• The Korean Journal of Physiology and Pharmacology
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• 제7권1호
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• pp.15-23
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• 2003

Cellular redox state is known to be perturbed during ischemia and that $Ca^{2+}$ and $K^2$ channels have been shown to have functional thiol groups. In this study, the properties of thiol redox modulation of the ATP-sensitive $K^2$ ($K_{ATP}$) channel were examined in rabbit ventricular myocytes. Rabbit ventricular myocytes were isolated using a Langendorff column for coronary perfusion and collagenase. Single-channel currents were measured in excised membrane patch configuration of patch-clamp technique. The thiol oxidizing agent 5,5'-dithio-bis-(2-nitro-benzoic acid) (DTNB) inhibited the channel activity, and the inhibitory effect of DTNB was reversed by dithiothreitol (disulfide reducing agent; DTT). DTT itself did not have any effect on the channel activity. However, in the patches excised from the metabolically compromised cells, DTT increased the channel activity. DTT had no effect on the inhibitory action by ATP, showing that thiol oxidation was not involved in the blocking mechanism of ATP. There were no statistical difference in the single channel conductance for the oxidized and reduced states of the channel. Analysis of the open and closed time distributions showed that DTNB had no effect on open and closed time distributions shorter than 4 ms. On the other hand, DTNB decreased the life time of bursts and increased the interburst interval. N-ethylmaleimide (NEM), a substance that reacts with thiol groups of cystein residues in proteins, induced irreversible closure of the channel. The thiol oxidizing agents (DTNB, NEM) inhibited of the $K_{ATP}$ channel only, when added to the cytoplasmic side. The results suggested that metabolism-induced changes in the thiol redox can also modulate $K_{ATP}$ channel activity and that a modulatory site of thiol redox may be located on the cytoplasmic side of the $K_{ATP}$ channel in rabbit ventricular myocytes.

• 대한전기학회논문지:전력기술부문A
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• 제48권5호
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• pp.586-592
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• 1999

We investigate the characteristic of 소데 responses of the Manabe standard form which is used recently for design of the controller. We obtain some theorems and these theorems have the properties of the relationship between the roots of the polynomial and the stability indices which are used for the Manabe standard form. The Manabe standard form has the following properties: The sum of the squal to zero, the sum of the reciprocal of the squared roots is greater than zero and the parameter $\tau$ is the negative value of the sum of the reciprocal of the roots. We compare the step responses of the Manabe standard form with those of the ITAE form, the dead beat response and Bessel forms. We choose the 6th order closed loop polynomial and keep the same settling time for the four forms. Under these conditions we find that the Manabe standard form have faster 90% rising time than the Bessel and dead beat response. We see that the ITAE, bessel and dead beat responses have some overshoot, whereas the Manabe standard form has none. We also compare the Manabe form with the other three forms for the controller design using the pole assignment technique. If the open loop transfer function is a type-1 system (transfer functions having one integrator), then, for the closed loop system associated with the open loop transfer function, the steady state error of the unit ramp input is obtained in terms of the parameter $\tau$ of the Manabe standard form.

• Restorative Dentistry and Endodontics
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• 제40권3호
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• pp.179-187
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• 2015

Traditionally, apexification has been used to treat immature permanent teeth that have lost pulp vitality. This technique promotes the formation of an apical barrier to close the open apex so that the filling materials can be confined to the root canal. Because tissue regeneration cannot be achieved with apexification, a new technique called regenerative endodontic treatment was presented recently to treat immature permanent teeth. Regenerative endodontic treatment is a treatment procedure designed to replace damaged pulp tissue with viable tissue which restores the normal function of the pulp-dentin structure. After regenerative endodontic treatment, continued root development and hard tissue deposition on the dentinal wall can occur under ideal circumstances. However, it is difficult to predict the result of regenerative endodontic treatment. Therefore, the purpose of this study was to summarize multiple factors effects on the result of regenerative endodontic treatment in order to achieve more predictable results. In this study, we investigated the features of regenerative endodontic treatment in comparison with those of other pulp treatment procedures and analyzed the factors that have an effect on regenerative endodontic treatment.

