권2호
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    • pp.62-69
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    • 2016
  • It has been highly demanded to improve the accuracy of CFD(Computational Fluid Dynamics) methods for the assessment of the hydrodynamic performance of marine propellers in cavitating and non-cavitating flows. This paper presents a validation study on the numerical simulation of the tip vortex flow of a non-cavitating marine propeller SVA VP1304. The calculations are carried out by using the Reynolds averaged Navier-Stokes(RANS) approach, where the Reynolds Stress Model(RSM) is used for turbulence closure. The present paper contains a grid dependence test for the propeller open water simulations and a special emphasis is placed on conducting a local grid adaptation on the blade tip and in the tip vortex to reasonably reproduce the velocity and the pressure in the tip vortex flow field. The numerical results are compared with the experimental validation data, which are published in the second International Symposium on Marine Propulsors 2011(SMP'11). The present numerical results show a reasonable agreement with the experiments.

양파 간이저장시 통풍조건 및 통풍구 재료의 크기가 저장에 미치는 영향 (Effects of Ventilation Condition and Ventilating Hole Sizes to Improve Quality Onion(Allium cepu. L) under Room Temperature)

  • 이찬중;김희대;정은호;김우일;서전규
    • 한국식품저장유통학회지
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    • 제8권4호
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    • pp.356-361
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    • 2001
  • 양파 간이저장시 노지야적에 의해 발생하는 부패를 감소시켜 망과의 안전저장을 위하여 조립식 간이하우스를 이용하여 통풍조건 및 통풍구 재료의 크기에 따른 저장성을 조사한 결과는 다음과 같다. 평균온도는 노지야적에 비해 강제통풍에서 0.3~3.6$^{\circ}C$높았고, 무통풍에 비해서는 1.4~8.2$^{\circ}C$가 낮았다. 그러나 처리간 유의차는 없었다. 상대습도는 통풍처리구에서 무통풍 및 노지야적에 비해 약간 높았다. 구중감소율은 노지야적에서는 2.5%, 무통풍에서는 2.9%, 자연통풍 2단에서는 3%, 강제통풍 2단에서는 4.3%였다. 8월 하순까지의 부패율은 자연통풍 2단 27.7%, 강제통풍 2단 25.4%,인데 비해 무통풍 34.6%, 노지야적 37.8%로 통풍처리구에서 부패가 적었다. 통붕구 재료의 크기가 클수록 평균기온은 조금 낮았고, 상대습도는 7월에 조금 높은 경향을 보이다가 8월 이후에는 차이가 거의 없었다. 통풍 파이프 표면의 풍속은 통풍구의 크기가 작을수록 강했으며, 부위별로는 중간부위가 양끝쪽보다 낮았다. 부패율은 75mm통풍구 17.9%, 100mm통풍구 15.3%, 125mm통풍구 14.1%로 통풍구 크기가 클수록 부패는 적었다.

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풍동 조건의 마이크로폰 어레이 측정에서 전단층 보정에 관한 연구 (Study on Shear Layer Correction of Microphone Array Measurement in the Wind Tunnel Test)

  • 김위준;이욱;최종수
    • 한국소음진동공학회:학술대회논문집
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    • 한국소음진동공학회 2007년도 추계학술대회논문집
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    • pp.92-96
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    • 2007
  • Microphone array beamforming method has been recognized as an important aeroacoustic research field and become a standard technique in localizing sound sources. This method also used in flight acoustic measurement, and especially, it is very useful when measure sounds inside the wind tunnel. In measuring sound which is inside the wind tunnel by traditional beamforming method, there are some errors caused by airstream. The speed and the propagation path of the sound changes as it travel through the airstream. This makes the error which the position of sound is changed a little bit to the down stream direction. In this paper, validation test has made about the correction equation for this wind effects of previous researches. And beamforming including shear layer correction was performed about a sound source in the anechoic open-jet windtunnel.

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풍동 조건의 마이크로폰 어레이 측정에서 전단층 보정에 관한 연구 (Study on Shear Layer Correction of Microphone Array Measurement in the Wind Tunnel Test)

  • 김위준;이욱;최종수
    • 한국소음진동공학회논문집
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    • 제18권6호
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    • pp.612-618
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    • 2008
  • Microphone array beamforming method has been recognized as an important aeroacoustic research field and become a standard technique in localizing sound sources. This method also used in flight acoustic measurement, and especially, it is very useful when measure sounds inside the wind tunnel. In measuring sound which is inside the wind tunnel by traditional beamforming method, there are some errors caused by airstream. The speed and the propagation path of the sound changes as it travel through the airstream. This makes the error which the position of sound is changed a little bit to the down stream direction. In this paper, validation test has made about the correction equation for this wind effects of previous researches. And beamforming including shear layer correction was performed about a sound source in the anechoic open-jet wind tunnel.

Lessons from Korea's Response to COVID-19: Missing Factors of Sectoral Innovation System

  • Seol, Sung-Soo;Ko, Chang-Ryong
    • Asian Journal of Innovation and Policy
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    • 제9권2호
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    • pp.106-132
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    • 2020
  • This study intends to add a factor to the discussion on the sectoral systems of innovation through Korea's response to the COVID-19 pandemic. The Korean approach is summarized as follows: the first response centers on technology and innovation. These include the development of diagnostic test methods and accurate test kits, first in the world, the use of ICT technology in epidemiological investigations, the technical response in the field, and the competitive edge in the development of medicine and vaccines that were behind the developed countries. The second response is an aggressive effort implemented just after the Chinese announcement, before the domestic outbreak; the third response is the open policy that induces voluntary participation of all subjects and people by opening all information. More important is the leadership at the national level shown in the past Korean experience and most advanced countries. National leadership must be the missing factor.