• Journal of Korean Neurosurgical Society
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• 제60권5호
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• pp.485-497
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• 2017

Surgical treatment of the degenerative disc disease has evolved from traditional open spine surgery to minimally invasive spine surgery including endoscopic spine surgery. Constant improvement in the imaging modality especially with introduction of the magnetic resonance imaging, it is possible to identify culprit degenerated disc segment and again with the discography it is possible to diagnose the pain generator and pathological degenerated disc very precisely and its treatment with minimally invasive approach. With improvements in the optics, high resolution camera, light source, high speed burr, irrigation pump etc, minimally invasive spine surgeries can be performed with various endoscopic techniques for lumbar, cervical and thoracic regions. Advantages of endoscopic spine surgeries are less tissue dissection and muscle trauma, reduced blood loss, less damage to the epidural blood supply and consequent epidural fibrosis and scarring, reduced hospital stay, early functional recovery and improvement in the quality of life & better cosmesis. With precise indication, proper diagnosis and good training, the endoscopic spine surgery can give equally good result as open spine surgery. Initially, endoscopic technique was restricted to the lumbar region but now it also can be used for cervical and thoracic disc herniations. Previously endoscopy was used for disc herniations which were contained without migration but now days it is used for highly up and down migrated disc herniations as well. Use of endoscopic technique in lumbar region was restricted to disc herniations but gradually it is also used for spinal canal stenosis and endoscopic assisted fusion surgeries. Endoscopic spine surgery can play important role in the treatment of adolescent disc herniations especially for the persons who engage in the competitive sports and the athletes where less tissue trauma, cosmesis and early functional recovery is desirable. From simple chemonucleolysis to current day endoscopic procedures the history of minimally invasive spine surgery is interesting. Appropriate indications, clear imaging prior to surgery and preplanning are keys to successful outcome. In this article basic procedures of percutaneous endoscopic lumbar discectomy through transforaminal and interlaminar routes, percutaneous endoscopic cervical discectomy, percutaneous endoscopic posterior cervical foraminotomy and percutaneous endoscopic thoracic discectomy are discussed.

• 대한관절경학회지
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• 제4권2호
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• pp.144-147
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• 2000

목적 : 화농성 고관절 질환에 대한 치료 중 관절경적 처치의 방식을 제시하고, 경과를 평가하고자 하였다. 대상 및 방법 : 급성 성인형 화농성 고관절염 환자 9례를 대상으로 하였으며. 관절 천자와 임상 검사에 의해 확진되면 즉시 응급으로 관절경적 변연 절제술 및 세척술을 시행하였고, 술후 적혈구 침강 속도 및 C-반응성 단백의 수치를 검사하면서 경과 관찰을 시행하였다. 결과 : 혈액 검사상 적혈구 침강 속도의 정상화는 11.9일, C-반응성 단백은 평균 8.9일이 소요되었다. 1년 추시 결과 전례에서 관절 기능이 정상이었으며, 혈액 검사상 감염의 증거를 발견 할 수 없었다. 결론 : 화농성 고관절염 환자에서 시행되는 관절경적 변연 절제술 및 세척술은 개방적 관절 절개 술식에 비해 관절 주변의 구조물 손상을 최소화하면서도, 좋은 결과를 얻을 수 있는 유용한 방식 줌의 하나로 사료된다.

• 한국멀티미디어학회논문지
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• 제22권5호
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• pp.535-546
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• 2019

Recently, there have been a lot of researches on the whole face replacement system, but it is not easy to obtain stable results due to various attitudes, angles and facial diversity. To produce a natural synthesis result when replacing the face shown in the video image, technologies such as face area detection, feature extraction, face alignment, face area segmentation, 3D attitude adjustment and facial transposition should all operate at a precise level. And each technology must be able to be interdependently combined. The results of our analysis show that the difficulty of implementing the technology and contribution to the system in facial replacement technology has increased in facial feature point extraction and facial alignment technology. On the other hand, the difficulty of the facial transposition technique and the three-dimensional posture adjustment technique were low, but showed the need for development. In this paper, we propose four facial replacement models such as 2-D Faceswap, OpenPose, Deekfake, and Cycle GAN, which are suitable for the Cox platform. These models have the following features; i.e. these models include a suitable model for front face pose image conversion, face pose image with active body movement, and face movement with right and left side by 15 degrees, Generative Adversarial Network.