Test Result Analysis of a 1MW HTS Motor for Industry Application

  • Baik, S.K.;Kwon, Y.K.;Kim, H.M.;Lee, E.Y.;Kim, Y.C.;Park, H.J.;Kwon, W.S.;Park, G.S.
    • 한국초전도ㆍ저온공학회논문지
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    • 제11권2호
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    • pp.33-36
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    • 2009
  • A 1 MW class HTS (High-Temperature Superconducting) synchronous motor has been developed. This motor is aimed to be utilized for industrial application such as large motors operating in large plants. The HTS field coil of the developed motor is cooled by way of neon thermo siphonmechanism and the stator (armature) coil is cooled by water through hollow copper conductor. This paper also describes evaluation of some electrical parameters from performance test results of our motor, which was conducted at steady state in generator mode and motor mode. Open and short circuit tests were conducted in generator mode while a 1.1 MW rated induction machine was rotating the HTS machine. Electrical parameters such as mutual inductance and synchronous inductance are deduced from these tests. Load test was done upto rating torque during motor mode and efficiency was measured at each load torque.

Reliability and Validity of the Postural Balance Application Program Using the Movement Accelerometer Principles in Healthy Young Adults

  • Park, Seong-Doo;Kim, Ji-Seon;Kim, Suhn-Yeop
    • 한국전문물리치료학회지
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    • 제20권2호
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    • pp.52-59
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    • 2013
  • The purpose of this study was to determine the reliability and validity of the postural balance program which uses the movement accelerating field principles of posture balance training and evaluation equipment and smartphone movement accelerometer program (SMAP) in healthy young adults. A total of 34 people were appointed as the subject among the healthy young adults. By using Biodex stability system (BSS) and SMAP on the subject, the posture balance capability was evaluated. For the test-retest reliability, SMAP showed the intra-class correlation (ICC: .62~.91) and standard error measurement (SEM: .01~.08). BSS showed the moderate to high reliability of ICC (.88~.93) and SEM (.02~.20). In the reliability of inter-rater, ICC (.59~.73) as to SMAP, showed the reliability of moderate in eyes open stability all (EOSA), eyes open stability anterior posterior (EOSAP), eyes open stability medial lateral (EOSML) and eyes open dinamic all (EODA), eyes open danamic anterior posterior (EODAP), and eyes open danamic medial lateral (EODML). However, ICC showed reliability which was as low as .59 less than in other movements. In addition, BSS showed the reliability of high as ICC (.70~.75). It showed reliability which was as low as ICC (.59 less than) in other movements. In correlation to the balance by attitudes between SMAP and BSS, EOSML (r=.62), EODA (r=.75), EODML (r=.72), ECDAP (r=.64), and ECDML (r=.69) shown differ significantly (p<.05). However, the correlation noted in other movements did not differ significantly. Therefore, SMAP and BSS can be usefully used in the posture balance assessment of the static and dynamic condition with eyes opened and closed.

Walking path design considering with Slope for Mountain Terrain Open space

  • Seul-ki Kang;Ju-won Lee
    • 한국컴퓨터정보학회논문지
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    • 제28권10호
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    • pp.103-111
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    • 2023
  • 산악지대, 특히 오픈스페이스에서의 보행은 산악지형을 기반으로 이루어지는 특수 활동영역에서 중요하다. 그러나 최근의 보행 경로 연구는 보행자와 환경 요소를 포괄적으로 네트워크 분석에 포함시키지만, 주로 한정된 공간을 대상으로 하며 산악지형 등, 데이터가 부족한 지형은 분석 대상에서 제외된다. 본 논문에서는 산악지형의 오픈스페이스에서 그물망 기반의 가상 보행 네트워크를 만들며, 경사도를 반영한 산악 보행 경로 생성 방법을 제안한다. 이 방법은 거리측정에 경사도를 고려하여 실제 지형을 더 잘 반영하며, 기존 경로 분석 서비스에서 제공하지 않는 오픈스페이스를 이용한 산악 보행 경로를 제시하고, 시험을 통해 이를 입증하였다. 본 논문의 설계 방법은 조난, 산악구조, 전술 훈련 등에서 산악지형의 오픈스페이스를 포함한 경로 생성 방법으로 활용될 수 있을 것으로 기대한다.

강관압입후 슬롯 홀을 갖는 비개착 터널공법의 현장적용에 관한 연구 (A Study on Sites Application of Non-open-cut Tunnel Method with Slot Holes in Steel Pipe Pumping)

  • 채영석;송관권;민인기
    • 한국안전학회지
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    • 제30권1호
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    • pp.47-51
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    • 2015
  • In the study, a new non-open cut tunnel steel pipe method using slot hole has been developed. As is overcomes shortcomings of conventional methods, it is applied to the field. The main concept of the new method is the steel pipe pumping system with slot holes which, by means of formation slot holes between each steel pipe, applied to the magnitude of the relaxed earth pressure caused by excavation to the ground to prevent ground displacement. The stability of the support members and effect of displacement control of the new method were verified through several ways as numerical analysis and site test. The new method was applied to the construction of a 11.5m wide, 7.4m high and 50m long section that passes side subway and large buildings in inner city. By applying the new method, tunnel construction was successfully completed in 6 months. It decreases the construction period to 30% compared to that of conventional methods, and ground was almost negligible.