• Journal of Information Science Theory and Practice
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• 제10권3호
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• pp.40-56
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• 2022

This paper aims to implement a topic modeling technique for extracting the topics of online discussions among library professionals in India. Topic modeling is the established text mining technique popularly used for modeling text data from Twitter, Facebook, Yelp, and other social media platforms. The present study modeled the online discussions of Library and Information Science (LIS) professionals posted on Lis Links. The text data of these posts was extracted using a program written in R using the package "rvest." The data was pre-processed to remove blank posts, posts having text in non-English fonts, punctuation, URLs, emails, etc. Topic modeling with the Latent Dirichlet Allocation algorithm was applied to the pre-processed corpus to identify each topic associated with the posts. The frequency analysis of the occurrence of words in the text corpus was calculated. The results found that the most frequent words included: library, information, university, librarian, book, professional, science, research, paper, question, answer, and management. This shows that the LIS professionals actively discussed exams, research, and library operations on the forum of Lis Links. The study categorized the online discussions on Lis Links into ten topics, i.e. "LIS Recruitment," "LIS Issues," "Other Discussion," "LIS Education," "LIS Research," "LIS Exams," "General Information related to Library," "LIS Admission," "Library and Professional Activities," and "Information Communication Technology (ICT)." It was found that the majority of the posts belonged to "LIS Exam," followed by "Other Discussions" and "General Information related to the Library."

• 산업진흥연구
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• 제7권3호
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• pp.93-102
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• 2022

본 연구는 오프라인대학 35개와 사이버대학 20개의 상담 관련 학과 커리큘럼을 분석하여 개선점과 발전방향을 분석하는데 그 목적이 있다. 교육과정은 교육목표, 개설 과목, 실습, 운영과정을 분석하였다. 연구 결과 '상담' 용어를 사용하는 학과의 교육목표에서 '전문상담인, 심리전문가, 전문상담자'의 용어가 가장 높은 빈도로 사용되고 있었다. 교과목에서는 상담학 기초영역은 1학년, 상담이론과 기법 영역은 2학년, 심리평가 3학년, 통계 및 연구 2학년, 상담실습 4학년에서 가장 많이 개설되어 있었다. 실습기초는 상담이론과 실제, 상담과정과 면담기법은 저학년에서 운영되고 있으며, 상담실습, 수퍼비전, 상담실습 및 사례연구, 국내외 인턴십은 4학년에서 대부분 운영되고 있었다. 이상을 토대로 오프라인대학과 온라인대학 '상담' 용어를 사용하는 학과의 커리큘럼의 개선점 및 발전방향을 논의하겠다.

• Restorative Dentistry and Endodontics
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• 제47권2호
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• pp.15.1-15.18
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• 2022

This review aimed to characterize the effect of direct restorative material types and adhesive protocols on marginal adaptation and the bond strength of the interface between the material and the proximal dentin/cementum. An electronic search of 3 databases (the National Library of Medicine [MEDLINE/PubMed], Scopus, and ScienceDirect) was conducted. Studies were included if they evaluated marginal adaptation or bond strength tests for proximal restorations under the cementoenamel junction. Only 16 studies met the inclusion criteria and were included in this review. These studies presented a high degree of heterogeneity in terms of the materials used and the methodologies and evaluation criteria of each test; therefore, only a descriptive analysis could be conducted. The included studies were individually evaluated for the risk of bias following predetermined criteria. To summarize the results of the included studies, the type of restorative material affected the test results, whereas the use of different adhesive protocols had an insignificant effect on the results. It could be concluded that various categories of resin-based composites could be a suitable choice for clinicians to elevate proximal dentin/cementum margins, rather than the open sandwich technique with resin-modified glass ionomers. Despite challenges in bonding to proximal dentin/cementum margins, different adhesive protocols provided comparable outcomes.

• 한국산업보건학회지
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• 제33권4호
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• pp.419-426
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• 2023

Objectives: This study aims to develop an Occupational Safety and Health (OSH) guide for the safe cleaning of contaminated machinery, equipment, and parts used in the electronics manufacturing process. Methods: A literature review, field investigations, and discussions were conducted. An initial draft of an OSH guide was developed and reviewed by experts with significant experience in maintenance work in the electronics manufacturing process in order to refine the guide. Results: Workers involved in cleaning processes with chemicals, solvents, and abrasive blasting can face exposure to a wide range of chemicals, abrasives, and noise. Identifying potential risks associated with each cleaning technique was an essential first step toward enhancing safety measures. The OSH guide comprises approximately eleven to twelve sections spanning 20-25 pages. It includes engineering and administrative protocols systematically organized to address the necessary actions before, during, and after cleaning tasks, depending on the technique. It is recommended that airline respirator masks be used in conjunction with an air purification system to ensure adherence to air quality standard "D" for atmosphere level. The use of an oil-free air compressor is advised, preferably a stationary model that does not rely on fuel sources like diesel. Conclusions: This OSH guide is designed to protect workers involved in maintenance activity in the electronics industry and aligns with global standards, such as those from the International Organization for Standardization (ISO) and Semiconductor Equipment and Material International, ensuring a higher level of safety and compliance.